Postoperative Assessment of Surgical Clip Position in 16 Dogs With Cancer: A Pilot Study

2004 ◽  
Vol 40 (4) ◽  
pp. 300-308 ◽  
Author(s):  
Margaret C. McEntee ◽  
Valerie F. Samii ◽  
Peter Walsh ◽  
William J. Hornof
Keyword(s):  
Wound Healing ◽  
Pilot Study ◽  
Surgical Resection ◽  
Radiation Treatment ◽  
Tumor Bed ◽  
Postoperative Assessment ◽  
Tumor Bearing ◽  
Surgical Clip ◽  
Surgical Staples ◽  
Absolute Shift

Metallic hemoclips or surgical staples were inserted in 16 tumor-bearing dogs at the time of surgical resection of the tumor. Orthogonal radiographs were taken immediately postoperatively and after wound healing to visualize the location and number of hemoclips or metallic staples. A shift in hemoclip/staple position was identified in nine dogs, mainly from positioning during radiography. In three dogs, an absolute shift in marker position was identified. Based on this study, it appears that the placement of surgical clips is potentially useful in identifying the tumor bed, which may be of benefit in establishing radiation treatment fields.

Influence of Cisplatin on Wound Healing—An Experimental Model

1986 ◽  
Vol 95 (2) ◽  
pp. 210-212 ◽  
Author(s):  
Charles M. Stiernberg ◽  
R. Mark Williams ◽  
James A. Hokanson
Keyword(s):  
Wound Healing ◽  
Chemotherapeutic Agents ◽  
Optimal Time ◽  
Subcutaneous Injections ◽  
Treatment Groups ◽  
Cell Counts ◽  
Proliferative Stage ◽  
Significant Difference ◽  
Surgical Staples ◽  
Outbred Mice

Recent clinical studies have shown that adjuvant chemotherapy may improve response rates to treatment for advanced head and neck carcinomas. Given preoperatively, some chemotherapeutic agents adversely affect wound heallng. The specific purpose of this study was to evaluate the Influence of cisplatin on wound healing when it is given preoperatively. Forty-four Swiss outbred mice were divided into control and treatment groups. One week before surgery, the treatment group received cisplatin (2 mg/ kg body weight) by subcutaneous injections on 2 consecutive days. Each control animal was given an equal volume of normal saline. A 1.5 cm transverse incision was made in each animal, and wounds were closed with surgical staples. The mean woundbreaking strength was determined for a minimum of 5 treatment and 5 control mice on postoperative days 6, 10, 13, and 16. Serum creatinine, blood cell counts, and changes in weight were also monitored. Results showed wound strength on postoperative day 10 to be significantly reduced in mice treated with cisplatin (P < 0.05). There was no significant difference for wound strength on any other days and all other variables were simllar between both groups. In conclusion, cisplatin has an adverse effect on wound healing, the peak of which probably occurs during the proliferative stage of wound healing. Further studies are needed to determine the optimal time for surgery after preoperative chemotherapy. All new chemotherapeutic agents, particularly those being considered in a preoperative regimen, should be tested in this manner.

scholarly journals Biopolymeric materials for targeted drug delivery in the therapy accompanying radiation treatment of patients with head and neck tumors

2018 ◽  
pp. 76-82
Author(s):  
А.В. Бойко ◽  
А.Р. Геворков ◽  
Н.Д. Олтаржевская ◽  
В.И. Швец ◽  
С.В. Шашков
Keyword(s):  
Drug Delivery ◽  
Wound Healing ◽  
Head And Neck ◽  
Radiation Treatment ◽  
Supportive Therapy ◽  
Head And Neck Tumors ◽  
Local Drug Delivery ◽  
Optimal Timing ◽  
Neck Tumors ◽  
Key Factor

В работе освещены основные вопросы эффективности и переносимости лучевого и химиолучевого лечения больных опухолями головы и шеи. Представлен спектр побочных эффектов и затронуты ключевые аспекты терапии сопровождения. Особое внимание уделено роли местной ранозаживляющей терапии в борьбе с мукозитом и дерматитом в рамках обеспечения оптимальных сроков лучевой терапии, а также сохранения качества жизни пациентов на всех этапах их лечения и реабилитации. Отдельно описаны возможности эффективной местной доставки лекарственных средств путем применения отечественных биополимерных наноматериалов. Так, использование биополимера альгината натрия в качестве матрицы в сочетании с деринатом позволило получить необходимый ранозаживляющий эффект, а добавление других лекарственных наделило препарат противоинфекционным, обезболивающим, антиоксидантным, либо радиомодифицирующим действием. Применение адекватной терапии сопровождения с ранозаживляющим компонентом позволяет соблюдать оптимальные сроки лечения, что было достоверно показано на собственном опыте. The study highlighted major aspects of efficacy and tolerability of radiation and chemoradiation treatment in patients with head and neck tumors. A range of side effects is presented and key aspects of supportive care are discussed. Particular attention was paid to local wound healing as the main cure for mucositis and dermatitis and key factor for optimal timing of radiotherapy as well as to preserving patients’ quality of life. Possibilities for effective local drug delivery using biopolymeric nanomaterials are described. Thus, the use of biopolymeric sodium alginate as a matrix in combination with derinate allowed to achieve the required wound-healing effect. Addition of other drugs provided anti-infection, analgesic, antioxidant or radiomodifying effects. Appropriate supportive therapy in combination with a wound healing component allows to adhere to the optimal treatment duration, as our experience has convincingly demonstrated.

scholarly journals Vivostat Platelet-Rich Fibrin® for Complicated or Chronic Wounds—A Pilot Study

Biomedicines ◽  
2020 ◽  
Vol 8 (8) ◽  
pp. 276
Author(s):  
Andreas Bayer ◽  
Gesa Höntsch ◽  
Mark Kaschwich ◽  
Annika Dell ◽  
Markus Siggelkow ◽  
...  
Keyword(s):  
Wound Healing ◽  
Pilot Study ◽  
Clinical Efficacy ◽  
Chronic Wounds ◽  
Local Treatment ◽  
Entire Study ◽  
Platelet Rich Fibrin ◽  
Arterial Blood ◽  
Autologous Platelet Concentrate ◽  
Study Population

Vivostat Platelet-Rich Fibrin® (PRF) is an autologous platelet concentrate used for the local treatment of chronic or complicated wounds. Still, its application for this indication is not evidence-based. Therefore, we performed this monocentric retrospective pilot study investigating the clinical outcome of a local treatment of chronic or complicated wounds in 35 patients (23 male, 12 female, mean age 68.7 years) treated with Vivostat PRF®. This study population is the largest among published studies analyzing the clinical efficacy of Vivostat PRF® on chronic wounds so far. Using the perpendicular method we divided the wounds into three sizes (<10, 10–30, and >30 cm2). The clinical efficacy of the Vivostat PRF treatment was the primary endpoint and was divided into three groups of increasing degrees of wound improvement: (1) no improvement of the wound (wound area was not reduced > 10% under Vivostat PRF® treatment), (2) improvement of the wound (reduced area > 10% under Vivostat PRF® treatment) and (3) complete epithelialization (wounds that were completely re-epithelialized after Vivostat PRF® treatment). We included patients’ diagnosis and concomitant diseases (peripheral arterial occlusive disease (PAOD)), chronic venous insufficiency (CVI)), diabetic foot syndrome (DFS)) in our data analysis in order to investigate their potential impact on the wound healing capacity of Vivostat PRF®. Our results show that in the entire study population, 13 out of 35 (37.1%) patients experienced wound improvement and 14 out of 35 (40%) patients showed complete epithelialization of their wound under Vivostat PRF® treatment. In summary, 77.1% of the treated patients benefited from the Vivostat PRF® therapy. These positive wound healing effects were all observed within the first three to six Vivostat PRF® applications. Subgroup analyses showed that Vivostat PRF® appeared to be more efficient in patients without CVI in comparison to patients with CVI (p = 0.02). Moreover, Vivostat PRF® treatment seems to be particularly efficient in PAOD-related wounds with a reduced crural arterial blood supply (p = 0.01). Additionally, we performed an experimental human in vivo study on ten male students where we artificially generated bilateral gluteal wounds and analyzed the influence of the Vivostat PRF® treatment on the expression of two genes (human beta Defensin-2, ((hBD-2) and human beta-Defensin-3 (hBD-3)) in keratinocytes of resected wound specimens that are induced during wound healing. Interestingly, this analysis revealed that only seven of out ten individuals showed a relevant hBD-2 and hBD-3 gene induction after Vivostat PRF® treatment. This led to the novel “key-lock-hypothesis”. With the goal of an individualized precision medicine approach with optimized wound treatment strategies in the future, this is an important observation that demands further experimental and clinical studies.

scholarly journals Regenerating matrix-based therapy for chronic wound healing: a prospective within-subject pilot study

2010 ◽  
Vol 8 (1) ◽  
pp. 85-95 ◽  
Author(s):  
Suzanne L Groah ◽  
Alexander Libin ◽  
Miriam Spungen ◽  
Kim-Loan Nguyen ◽  
Earthaleen Woods ◽  
...  
Keyword(s):  
Wound Healing ◽  
Pilot Study ◽  
Chronic Wound

Comparison of amethocaine gel versus 1% lidocaine infiltration on wound healing. A pilot study in animals

2007 ◽  
Vol 8 (3) ◽  
pp. 110-114
Author(s):  
Rodrick K Lim ◽  
Bertha Garcia ◽  
Michael J Rieder ◽  
Priya Iyer ◽  
Jamie A Seabrook
Keyword(s):  
Wound Healing ◽  
Pilot Study
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