Due giraffe in corsia: una encefalite da Mycoplasma pneumoniae

2021 ◽  
Vol 40 (10) ◽  
pp. 657-657
Author(s):  
Antonella Amendolea ◽  
Manuela Fierabracci ◽  
Antonella Gucci ◽  
Liliana Malandra ◽  
Giovanni Suriano
Keyword(s):  
Mycoplasma Pneumoniae ◽  
Mycoplasma Infection

The article describes the case of an encephalitic involvement during Mycoplasma infection with pneumonia. As it often happens in paediatrics, the peculiarity lies in a nuanced symptomatology that may be underestimated. A repeated anamnesis was important and allowed to manage the case better.

scholarly journals Effects of Respiratory Mycoplasma pneumoniae Infection on Allergen-Induced Bronchial Hyperresponsiveness and Lung Inflammation in Mice

2003 ◽  
Vol 71 (3) ◽  
pp. 1520-1526 ◽  
Author(s):  
Hong Wei Chu ◽  
Joyce M. Honour ◽  
Catherine A. Rawlinson ◽  
Ronald J. Harbeck ◽  
Richard J. Martin
Keyword(s):  
Mycoplasma Pneumoniae ◽  
Lung Inflammation ◽  
Bronchial Hyperresponsiveness ◽  
Lavage Fluid ◽  
Interleukin 4 ◽  
Mycoplasma Infection ◽  
Temporary Reduction ◽  
Protein Levels ◽  
Asthma Model ◽  
Ifn Γ

ABSTRACT Airway mycoplasma infection may be associated with asthma pathophysiology. However, the direct effects of mycoplasma infection on asthma remain unknown. Using a murine allergic-asthma model, we evaluated the effects of different timing of airway Mycoplasma pneumoniae infection on bronchial hyperresponsiveness (BHR), lung inflammation, and the protein levels of Th1 (gamma interferon [IFN-γ]) and Th2 (interleukin 4 [IL-4]) cytokines in bronchoalveolar lavage fluid. When mycoplasma infection occurred 3 days before allergen (ovalbumin) sensitization and challenge, the infection reduced the BHR and inflammatory-cell influx into the lung. This was accompanied by a significant induction of Th1 responses (increased IFN-γ and decreased IL-4 production). Conversely, when mycoplasma infection occurred 2 days after allergen sensitization and challenge, the infection initially caused a temporary reduction of BHR and then increased BHR, lung inflammation, and IL-4 levels. Our data suggest that mycoplasma infection could modulate both physiological and immunological responses in the murine asthma model. Our animal models may also provide a new means to understand the role of infection in asthma pathogenesis and give evidence for the asthma hygiene hypothesis.

scholarly journals Bronhoadenitis simplex in mycoplasma pneumonia in the child (differential diagnostics and treatment)

2019 ◽  
Vol 11 (2) ◽  
pp. 71-78 ◽  
Author(s):  
Aleksandr V. Orlov ◽  
Aleksandr A. Pashkevich ◽  
Natal'ya V. Gonchar ◽  
Taras S. Borisenko ◽  
Irina V. Babachenko ◽  
...  
Keyword(s):  
Mycoplasma Pneumoniae ◽  
Respiratory Diseases ◽  
Differential Diagnostics ◽  
Mycoplasma Infection ◽  
Radiological Data ◽  
Atypical Pathogens ◽  
Mycoplasma Pneumonia ◽  
Acute Respiratory Diseases ◽  
Serological Diagnostics

Background. Mycoplasma pneumoniae is included in the group of atypical pathogens of acute respiratory diseases. Mycoplasma pneumoniae is characterized by a tendency to prolonged course with progressive changes in the lungs. Main value in the confirmation of mycoplasma infection has microbiome in biosubstrates selection and serological diagnostics: the determination of specific immunoglobulins IgM or IgG in the dynamics to M. pneumoniae. Antibacterial therapy of mycoplasma pneumonia is prescribed based on the sensitivity of the pathogen to them. The duration of antibiotic treatment of mycoplasma pneumonia is determined by the dynamics of clinical and radiological data. Materials and methods. The article describes the features of the clinical course of mycoplasma pneumonia in a patient with tubinfection proceeding with bronchoadenitis and obstruction of the bronchus, which necessitated a differential diagnosis with tuberculosis of the intrathoracic lymph nodes and the appointment of repeated courses of antibiotic treatment.Results. In the described clinical case, the duration of Mycoplasma infection exceeded 3.5 months, during which time the patient received several courses of antibiotics. Mycoplasma pneumonia had a prolonged course, accompanied by bronchoadenitis.Conclusion. Our observations show the need to study the effectiveness of extended courses of antibiotics from the azalid group in the treatment of prolonged and complicated forms of Mycoplasma pneumonia.

scholarly journals Impact of viral coinfection and macrolide-resistant mycoplasma infection in children with refractory Mycoplasma pneumoniae pneumonia

2020 ◽  
Author(s):  
Yajuan Zhou ◽  
Jing Wang ◽  
Wenjuan Chen ◽  
Nan Shen ◽  
Yue Tao ◽  
...  
Keyword(s):  
Prediction Model ◽  
Mycoplasma Pneumoniae ◽  
Medical Center ◽  
Classification Tree ◽  
Severe Disease ◽  
Drug Resistant ◽  
Mycoplasma Infection ◽  
Prolonged Fever ◽  
Lung Consolidation ◽  
Viral Coinfection

Abstract Background: Cases of refractory Mycoplasma pneumoniae pneumonia have been increasing recently; however, whether viral coinfection or macrolide-resistant M. infection contribute to the development of refractory M. pneumoniae pneumonia remains unclear. This study aimed to investigate the impacts of viral coinfection and macrolide-resistant M. pneumoniae infection on M. pneumoniae pneumonia in hospitalized children and build a model to predict a severe disease course. Methods: Nasopharyngeal swabs or sputum specimens were collected from patients with community-acquired pneumonia meeting our protocol who were admitted to Shanghai Children’s Medical Center from December 1, 2016, to May 31, 2019. The specimens were tested with the FilmArray Respiratory Panel, a multiplex polymerase chain reaction assay that detects 16 viruses, Bordetella pertussis, M. pneumoniae, and Chlamydophila pneumoniae. Univariate and multivariate logistic regression models were used to identify the risk factors for adenovirus coinfection and macrolide-resistant mycoplasma infection.Results: Among the 107 M. pneumoniae pneumonia patients, the coinfection rate was 56.07%, and 60 (60/107, 56.07%) patients were infected by drug-resistant M. pneumoniae. Adenovirus was the most prevalent coinfecting organism, accounting for 22.43% (24/107). The classification tree confirmed that viral coinfection was more common in patients younger than 3 years old. Adenovirus coinfection and drug-resistant M. pneumoniae infection occurred more commonly in patients with refractory M. pneumoniae pneumonia (P=0.019; P=0.001). A prediction model including wheezing, lung consolidation and extrapulmonary complications was used to predict adenovirus coinfection. The area under the receiver operating characteristic curve of the prediction model was 0.795 (95% CI 0.679-0.893, P<0.001). A prolonged fever duration after the application of macrolides for 48 hours was found more commonly in patients infected by drug-resistant M. pneumoniae (P=0.002). A fever duration longer than 7 days was an independent risk factor for drug-resistant Mycoplasma infection (OR=3.500, 95% CI=1.310-9.353, P=0.012).Conclusions: The occurrence of refractory M. pneumoniae pneumonia is associated with adenovirus coinfection and infection by drug-resistant M. pneumoniae. A prediction model combining wheezing, extrapulmonary complications and lung consolidation can be used to predict adenovirus coinfection in children with M. pneumoniae pneumonia. A prolonged fever duration indicates drug-resistant M. pneumoniae infection, and a reasonable change in antibiotics is necessary.

scholarly journals Impact of viral coinfection and macrolide-resistant mycoplasma infection in children with refractory Mycoplasma pneumoniae pneumonia

2020 ◽  
Author(s):  
Yajuan Zhou ◽  
Jing Wang ◽  
Wenjuan Chen ◽  
Nan Shen ◽  
Yue Tao ◽  
...  
Keyword(s):  
Prediction Model ◽  
Mycoplasma Pneumoniae ◽  
Medical Center ◽  
Classification Tree ◽  
Severe Disease ◽  
Drug Resistant ◽  
Mycoplasma Infection ◽  
Prolonged Fever ◽  
Lung Consolidation ◽  
Viral Coinfection

Abstract Background: Cases of refractory Mycoplasma pneumoniae pneumonia have been increasing recently; however, whether viral coinfection or macrolide-resistant M. infection contribute to the development of refractory M. pneumoniae pneumonia remains unclear. This study aimed to investigate the impacts of viral coinfection and macrolide-resistant M. pneumoniae infection on M. pneumoniae pneumonia in hospitalized children and build a model to predict a severe disease course. Methods: Nasopharyngeal swabs or sputum specimens were collected from patients with community-acquired pneumonia meeting our protocol who were admitted to Shanghai Children’s Medical Center from December 1, 2016, to May 31, 2019. The specimens were tested with the FilmArray Respiratory Panel, a multiplex polymerase chain reaction assay that detects 16 viruses, Bordetella pertussis, M. pneumoniae, and Chlamydophila pneumoniae. Univariate and multivariate logistic regression models were used to identify the risk factors for adenovirus coinfection and macrolide-resistant mycoplasma infection.Results: Among the 107 M. pneumoniae pneumonia patients, the coinfection rate was 56.07%, and 60 (60/107, 56.07%) patients were infected by drug-resistant M. pneumoniae. Adenovirus was the most prevalent coinfecting organism, accounting for 22.43% (24/107). The classification tree confirmed that viral coinfection was more common in patients younger than 3 years old. Adenovirus coinfection and drug-resistant M. pneumoniae infection occurred more commonly in patients with refractory M. pneumoniae pneumonia (P=0.019; P=0.001). A prediction model including wheezing, lung consolidation and extrapulmonary complications was used to predict adenovirus coinfection. The area under the receiver operating characteristic curve of the prediction model was 0.795 (95% CI 0.679-0.893, P<0.001). A prolonged fever duration after the application of macrolides for 48 hours was found more commonly in patients infected by drug-resistant M. pneumoniae (P=0.002). A fever duration longer than 7 days was an independent risk factor for drug-resistant Mycoplasma infection (OR=3.500, 95% CI=1.310-9.353, P=0.012).Conclusions: The occurrence of refractory M. pneumoniae pneumonia is associated with adenovirus coinfection and infection by drug-resistant M. pneumoniae. A prediction model combining wheezing, extrapulmonary complications and lung consolidation can be used to predict adenovirus coinfection in children with M. pneumoniae pneumonia. A prolonged fever duration indicates drug-resistant M. pneumoniae infection, and a reasonable change in antibiotics is necessary.

scholarly journals Rhabdomyolysis: An Unusual Presentation of Mycoplasma pneumoniae Infection in an Adult—A Case Report and Literature Review

2018 ◽  
Vol 2018 ◽  
pp. 1-4
Author(s):  
Jaspreet Kaler ◽  
Osama Mukhtar ◽  
Bilal Khan ◽  
Binav Shrestha ◽  
Ravinder Kaler ◽  
...  
Keyword(s):  
Mycoplasma Pneumoniae ◽  
Community Acquired Pneumonia ◽  
Immunoglobulin M ◽  
Review Of The Literature ◽  
Mycoplasma Infection ◽  
Radiographic Evidence ◽  
X Ray ◽  
Intravenous Hydration ◽  
Chest X Ray ◽  
Mycoplasma Pneumoniae Infection

Mycoplasma pneumoniae is a common cause of community-acquired pneumonia, and many extrapulmonary manifestations have been described, but rhabdomyolysis is infrequently reported in adults. Of the few cases that have been reported in adults, it was almost exclusively seen when pneumonia was present. We report a case of a 30-year-old male who came in with complaints of fever and myalgia for three days. Immunoglobulin M antibodies for Mycoplasma pneumoniae were positive and trending up, despite having no radiographic evidence of pneumonia on chest X-ray or CT scan. He was treated successfully with levofloxacin and intravenous hydration. Later, his condition was clinically and biochemically improved, and he was discharged. Our patient did not present with typical respiratory tract symptoms of a mycoplasma infection. In addition, there was an absence of pneumonia on imaging, suggesting that rhabdomyolysis secondary to mycoplasma might be underdiagnosed and go untreated in the setting of low clinical suspicion. Upon review of the literature, there is only one other case of mycoplasma infection where rhabdomyolysis occurred in the absence of pneumonia. However, the degree of rhabdomyolysis in our case was much more severe. Although rare, when faced with rhabdomyolysis, Mycoplasma pneumoniae should be kept as a differential diagnosis even in the absence of pneumonia on radiological imaging.

scholarly journals Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Associated with Mycoplasma pneumoniae Infection

2020 ◽  
Vol 12 (3) ◽  
pp. 225-230
Author(s):  
Guy Shalom ◽  
Raed Khoury ◽  
Amir Horev
Keyword(s):  
Drug Reaction ◽  
Mycoplasma Pneumoniae ◽  
Drug Allergy ◽  
Drug Eruption ◽  
Interferon Γ ◽  
Mycoplasma Infection ◽  
Release Test ◽  
Tnf Α ◽  
Systemic Symptoms

Mycoplasma infection may lower the threshold for drug allergy in particular patients. We present a case of drug reaction with eosinophilia and systemic symptoms (DRESS), with drug etiology and non-drug etiology (Mycoplasma infection). Possible synergism between previously known drug allergy and the acute Mycoplasma infection may have led to DRESS eruption. Interferon-γ release test and TNF-α release test yielded different patterns in the present case, suggesting a different role for each in different drug eruption types.

scholarly journals Deep Vein Thrombosis and Pulmonary Embolism in the Setting of Mycoplasma Infection

2020 ◽  
Vol 2020 ◽  
pp. 1-3
Author(s):  
Sandal Saleem ◽  
Brian Berman
Keyword(s):  
Pulmonary Embolism ◽  
Deep Vein Thrombosis ◽  
Mycoplasma Pneumoniae ◽  
Comprehensive Evaluation ◽  
Anticoagulation Therapy ◽  
Pulmonary Emboli ◽  
Mycoplasma Infection ◽  
Vein Thrombosis ◽  
Thrombotic Complications ◽  
Deep Vein

Thirteen-year-old female twins presented one week apart with documented Mycoplasma pneumoniae respiratory infection. Each developed venous thrombosis and pulmonary emboli in association with transient self-limited para-infectious anti-phospholipid antibodies. Comprehensive evaluation revealed no identifiable genetic prothrombotic variables. Both children recovered after receiving antibiotics and anticoagulation therapy. Thrombotic complications associated with Mycoplasma pneumoniae infections are rare, particularly in children; the occurrence of this complication in identical twins has not been previously reported.

scholarly journals Impact of viral coinfection and macrolide-resistant mycoplasma infection in children with refractory Mycoplasma pneumoniae pneumonia

2020 ◽  
Author(s):  
Yajuan Zhou ◽  
Jing Wang ◽  
Wenjuan Chen ◽  
Nan Shen ◽  
Yue Tao ◽  
...  
Keyword(s):  
Prediction Model ◽  
Mycoplasma Pneumoniae ◽  
Medical Center ◽  
Classification Tree ◽  
Severe Disease ◽  
Drug Resistant ◽  
Mycoplasma Infection ◽  
Prolonged Fever ◽  
Lung Consolidation ◽  
Viral Coinfection

Abstract Background: The cases of of refractory Mycoplasma pneumoniae pneumonia have been increasing recently; however, whether viral coinfection or macrolide-resistant M. infection contribute to the development of refractory M. pneumoniae pneumonia remains unclear. This study aimed to investigate the impacts of viral coinfection and macrolide-resistant M. pneumoniae infection on hospitalized M. pneumoniae pneumonia in hospitalized children and build a model to predict a severe disease course. Methods: Nasopharyngeal swabs or sputum specimens were collected from patients with community-acquired pneumonia who were admitted to Shanghai Children’s Medical Center from December 1, 2016, to May 31, 2019. The specimens were tested with the FilmArray Respiratory Panel, a multiplex polymerase chain reaction assay that detects 16 viruses, Bordetella pertussis, M. pneumoniae, and Chlamydophila pneumoniae. Univariate and multivariate logistic regression models were used to identify the risk factors for adenovirus coinfection and macrolide-resistant mycoplasma infection.Results: Among the 107 M. pneumoniae pneumonia patients, the coinfection rate was 56.07%, and 68 (68/107, 63.55%) patients were infected by drug-resistant M. pneumoniae. Adenovirus was the most prevalent coinfecting organism, accounting for 22.43% (24/107). The classification tree confirmed that viral coinfection was more common in patients younger than 3 years. Adenovirus coinfection and drug-resistant M. pneumoniae infection occurred more commonly in patients with refractory M. pneumoniae pneumonia (P=0.019; P=0.001). A prediction model including wheezing, lung consolidation and extrapulmonary complications was used to predict adenovirus coinfection. The area under the receiver operating characteristic curve of the prediction model was 0.795 (95% CI 0.679-0.893, P<0.001). A prolonged fever duration after the application of macrolides for 48 hours was found more commonly in patients infected by drug-resistant M. pneumoniae (P=0.002). A fever duration longer than 7 days was an independent risk factor for drug-resistant Mycoplasma infection (OR=3.500, 95% CI=1.310-9.353, P=0.012).Conclusions: The occurrence of refractory M. pneumoniae pneumonia is associated with adenovirus coinfection and infection by drug-resistant M. pneumoniae. A prediction model combining wheezing, extrapulmonary complications and lung consolidation can be used to predict adenovirus coinfection in children with M. pneumoniae pneumonia. A prolonged fever duration indicates drug-resistant M. pneumoniae infection, and a reasonable change in antibiotics is necessary.

scholarly journals Evidence of Acute Mycoplasma Infection in a Patient with Incomplete and Atypical Kawasaki Disease: A Case Report

2011 ◽  
Vol 2011 ◽  
pp. 1-4 ◽  
Author(s):  
M. Ebrahim ◽  
M. Gabay ◽  
R. F. Rivas-Chacon
Keyword(s):  
Case Report ◽  
Kawasaki Disease ◽  
Mycoplasma Pneumoniae ◽  
Case Reports ◽  
Infectious Agent ◽  
Mycoplasma Infection ◽  
Incomplete Kawasaki Disease ◽  
Atypical Kawasaki Disease

The etiology of Kawasaki disease remains unknown despite extensive studies. Some researchers suggest that it is caused by an infectious agent. This is a case report where a patient with incomplete Kawasaki disease was found to have evidence compatible with acuteMycoplasma pneumoniaeinfection. This is one of the several case reports linkingMycoplasma pneumoniaeto Kawasaki disease as a possible trigger. This is perhaps due to a superantigen or is mediated by some other mechanism. Accurate and timely testing forMycoplasma infectionsis difficult and has its limitations. Despite this,Mycoplasma pneumoniaeshould be considered in the differential and workup for Kawasaki disease.

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