Radiation Therapy for Incompletely Excised Grade II Canine Mast Cell Tumors

2006 ◽  
Vol 42 (6) ◽  
pp. 430-434 ◽  
Author(s):  
Valerie Jasmine Poirier ◽  
William M. Adams ◽  
Lisa J. Forrest ◽  
Eric M. Green ◽  
Richard R. Dubielzig ◽  
...  
Keyword(s):  
Mast Cell ◽  
Lymph Node ◽  
Regional Lymph Node ◽  
Overall Survival Rate ◽  
Mast Cell Tumors ◽  
Mast Cell Tumor ◽  
Grade Ii ◽  
Cutaneous Mast Cell ◽  
Lymph Node Irradiation ◽  
Prophylactic Irradiation

Forty-five dogs with incompletely excised grade II mast cell tumors were treated with radiation using a cobalt 60 teletherapy unit (15 fractions of 3.2 Gy for a total of 48 Gy). Twenty-four of the dogs underwent prophylactic regional lymph node irradiation. Three (6.7%) dogs had tumor recurrence, two (4.4%) dogs developed metastasis, and 14 (31%) dogs developed a second cutaneous mast cell tumor. No difference in overall survival rate was observed between the dogs receiving and not receiving prophylactic irradiation of the regional lymph node.

scholarly journals Prognosis of Grade II Cutaneous Mast Cell Tumors in 17 Dogs

2003 ◽  
Vol 56 (2) ◽  
pp. 87-91
Author(s):  
Teruo ITOH ◽  
Kiyotaka KUSHIMA ◽  
Kazumi NIBE ◽  
Kazuyuki UCHIDA ◽  
Hiroki SHII
Keyword(s):  
Mast Cell ◽  
Mast Cell Tumors ◽  
Grade Ii ◽  
Cutaneous Mast Cell

Recurrence Rates and Sites for Grade II Canine Cutaneous Mast Cell Tumors Following Complete Surgical Excision

2002 ◽  
Vol 38 (1) ◽  
pp. 71-73 ◽  
Author(s):  
Chick Weisse ◽  
Frances S. Shofer ◽  
Karin Sorenmo
Keyword(s):  
Mast Cell ◽  
Tumor Recurrence ◽  
Surgical Excision ◽  
Adjuvant Radiation ◽  
Recurrence Rates ◽  
Mast Cell Tumors ◽  
Complete Surgical Excision ◽  
Grade Ii ◽  
Cutaneous Mast Cell ◽  
Distant Tumor

A retrospective study was performed on 31 dogs with completely excised, grade II, cutaneous mast cell tumors in order to determine recurrence rates and sites. Distant tumor recurrence developed in 22% of dogs, and local tumor recurrence developed in 11% of dogs; however, the vast majority of these animals were incompletely staged initially. Complete surgical excision of grade II mast cell tumors was associated with effective local control in 89% of these dogs. Therefore, adjuvant radiation therapy might not be indicated in the majority of dogs with complete surgical excision.

scholarly journals Morphometry of Canine Cutaneous Mast Cell Tumors

2003 ◽  
Vol 40 (3) ◽  
pp. 268-275 ◽  
Author(s):  
R. De F. Strefezzi ◽  
J. G. Xavier ◽  
J. L. Catão-Dias
Keyword(s):  
Mast Cell ◽  
Needle Aspiration ◽  
Nuclear Area ◽  
Mast Cell Tumors ◽  
Mast Cell Tumor ◽  
Mean Diameter ◽  
Poorly Differentiated ◽  
Cutaneous Mast Cell ◽  
Histopathologic Analysis ◽  
Well Differentiated

Twenty-four canine cutaneous nodules, diagnosed as mast cell tumors by fine-needle aspiration biopsy and confirmed by histopathologic analysis by staining with hematoxylin and eosin (HE) and toluidine blue, were analyzed by computerized nuclear morphometry on panoptic- and HE-stained cytopathology slides. Two hundred nuclei per lesion were examined. The morphometric parameters investigated were nuclear area, mean diameter, perimeter, regularity factor, and ellipticity factor. Lesions were graded as I (well differentiated), II (intermediate differentiation), or III (poorly differentiated) according to the following morphologic features: invasiveness, cellularity and cellular morphology, mitotic index, and stromal reaction. Nuclear morphometric results were then compared with histopathologic grades. Values of nuclear area, mean diameter, and perimeter increased with increase in histopathologic grade, but statistical analysis revealed significant differences only between grades II and III and between grades I and III when HE was used ( P, 0.01) and between grades I and III with panoptic stain ( P, 0.05). The ellipticity factor and regularity factor did not reveal significant differences between histopathologic grades. The results indicate that nuclear morphometric analysis, in combination with the rapid and inexpensive cytopathology technique, can help in mast cell tumor grading, thus contributing to the establishment of a more precise prognosis and treatment.

Evaluation of a two-centimeter lateral surgical margin for excision of grade I and grade II cutaneous mast cell tumors in dogs

2006 ◽  
Vol 228 (2) ◽  
pp. 210-215 ◽  
Author(s):  
Ryan P. Fulcher ◽  
Lori L. Ludwig ◽  
Philip J. Bergman ◽  
Shelley J. Newman ◽  
Amelia M. Simpson ◽  
...  
Keyword(s):  
Mast Cell ◽  
Surgical Margin ◽  
Mast Cell Tumors ◽  
Grade Ii ◽  
Cutaneous Mast Cell

Extracutaneous Mast-Cell Tumor in the Dog

1982 ◽  
Vol 19 (6) ◽  
pp. 608-615 ◽  
Author(s):  
A. K. Patnaik ◽  
E. G. MacEwen ◽  
A. P. Black ◽  
S. Luckow
Keyword(s):  
Duodenal Ulcer ◽  
Mast Cell ◽  
Lymph Nodes ◽  
Cell Tumor ◽  
Regional Lymph Nodes ◽  
Duodenal Ulcers ◽  
Mast Cell Tumors ◽  
Mast Cell Tumor ◽  
Cutaneous Mast Cell ◽  
Limited Metastasis

Three neoplasms of extracutaneous mast-cell origin, arising from the nasopharynx, oral cavity, and hepatopancreatic lymph nodes respectively, were diagnosed in three dogs. The neoplasms had histologic features similar to those of cutaneous mast-cell tumors, but had limited metastasis mostly involving the regional lymph nodes. One dog had a perforating duodenal ulcer, suggesting that duodenal ulcers can occur with extracutaneous tumors as they do with some cutaneous mast-cell tumors in the dog.

scholarly journals Nanog Expression and Proliferation Indices in Canine Cutaneous Mast Cell Tumors

2018 ◽  
Vol 55 (6) ◽  
pp. 849-852
Author(s):  
Julia A. Joselevitch ◽  
Camila N. Barra ◽  
Thiago Henrique M. Vargas ◽  
Lidia H. Pulz ◽  
Adriana T. Nishiya ◽  
...  
Keyword(s):  
Mast Cell ◽  
Histological Grade ◽  
Clinical Information ◽  
Ki67 Index ◽  
Mast Cell Tumors ◽  
Proliferation Indices ◽  
Nanog Expression ◽  
Mast Cell Tumor ◽  
Wide Range ◽  
Cutaneous Mast Cell

Mast cell tumors are one of the most frequent skin tumors in dogs. Treatment decisions often depend on a wide range of clinical information and the main criteria for prognostic formulation are histological grade, mitotic count, Ki67 index, and KIT immunostaining pattern. NANOG is a pluripotency factor expressed by normal and cancer stem cells, which is a prognostic marker and a potential therapeutic target for several human tumors. In the present study, mast cell tumor samples from 41 dogs were evaluated for NANOG and Ki67 by immunohistochemistry. All samples were positive for NANOG but its expression was not correlated with Ki67 index and no significant differences were found with respect to histopathological grades, disease-related mortality, or survival. Our results suggest that, although related to pluripotency, NANOG expression does not correlate with proliferative activity, and is not a reliable prognostic factor for canine cutaneous mast cell tumors.

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