scholarly journals The First Two Total Cystectomies – A brief history of failed-successes

2021 ◽  
Author(s):  
Harry Herr
Keyword(s):  
Bladder Cancer ◽  
Radical Cystectomy ◽  
Vascular Control ◽  
Secondary Sources ◽  
History Of ◽  
Proper Perspective ◽  
Contemporary Technology ◽  
Complex Surgery

Objectives Radical cystectomy is a complex surgery for bladder cancer which has undergone progressive changes for a century. The originators of the procedure required pioneering innovation and their biographies place the challenges of radical cystectomy in proper perspective Methods English and German textbooks and secondary sources Results Bernard Bardenheuer (1839-1913) and Karl Pawlik (1849-1914) performed the world’s first two cystectomies for bladder cancer, overcoming challenges of contemporary anesthesia, vascular control, and renal drainage. Conclusions The originators of radical cystectomy illustrate that true advances in surgery require bold innovation and forward thinking but also that the limitations of contemporary technology must be overcome.

1233: Natural History of Bladder Cancer in Patients with P0 Disease at Radical Cystectomy

2006 ◽  
Vol 175 (4S) ◽  
pp. 397-397 ◽  
Author(s):  
Wassim Kassouf ◽  
Philippe E. Spiess ◽  
Gordon A. Brown ◽  
Mark F. Munsell ◽  
H. Barton Grossman ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Natural History ◽  
Radical Cystectomy ◽  
History Of

scholarly journals Natural history of pT3-4 or node positive bladder cancer treated with radical cystectomy and no neoadjuvant chemotherapy in a contemporary North-American multi-institutional cohort

2012 ◽  
Vol 6 (6) ◽  
pp. 217 ◽  
Author(s):  
Nicholas E. Power ◽  
Wassim Kassouf ◽  
David Bell ◽  
Armen Aprikian ◽  
Yves Fradet ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
High Risk ◽  
Adjuvant Chemotherapy ◽  
Neoadjuvant Chemotherapy ◽  
Natural History ◽  
Radical Cystectomy ◽  
Node Positive ◽  
Number Of Patients ◽  
History Of ◽  
Modern Era

Background: The present study documents the natural history and outcomes of high-risk bladder cancer after radical cystectomy (RC) in patients who did not receive neoadjuvant chemotherapy during a contemporary time period.Methods: We analyzed 1180 patients from 1993 to 2008 with >pT3N0 or pT0-4N+ bladder cancer who underwent RC ± standard (sLND) or extended (eLND) lymph node dissection from 8 Canadian centres.Results: Of the 1180 patients, 55% (n = 643) underwent sLND, 34% (n = 402) underwent ePLND and 11% did not undergo a formal LND. Of the total number of patients, 321 (27%) received adjuvant chemotherapy. The median follow-up was 2.1 years (range: 0.6 to 12.9). Overall 30-day mortality was 3.2%. Clinical and pathological stages T3-4 were present in 6.1% and 86.7% of the patients, respectively; this demonstrates a dramatic understaging. Overall survival (OS) at 2 and 5 years was 60% and 43%, respectively. Patients who received adjuvant chemotherapy hada 2- and 5-year disease-specific survival (DSS) of 72% and 57% versus 64% and 51% for those who did not (log-rank p = 0.0039). The 2- and 5-year OS for high-risk node-negative disease was 67%and 52%, respectively, whereas for node-positive patients, the OS was 52% and 32%, respectively (p < 0.001). The OS, DSS and RFS for patients with pN0 were significantly improved compared to those who did not undergo a LND (log-rank p = 0.0035, 0.0241 and 0.0383, respectively).Interpretation: This series suggests that bladder cancer outcomes inadvanced disease have improved in the modern era. The need for improved staging investigations, use of neoadjuvant chemotherapyand performance of complete LND is emphasized.

scholarly journals Re-operation within 30 days of radical cystectomy: Identifying high-risk patients and complications using ACS-NSQIP database

2020 ◽  
Vol 15 (1) ◽  
Author(s):  
Rashid K. Sayyid ◽  
Diana Magee ◽  
Amanda E. Hird ◽  
Benjamin T. Harper ◽  
Eric Webb ◽  
...  
Keyword(s):  
Risk Factors ◽  
Bladder Cancer ◽  
African American ◽  
High Risk ◽  
Radical Cystectomy ◽  
High Risk Patients ◽  
Metastatic Bladder Cancer ◽  
Risk Patients ◽  
History Of ◽  
African American Race

Introduction: Radical cystectomy (RC) is a highly morbid procedure, with 30-day complication rates approaching 31%. Our objective was to determine risk factors for re-operation within 30 days following a RC for non-metastatic bladder cancer. Methods: We included all patients who underwent a RC for non-metastatic bladder cancer using The American College of Surgeons National Surgical Quality Improvement Program database between January 1, 2007 and December 31, 2014. Logistic regression analyses were used to evaluate predictors of re-operation. Results: A total of 2608 patients were included; 5.8% of patients underwent re-operation within 30 days. On multivariable analysis, increasing body mass index (BMI) (odds ratio [OR] 1.04; 95% confidence interval [CI] 1.01–1.07), African-American race (vs. Caucasian OR 2.29; 95% CI 1.21–4.34), and history of chronic obstructive pulmonary disease (COPD) (OR 2.33; 95% CI 1.45–3.74) were significant predictors of re-operation within 30 days of RC. Urinary diversion type (ileal conduit vs. continent) and history of chemotherapy or radiotherapy within 30 days prior to RC were not. Patients who underwent re-operation within this timeframe had a significantly higher mortality rate (4.0% vs. 1.6%) and were more likely to experience cardiac (7.2% vs. 1.9%), pulmonary (23.0% vs. 3.0%), neurological (2.0% vs. 0.49%), and venous thromboembolic events (10.5% vs. 5.4%), as well as infectious complications (64.5% vs. 24.1%) with a significantly longer hospital length of stay (16.5 vs. 7.0 days). Conclusions: Recognizing increasing BMI, COPD, and African-American race as risk factors for re-operation within 30 days of RC will allow urologists to preoperatively identify such high-risk patients and prompt them to adopt more aggressive approaches to minimize postoperative surgical complications.

scholarly journals Vaginal metastasis of bladder urothelial carcinoma: Description of a case and revision of literature

2017 ◽  
Vol 89 (2) ◽  
pp. 156 ◽  
Author(s):  
Carmelo A. Di Franco ◽  
Daniele Porru ◽  
Giovanni Giliberto ◽  
Alessandra Viglio ◽  
Bruno Rovereto
Keyword(s):  
Bladder Cancer ◽  
Urothelial Carcinoma ◽  
Radical Cystectomy ◽  
Vaginal Bleeding ◽  
Urothelial Cancer ◽  
Vaginal Wall ◽  
Rare Entity ◽  
Bladder Urothelial Carcinoma ◽  
Vaginal Metastasis ◽  
History Of

Vaginal metastases from urothelial cancer are a rare entity and in literature, few cases are described. We report a case of a 68 year-old woman with history of bladder urothelial carcinoma underwent to radical cystectomy who came in our department after 5 months for pelvic pain and vaginal bleeding. Objective examination revealed an ulcerative, solid vaginal lesion in the upper vaginal wall. We performed a vaginal biopsy that showed urothelial carcinoma compatible with the primitive bladder cancer. The patient underwent to surgery and was sent to oncological evaluation.

scholarly journals Radical Cystectomy after BCG Immunotherapy for High-Risk Nonmuscle-Invasive Bladder Cancer in Patients with Previous Prostate Radiotherapy

ISRN Urology ◽  
2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Manoj V. Rao ◽  
Marcus L. Quek ◽  
Gautam Jayram ◽  
Chandy Ellimoottil ◽  
Timothy Sondej ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Radical Cystectomy ◽  
Invasive Bladder Cancer ◽  
Recurrence Free Survival ◽  
Free Survival ◽  
Prostate Radiotherapy ◽  
Bcg Immunotherapy ◽  
Bcg Therapy ◽  
History Of ◽  
Nonmuscle Invasive Bladder Cancer

Purpose. Intravesical Bacillus Calmette-Guerin (BCG) immunotherapy is indicated for high-grade nonmuscle-invasive bladder cancer (NMIBC). The efficacy of BCG in patients with a history of previous pelvic radiotherapy (RT) may be diminished. We evaluated the outcomes of radical cystectomy for BCG-treated recurrent bladder cancer in patients with a history of RT for prostate cancer (PC). Methods. A retrospective chart review was performed to identify patients with primary NMIBC. We compared the outcomes of three groups of patients who underwent radical cystectomy for BCG-refractory NMIBC: those with a history of RT for PC, those who previously underwent radical prostatectomy (RP), and a cohort without PC or RT exposure. Results. From 1996 to 2008, 53 patients underwent radical cystectomy for recurrent NMIBC despite BCG. Those with previous pelvic RT were more likely to have a higher pathologic stage and decreased recurrence-free survival compared to the groups without prior RT exposure. Conclusion. Response rates for intravesical BCG therapy may be impaired in those with prior prostate radiotherapy. Patients with a history of RT who undergo radical cystectomy after failed BCG are more likely to be pathologically upstaged and have decreased recurrence-free survival. Earlier consideration of radical cystectomy may be warranted for those with NMIBC who previously received RT for PC.

scholarly journals Pathology of bladder cancer among diabetic patients undergoing radical cystectomy with a history of pioglitazone (Actos) use

BMC Urology ◽  
2014 ◽  
Vol 14 (1) ◽  
Author(s):  
Victoriano Romero ◽  
Charles Peyton ◽  
Ian Gray ◽  
Ashok Hemal ◽  
Ryan Terlecki
Keyword(s):  
Bladder Cancer ◽  
Radical Cystectomy ◽  
Diabetic Patients ◽  
History Of

MP72-03 RADICAL CYSTECTOMY FOR BLADDER CANCER IN PATIENTS WITH AND WITHOUT A HISTORY OF PELVIC IRRADIATION: A COMPARISON OF SURVIVAL OUTCOMES AND DIVERSION-RELATED COMPLICATIONS

2015 ◽  
Vol 193 (4S) ◽  
Author(s):  
Daniel Nguyen ◽  
Bashir Al Hussein Al Awamlh ◽  
Bishoy Faltas ◽  
Padraic O'Malley ◽  
Abimbola Ayangbesan ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Radical Cystectomy ◽  
Survival Outcomes ◽  
Pelvic Irradiation ◽  
History Of

Radical Cystectomy for Bladder Cancer in Patients With and Without a History of Pelvic Irradiation: Survival Outcomes and Diversion-related Complications

Urology ◽  
2015 ◽  
Vol 86 (1) ◽  
pp. 99-107 ◽  
Author(s):  
Daniel P. Nguyen ◽  
Bashir Al Hussein Al Awamlh ◽  
Bishoy M. Faltas ◽  
Padraic O'Malley ◽  
Abimbola Ayangbesan ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Radical Cystectomy ◽  
Survival Outcomes ◽  
Pelvic Irradiation ◽  
History Of
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