Adipose-Derived Cell Transplantation in Systemic Sclerosis: State of the Art and Future Perspectives

2016 ◽  
Vol 2 (1) ◽  
pp. 33-41 ◽  
Author(s):  
Nicoletta Del Papa ◽  
Eleonora Zaccara ◽  
Gabriele Di Luca ◽  
Romina Andracco ◽  
Wanda Maglione ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Cell Transplantation ◽  
State Of The Art ◽  
Future Perspectives

scholarly journals Current and future perspectives on management of systemic sclerosis-associated interstitial lung disease

2019 ◽  
Vol 15 (10) ◽  
pp. 1009-1017 ◽  
Author(s):  
Oliver Distler ◽  
Elizabeth R. Volkmann ◽  
Anna Maria Hoffmann-Vold ◽  
Toby M. Maher
Keyword(s):  
Systemic Sclerosis ◽  
Interstitial Lung Disease ◽  
Lung Disease ◽  
Future Perspectives

scholarly journals A review on the properties, reinforcing effects, and commercialization of nanomaterials for cement-based materials

2020 ◽  
Vol 9 (1) ◽  
pp. 303-322 ◽  
Author(s):  
Zhifang Zhao ◽  
Tianqi Qi ◽  
Wei Zhou ◽  
David Hui ◽  
Cong Xiao ◽  
...  
Keyword(s):  
Cement Hydration ◽  
State Of The Art ◽  
Research Progress ◽  
Market Survey ◽  
Future Perspectives ◽  
Nano Silica ◽  
Physical Processes ◽  
Existing Problems ◽  
Cement Based Materials ◽  
The Cost

AbstractThe behavior of cement-based materials is manipulated by chemical and physical processes at the nanolevel. Therefore, the application of nanomaterials in civil engineering to develop nano-modified cement-based materials is a promising research. In recent decades, a large number of researchers have tried to improve the properties of cement-based materials by employing various nanomaterials and to characterize the mechanism of nano-strengthening. In this study, the state of the art progress of nano-modified cement-based materials is systematically reviewed and summarized. First, this study reviews the basic properties and dispersion methods of nanomaterials commonly used in cement-based materials, including carbon nanotubes, carbon nanofibers, graphene, graphene oxide, nano-silica, nano-calcium carbonate, nano-calcium silicate hydrate, etc. Then the research progress on nano-engineered cementitious composites is reviewed from the view of accelerating cement hydration, reinforcing mechanical properties, and improving durability. In addition, the market and applications of nanomaterials for cement-based materials are briefly discussed, and the cost is creatively summarized through market survey. Finally, this study also summarizes the existing problems in current research and provides future perspectives accordingly.

scholarly journals Annelid Diversity: Historical Overview and Future Perspectives

Diversity ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 129
Author(s):  
María Capa ◽  
Pat Hutchings
Keyword(s):  
State Of The Art ◽  
Molecular Taxonomy ◽  
Evolutionary Relationships ◽  
Diverse Group ◽  
Future Perspectives ◽  
Special Issue ◽  
Species Numbers ◽  
Species Complexes ◽  
Taxonomic Groups ◽  
A New Species

Annelida is a ubiquitous, common and diverse group of organisms, found in terrestrial, fresh waters and marine environments. Despite the large efforts put into resolving the evolutionary relationships of these and other Lophotrochozoa, and the delineation of the basal nodes within the group, these are still unanswered. Annelida holds an enormous diversity of forms and biological strategies alongside a large number of species, following Arthropoda, Mollusca, Vertebrata and perhaps Platyhelminthes, among the species most rich in phyla within Metazoa. The number of currently accepted annelid species changes rapidly when taxonomic groups are revised due to synonymies and descriptions of a new species. The group is also experiencing a recent increase in species numbers as a consequence of the use of molecular taxonomy methods, which allows the delineation of the entities within species complexes. This review aims at succinctly reviewing the state-of-the-art of annelid diversity and summarizing the main systematic revisions carried out in the group. Moreover, it should be considered as the introduction to the papers that form this Special Issue on Systematics and Biodiversity of Annelids.

scholarly journals Rituximab as a Treatment Option after Autologous Hematopoietic Stem Cell Transplantation in a Patient with Systemic Sclerosis

2021 ◽  
Vol 11 (7) ◽  
pp. 600
Author(s):  
Paul Gressenberger ◽  
Philipp Jud ◽  
Gabor Kovacs ◽  
Sonja Kreuzer ◽  
Hans-Peter Brezinsek ◽  
...  
Keyword(s):  
Stem Cell ◽  
Systemic Sclerosis ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Hematopoietic Stem Cell ◽  
Treatment Option ◽  
Clinical Symptoms ◽  
Stable Condition ◽  
Hematopoietic Stem

Systemic sclerosis (SSc) is an intractable autoimmune disease characterized by vasculopathy and organ fibrosis. Autologous hematopoietic stem cell transplantation (AHSCT) should be considered for the treatment of selected patients with rapid progressive SSc at high risk of organ failure. It, however, remains elusive whether immunosuppressive therapies such as rituximab (RTX) are still necessary for such patients after AHSCT, especially in those with bad outcomes. In the present report, a 43-year-old man with diffuse cutaneous SSc received AHSCT. Despite AHSCT, SSc further progressed with progressive symptomatic heart failure with newly developed concomitant mitral and tricuspid valve insufficiency, thus the patient started on RTX 8 months after AHSCT. Shortly after initiation of RTX, clinical symptoms and organ functions ameliorated subsequently. Heart valve regurgitations were reversible after initiation of RTX treatment. Currently, the patient remains in a stable condition with significant improvement of clinical symptoms and organ functions. Reporting about therapies after AHSCT in SSc is a very important issue, as randomized controlled trials are lacking, and therefore this report adds to evidence that RTX can be considered as a treatment option in patients with SSc that do not respond to AHSCT.

scholarly journals Age-Friendly Cities and Communities: State of the Art and Future Perspectives

2021 ◽  
Vol 18 (4) ◽  
pp. 1644
Author(s):  
Joost van Hoof ◽  
Hannah R. Marston
Keyword(s):  
Older Adults ◽  
State Of The Art ◽  
Future Perspectives ◽  
Demographic Shift ◽  
Welfare Systems

The number of older adults is increasing rapidly, and this demographic shift places an increased level of strain and tension on the various international healthcare and welfare systems [...]

scholarly journals Nanomedicine-Based Strategies Assisting Photodynamic Therapy for Hypoxic Tumors: State-of-the-Art Approaches and Emerging Trends

Biomedicines ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 137
Author(s):  
Chun-Yan Shih ◽  
Pei-Ting Wang ◽  
Wu-Chou Su ◽  
Hsisheng Teng ◽  
Wei-Lun Huang
Keyword(s):  
Photodynamic Therapy ◽  
State Of The Art ◽  
Metal Organic Framework ◽  
Basic Knowledge ◽  
Future Perspectives ◽  
Effective Strategies ◽  
Emerging Trends ◽  
Tumor Tissues ◽  
Metal Organic ◽  
Manipulating Hypoxia

Since the first clinical cancer treatment in 1978, photodynamic therapy (PDT) technologies have been largely improved and approved for clinical usage in various cancers. Due to the oxygen-dependent nature, the application of PDT is still limited by hypoxia in tumor tissues. Thus, the development of effective strategies for manipulating hypoxia and improving the effectiveness of PDT is one of the most important area in PDT field. Recently, emerging nanotechnology has benefitted progress in many areas, including PDT. In this review, after briefly introducing the mechanisms of PDT and hypoxia, as well as basic knowledge about nanomedicines, we will discuss the state of the art of nanomedicine-based approaches for assisting PDT for treating hypoxic tumors, mainly based on oxygen replenishing strategies and the oxygen dependency diminishing strategies. Among these strategies, we will emphasize emerging trends about the use of nanoscale metal–organic framework (nMOF) materials and the combination of PDT with immunotherapy. We further discuss future perspectives and challenges associated with these trends in both the aspects of mechanism and clinical translation.

Smart nano-micro platforms for ophthalmological applications: The state-of-the-art and future perspectives

Biomaterials ◽  
2021 ◽  
Vol 270 ◽  
pp. 120682
Author(s):  
Qinghua Lyu ◽  
Ling Peng ◽  
Xiangqian Hong ◽  
Taojian Fan ◽  
Jingying Li ◽  
...  
Keyword(s):  
State Of The Art ◽  
The State ◽  
Future Perspectives

scholarly journals The virtual liver: state of the art and future perspectives

2014 ◽  
Vol 88 (12) ◽  
pp. 2071-2075 ◽  
Author(s):  
Dirk Drasdo ◽  
Johannes Bode ◽  
Uta Dahmen ◽  
Olaf Dirsch ◽  
Steven Dooley ◽  
...  
Keyword(s):  
State Of The Art ◽  
Future Perspectives
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