Challenges to enrollment and randomization of the frequent hemodialysis network (FHN) daily trial

2012 ◽  
Vol 25 (3) ◽  
pp. 302-309 ◽  
Author(s):  
Olga Sergeyeva ◽  
Irina Gorodetskaya ◽  
Rosio Ramos ◽  
Brigitte M. Schiller ◽  
Brett Larive ◽  
...  
Keyword(s):  
Daily Trial ◽  
Frequent Hemodialysis

scholarly journals Effects of daily hemodialysis on heart rate variability: results from the Frequent Hemodialysis Network (FHN) Daily Trial

2013 ◽  
Vol 29 (1) ◽  
pp. 168-178 ◽  
Author(s):  
C. T. Chan ◽  
G. M. Chertow ◽  
J. T. Daugirdas ◽  
T. H. Greene ◽  
P. Kotanko ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Daily Trial ◽  
Daily Hemodialysis ◽  
Frequent Hemodialysis

scholarly journals Agreement of Single- and Multi-Frequency Bioimpedance Measurements in Hemodialysis Patients: An Ancillary Study of the Frequent Hemodialysis Network Daily Trial

2014 ◽  
Vol 128 (1-2) ◽  
pp. 115-126 ◽  
Author(s):  
Jochen G. Raimann ◽  
Samer R. Abbas ◽  
Li Liu ◽  
Fansan Zhu ◽  
Brett Larive ◽  
...  
Keyword(s):  
Hemodialysis Patients ◽  
Daily Trial ◽  
Ancillary Study ◽  
Frequent Hemodialysis

scholarly journals The Predialysis Serum Sodium Level Modifies the Effect of Hemodialysis Frequency on Left-Ventricular Mass: The Frequent Hemodialysis Network Trials

2021 ◽  
pp. 1-9
Author(s):  
Jochen G. Raimann ◽  
Christopher T. Chan ◽  
John T. Daugirdas ◽  
Thomas Depner ◽  
Tom Greene ◽  
...  
Keyword(s):  
Left Ventricular Mass ◽  
Serum Sodium ◽  
Statistical Significance ◽  
Extracellular Fluid ◽  
Bioelectrical Impedance ◽  
Impedance Analysis ◽  
Left Ventricular ◽  
Daily Trial ◽  
Ventricular Mass ◽  
Frequent Hemodialysis

<b><i>Introduction:</i></b> The Frequent Hemodialysis Network (FHN) Daily and Nocturnal trials aimed to compare the effects of hemodialysis (HD) given 6 versus 3 times per week. More frequent in-center HD significantly reduced left-ventricular mass (LVM), with more pronounced effects in patients with low urine volumes. In this study, we aimed to explore another potential effect modifier: the predialysis serum sodium (SNa) and related proxies of plasma tonicity. <b><i>Methods:</i></b> Using data from the FHN Daily and Nocturnal Trials, we compared the effects of frequent HD on LVM among patients stratified by SNa, dialysate-to-predialysis serum-sodium gradient (GNa), systolic and diastolic blood pressure, time-integrated sodium-adjusted fluid load (TIFL), and extracellular fluid volume estimated by bioelectrical impedance analysis. <b><i>Results:</i></b> In 197 enrolled subjects in the FHN Daily Trial, the treatment effect of frequent HD on ∆LVM was modified by SNa. When the FHN Daily Trial participants are divided into lower and higher predialysis SNa groups (less and greater than 138 mEq/L), the LVM reduction in the lower group was substantially higher (−28.0 [95% CI −40.5 to −15.4] g) than in the higher predialysis SNa group (−2.0 [95% CI −15.5 to 11.5] g). Accounting for GNa, TIFL also showed more pronounced effects among patients with higher GNa or higher TIFL. Results in the Nocturnal Trial were similar in direction and magnitude but did not reach statistical significance. <b><i>Discussion/Conclusion:</i></b> In the FHN Daily Trial, the favorable effects of frequent HD on left-ventricular hypertrophy were more pronounced among patients with lower predialysis SNa and higher GNa and TIFL. Whether these metrics can be used to identify patients most likely to benefit from frequent HD or other dialytic or nondialytic interventions remains to be determined. Prospective, adequately powered studies studying the effect of GNa reduction on mortality and hospitalization are needed.

The Effect of Increased Frequency of Hemodialysis on Volume-Related Outcomes: A Secondary Analysis of the Frequent Hemodialysis Network Trials

2016 ◽  
Vol 41 (4) ◽  
pp. 277-286 ◽  
Author(s):  
Jochen G. Raimann ◽  
Christopher T. Chan ◽  
John T. Daugirdas ◽  
Tom Depner ◽  
Frank A. Gotch ◽  
...  
Keyword(s):  
Journal Club ◽  
Secondary Analysis ◽  
Urine Volume ◽  
Extracellular Fluid ◽  
Left Ventricular ◽  
Volume Control ◽  
Daily Trial ◽  
Interdialytic Weight Gain ◽  
Sodium Gradient ◽  
Frequent Hemodialysis

In previous reports of the Frequent Hemodialysis Network trials, frequent hemodialysis (HD) reduced extracellular fluid (ECF) and left ventricular mass (LVM), with more pronounced effects observed among patients with low urine volume (UVol). We analyzed the effect of frequent HD on interdialytic weight gain (IDWG) and a time-integrated estimate of ECF load (TIFL). We also explored whether volume and sodium loading contributed to the change in LVM over the study period. Treatment effects on volume parameters were analyzed for modification by UVol and the dialysate-to-serum sodium gradient. Predictors of change in LVM were determined using linear regression. Frequent HD reduced IDWG and TIFL in the Daily Trial. Among patients with UVol <100 ml/day, reduction in TIFL was associated with LVM reduction. This suggests that achievement of better volume control could attenuate changes in LVM associated with mortality and cardiovascular morbidity. TIFL may prove more useful than IDWG alone in guiding HD practice. Video Journal Club ‘Cappuccino with Claudio Ronco' at http://www.karger.com/?doi=441966.

scholarly journals Limited reduction in uremic solute concentrations with increased dialysis frequency and time in the Frequent Hemodialysis Network Daily Trial

2017 ◽  
Vol 91 (5) ◽  
pp. 1186-1192 ◽  
Author(s):  
Tammy L. Sirich ◽  
Kara Fong ◽  
Brett Larive ◽  
Gerald J. Beck ◽  
Glenn M. Chertow ◽  
...  
Keyword(s):  
Daily Trial ◽  
Dialysis Frequency ◽  
Frequent Hemodialysis

Implications of the Frequent Hemodialysis Network-Daily Trial

2011 ◽  
Vol 24 (6) ◽  
pp. 621-628 ◽  
Author(s):  
Kalani L. Raphael ◽  
Alfred K. Cheung
Keyword(s):  
Daily Trial ◽  
Frequent Hemodialysis
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