scholarly journals Proper movement through Spec-CP: An argument from hyperraising in Mongolian

2019 ◽  
Vol 4 (1) ◽  
Author(s):  
Suzana Fong
Keyword(s):  
2017 ◽  
Vol 216 (2) ◽  
pp. 393-408 ◽  
Author(s):  
Benjamin Alleva ◽  
Nathan Balukoff ◽  
Amy Peiper ◽  
Sarit Smolikove

In meiotic prophase I, homologous chromosome pairing is promoted through chromosome movement mediated by nuclear envelope proteins, microtubules, and dynein. After proper homologue pairing has been established, the synaptonemal complex (SC) assembles along the paired homologues, stabilizing their interaction and allowing for crossing over to occur. Previous studies have shown that perturbing chromosome movement leads to pairing defects and SC polycomplex formation. We show that FKB-6 plays a role in SC assembly and is required for timely pairing and proper double-strand break repair kinetics. FKB-6 localizes outside the nucleus, and in its absence, the microtubule network is altered. FKB-6 is required for proper movement of dynein, increasing resting time between movements. Attenuating chromosomal movement in fkb-6 mutants partially restores the defects in synapsis, in agreement with FKB-6 acting by decreasing chromosomal movement. Therefore, we suggest that FKB-6 plays a role in regulating dynein movement by preventing excess chromosome movement, which is essential for proper SC assembly and homologous chromosome pairing.


Author(s):  
Kyle Myers ◽  
Collier Fais ◽  
Matthew Zacharias ◽  
Muhammad Ali ◽  
Khairul Alam

The purpose of this experiment was to explore the operational behavior of hydrodynamic thrust bearings machined from various composite materials (PTFE-Filled Delrin Acetal Resin and MDS-Filled Nylon) and general Aluminum under a set of different axial loading conditions. Since thrust bearings allow mechanical components subjected to axial loads to rotate more freely, they must counter a great deal of friction which can cause bearing failure in order to maintain proper movement. In order to reduce friction and weight, this research posits that thrust bearings machined from composite materials of lower friction coefficients and densities to that of conventionally used materials such as aluminum may provide some advantages. This hypothesis was tested by machining three thrust bearings, all to the same geometric specifications (two composites and one Aluminum) and subjecting them to thrust loads of 25, 50, 75, and 100 pounds while rotating them at a constant rotational speed of 3050 RPM for 10 minutes at each load using a customized test rig. A thermocouple implanted into the bearings themselves recorded the operation temperatures at a sampling rate of 20 Hz. Based on the average temperatures recorded at the 100 pound axial/thrust load, the experiments suggest that the PTFE-Filled Delrin Acetal maintains the lowest average operating temperature of 29.5 °C, followed by the MDS-Filled Nylon at 41.6 °C and lastly the Aluminum at 54.4 °C — a trend that is observed at each axial load albeit less pronounced. These results suggest that composite materials such as PTFE-Filled Acetal and MDS-Filled Nylon to be used in lieu of conventional metals and operate at lower temperatures and lower friction.


2021 ◽  
pp. 2055-2063
Author(s):  
Fahd Al-Sobayil ◽  
Madeh A. Sadan ◽  
Elsayed A. El-Shafaey ◽  
Jamal Allouch

Background and Aim: A healthy joint is an important structure for the proper movement of the camel limb. Intra-articular (IA) injection is frequently used in veterinary practice for diagnostic and therapeutic purposes of joint injuries. Thus, the current study aimed to describe the injection of the hindlimb joints in dromedary camels based on the anatomical and arthrographic-guided landmarks. Materials and Methods: Eighteen orthopedically sound adult camels (mean±standard deviation age: 78±12 months) of both sexes were included in this study. Three camels were euthanized to identify anatomical features in the hindlimb joints and related structures. IA injections were performed in the hindlimbs of 5 camel cadavers to evaluate the optimal IA injection site, which was confirmed by arthrography. The optimized IA injection technique was applied in 10 live camels and confirmed by arthrocentesis and arthrography. For each joint, injection criteria (number of attempts, difficulty of injection, and successful injection) were assessed, scored, and statistically compared to the other joints. Results: The summation of IA injection criteria scores was significantly higher (p<0.05) in the femorotibial, femoropatellar, tibiotarsal, fetlock, pastern, and coffin joints in comparison to the hip joint. Conclusion: Anatomical and arthrographic-guided techniques offer considerable advantages for the characterization of anatomical landmarks and selection of the appropriate IA injection site in the hindlimb in dromedary camels. Furthermore, a reference approach for camels was established that is different from the approach for cattle and horses.


sjesr ◽  
2021 ◽  
Vol 4 (1) ◽  
pp. 295-303
Author(s):  
Ali Raza ◽  
Yasmeen Tabassum ◽  
Wu Hao

Background: Functional Movement Screening (FMS) is a tool to screen the musculoskeletal factors of injury or dysfunctionality patterns in sports. The establishment of functional movement screening (FMS) has built a bridge between physiotherapy, rehabilitation, and physical training, to realize the integration of multiple disciplines. This study tends to investigate musculoskeletal risk factors through the FMS of Judo players in Pakistan. Method: A total of 10 national-level athletes were selected who had been national-level competitors in Pakistan. Different movement patterns/drills prescribed by FMS were performed by them under a secure environment. These movement patterns were designed to provide observable performance of basic locomotor, scheming, and stabilizing movements by putting a person in severe positions where weaknesses and imbalances become noticeable if proper movement and motor control are not utilized。FMS score sheet was used for marking along with total scores of all drills. Conclusion: Results showed that the majority of the Judo athletes were found under standardized grading out of whom only three players were able to get marked above 16 out of 21. Athletes were unaware of FMS and the majority of athletes failed to perform FMS drills which caused them problems in their balance, flexibility, and agility.


2008 ◽  
Vol 33-37 ◽  
pp. 1477-1482 ◽  
Author(s):  
Jian Jin ◽  
Ting Yu Zhang ◽  
Guo Xian Zhang

According to the requirements of the power department, a new type of inspection robot that works along ground wires is developed in this paper. The robot can navigate counterweights, clamps and particular the towers autonomously. The locomotion principle of tower-navigation is presented. In order to decrease the mass eccentricity of the robot, a centroid balance method is proposed. Virtual prototyping technical is used to validate the centroid balance method. It proved that the proper movement of the electric box can adjust the robot centroid distribution efficiently. Driven torque and the power cost of the whole system both decrease a lot. And the robot works more safely.


Author(s):  
Pratik Agarwal

ABSTRACT Velopharyngeal (VP) dysfunction takes place when palatopharyngeal valve is unable to perform its own closing due to a lack of tissue or lack of proper movement. Insufficiency induces nasal regurgitation of liquids, hypernasal speech, nasal escape, disarticulations, and impaired speech intelligibility. Treatment options include surgical correction, prosthetic rehabilitation, and speech therapy, though optimal results often require a multidisciplinary approach. This case report describes a novel approach for rehabilitation of a patient with soft palate defect (VP incompetence). How to cite this article Agarwal P, Dhawan P, Madhukar P, Tandan P. Prosthetic Rehabilitation of Velopharyngeal Incompetence. Int J Prosthodont Restor Dent 2017;7(2):71-76.


2019 ◽  
Vol 8 (3) ◽  
pp. 6160-6161

Dust and dirt particles which fall on solar panel decreases the output of solar panel. Hence the cleaning of solar panel is one of the biggest challenge of engineering. In this paper the problem is discussed and a device for cleaning the surface of solar panel is disclosed. The device is portable in nature which is controlled by using a microcontroller and a feedback from a sensor for proper movement over the surface of solar panel. Initial test of the prototype device show some great result.


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