Addition of 2% crushed fenugreek seed to a high-fat diet reduces bone mineral density in C57BL/6J mice

2014 ◽  
Vol 32 (3) ◽  
pp. 146-151
Author(s):  
Simon A. Cichello ◽  
Denovan Begg ◽  
Markendya Jois ◽  
Richard Weisinger
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
High Fat Diet ◽  
High Fat ◽  
Mineral Density ◽  
Fenugreek Seed

scholarly journals Inulin supplementation reduces the negative effect of a high-fat diet rich in SFA on bone health of growing pigs

2018 ◽  
Vol 119 (10) ◽  
pp. 1111-1118 ◽  
Author(s):  
Monika Sobol ◽  
Stanisława Raj ◽  
Grzegorz Skiba
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Bone Health ◽  
High Fat Diet ◽  
Growing Pigs ◽  
Whole Body ◽  
Standard Diet ◽  
High Fat ◽  
Mineral Density ◽  
Negative Effect

AbstractConsumption of a high-fat diet, rich in SFA, causes deterioration of bone properties. Some studies suggest that feeding inulin to animals may increase mineral absorption and positively affect bone quality; however, these studies have been carried out only on rodents fed a standard diet. The primary objective of this study was to determine the effect of inulin on bone health of pigs (using it as an animal model for humans) fed a high-fat diet rich in SFA, having an unbalanced ratio of lysine:metabolisable energy. It was hypothesised that inulin reduces the negative effects of such a diet on bone health. At 50 d of age, twenty-one pigs were randomly allotted to three groups: the control (C) group fed a standard diet, and two experimental (T and TI) groups fed a high-fat diet rich in SFA. Moreover, TI pigs consumed an extra inulin supply (7 % of daily feed intake). After 10 weeks, whole-body bone mineral content (P=0·0054) and bone mineral density (P=0·0322) were higher in pigs of groups TI and C compared with those of group T. Femur bone mineral density was highest in pigs in group C, lower in group TI and lowest in group T (P=0·001). Femurs of pigs in groups TI and C had similar, but higher, maximum strength compared with femurs of pigs in group T (P=0·0082). In conclusion, consumption of a high-fat diet rich in SFA adversely affected bone health, but inulin supplementation in such a diet diminishes this negative effect.

scholarly journals Blueberry and blackcurrant consumption increases bone mineral density and content in high fat diet‐induced obese male mice

2013 ◽  
Vol 27 (S1) ◽  
Author(s):  
Sang Gil Lee ◽  
Terrence Vance ◽  
Do Yu Soung ◽  
Bohkyung Kim ◽  
Jiyoung Lee ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
High Fat Diet ◽  
Male Mice ◽  
High Fat ◽  
Mineral Density ◽  
Obese Male

scholarly journals Effect of Vitamin E Isoforms on Bone Metabolism in C57BL/6 J Mice Fed a High Fat Diet

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 1795-1795
Author(s):  
Chen Du ◽  
Gina Tran ◽  
Victorine Imrhan ◽  
Chandan Prasad ◽  
Parakat Vijayagopal ◽  
...  
Keyword(s):  
Vitamin E ◽  
Bone Loss ◽  
Bone Metabolism ◽  
Bone Mineral ◽  
High Fat Diet ◽  
Alpha Tocopherol ◽  
Type I ◽  
High Fat ◽  
Mineral Density ◽  
Gamma Tocopherol

Abstract Objectives The purpose of this study was to compare the effects of alpha tocopherol, gamma tocopherol, and the combination of alpha and gamma tocopherols on bone mineral density (BMD), bone mineral content (BMC), and bone metabolism in C57BL/6 J mice fed a high-fat diet. Methods A total of 75 male C57BL/6 mice were randomized to either a low fat diet (LFD) with 6% fat, a high fat diet (HFD) with 20% fat, HFD supplemented with alpha tocopherol (AT), gamma tocopherol (GT), or the combination of AT and GT. LFD and HFD were provided to corresponding groups of mice without vitamin E isoform supplements for 15 weeks to induce bone loss. At the end of the 15 weeks, AT, GT, and a combination of AT and GT were added to 3 of the HFD groups and fed for 10 weeks. LFD group and one of the HFD groups were continued on the same diet for another 10 weeks without additional supplements. All mice were euthanized at the end of the 25 weeks period. Left and right fibula bones were excised, cleaned, and scanned using the Lunar PIXImus dual-energy x-ray absorptiometry (DEXA) densitometer to assess BMD, BMC, lean tissue, and fat tissue content. Serum biomarkers of bone metabolism were evaluated post euthanization. Results HFD resulted in significantly lower fibular BMD and higher tibial bone fat content in comparison to LFD. Animals in the HFD supplemented with GT, but not AT, showed significantly reduced effect of HFD in lowering BMD. Additionally, in the group fed HFD supplemented with GT, a significantly higher concentration of alkaline phosphatase (ALP) and N-terminal propeptide of type I procollagen (PINP) were noted, compared to LFD. This may be indicative of increased bone formation resulting from GT incorporated into the HFD diet. Conclusions The findings of the study suggest that different isoforms of vitamin E affect bone density and bone metabolism differently. Within the different isoforms of vitamin E, gamma tocopherol may have protective effects in bone, especially in the situation of high fat diet induced bone loss. Further examination of the mechanistic action of vitamin E isoforms on skeletal health is warranted. Funding Sources Texas Woman's University.

scholarly journals FGF21 decreases body weight without reducing food intake or bone mineral density in high-fat fed obese rhesus macaque monkeys

2018 ◽  
Vol 42 (6) ◽  
pp. 1151-1160 ◽  
Author(s):  
Birgitte Andersen ◽  
Ellen M. Straarup ◽  
Kristy M. Heppner ◽  
Diana L. Takahashi ◽  
Virginia Raffaele ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Body Weight ◽  
Food Intake ◽  
Rhesus Macaque ◽  
Bone Mineral ◽  
High Fat ◽  
Mineral Density ◽  
Macaque Monkeys

scholarly journals Consequences of high‐fat diets on body growth and bone mineral density, in growing rats

2008 ◽  
Vol 22 (S1) ◽  
Author(s):  
Silvia Maria Friedman ◽  
Elisa Vanesa Macri ◽  
Patricia Noemi Rodriguez ◽  
Natalia Juiz ◽  
Cristina Graciela Suarez ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Body Growth ◽  
High Fat ◽  
Mineral Density ◽  
Growing Rats ◽  
High Fat Diets ◽  
Fat Diets

scholarly journals Short-term exposure to low-carbohydrate, high-fat diets induces low bone mineral density and reduces bone formation in rats

2009 ◽  
Vol 25 (2) ◽  
pp. 275-284 ◽  
Author(s):  
Maximilian Bielohuby ◽  
Maiko Matsuura ◽  
Nadja Herbach ◽  
Ellen Kienzle ◽  
Marc Slawik ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Formation ◽  
Bone Mineral ◽  
High Fat ◽  
Mineral Density ◽  
Short Term ◽  
Short Term Exposure ◽  
Low Carbohydrate ◽  
High Fat Diets ◽  
Fat Diets

Design of a Torsion Tester for Measuring Murine Bone Properties for Studies on the Effects of Diabetes and Obesity

2013 ◽  
Author(s):  
Brandon Sherrod ◽  
Shawn Gilbert ◽  
Krista Casazza ◽  
Alan Eberhardt
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Fracture Incidence ◽  
Type I ◽  
Healthy Weight ◽  
High Fat ◽  
Mineral Density ◽  
Body Regions ◽  
Increased Risk ◽  
Diabetes And Obesity

Conditions such as diabetes and obesity have been found to affect the mechanical integrity of bone. Studies have shown that diabetic rodent models exhibit lower levels of new bone formation during fracture healing 1, lower bone mineral density (BMD) 2, and increased risk of fracture 3. There are differences, however, in the bone integrity of bone samples from type I and type II diabetics, which is most likely due to obesity 2. Findings from research on obesity’s effects on bone integrity have been controversial; although there is an increase in bone mineral density (BMD) with increasing body mass index (BMI) and a decrease in fracture incidence in the central body regions in obese women compared to healthy weight women due to soft tissue padding, there is an increase in fracture incidence at extremeties 4. Other studies have shown that while cortical bone strength may not be adversely affected by high-fat diets, cancellous bone BMD and mechanical strength was significantly lower in high-fat diet mice than low-fat diet mice 5. In addition, extreme obesity has been associated with lower BMD despite the general trend of increased BMD with higher BMI 6.

The Effect Of A High Fat/high Sugar Diet And Physical Activity On Body Fat Percentage And Bone Mineral Density

2016 ◽  
Vol 48 ◽  
pp. 525
Author(s):  
Ayland C. Letsinger ◽  
Heather L. Vellers ◽  
Jorge Z. Granados ◽  
Nick R. Walker ◽  
Madison E. Spier ◽  
...  
Keyword(s):  
Physical Activity ◽  
Bone Mineral Density ◽  
Body Fat ◽  
Bone Mineral ◽  
Body Fat Percentage ◽  
High Fat ◽  
Fat Percentage ◽  
Mineral Density ◽  
High Sugar ◽  
Diet And Physical Activity
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