scholarly journals Lactate peak

2014 ◽  
Author(s):  
Andrew Murphy ◽  
Frank Gaillard
Keyword(s):  
Lactate Peak

Contribution of advanced MRI to the diagnosis of giant tumefactive perivascular spaces

2021 ◽  
pp. 028418512110472
Author(s):  
Veysel Ayyildiz ◽  
Ali Koksal ◽  
Onur Taydas ◽  
Hayri Ogul
Keyword(s):  
Mr Spectroscopy ◽  
Mr Angiography ◽  
Diffusion Tensor ◽  
Perivascular Spaces ◽  
Cerebral Lesions ◽  
Contrast Enhanced ◽  
Cerebral Mri ◽  
Mri Sequences ◽  
Perfusion Mr ◽  
Lactate Peak

Background Giant tumefactive perivascular spaces (PVSs) are uncommon benign cystic lesions. They can imitate cystic neoplasms. Purpose To evaluate the contribution of advanced neuro magnetic resonance imaging (MRI) techniques in the diagnosis of giant tumefactive PVSs and to further characterize these unusual cerebral lesions. Material and Methods The MRI scans of patients with tumefactive PVS diagnosed between 2010 and 2019 were retrospectively reviewed. All imaging studies included three plane conventional cerebral MRI sequences as well as precontrast 3D T1 MPRAGE, post-gadolinium 3D T1 acquisitions, sagittal plane 3D T2 SPACE, diffusion-weighted imaging, and time-of-flight (TOF) angiography. Some patients received perfusion MR, MR spectroscopy, diffusion tensor imaging (DTI), and contrast-enhanced TOF MR angiography. Results A perforating vessel was demonstrated in 16 patients (66.7%) by TOF imaging. In four patients, there were intracystic vascular collaterals on contrast-enhanced TOF MR angiography. Septal blooming was observed in four patients in susceptibility-weighted imaging. On perfusion MR, central hyperperfusion was observed in four patients, and peripheral hyperperfusion was observed in one patient. On MR spectroscopy, choline increase was observed in two patients, and there was a lactate peak in three patients, and both a choline increase and lactate peak in one patient. On DTI, there was fiber distortion in five patients and fiber deformation in one patient. Conclusion Advanced MRI techniques and 3D volumetric high-resolution MRI sequences can provide a valuable contribution to the diagnosis and can be successfully used in the management of these lesions.

scholarly journals Lactate peak on brain MRS in children with syndromic mitochondrial diseases

2011 ◽  
Vol 74 (7) ◽  
pp. 305-309 ◽  
Author(s):  
Ching-Shiang Chi ◽  
Hsiu-Fen Lee ◽  
Chi-Ren Tsai ◽  
Wen-Shien Chen ◽  
Jai-Nien Tung ◽  
...  
Keyword(s):  
Mitochondrial Diseases ◽  
Lactate Peak

scholarly journals In vivo Assessment of Focal Brain Lactate Alterations with NMR Proton Spectroscopy

1988 ◽  
Vol 8 (2) ◽  
pp. 208-214 ◽  
Author(s):  
C. C. Hanstock ◽  
D. P. J. Boisvert ◽  
M. R. Bendall ◽  
P. S. Allen
Keyword(s):  
Pulse Sequence ◽  
Spin Echo ◽  
Resonance Region ◽  
Surface Coil ◽  
Spectral Difference ◽  
In Vivo Evaluation ◽  
Similar Frequency ◽  
Cold Lesion ◽  
Lactate Peak

Spectral editing techniques and localization of 1H signals were applied to monitor lactate accumulation in a circumscribed region of brain damage. The experiments were performed at 2.35 T (100 MHz) in a 40-cm bore magnet. Following unilateral craniectomy in anesthetized adult cats, a two-turn surface coil was positioned over the dural surface. Proton spectra were obtained before and 1–5 h after production of a cortical cold lesion from three curved shells of brain tissue, each ∼3 mm thick. The localized spectrum was obtained from each region with and without spectral difference editing for the lactate CH3 protons, but always with the maximum excitation produced by the semiselective binomial pulse centered on the lactate CH3 resonance. Region 1 represented the damaged area, Region 2 was located immediately below Region 1, and Region 3 was immediately below Region 2. Spin-echo magnetic resonance imaging was used to confirm the relationship between the location of the lesion and the regions from which the spectra were obtained. Spectra obtained without lactate editing showed, in addition to the N-acetylaspartate peak, a large lactate peak in Region 1 after production of the cold lesion. In Regions 2 and 3, changes in lactate were more difficult to assess owing to the presence of a lipid peak at a similar frequency that results from incomplete suppression by the spin-echo pulse sequence alone. Spectra acquired using lactate editing did not contain the lipid peak and clearly showed relatively small lactate accumulations in Regions 2 and 3. Examination of signal intensity profiles through brain images upon which the region of spectral acquisition was highlighted revealed a good consistency between the position of the spectral acquisition region and the appearance of a lactate peak in the spectra. Our results demonstrate that spectrally selective, localized 1H spectra can be obtained for the in vivo evaluation of changes in a single resonance, in this case lactate, which are associated with focal surface lesions of the brain. Moreover, by utilizing a combination of localized spectroscopy and imaging, the anatomical content of the region of spectral acquisition is known.

scholarly journals Lactate Accumulation during Moderate Hypoxic Hypoxia in Neocortical Rat Brain

1996 ◽  
Vol 16 (6) ◽  
pp. 1345-1352 ◽  
Author(s):  
Jean-François Payen ◽  
Emmanuelle LeBars ◽  
Bernard Wuyam ◽  
Bernard Tropini ◽  
Jean-Louis Pépin ◽  
...  
Keyword(s):  
Control Period ◽  
Relaxation Times ◽  
Significant Rise ◽  
Hypoxic Hypoxia ◽  
Metabolic Effects ◽  
Marked Rise ◽  
Arterial Lactate ◽  
Apparent Decrease ◽  
Lactate Infusion ◽  
Lactate Peak

Neocortical metabolism was studied during moderate hypoxic hypoxia, reoxygenation, and postmortem periods in anesthetized normocapnic rats using 1H nuclear magnetic resonance (NMR) spectroscopic imaging. Rats were prepared with unilateral common carotid occlusion to determine the ipsilateral metabolic effects of inadequate cerebral blood flow (CBF) response to hypoxia. No difference in brain metabolism between the two hemispheres was found during the control period. Hypoxic hypoxia (Pao2 = 54.1 ± 5.8 mm Hg) resulted in a significant rise in neocortical lactate peak in both hemispheres, with an additional marked rise in the clamped side compared to the unclamped side (53 ± 27 vs. 22 ± 13% of postmortem value, p < 0.001). These lactate changes were not reversible within 30 min of reoxygenation in the clamped hemisphere. No changes in neocortical lactate peak were observed while elevating arterial lactate via intravenous lactate infusion without hypoxia. In addition, hypoxic hypoxia resulted in an apparent decrease in neocortical water and N-acetyl aspartate (NAA) signals, which were related to a shortening in T2 relaxation times. It is concluded that neocortical lactate is an early metabolic indicator during moderate hypoxic hypoxia in normocapnic conditions.

Posterior Fossa Tuberculous Abscess Mimicking as Mass Lesions. MRI Features

2005 ◽  
Vol 18 (2) ◽  
pp. 180-184
Author(s):  
N.K. Bodhey ◽  
S. Purkayastha ◽  
A.K. Gupta
Keyword(s):  
Posterior Fossa ◽  
Mr Spectroscopy ◽  
Antituberculous Therapy ◽  
Mri Features ◽  
Tuberculous Lesion ◽  
Tuberculous Abscess ◽  
Neoplastic Lesions ◽  
Mass Lesions ◽  
The Brain ◽  
Lactate Peak

With rising incidences of immunosuppression including HIV infection and various other factors, a resurgence of tuberculosis has been observed. We herewith describe two cases of posterior fossa tuberculomas with presentation mimicking mass lesions. Tuberculomas in the brain are not uncommon in the developing countries. Although they can mimic neoplastic lesions, the early diagnosis of tuberculous lesion with MRI and MR spectroscopy results in prompt institution of antituberculous therapy. Hypointensity in T2-weighted sequence with ring enhancement and the presence of a prominent lipid-lactate peak on MR spectroscopy is highly suggestive of the tuberculous nature of the lesion.

scholarly journals Does MRS Lactate Peak Correlate with Lactate in the CSF and Blood?

2015 ◽  
Vol 04 (01) ◽  
pp. 001-006 ◽  
Author(s):  
Simone Shibao ◽  
Maria Otaduy ◽  
Fernando Kok ◽  
Claudia Leite
Keyword(s):  
Lactate Peak

scholarly journals Lactate peak in muscle disclosed by magnetic resonance spectroscopy in a patient with CPEO-plus syndrome

2021 ◽  
pp. 100360
Author(s):  
Sung-Pin Fan ◽  
Hsueh-Wen Hsueh ◽  
Hsin-Chieh Huang ◽  
Koping Chang ◽  
Ni-Chung Lee ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Resonance Spectroscopy ◽  
Lactate Peak

Role of microtubules in the regulation of metabolism in isolated cerebral microvessels

1999 ◽  
Vol 277 (6) ◽  
pp. C1250-C1262 ◽  
Author(s):  
Pamela G. Lloyd ◽  
Christopher D. Hardin
Keyword(s):  
Carbohydrate Metabolism ◽  
Lactate Production ◽  
Glycolytic Enzymes ◽  
Microtubule Assembly ◽  
Control Treatment ◽  
Resonance Spectroscopy ◽  
Glycolytic Intermediate ◽  
Cerebral Microvessels ◽  
Peak Intensity ◽  
Lactate Peak

We used13C-labeled substrates and nuclear magnetic resonance spectroscopy to examine carbohydrate metabolism in vascular smooth muscle of freshly isolated pig cerebral microvessels (PCMV). PCMV utilized [2-13C]glucose mainly for glycolysis, producing [2-13C]lactate. Simultaneously, PCMV utilized the glycolytic intermediate [1-13C]fructose 1,6-bisphosphate (FBP) mainly for gluconeogenesis, producing [1-13C]glucose with only minor [3-13C]lactate production. The dissimilarity in metabolism of [2-13C]FBP derived from [2-13C]glucose breakdown and metabolism of exogenous [1-13C]FBP demonstrates that carbohydrate metabolism is compartmented in PCMV. Because glycolytic enzymes interact with microtubules, we disrupted microtubules with vinblastine. Vinblastine treatment significantly decreased [2-13C]lactate peak intensity (87.8 ± 3.7% of control). The microtubule-stabilizing agent taxol also reduced [2-13C]lactate peak intensity (90.0 ± 2.4% of control). Treatment with both agents further decreased [2-13C]lactate production (73.3 ± 4.0% of control). Neither vinblastine, taxol, or the combined drugs affected [1-13C]glucose peak intensity (gluconeogenesis) or disrupted the compartmentation of carbohydrate metabolism. The similar effects of taxol and vinblastine, drugs that have opposite effects on microtubule assembly, suggest that they produce their effects on glycolytic rate by competing with glycolytic enzymes for binding, not by affecting the overall assembly state of the microtubule network. Glycolysis, but not gluconeogenesis, may be regulated in part by glycolytic enzyme-microtubule interactions.

Radiological and Immunostaining Characteristics of H3.3 G34R-Mutant Glioma: A Report of 3 Cases and Review of the Literature

2020 ◽  
Vol 55 (5) ◽  
pp. 319-325
Author(s):  
Shumpei Onishi ◽  
Vishwa Jeet Amatya ◽  
Vega Karlowee ◽  
Yukio Takeshima ◽  
Kazuhiko Sugiyama ◽  
...  
Keyword(s):  
Marked Decrease ◽  
High Grade Glioma ◽  
Histopathological Diagnosis ◽  
Review Of The Literature ◽  
Case Presentation ◽  
Idh1 R132h ◽  
P53 Antibodies ◽  
Single Voxel ◽  
Lactate Peak ◽  
Pyrosequencing Analysis

<b><i>Introduction:</i></b> H3.3 G34R/V mutation is predominantly identified in the supratentorial nonmidline tumors. However, this tumor is not yet categorized as an entity in 2016 WHO CNS classification. More information is necessary to further determine the characteristics of this tumor. <b><i>Case Presentation:</i></b> Three cases of adolescent hemispheric glioma were treated in our institution. All tumors showed the characteristics of huge tumor size with mild peritumoral edema on T2WI/FLAIR, hyperintense on DWI, and slight partial enhancement by gadolinium. The single-voxel proton MR spectroscopy revealed characteristics of high choline peak, marked decrease in N-acetyl aspartate peak, and small lactate peak. The histopathological diagnosis, based on 2007 WHO CNS classification, was high-grade glioma in 2 cases and a PNET. Immuno­staining revealed that the tumor cells were positive against H3.3 G34R, H3K27me3, and p53 antibodies and negative against H3K27M, IDH1-R132H, ATRX, and Olig2 antibodies. Pyrosequencing analysis confirmed H3.3 G34R mutation, IDH-wildtype, and BRAF-wildtype. <b><i>Conclusion:</i></b> Radiological and immunostaining findings are characteristic in our 3 cases of H3.3 G34-mutant glioma. It is essential to consider H3.3 G34-mutant glioma as a differential diagnosis particularly in pediatric and adolescents and young adult hemispheric tumors.

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