Phase II Clinical Trial of Combination Chemotherapy With Dexamethasone for Lymphoma in Dogs

2007 ◽  
Vol 43 (1) ◽  
pp. 27-32 ◽  
Author(s):  
Chelsea B. Greenberg ◽  
Pedro A. Boria ◽  
Antonella Borgatti-Jeffreys ◽  
Rose E. Raskin ◽  
Michael D. Lucroy
Keyword(s):  
Clinical Trial ◽  
Complete Remission ◽  
Induction Chemotherapy ◽  
Phase Ii ◽  
Combination Chemotherapy ◽  
Phase Ii Clinical Trial ◽  
Two Stage ◽  
Stage Design ◽  
Free Interval ◽  
Chemotherapy Protocol

Dogs with histologically confirmed lymphoma were treated with a 14-week induction chemotherapy protocol that included dexamethasone. A phase II clinical trial was done using a standard two-stage design. Complete remission occurred in 21 (88%) dogs, with a median initial progression-free interval of 186 days. Toxicity was mild and self-limiting in the majority of dogs.

A two-stage design for a phase II clinical trial of coenzyme Q10 in ALS

Neurology ◽  
2006 ◽  
Vol 66 (5) ◽  
pp. 660-663 ◽  
Author(s):  
G. Levy ◽  
P. Kaufmann ◽  
R. Buchsbaum ◽  
J. Montes ◽  
A. Barsdorf ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Phase Ii ◽  
Coenzyme Q10 ◽  
Phase Ii Clinical Trial ◽  
Two Stage ◽  
Stage Design ◽  
Two Stage Design

scholarly journals A two‐stage phase II clinical trial design with nested criteria for early stopping and efficacy

2019 ◽  
Vol 18 (6) ◽  
pp. 700-713
Author(s):  
Michelle DeVeaux ◽  
Michael Kane ◽  
Wei Wei ◽  
Daniel Zelterman
Keyword(s):  
Clinical Trial ◽  
Phase Ii ◽  
Trial Design ◽  
Clinical Trial Design ◽  
Phase Ii Clinical Trial ◽  
Early Stopping ◽  
Two Stage

Phase II clinical trial of lastet capsule in combination chemotherapy of malignant tumors in China

1995 ◽  
Vol 7 (3) ◽  
pp. 181-186
Author(s):  
Tianze Zhang ◽  
Jiliang Yin ◽  
Youjian He ◽  
Deyuan Wang ◽  
Yi Wang
Keyword(s):  
Clinical Trial ◽  
Phase Ii ◽  
Combination Chemotherapy ◽  
Malignant Tumors ◽  
Phase Ii Clinical Trial

A Bayesian-frequentist two-stage single-arm phase II clinical trial design

2012 ◽  
Vol 31 (19) ◽  
pp. 2055-2067 ◽  
Author(s):  
Gaohong Dong ◽  
Weichung Joe Shih ◽  
Dirk Moore ◽  
Hui Quan ◽  
Stephen Marcella
Keyword(s):  
Clinical Trial ◽  
Phase Ii ◽  
Trial Design ◽  
Clinical Trial Design ◽  
Phase Ii Clinical Trial ◽  
Two Stage
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