scholarly journals Thymic rebound hyperplasia

2013 ◽  
Author(s):  
Yuranga Weerakkody ◽  
David Clopton
Keyword(s):  
Thymic Rebound

Thymic rebound after treatment of childhood tumors

1980 ◽  
Vol 135 (1) ◽  
pp. 151-156 ◽  
Author(s):  
M Cohen ◽  
CA Hill ◽  
A Cangir ◽  
MP Sullivan
Keyword(s):  
Childhood Tumors ◽  
Thymic Rebound

Positive gallium-67 and thallium-201 scans in thymic rebound after chemotherapy for lymphoma

2006 ◽  
Vol 20 (2) ◽  
pp. 161-163 ◽  
Author(s):  
Shiro Akaki ◽  
Takayoshi Shinya ◽  
Shuhei Sato ◽  
Masahiro Kuroda ◽  
Susumu Kanazawa
Keyword(s):  
Thallium 201 ◽  
Thymic Rebound ◽  
Gallium 67

CASE 127: THYMIC REBOUND

2016 ◽  
pp. 165-165
Author(s):  
Munir Ghesani ◽  
Nasrin Ghesani ◽  
E DePuey ◽  
Amir Kashefi ◽  
Yi Zhang
Keyword(s):  
Thymic Rebound

Recovery of immune reactivity after T-cell–depleted bone marrow transplantation depends on thymic activity

Blood ◽  
2000 ◽  
Vol 96 (6) ◽  
pp. 2299-2303 ◽  
Author(s):  
Etienne Roux ◽  
Florence Dumont-Girard ◽  
Michel Starobinski ◽  
Claire-Anne Siegrist ◽  
Claudine Helg ◽  
...  
Keyword(s):  
Bone Marrow ◽  
T Cells ◽  
T Cell ◽  
Young Patients ◽  
Immune Reactivity ◽  
Normal Numbers ◽  
Cell Repertoire ◽  
Naive T Cells ◽  
Naïve T Cells ◽  
Thymic Rebound

To evaluate the importance of the thymus for the reconstitution of immunity in recipients of a T-cell–depleted bone marrow, we measured the appearance of CD4+CD45RA+RO−naive T cells (thymic rebound), restoration of the diversity of the T-cell–receptor (TCR) repertoire and the response to vaccinations with tetanus toxoid (TT). Repopulation by CD4+CD45RA+RO− thymic emigrants varied among patients, starting at approximately 6 months after transplantation. Young patients reconstituted swiftly, whereas in older patients, the recovery of normal numbers of naive CD4+ T cells could take several years. Restoration of TCR diversity was correlated with the number of naive CD4+CD45RA+RO− T cells. Moreover, the extent of the thymic rebound correlated with the patient's capacity to respond to vaccinations. Patients without a significant thymic rebound at the moment of vaccination (CD4+CD45RA+RO− T cells less than 30 μL) did not respond, or responded only marginally even after 3 boosts with TT. We conclude that during the first year after transplantation, the absence of an immune response is due mainly to the loss of an adequate T-cell repertoire. Restoration of the repertoire can come only from a thymic rebound that can be monitored by measuring the increase of CD4+CD45RA+RO−naive T cells. This will allow postponing revaccinations to a moment when the patient will be able to respond more effectively. This may be particularly useful in the elderly patient who, owing to low thymic activity, might not yet be able to respond 1 year after transplant when revaccinations are usually scheduled.

Cervical thymic rebound after cancer treatment

2005 ◽  
Vol 40 (7) ◽  
pp. 1188-1190 ◽  
Author(s):  
Kerry Bergman ◽  
Robyn Murphy ◽  
Michelle Miller
Keyword(s):  
Cancer Treatment ◽  
After Cancer ◽  
Thymic Rebound

Gallium 67 Uptake in Thymic Rebound

1988 ◽  
Vol 81 (9) ◽  
pp. 1167-1169 ◽  
Author(s):  
ROBERT HURST ◽  
HERNAN SABIO ◽  
CHARLES D. TEATES
Keyword(s):  
Thymic Rebound ◽  
Gallium 67

scholarly journals Intrathymic Deletion of IL-7 Reveals a Contribution of the Bone Marrow to Thymic Rebound Induced by Androgen Blockade

2018 ◽  
Vol 200 (4) ◽  
pp. 1389-1398 ◽  
Author(s):  
Pedro M. Rodrigues ◽  
Ana R. Ribeiro ◽  
Nicolas Serafini ◽  
Catarina Meireles ◽  
James P. Di Santo ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Thymic Rebound ◽  
Androgen Blockade

Recovery of immune reactivity after T-cell–depleted bone marrow transplantation depends on thymic activity

Blood ◽  
2000 ◽  
Vol 96 (6) ◽  
pp. 2299-2303 ◽  
Author(s):  
Etienne Roux ◽  
Florence Dumont-Girard ◽  
Michel Starobinski ◽  
Claire-Anne Siegrist ◽  
Claudine Helg ◽  
...  
Keyword(s):  
Bone Marrow ◽  
T Cells ◽  
T Cell ◽  
Young Patients ◽  
Immune Reactivity ◽  
Normal Numbers ◽  
Cell Repertoire ◽  
Naive T Cells ◽  
Naïve T Cells ◽  
Thymic Rebound

Abstract To evaluate the importance of the thymus for the reconstitution of immunity in recipients of a T-cell–depleted bone marrow, we measured the appearance of CD4+CD45RA+RO−naive T cells (thymic rebound), restoration of the diversity of the T-cell–receptor (TCR) repertoire and the response to vaccinations with tetanus toxoid (TT). Repopulation by CD4+CD45RA+RO− thymic emigrants varied among patients, starting at approximately 6 months after transplantation. Young patients reconstituted swiftly, whereas in older patients, the recovery of normal numbers of naive CD4+ T cells could take several years. Restoration of TCR diversity was correlated with the number of naive CD4+CD45RA+RO− T cells. Moreover, the extent of the thymic rebound correlated with the patient's capacity to respond to vaccinations. Patients without a significant thymic rebound at the moment of vaccination (CD4+CD45RA+RO− T cells less than 30 μL) did not respond, or responded only marginally even after 3 boosts with TT. We conclude that during the first year after transplantation, the absence of an immune response is due mainly to the loss of an adequate T-cell repertoire. Restoration of the repertoire can come only from a thymic rebound that can be monitored by measuring the increase of CD4+CD45RA+RO−naive T cells. This will allow postponing revaccinations to a moment when the patient will be able to respond more effectively. This may be particularly useful in the elderly patient who, owing to low thymic activity, might not yet be able to respond 1 year after transplant when revaccinations are usually scheduled.

Thymic Rebound in a Patient with Scrotal Mesothelioma

1994 ◽  
Vol 9 (3) ◽  
pp. 145-147 ◽  
Author(s):  
Michael C. Wenger ◽  
Allen J. Cohen ◽  
Fred Greensite
Keyword(s):  
Thymic Rebound

Thymic rebound following successful chemotherapy of B-lymphoma in an adolescent boy

1992 ◽  
Vol 151 (2) ◽  
pp. 95-97 ◽  
Author(s):  
K. Leibundgut ◽  
U. Willi ◽  
H. -J. Plüss
Keyword(s):  
B Lymphoma ◽  
Thymic Rebound
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