scholarly journals Analysis of the Mediatory Role of Collateral Behaviour, Using a Differential Reinforcement of Response Duration (DRRD) Schedule with External Cues, in the Dog

1988 ◽  
Vol 28 (2) ◽  
pp. 123
Author(s):  
Michel Mercier ◽  
Eric Chleide ◽  
Jacques Bruhwyler
Keyword(s):  
Differential Reinforcement ◽  
Response Duration ◽  
External Cues

The role of GABA-mediated inhibition in the rat ventral posterior medial thalamus. II. Differential effects of GABAA and GABAB receptor antagonists on responses of VPM neurons

1994 ◽  
Vol 71 (5) ◽  
pp. 1716-1726 ◽  
Author(s):  
S. M. Lee ◽  
M. H. Friedberg ◽  
F. F. Ebner
Keyword(s):  
Receptive Field ◽  
Gabab Receptor ◽  
Response Duration ◽  
Fold Increase ◽  
Gamma Aminobutyric Acid ◽  
Recording Conditions ◽  
Peripheral Areas ◽  
Gabab Receptor Antagonists ◽  
Spontaneous Firing Rate

1. Changes in the response properties of 106 ventral posterior medial (VPM) units were assessed after iontophoretic blockade of gamma-aminobutyric acid-A or -B (GABAA or GABAB) receptor-mediated inhibition using bicuculline methiodide (BIC) or 2-hydroxy-saclofen (2-OH-S), respectively. 2. The iontophoretic administration of either BIC or 2-OH-S did not alter significantly the average spontaneous firing rate of VPM neurons for current intensities between 40 and 80 nA. The presence of 10 mM 2-OH-S (60 nA) was effective in completely reversing the depressant effects of the selective GABAB receptor agonist, baclofen, on the spontaneous activity of VPM neurons. 3. The effect of BIC on whisker-evoked responses was a preferential enhancement in the responses elicited by the whisker giving rise to the highest probability response (center receptive field whisker or CRF). The effect of 2-OH-S (40-80 nA iontophoretic currents) was to increase the responsiveness of VPM neurons to the stimulation of whiskers in all parts of the receptive field (RF), although its influence was much more pronounced in the peripheral areas of the RF (surround receptive field whisker or SRF). This preferential enhancement of SRF-whisker responses after the blockade of GABAB receptor-mediated inhibition resulted in a 2.3-fold increase in the average RF size of VPM neurons; no statistically significant increases in the size of the RF were seen in the presence of BIC. 4. The primary influence of BIC and, to a lesser degree, 2-OH-S was to prolong the response duration of VPM neurons to CRF whisker stimulation. Under our recording conditions, approximately 25% of VPM neurons in normal animals responded with sustained discharges. In the presence of BIC and 2-OH-S, the percent of VPM units that could be classified as tonically responding increased to 82% and 67%, respectively. 5. The proportion of VPM neurons that was selective to the deflection of whiskers in a particular direction (87%) was not altered in the presence of BIC or 2-OH-S. 6. BIC was effective in antagonizing GABA-mediated inhibition within the first 40 ms of a stimulus; BIC was completely ineffective in reversing a late suppression seen between 80 and 140 ms. In contrast, no statistically significant changes in the initial GABA-mediated inhibition were seen in the presence of 2-OH-S, but 2-OH-S was partially effective in antagonizing the late suppression of responses in VPM neurons.(ABSTRACT TRUNCATED AT 400 WORDS)

scholarly journals A structured literature review on the role of mindfulness, mindful eating and intuitive eating in changing eating behaviours: effectiveness and associated potential mechanisms

2017 ◽  
Vol 30 (2) ◽  
pp. 272-283 ◽  
Author(s):  
Janet M. Warren ◽  
Nicola Smith ◽  
Margaret Ashwell
Keyword(s):  
Food Intake ◽  
Literature Review ◽  
Evidence Base ◽  
Normal Weight ◽  
Intuitive Eating ◽  
Mindful Eating ◽  
Eating Behaviours ◽  
External Cues ◽  
Structured Literature Review

AbstractThe role of mindfulness, mindful eating and a newer concept of intuitive eating in modulating eating habits is an area of increasing interest. In this structured literature review, a summary of the current evidence is presented, together with details of interventions undertaken and the tools to measure outcomes. It is broad in scope given the emerging evidence base in this area. The review yielded sixty-eight publications: twenty-three interventions in obese/overweight populations; twenty-nine interventions in normal-weight populations; sixteen observational studies, three of which were carried out in overweight/obese populations. Mindfulness-based approaches appear most effective in addressing binge eating, emotional eating and eating in response to external cues. There is a lack of compelling evidence for the effectiveness of mindfulness and mindful eating in weight management. Mindfulness-based approaches may prevent weight gain. Reduced food intake was seen in some of the studies in overweight and obese populations, but this was less apparent in the studies in normal-weight populations. The evidence base for intuitive eating is limited to date and further research is needed to examine its potential in altering eating behaviours. Mindfulness appears to work by an increased awareness of internal, rather than external, cues to eat. Mindfulness and mindful eating have the potential to address problematic eating behaviours and the challenges many face with controlling their food intake. Encouraging a mindful eating approach would seem to be a positive message to be included in general weight management advice to the public.

Anorexia Nervosa and Dysmorphobia

1986 ◽  
Vol 149 (6) ◽  
pp. 780-782 ◽  
Author(s):  
P. Sturmey ◽  
P. D. Slade
Keyword(s):  
Anorexia Nervosa ◽  
The Family ◽  
External Cues ◽  
History Of ◽  
Definition Of ◽  
Control Behaviour

Anorexia nervosa is frequently associated with neurotic traits and symptoms. The symptomatology and history of a housebound 20-year-old woman with anorexia nervosa and dysmorphophobia are described. The role of the family In maintaining the problems, use of external cues to control behaviour, overvalued somatic ideas and the definition of dysmorphophobia are discussed.

scholarly journals Nonmyeloablative allografting for newly diagnosed multiple myeloma: the experience of the Gruppo Italiano Trapianti di Midollo

Blood ◽  
2009 ◽  
Vol 113 (14) ◽  
pp. 3375-3382 ◽  
Author(s):  
Benedetto Bruno ◽  
Marcello Rotta ◽  
Francesca Patriarca ◽  
Daniele Mattei ◽  
Bernardino Allione ◽  
...  
Keyword(s):  
Chronic Gvhd ◽  
Human Leukocyte ◽  
Response Duration ◽  
Tumor Burden ◽  
New Drugs ◽  
Newly Diagnosed ◽  
Leukocyte Antigen ◽  
Total Body

Abstract Despite recent advances, allografting remains the only potential cure for myeloma. From July 1999 to June 2005, 100 newly diagnosed patients younger than 65 years were enrolled in a prospective multicenter study. First-line treatment included vincristin, adriamycin, and dexamethasone (VAD)–based induction chemotherapy, a cytoreductive autograft (melphalan 200 mg/m2) followed by a single dose of nonmyeloablative total body irradiation and allografting from an human leukocyte antigen (HLA)–identical sibling. Primary end points were the overall survival (OS) and event-free survival (EFS) from diagnosis. After a median follow-up of 5 years, OS was not reached, and EFS was 37 months. Incidences of acute and chronic graft-versus-host disease (GVHD) were 38% and 50%, respectively. Complete remission (CR) was achieved in 53% of patients. Profound cytoreduction (CR or very good partial remission) before allografting was associated with achievement of posttransplantation CR (hazard ratio [HR] 2.20, P = .03) and longer EFS (HR 0.33, P < .01). Conversely, development of chronic GVHD was not correlated with CR or response duration. This tandem transplantation approach allows prolonged survival and long-term disease control in patients with reduced tumor burden at the time of allografting. We are currently investigating the role of “new drugs” in intensifying pretransplantation cytoreduction and posttransplantation graft-versus-myeloma effects to further improve clinical outcomes. (http://ClinicalTrials.gov; NCT-00702247.)

The Utilization of External and Movement Cues in Simple Spatial Tasks by Blind and Sighted Children

Perception ◽  
1979 ◽  
Vol 8 (1) ◽  
pp. 11-20 ◽  
Author(s):  
Susanna Millar
Keyword(s):  
Visual Experience ◽  
Spatial Information ◽  
Spatial Position ◽  
Spatial Tasks ◽  
External Cues ◽  
Self Reference

The role of visual experience in coding spatial position by movements or by external cues was examined in simple (nonrotational) shift tasks with blind and sighted children. Age and the salience of external cues were also of interest. Results showed that the congenitally totally blind used movement cues significantly more even when external cues were present and prominent. The blind with minimal visual experience coded by external cues, but made errors beyond the age by which blindfolded sighted children performed correctly. It was argued that visual experience affects coding by drawing attention to external cues, and by providing more adequate spatial information than other sources usually available to the blind. In its absence, movement coding and self-reference can become preferred strategies.

The role of adventitious reinforcement during differential reinforcement of other behavior: A systematic replication

2020 ◽  
Vol 53 (4) ◽  
pp. 2440-2449
Author(s):  
Catalina N. Rey ◽  
Alison M. Betz ◽  
Andressa A. Sleiman ◽  
Toshikazu Kuroda ◽  
Christopher A. Podlesnik
Keyword(s):  
Differential Reinforcement ◽  
Adventitious Reinforcement ◽  
Systematic Replication

scholarly journals Calorie Restriction: Is AMPK a Key Sensor and Effector?

Physiology ◽  
2011 ◽  
Vol 26 (4) ◽  
pp. 214-224 ◽  
Author(s):  
Carles Cantó ◽  
Johan Auwerx
Keyword(s):  
Protein Kinase ◽  
Life Span ◽  
Calorie Restriction ◽  
Energy Availability ◽  
Beneficial Effects ◽  
Extend Life Span ◽  
Energy Sensor ◽  
External Cues ◽  
Amp Activated Protein Kinase

Dietary restriction can extend life span in most organisms tested to date, suggesting that mechanisms sensing nutrient and energy availability might regulate longevity. The AMP-activated protein kinase (AMPK) has emerged as a key energy sensor with the ability to transcriptionally reprogram the cell and metabolically adapt to external cues. In this review, we will discuss the possible role of AMPK in the beneficial effects of calorie restriction on health and life span.

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