scholarly journals Meniscal degeneration

2018 ◽  
Author(s):  
David Luong ◽  
Yuranga Weerakkody
Keyword(s):  
Meniscal Degeneration

scholarly journals Analysis of meniscal degeneration and meniscal gene expression

2010 ◽  
Vol 11 (1) ◽  
Author(s):  
Yubo Sun ◽  
David R Mauerhan ◽  
Patrick R Honeycutt ◽  
Jeffrey S Kneisl ◽  
James H Norton ◽  
...  
Keyword(s):  
Gene Expression ◽  
Meniscal Degeneration

scholarly journals An animal model study on the gene expression profile of meniscal degeneration

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Yehan Fang ◽  
Hui Huang ◽  
Gang Zhou ◽  
Qinghua Wang ◽  
Feng Gao ◽  
...  
Keyword(s):  
Gene Expression ◽  
Pathway Analysis ◽  
Molecular Mechanisms ◽  
Expression Patterns ◽  
Control Group ◽  
Ion Binding ◽  
Endoplasmic Reticulum Membrane ◽  
Rt Pcr ◽  
Go Analysis ◽  
Meniscal Degeneration

AbstractMeniscal degeneration is a very common condition in elderly individuals, but the underlying mechanisms of its occurrence are not completely clear. This study examines the molecular mechanisms of meniscal degeneration. The anterior cruciate ligament (ACL) and lateral collateral ligament (LCL) of the right rear limbs of seven Wuzhishan mini-pigs were resected (meniscal degeneration group), and the left rear legs were sham-operated (control group). After 6 months, samples were taken for gene chip analysis, including differentially expressed gene (DEG) analysis, gene ontology (GO) analysis, clustering analysis, and pathway analysis. The selected 12 DEGs were validated by real time reverse transcription-polymerase chain reaction (RT-PCR). The two groups showed specific and highly clustered DEGs. A total of 893 DEGs were found, in which 537 are upregulated, and 356 are downregulated. The GO analysis showed that the significantly affected biological processes include nitric oxide metabolic process, male sex differentiation, and mesenchymal morphogenesis, the significantly affected cellular components include the endoplasmic reticulum membrane, and the significantly affected molecular functions include transition metal ion binding and iron ion binding. The pathway analysis showed that the significantly affected pathways include type II diabetes mellitus, inflammatory mediator regulation of TRP channels, and AMPK signaling pathway. The results of RT-PCR indicate that the microarray data accurately reflects the gene expression patterns. These findings indicate that several molecular mechanisms are involved in the development of meniscal degeneration, thus improving our understanding of meniscal degeneration and provide molecular therapeutic targets in the future.

Dose-Dependent Effects of Interleukin-1Alpha on Functional Degradation of Lateral and Medial Menisci

2010 ◽  
Author(s):  
Carrie H. Ling ◽  
Janice H. Lai ◽  
James F. Nishimuta ◽  
Marc E. Levenston
Keyword(s):  
Interleukin 1 ◽  
Cartilage Degeneration ◽  
Meniscal Extrusion ◽  
Knee Oa ◽  
Degenerative Lesion ◽  
Disease Modifying Treatment ◽  
Dose Dependent ◽  
Meniscal Degeneration ◽  
Pro Inflammatory Cytokines

Despite a growing recognition that meniscal degeneration often precedes cartilage degeneration in the development of knee osteoarthritis (OA), little is known about the role of meniscal degeneration in the onset and progression of knee OA. Even a mild degenerative lesion increases meniscal extrusion, implying changes in biomechanical function. Understanding the mechanisms of meniscal degeneration may enable the diagnosis and disease-modifying treatment of early knee OA, potentially preventing or slowing the progression of the disease. The roles of pro-inflammatory cytokines such as interleukin-1 (IL-1) in promoting cartilage matrix degradation and mediating inflammation in the progression of OA have been widely demonstrated [1,2]. Recent results from our group indicated that 20ng/ml hrIL-1α produced similar cell-mediated degradation and loss of mechanical properties in immature cartilage and meniscus, but progresses more rapidly in meniscus explants [3]. This study further explored the effects of IL-1α dosage and medial-lateral differences on the functional degradation of meniscal explants.

Relationship Between Meniscal Degeneration and Element Contents

2001 ◽  
Vol 79 (3) ◽  
pp. 247-256 ◽  
Author(s):  
Takashi Habata ◽  
Hajime Ohgushi ◽  
Yoshinori Takakura ◽  
Yoshiyuki Tohno ◽  
Yumi Moriwake ◽  
...  
Keyword(s):  
Element Contents ◽  
Meniscal Degeneration

The Updated Role of Ultrasound in the Assessment of Knee Osteoarthritis

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Khalid Esmat Alaam ◽  
Hazem Ibrahim Abd El Rahman ◽  
Nouran Saieed Ahmed
Keyword(s):  
Knee Osteoarthritis ◽  
Clinical Examination ◽  
Structural Damage ◽  
Cartilage Degeneration ◽  
University Hospitals ◽  
Meniscal Extrusion ◽  
Clinical Criteria ◽  
Knee Effusion ◽  
Monitoring Therapy ◽  
Meniscal Degeneration

Abstract Background Osteoarthritis (OA) of the knee is the most common form of knee arthritis and a leading cause of chronic disability. Objective The aim of the current study is to reassess the utility of the updated ultrasound in the patients with knee osteoarthritis and outline its clinical application. Patients and Methods The studied group included 36 patient 23females and 13 males with their ages ranged between 39 and 58 years (average age 44 years). The patients were referred to US examination fulfilling the ACR clinical criteria for knee OA after orthopedic and /or rheumatologist consultation. The study was performed in Radiodiagnosis department Ain Shams University Hospitals (20 patients ) and at one private center (16 patients). Results There was a discrepancy between the results obtained by clinical examination and those demonstrated by ultrasonography. Clinical examination detected 22 (61.1%) of our cases. Prevalence of US findings in our cases were femoral articular degeneration in 28 (77.7%) patients, Tibiofemoral osteophytes were seen in 26 patients (72.2%), knee effusion in 22 patients (61.1%),meniscal extrusion in 22 patients (61.1%) meniscal degeneration in 17 patients (47.2%) and synovial hypertrophy in 15patients (41.6%). Baker’s cysts were demonstrated in 14patients (38.8%) while pes anserine syndrome was demonstrated in 4 cases. Meniscal degeneration and meniscal extrusion were correlated significantly with femoral cartilage degeneration (P<.001). Although knee effusion did not correlate with advanced knee effusion did significantly (P > 0.05). Baker's cysts is statistically related to the presence and severity of mensical changes and also related to the degree of femoral articular cartilage degeneration. Conclusion US is a valuable technique that can assess soft tissue structures within the knee and their involvement in the osteoarthritic process .US enables in guiding and monitoring therapy through detection of knee structural damage.

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