Baseline C-Reactive Protein Level Predicts Survival of Early-Stage Lung Cancer: Evidence from a Systematic Review and Meta-Analysis

2016 ◽  
Vol 102 (5) ◽  
pp. 441-449 ◽  
Author(s):  
Giovanni Leuzzi ◽  
Carlotta Galeone ◽  
Mara Gisabella ◽  
Leonardo Duranti ◽  
Francesca Taverna ◽  
...  
Medicina ◽  
2011 ◽  
Vol 47 (8) ◽  
pp. 421 ◽  
Author(s):  
Neringa Vagulienė ◽  
Marius Žemaitis ◽  
Skaidrius Miliauskas ◽  
Daiva Urbonienė ◽  
Brigita ◽  
...  

Objective. The aim of this study was to establish C-reactive protein (CRP) levels in serum of patients with lung cancer and chronic obstructive pulmonary disease (COPD) and evaluate the associations of CRP levels with clinicopathological characteristics. Materials and Methods. In total, 140 persons were included in the study: 43 patients with lung cancer, 34 patients with lung cancer and COPD, 42 patients with COPD, and 21 healthy subjects. CRP analysis was performed with a serum protein analyzer using commercially available highsensitivity reagent kits. Results. The C-reactive protein levels were significantly higher in the lung cancer patients with or without COPD compared with the COPD patients or the control group (20.42±1.95 and 22.49±2.31 vs. 8.37±0.91 and 2.49±0.47 mg/L, respectively; P<0.01). The patients with advanced lung cancer had higher CRP levels compared with the patients suffering from early stage lung cancer (23.11±1.72 vs. 14.59±2.23 mg/L, P<0.01). The CRP levels were significantly higher in the patients with early stage lung cancer compared with the COPD patients (14.59±2.23 mg/L vs. 8.37±0.91 mg/L, P<0.05). No association was found between CRP and histology, lung function, and smoking status in the patients with lung cancer. Conclusions. Chronic inflammation plays an important role in both diseases: lung cancer and COPD. However, it seems that inflammation is more pronounced in patients with lung cancer, as the CRP levels were significantly higher in these patients than other groups.


2013 ◽  
Vol 46 (1) ◽  
pp. 1-7 ◽  
Author(s):  
F. Bao ◽  
P. Ye ◽  
Y. Yang ◽  
L. Wang ◽  
C. Zhang ◽  
...  

Oncotarget ◽  
2019 ◽  
Vol 10 (67) ◽  
pp. 7142-7155 ◽  
Author(s):  
Stephanie Tuminello ◽  
Rajwanth Veluswamy ◽  
Wil Lieberman-Cribbin ◽  
Sacha Gnjatic ◽  
Francesca Petralia ◽  
...  

PLoS ONE ◽  
2015 ◽  
Vol 10 (12) ◽  
pp. e0144406 ◽  
Author(s):  
Jian Song ◽  
Song Chen ◽  
Xiaoting Liu ◽  
Hongtao Duan ◽  
Jiahui Kong ◽  
...  

2019 ◽  
Vol 45 ◽  
pp. 98-103 ◽  
Author(s):  
Somayeh Saboori ◽  
Ebrahim Falahi ◽  
Esmaeil Yousefi Rad ◽  
Omid Asbaghi ◽  
Mohammad Zeinali Khosroshahi

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