scholarly journals Age-Dependent Hemoglobin A1c Therapeutic Targets Reduce Diabetic Medication Changes in the Elderly

2019 ◽  
Vol 7 (1) ◽  
pp. 46
Author(s):  
Thomas A. McCormick ◽  
John L. Adams ◽  
Eric A. Lee ◽  
Nicholas P. Emptage ◽  
Darryl E. Palmer-Toy ◽  
...  
Keyword(s):  
Hemoglobin A1c ◽  
Therapeutic Targets ◽  
The Elderly ◽  
Age Dependent ◽  
Medication Changes

CLINICALAND ELECTROPHYSIOLOGICAL STUDY OF THE PERIPHERAL NERVOUS SYSTEM IN THE ELDERLY PEOPLE IN DARBHANGA

2021 ◽  
pp. 19-21
Author(s):  
Nutan Bala ◽  
Priyanka Priyanka ◽  
Sheela Kumari ◽  
Debarshi Jana
Keyword(s):  
Nervous System ◽  
Peripheral Nervous System ◽  
Linear Models ◽  
Electrophysiological Study ◽  
The Elderly ◽  
Elderly Subjects ◽  
Neurophysiological Studies ◽  
Age Dependent ◽  
Young Subjects ◽  
Effect Of Age

The effect of age on the peripheral nervous system was investigated by clinical examination and neurophysiological studies in 59 subjects aged 60- 103 years and 23 young subjects. Afull laboratory screen for factors which, though clinically silent, may constitute risk factors (RFs) for peripheral neuropathy was also performed in the elderly subjects. Our ndings show that the presence of RFs affects exceptionally the electrophysiological parameters in a statistically signicant way. The age-dependent changes in nerve conduction parameters were well predicted by non-linear models. The simultaneous electromyographical study demonstrates the re-innervation capacity of the motor system

scholarly journals Early vascular ageing biomarkers in osteoporotic outpatients: a pilot study

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Agostino Gaudio ◽  
Anastasia Xourafa ◽  
Luca Zanoli ◽  
Rosario Rapisarda ◽  
Antonino Catalano ◽  
...  
Keyword(s):  
Inverse Correlation ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
The Elderly ◽  
X Ray ◽  
Dependent Relationship ◽  
Vascular Ageing ◽  
Age Dependent ◽  
Significant Public Health ◽  
Healthy Control

Abstract Osteoporosis and atherosclerosis are significant public health problems that often coexist, especially in the elderly. Although some studies have reported an age-dependent relationship, others have suggested a causal relationship between osteoporosis and atherosclerosis. The aim of our study was to evaluate the cardiovascular risk in a population of patients with osteoporosis by measuring carotid intima-media thickness (cIMT) and carotid-femoral pulse wave velocity (cf-PWV). A total of 58 patients with osteoporosis and an equal number of healthy control subjects were enrolled. All subjects underwent (1) a bone densitometry examination using dual X-ray absorptiometry, (2) a vascular evaluation for the measurements of cIMT and cf-PWV and (3) a blood sample for the evaluation of lipids and phosphocalcic metabolism. Patients with osteoporosis had a significant increase in cIMT and cf-PWV. There was also a significant inverse correlation between the femoral neck BMD and cf-PWV values. In conclusion, osteoporotic outpatients have earlier vascular ageing, with an increase of arterial stiffness. These data support a possible association between osteoporosis and atherosclerosis independent of age.

Age-Dependent Replication of Respiratory Syncytial Virus in the Cotton Rat

2002 ◽  
Vol 227 (9) ◽  
pp. 799-802 ◽  
Author(s):  
Spencer J. Curtis ◽  
Martin G. Ottolini ◽  
David D. Porter ◽  
Gregory A. Prince
Keyword(s):  
Respiratory Syncytial Virus ◽  
Age Groups ◽  
Fold Increase ◽  
The Elderly ◽  
Geriatric Population ◽  
Cotton Rat ◽  
Dependent Change ◽  
Age Dependent ◽  
Syncytial Virus ◽  
Viral Titers

Despite the documented disease burden of respiratory syncytial virus (RSV) in the elderly, little is known about the underlying risk factors or pathogenesis of RSV in a geriatric population. This report describes an age-dependent change of RSV clearance in the lung and nose of the cotton rat. Six days postinfection with RSV, lung and nose viral titers were significantly higher in all older age groups as compared with 4- to 6-week old cotton rats (P < 0.05). When comparing the 4- to 6-week old animals to the 15- to 16-month old animals 6 days postinfection, there was over an 800- and 100-fold increase in lung and nose viral titers, respectively. The cotton rat may prove to be a useful model in eliciting mechanisms of severe RSV disease in the elderly.

Telomere Length Among the Elderly and Oldest-Old

2005 ◽  
Vol 8 (5) ◽  
pp. 425-432 ◽  
Author(s):  
Claus Bischoff ◽  
Jesper Graakjaer ◽  
Hans Christian Petersen ◽  
Bernard Jeune ◽  
Vilhelm A. Bohr ◽  
...  
Keyword(s):  
Telomere Length ◽  
Oldest Old ◽  
The Elderly ◽  
Specific Difference ◽  
Cross Sectional ◽  
Telomere Shortening ◽  
Telomere Sequence ◽  
Age Dependent ◽  
The Mean ◽  
Telomere Loss

AbstractHuman chromosomes terminate in a number of repeats of the sequence TTAGGG. At birth, each chromosome end is equipped with approximately 15 kb of telomere sequence, but this sequence is shortened during each cell division. In cell cultures telomere shortening is associated with senescence, a phenomenon that has also been observed in normal adult tissues, indicating that telomere loss is associated with organismal ageing. Previous work has established that the rate of telomere loss in humans is age dependent, and recent work shows a sex-specific difference in telomere length and shortening in individuals over the age span of 20 to 75 years. Here, terminal restriction fragment lengths on DNA purified from whole blood were measured to examine the mean telomere length in a cross-sectional cohort of 816 Danish individuals of age 73 to 101 years. In this age group, females show a linear correlation between telomere length and age, whereas the pattern tends to be nonlinear (quadratic in age) for males. This difference in telomere length dynamics between the 2 sexes may be caused by several different mechanisms, including differences in selection by mortality, differences in leukocyte population or different telomerase expression pattern.

What Is the Proper Use of Hemoglobin A1c Monitoring in the Elderly?

2005 ◽  
Vol 6 (3) ◽  
pp. 200-204 ◽  
Author(s):  
Tarannum Alam ◽  
Nancy Weintraub ◽  
Jane Weinreb
Keyword(s):  
Hemoglobin A1c ◽  
The Elderly

scholarly journals Age-dependent accumulation of monoclonal CD4+CD8+double positive T lymphocytes in the peripheral blood of the elderly

2007 ◽  
Vol 139 (5) ◽  
pp. 780-790 ◽  
Author(s):  
Paolo Ghia ◽  
Giuseppina Prato ◽  
Stefania Stella ◽  
Cristina Scielzo ◽  
Massimo Geuna ◽  
...  
Keyword(s):  
T Lymphocytes ◽  
Peripheral Blood ◽  
The Elderly ◽  
Double Positive ◽  
Age Dependent

scholarly journals Antihypertensive Treatment in the Elderly and Very Elderly: Always “the Lower, the Better?”

2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
Alberto Mazza ◽  
Emilio Ramazzina ◽  
Stefano Cuppini ◽  
Michela Armigliato ◽  
Laura Schiavon ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Clinical Trials ◽  
Antihypertensive Treatment ◽  
Antihypertensive Drugs ◽  
The Elderly ◽  
Organ Damage ◽  
Very Elderly ◽  
Age Dependent ◽  
Prolongation Of Life ◽  
Per Se

Arterial hypertension (HT) is age dependent and, with the prolongation of life expectancy, affects more and more elderly people. In the elderly, HT is a risk factor for organ damage and cardiovascular (CV) events. Both pharmacologic and nonpharmacologic reduction of blood pressure (BP) is associated with a corresponding decrease in systolic-diastolic or isolated systolic HT. Clinical trials have shown that BP lowering is associated with a decrease in stroke and other CV events. Therefore, BP reductionper seappears more important than a particular class of antihypertensive drugs. The benefit of antihypertensive treatment has been confirmed up to the age of 80 years, remaining unclear in the octogenarians. The benefit in lowering diastolic BP between 80 and 90 mmHg is well established, while that of lowering systolic BP below 140 mmHg requires further confirmations.

scholarly journals Neonatal hyperoxia enhances age-dependent expression of SARS-CoV-2 receptors in mice

2020 ◽  
Author(s):  
Min Yee ◽  
E. David Cohen ◽  
Jeannie Haak ◽  
Andrew M. Dylag ◽  
Michael A. O’Reilly
Keyword(s):  
Lung Disease ◽  
Influenza A ◽  
The Elderly ◽  
Virus Infections ◽  
Alveolar Epithelial ◽  
Mitochondrial Superoxide ◽  
Adult Mice ◽  
Club Cells ◽  
Age Dependent ◽  
Neonatal Hyperoxia

ABSTRACTThe severity of COVID-19 lung disease is higher in the elderly and people with pre-existing co-morbidities. People who were born preterm may be at greater risk for COVID-19 because their early exposure to oxygen at birth increases their risk of being hospitalized when infected with RSV and other respiratory viruses. Our prior studies in mice showed how high levels of oxygen (hyperoxia) between postnatal days 0-4 increases the severity of influenza A virus infections by reducing the number of alveolar epithelial type 2 (AT2) cells. Because AT2 cells express the SARS-CoV-2 receptors angiotensin converting enzyme (ACE2) and transmembrane protease/serine subfamily member 2 (TMPRSS2), we expected their expression would decline as AT2 cells were depleted by hyperoxia. Instead, we made the surprising discovery that expression of Ace2 and Tmprss2 mRNA increases as mice age and is accelerated by exposing mice to neonatal hyperoxia. ACE2 is primarily expressed at birth by airway Club cells and becomes detectable in AT2 cells by one year of life. Neonatal hyperoxia increases ACE2 expression in Club cells and makes it detectable in 2-month-old AT2 cells. This early and increased expression of SARS-CoV-2 receptors was not seen in adult mice who had been administered the mitochondrial superoxide scavenger mitoTEMPO during hyperoxia. Our finding that early life insults such as hyperoxia enhances the age-dependent expression of SARS-CoV-2 receptors in the respiratory epithelium helps explain why COVID-19 lung disease is greater in the elderly and people with pre-existing co-morbidities.

Changes in lung permeability and lung mechanics accompany homeostatic instability in senescent mice

2003 ◽  
Vol 95 (4) ◽  
pp. 1681-1687 ◽  
Author(s):  
Clarke G. Tankersley ◽  
Jessica A. Shank ◽  
Susan E. Flanders ◽  
Shawn E. Soutiere ◽  
Richard Rabold ◽  
...  
Keyword(s):  
Lung Disease ◽  
Lung Volume ◽  
Inbred Mouse ◽  
Body Weight Loss ◽  
The Elderly ◽  
Lung Mechanics ◽  
Barrier Dysfunction ◽  
Lung Permeability ◽  
Age Dependent ◽  
Imminent Death

Aging and lung disease are recognized factors that increase mortality risk in subjects exposed to ambient particulate matter (PM). In an effort to understand the mechanisms of enhanced susceptibility, the present study examined an inbred mouse model of senescence to 1) determine changes in lung permeability as animals approach the end-of-life and 2) characterize age-dependent changes in lung mechanics in presenescent and terminally senescent mice. The clearance of technetium-99m (99mTc)-diethylenetriamine pentaacetic acid (DTPA) was used to test the hypothesis that lung permeability increases with age and enhances uptake of soluble components of PM principally during the period several weeks before death in AKR/J mice. Quasistatic pressure-volume curves were conducted on robust and on terminally senescent AKR/J mice several weeks before death to assess the relative importance of lung mechanics. Abrupt body weight loss was used to signal imminent death because it accompanies indexes of physiological aging and terminal senescence. 99mTc-DTPA clearance from the lung 30 min after tracheal instillation was significantly ( P < 0.05) enhanced in senescent mice. Age-dependent changes in lung mechanics were indicative of significant ( P < 0.05) decrements in lung volume and compliance several weeks before death. Thus, during a period of homeostatic instability leading toward natural death, AKR/J mice showed enhanced permeability of soluble particles despite a decrease in lung volume and concomitant alveolar surface area. These results suggest that pulmonary epithelial-endothelial barrier dysfunction occurs in terminally senescent mice just before death. Furthermore, this senescent-dependent increase in lung permeability may be a contributing factor for increased PM susceptibility in the elderly and patients with lung disease.

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