scholarly journals Kartagener’s Syndrome: Situs Inversus, Chronic Sinusitis and Bronchiectasis

2016 ◽  
Vol 100 (1) ◽  
1953 ◽  
Vol 248 (17) ◽  
pp. 730-731 ◽  
Author(s):  
Melvin Katz ◽  
E. Edward Benzier ◽  
Louis Nangeroni ◽  
Benjamin Sussman

2018 ◽  
Vol 08 (04) ◽  
pp. 274-277
Author(s):  
Zeba Ahmed ◽  
Warda Waseem ◽  
Uroosa Saman

Kartagener's syndrome is a very rare congenital disease consists of a classic triad, sinusitis, situs inversus and bronchiectasis. Approximately one half of patients with primary ciliary dyskinesia have situs inversus and Kartagener syndrome. We are presenting a case of Kartagener’s syndrome in a 10-year-old boy presented with chronic sinusitis leading to bilateral multiple nasal polyposis. He also had situs inversus and chronic bronchiectasis. He had undergone surgery two years back for nasal polyposis but now again presenting as recurrent nasal polyposis. In order to prevent the dreadful complications correct diagnosis in early life is very important in such patients.


2010 ◽  
Vol 1 (1) ◽  
pp. 16-17
Author(s):  
Amit Nandan Dhar Dwivedi

We report a rare case of Kartagener's Syndrome, congenital variety of Primary Ciliary Dyskinesia (PCD) with infertility. The patient exhibited the classical triad of which was elucidated by Manes Kartagener in 1933. The frequency of KS in the United States is 1 case per 32,000 live births. Situs inversus occurs randomly in half the patients with PCD; therefore, for every patient with KS, another patient has PCD but not situs inversus.  Current nomenclature classifies all congenital ciliary disorders as PCDs in order to differentiate them from acquired types. KS is part of the larger group of disorders referred to as PCDs. Approximately one half of patients with PCD have situs inversus and, thus, are classified as having KS.Keywords: Immotile cilia syndrome; Primary ciliary dyskinesia (PCD); Situs inversus; Chronic sinusitis; Bronchiectasis.DOI: 10.3126/ajms.v1i1.2605Asian Journal of Medical Sciences Vol.1(1) 2010 p.16-17


2008 ◽  
Vol 22 (2) ◽  
pp. 491-494 ◽  
Author(s):  
K. Palmers ◽  
G. van Loon ◽  
M. Jorissen ◽  
F. Verdonck ◽  
K. Chiers ◽  
...  

1994 ◽  
Vol 108 (1) ◽  
pp. 86-91 ◽  
Author(s):  
Paolo Macchiarini ◽  
Alain Chapelier ◽  
Pascal Vouhé ◽  
Jacques Cerrina ◽  
François Le Roy Ladurie ◽  
...  

2014 ◽  
Vol 1 (7) ◽  
pp. 485-488
Author(s):  
Vidya B Thimmaiah ◽  
Karthik Shamanna ◽  
Kamal Goyal

2002 ◽  
Vol 22 (8) ◽  
pp. 2769-2776 ◽  
Author(s):  
Yosuke Kobayashi ◽  
Miho Watanabe ◽  
Yuki Okada ◽  
Hirofumi Sawa ◽  
Hiroyuki Takai ◽  
...  

ABSTRACT A growing number of DNA polymerases have been identified, although their physiological function and relation to human disease remain mostly unknown. DNA polymerase λ (Pol λ; also known as Pol β2) has recently been identified as a member of the X family of DNA polymerases and shares 32% amino acid sequence identity with DNA Pol β within the polymerase domain. With the use of homologous recombination, we generated Pol λ−/− mice. Pol λ−/− mice develop hydrocephalus with marked dilation of the lateral ventricles and exhibit a high rate of mortality after birth, although embryonic development appears normal. Pol λ−/− mice also show situs inversus totalis and chronic suppurative sinusitis. The surviving male, but not female, Pol λ−/− mice are sterile as a result of spermatozoal immobility. Microinjection of sperm from male Pol λ−/− mice into oocytes gives rise to normal offspring, suggesting that the meiotic process is not impaired. Ultrastructural analysis reveals that inner dynein arms of cilia from both the ependymal cell layer and respiratory epithelium are defective, which may underlie the pathogenesis of hydrocephalus, situs inversus totalis, chronic sinusitis, and male infertility. Sensitivity of Pol λ−/− cells to various kinds of DNA damage is indistinguishable from that of Pol λ+/+ cells. Collectively, Pol λ−/− mice may provide a useful model for clarifying the pathogenesis of immotile cilia syndrome.


2014 ◽  
Vol 3 (24) ◽  
pp. 6694-6697
Author(s):  
Panchasheelan J C ◽  
Kavya K ◽  
Sai Shruthi ◽  
Jeetendra Kumar J M ◽  
Sathyanarayana N

2000 ◽  
Vol 25 (12) ◽  
pp. 1050-1051 ◽  
Author(s):  
MURRAY D. BECKER ◽  
YAHYA M. BERKMEN ◽  
RASHID FAWWAZ ◽  
RONALD VAN HEERTUM

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