History of Botulinum Toxin Treatment in Movement Disorders

Thoracic outlet syndrome (TOS) is frequently caused by bone abnormalities and congenital or acquired soft-tissue alterations. Among these, isolated Subclavius Muscle (SM) hypertrophy represents a rare condition that could lead to a reduction in costoclavicular space and brachial plexus compression. A 47-year-old forest ranger with a history of gun shooting during animal hunting and training sessions of skeet shooting for 20 years developed TOS due to ultrasonography-detected isolated SM hypertrophy, successfully treated with an ultrasound-guided Botulinum Toxin (BTX)-A injection. In our patient, ultrasonography of the brachial plexus has allowed SM hypertrophy to be recognized and to perform BTX-A injection just in the muscle, with a complete resolution of the symptoms.

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Clinical features and treatment with botulinum toxin in blepharospasm: a 17-year experience

Arquivos de Neuro-Psiquiatria ◽

10.1590/s0004-282x2012000900003 ◽

2012 ◽

Vol 70 (9) ◽

pp. 662-666 ◽

Cited By ~ 2

Author(s):

Camila Catherine Aquino ◽

Andre C. Felício ◽

Pollyanna Celso Felipe de Castro ◽

Ricardo Araujo Oliveira ◽

Sonia Maria Cesar Azevedo Silva ◽

...

Keyword(s):

Botulinum Toxin ◽

Clinical Features ◽

Age Of Onset ◽

Smoking History ◽

Clinical Aspects ◽

Lower Face ◽

Therapeutic Outcomes ◽

History Of ◽

Botulinum Toxin Treatment ◽

The Mean

OBJECTIVE: It was to analyze clinical aspects of patients with blepharospasm, including outcomes of botulinum toxin treatment. Additionally, clinical characteristics of isolated blepharospasm were compared to those of blepharospasm plus other movement disorders. METHODS: Clinical data recorded during 17 years were reviewed. The variables included age, gender, age of onset, past medical history, head trauma, smoking history, family history of dystonia, severity, duration of botulinum toxin relief and adverse effects. RESULTS: A total of 125 patients were included and 75.2% were female. The mean age of onset was 54.3 years; 89.6% of the individuals started with contractions in eye region, and 39.2% of them spread to lower face or neck. Isolated blepharospasm group was compared with blepharospasm-plus group for demographic and clinical features, and therapeutic outcomes, without significant differences. Botulinum toxin treatment improved the severity of contractions (p=0.01) with low rate of side effects (14%). CONCLUSIONS: Both groups - isolated blepharospasm and blepharospasm-plus - shared similar results concerning epidemiology, clinical features and therapeutic response to botulinum toxin.

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Laryngeal electromyography in movement disorders: preliminary data

Arquivos de Neuro-Psiquiatria ◽

10.1590/s0004-282x2004000400034 ◽

2004 ◽

Vol 62 (3a) ◽

pp. 741-744 ◽

Cited By ~ 5

Author(s):

Paulo A.T. Kimaid ◽

Elizabeth M.A.B. Quagliato ◽

Agrício N. Crespo ◽

Aline Wolf ◽

Maura A. Viana ◽

...

Keyword(s):

Botulinum Toxin ◽

Tourette Syndrome ◽

Movement Disorders ◽

Preliminary Data ◽

Spasmodic Dysphonia ◽

Laryngeal Electromyography ◽

Botulinum Toxin Therapy ◽

Monopolar Electrodes ◽

Botulinum Toxin Treatment ◽

Vocal Tremor

This study describes preliminary laryngeal electromyography (LEMG) data and botulinum toxin treatment in patients with dysphonia due to movement disorders. Twenty-five patients who had been clinically selected for botulinum toxin administration were examined, 19 with suspected laryngeal dystonia or spasmodic dysphonia (SD), 5 with vocal tremor, and 1 with Gilles de la Tourette syndrome (GTS). LEMG evaluations were performed before botulinum toxin administration using monopolar electrodes. Electromyography was consistent with dystonia in 14 patients and normal in 5, and differences in frequency suggesting essential tremor in 3 and Parkinson tremors in 2. The different LEMG patterns and significant improvement in our patients from botulinum toxin therapy has led us to perform laryngeal electromyography as a routine in UNICAMP movement disorders ambulatory.

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