scholarly journals Inferior cerebellar peduncle

2017 ◽  
Author(s):  
Craig Hacking ◽  
Callum Smith
Keyword(s):  
Cerebellar Peduncle ◽  
Inferior Cerebellar Peduncle

Plasticity of γ-aminobutyrate receptors in the medial vestibular nucleus of rat after inferior cerebellar peduncle transection

2002 ◽  
Vol 12 (1) ◽  
pp. 1-14
Author(s):  
Yizhe Sun ◽  
Donald A. Godfrey ◽  
Allan M. Rubin
Keyword(s):  
Vestibular Nucleus ◽  
Brain Slices ◽  
Medial Vestibular Nucleus ◽  
Grouped Data ◽  
Spontaneous Firing ◽  
Gaba A ◽  
Endogenous Gaba ◽  
Single Unit Recordings ◽  
Cerebellar Peduncle ◽  
Inferior Cerebellar Peduncle

Extracellular single unit recordings were made from regularly discharging medial vestibular nucleus neurons in brain slices from control rats and from rats surviving 7 days after bilateral transection of the inferior cerebellar peduncle. Decreases in firing rate during perfusion with the Îş-aminobutyric acid (GABA) agonists, muscimol (GABA A ) and baclofen (GABA B ), were greater in lesioned rats than in control rats. For the grouped data, the half-maximally-effective concentrations of muscimol and baclofen were 3.2 µM, as compared with 19.6 µM for control, and 0.8 µM, as compared with 2.7 µM for control, respectively. The antagonists bicuculline (GABA A ) and 2-OH-saclofen (GABA B ) only minimally affected the spontaneous firing rates of neurons in lesioned rats, significantly less than in control rats. The data suggest that the decreases of endogenous GABA levels in the medial vestibular nucleus after inferior cerebellar peduncle transection are accompanied by up-regulation of GABA A and, to a lesser extent, GABA B receptors.

Locomotor Adaptation Is Associated with Microstructural Properties of the Inferior Cerebellar Peduncle

2020 ◽  
Vol 19 (3) ◽  
pp. 370-382 ◽  
Author(s):  
Sivan Jossinger ◽  
Firas Mawase ◽  
Michal Ben-Shachar ◽  
Lior Shmuelof
Keyword(s):  
Microstructural Properties ◽  
Locomotor Adaptation ◽  
Cerebellar Peduncle ◽  
Inferior Cerebellar Peduncle

The Supratonsillar Approach to the Inferior Cerebellar Peduncle: Anatomy, Surgical Technique, and Clinical Application to Cavernous Malformations

2006 ◽  
Vol 59 (suppl_4) ◽  
pp. ONS-244-ONS-252 ◽  
Author(s):  
Michael T. Lawton ◽  
Alfredo Quiñones-Hinojosa ◽  
Peter Jun
Keyword(s):  
Surgical Technique ◽  
Surgical Approach ◽  
Fourth Ventricle ◽  
Cerebellar Tonsil ◽  
Cavernous Malformations ◽  
Suboccipital Craniotomy ◽  
Cerebellar Tissue ◽  
Cerebellar Peduncle ◽  
Arteries And Veins ◽  
Inferior Cerebellar Peduncle

Abstract OBJECTIVE: To introduce the supratonsillar approach, an approach that traverses the tonsillobiventral fissure in a trajectory over the cerebellar tonsil to the inferior cere-bellar peduncle, and to demonstrate the utility of this approach for resecting peduncular cavernous malformations. METHODS: Anatomy of the cerebellar tonsil and surrounding fissures, arteries, and veins are reviewed using cadaveric brain specimens. The surgical approach uses the three-quarter prone position, a suboccipital craniotomy, and wide splitting of the tonsillobiventral fissure. RESULTS: Of our experience with 171 patients with cavernous malformations, six patients had lesions in the inferior cerebellar peduncle that were resected using the supratonsillar approach. All cavernous malformations were removed completely and no patients experienced surgical complications or new deficits. @@CONCLUSION:@@ The supratonsillar approach differs from the transvermian and telove-lar approaches to the fourth ventricle, with a more superolateral trajectory that leads instead to the inferior cerebellar peduncle. By splitting the tonsillobiventral fissure and mobilizing the tonsil inferomedially, the point of access to the lesion is deepened and transgression of normal cerebellar tissue is minimized. This elegant approach is ideally suited to the removal of cavernous malformations.

Lateral inferior cerebellar peduncle approach to dorsolateral medullary cavernous malformation

2014 ◽  
Vol 121 (3) ◽  
pp. 723-729 ◽  
Author(s):  
Vivek R. Deshmukh ◽  
Leonardo Rangel-Castilla ◽  
Robert F. Spetzler
Keyword(s):  
Cavernous Malformation ◽  
Case Series ◽  
Cavernous Malformations ◽  
Excellent Outcome ◽  
Suboccipital Craniotomy ◽  
Scale Scores ◽  
Far Lateral ◽  
Cerebellar Peduncle ◽  
Inferior Cerebellar Peduncle ◽  
Foramen Of Luschka

Object Brainstem cavernous malformations (BSCMs) present a unique therapeutic challenge to neurosurgeons. Resection of BSCMs is typically reserved for lesions that reach pial or ependymal surfaces. The current study investigates the lateral inferior cerebellar peduncle as a corridor to dorsolateral medullary BSCMs. Methods In this retrospective review, the authors present the cases of 4 patients (3 women and 1 man) who had a symptomatic dorsolateral cavernous malformation with radiographic and clinical evidence of hemorrhage. Results All patients underwent excision of the cavernous malformation via a far-lateral suboccipital craniotomy through the foramen of Luschka and with an incision in the inferior cerebellar peduncle. On intraoperative examination, 2 of the 4 patients had hemosiderin staining on the surface of the peduncle. All lesions were completely excised and all patients had a good or excellent outcome (modified Rankin Scale scores of 0 or 1). Conclusions This case series illustrates that intrinsic lesions of the dorsolateral medulla can be safely removed laterally through the foramen of Luschka and the inferior cerebellar peduncle.

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