Taste receptor stimulation in the oral cavity contributes to triggering deglutition and enhancing its performance in amyotrophic lateral sclerosis patients with oropharyngeal dysphagia

2014 ◽  
Vol 32 (2) ◽  
pp. 79-84
Author(s):  
Luca Piretta ◽  
Valentina Settipani ◽  
Ilenia Schettino ◽  
Maurizio Inghilleri ◽  
Enrico Corazziari
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Oral Cavity ◽  
Oropharyngeal Dysphagia ◽  
Taste Receptor ◽  
Receptor Stimulation ◽  
Lateral Sclerosis

scholarly journals A Case of Amyotrophic Lateral Sclerosis Presented as Oropharyngeal Dysphagia

2010 ◽  
Vol 16 (3) ◽  
pp. 319-322 ◽  
Author(s):  
Eun Ji Noh ◽  
Moo In Park ◽  
Seun Ja Park ◽  
Won Moon ◽  
Hyun Joo Jung
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Oropharyngeal Dysphagia ◽  
Lateral Sclerosis

scholarly journals Progression of Oropharyngeal Dysphagia in Amyotrophic Lateral Sclerosis: A Retrospective Cohort Study

Dysphagia ◽  
2021 ◽  
Author(s):  
Laura Mariani ◽  
Giovanni Ruoppolo ◽  
Armando Cilfone ◽  
Chiara Cocchi ◽  
Jacopo Preziosi Standoli ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Cohort Study ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Cox Regression ◽  
Oropharyngeal Dysphagia ◽  
Incidence Rates ◽  
Increased Risk ◽  
Als Patients ◽  
Lateral Sclerosis

AbstractLittle is known regarding the optimal timing of dysphagia assessment and PEG indication in amyotrophic lateral sclerosis (ALS). The study aims to investigate the progression of dysphagia in a cohort of ALS patients and to analyse whether there are variables linked to a faster progression of dysphagia and faster indication of PEG placement. A retrospective cohort study in 108 individuals with ALS. Fiberoptic endoscopic evaluation of swallowing was performed 6 monthly until PEG indication or death. Dysphagia severity and PEG indication were assessed using Penetration Aspiration Scale. Progression Index (PI) analysed the risk of disease progression (fast/slow) in relation to dysphagia onset and PEG indication. Patients were grouped based on ALS onset and PI. Person-time incidence rates were computed considering dysphagia onset and PEG indication from ALS symptoms during the entire observation period and have been reported as monthly and 6-month rates. Cox regression survival analysis assessed dysphagia and PEG risk factors depending on onset. Person-time incidence rates of dysphagia progression and PEG risk were increased based on type of ALS onset and PI. Patients with a fast progressing disease and with bulbar onset (BO) show statistically significant increased risk of dysphagia (BO 178.10% hazard ratio (HR) = 2.781 P < 0.01; fast 181.10% HR 2.811 P < 0.01). Regarding PEG risk, fast patients and patients with BO had a statistically significant increased risk (fast 147.40% HR 2.474 P < 0.01, BO 165.40% HR 2.654 P < 0.01). Fast PI predicts the likelihood of faster progression of dysphagia and PEG indication and should be included in multidisciplinary assessments and considered in the design of future guidelines regarding dysphagia management in ALS patients.Level of Evidence Level IV.

Oropharyngeal dysphagia in amyotrophic lateral sclerosis alters quality of life

2012 ◽  
Vol 40 (3) ◽  
pp. 199-204 ◽  
Author(s):  
G. Paris ◽  
O. Martinaud ◽  
A. Petit ◽  
A. Cuvelier ◽  
D. Hannequin ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Amyotrophic Lateral Sclerosis ◽  
Oropharyngeal Dysphagia ◽  
Lateral Sclerosis

scholarly journals Pathophysiological mechanisms of oropharyngeal dysphagia in amyotrophic lateral sclerosis

Brain ◽  
2000 ◽  
Vol 123 (1) ◽  
pp. 125-140 ◽  
Author(s):  
Cumhur Ertekin ◽  
Ibrahim Aydogdu ◽  
Nur Yüceyar ◽  
Nefati Kiylioglu ◽  
Sultan Tarlaci ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Oropharyngeal Dysphagia ◽  
Pathophysiological Mechanisms ◽  
Lateral Sclerosis

Automated Acoustic Analysis of Oral Diadochokinesis to Assess Bulbar Motor Involvement in Amyotrophic Lateral Sclerosis

2020 ◽  
Vol 63 (1) ◽  
pp. 59-73 ◽  
Author(s):  
Panying Rong
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Acoustic Analysis ◽  
Speaking Rate ◽  
Disease Stage ◽  
Healthy Controls ◽  
Tongue Movement ◽  
Major Barrier ◽  
Syllable Repetition ◽  
Oral Diadochokinesis ◽  
Lateral Sclerosis

Purpose The purpose of this article was to validate a novel acoustic analysis of oral diadochokinesis (DDK) in assessing bulbar motor involvement in amyotrophic lateral sclerosis (ALS). Method An automated acoustic DDK analysis was developed, which filtered out the voice features and extracted the envelope of the acoustic waveform reflecting the temporal pattern of syllable repetitions during an oral DDK task (i.e., repetitions of /tɑ/ at the maximum rate on 1 breath). Cycle-to-cycle temporal variability (cTV) of envelope fluctuations and syllable repetition rate (sylRate) were derived from the envelope and validated against 2 kinematic measures, which are tongue movement jitter (movJitter) and alternating tongue movement rate (AMR) during the DDK task, in 16 individuals with bulbar ALS and 18 healthy controls. After the validation, cTV, sylRate, movJitter, and AMR, along with an established clinical speech measure, that is, speaking rate (SR), were compared in their ability to (a) differentiate individuals with ALS from healthy controls and (b) detect early-stage bulbar declines in ALS. Results cTV and sylRate were significantly correlated with movJitter and AMR, respectively, across individuals with ALS and healthy controls, confirming the validity of the acoustic DDK analysis in extracting the temporal DDK pattern. Among all the acoustic and kinematic DDK measures, cTV showed the highest diagnostic accuracy (i.e., 0.87) with 80% sensitivity and 94% specificity in differentiating individuals with ALS from healthy controls, which outperformed the SR measure. Moreover, cTV showed a large increase during the early disease stage, which preceded the decline of SR. Conclusions This study provided preliminary validation of a novel automated acoustic DDK analysis in extracting a useful measure, namely, cTV, for early detection of bulbar ALS. This analysis overcame a major barrier in the existing acoustic DDK analysis, which is continuous voicing between syllables that interferes with syllable structures. This approach has potential clinical applications as a novel bulbar assessment.

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