The Optimal Timing to Perform 18F/11C-Choline PET/CT in Patients with Suspicion of Relapse of Prostate Cancer: Trigger PSA versus PSA Velocity and PSA Doubling Time

2014 ◽  
Vol 29 (4) ◽  
pp. 423-430 ◽  
Author(s):  
Ferdinando Calabria ◽  
Domenico Rubello ◽  
Orazio Schillaci
Keyword(s):  
Prostate Cancer ◽  
Doubling Time ◽  
Short Communication ◽  
Specific Antigen ◽  
Serum Levels ◽  
Optimal Time ◽  
Optimal Timing ◽  
Choline Pet ◽  
Pet Ct ◽  
Psa Velocity

In the present short communication we considered the main publications focused on trigger prostate-specific antigen (PSA) and PSA kinetics that systematically compared 18F to 11C-choline PET/CT in order to establish the optimal time to perform choline PET/CT in relation to the trigger values and velocity, as well as doubling time of PSA serum levels.

scholarly journals ROLE OF KINETIC PERFORMANCE OF PSA IN SELECTION OF THE PATIENTS FOR CONDUCTION OF ¹¹C-CHOLINE PET/CT AIMED TO REVEAL LOCAL RECURRENCES OF PROSTATE CANCER

2015 ◽  
Vol 174 (6) ◽  
pp. 25-28
Author(s):  
M. A. Rybalov ◽  
I. Ya. De Iong ◽  
A. I. Breusma ◽  
S. Kh. Al’-Shukri ◽  
S. Yu. Borovets
Keyword(s):  
Prostate Cancer ◽  
Growth Rate ◽  
Radiation Therapy ◽  
Tumor Recurrence ◽  
Doubling Time ◽  
Local Recurrences ◽  
Choline Pet ◽  
Pet Ct ◽  
Selection Of

Given study was aimed to research a role of kinetic performance of PSA in selection of the patients for conduction ¹¹C-choline PET/CT in order to reveal local recurrences in patient with prostate cancer after radiation therapy (RT) and radical prostatectomy (RP). The study included 185 patients with histologically distinctive prostate cancer and biochemical signs of tumor recurrence after RP (61 patients) or RT (124 patients). All the patients were examined using ¹¹C-choline PET/ CT in order to detect local relapses. Calculation of growth rate of the PSA level and PSA doubling time were made. According to results of ¹¹C-choline PET/CT, recurrences of prostate cancer were detected in 124 out of 185 (65%). There were 22 patients out of 61 (36%) after RP and there were 102 patients out of 124 (82%) after RT. It was stated a correlation between PSA rates, growth rate of PSA level and presence or absence of relapse according to PET/CT results. PSA level and growth rate of PSA were indicated as the most significant predictive signs, which could influence on the selection of the patients for conduction of ¹¹C-choline PET/CT in relation to detection of local recurrence after RT and RP.

PSA and PSA Kinetics as Predictors for 18F-Fluciclovine PET/CT Positivity in Biochemically Recurrent Prostate Cancer

2021 ◽  
pp. 1-8
Author(s):  
Fabio Crocerossa ◽  
Umberto Carbonara ◽  
Jayashree Parekh ◽  
Alfredo Urdaneta ◽  
Samuel Weprin ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Sequential Analysis ◽  
Doubling Time ◽  
Alternative Hypothesis ◽  
Imaging Techniques ◽  
Psa Kinetics ◽  
Psa Doubling Time ◽  
Pet Ct ◽  
Wide Range ◽  
Psa Velocity

<b><i>Introduction:</i></b> <sup>18</sup>F-Fluciclovine PET/CT is one of the imaging techniques currently employed to restage prostate cancer (PCa). Due to the conflicting results reported in the literature, it is not yet known at what PSA threshold <sup>18</sup>F-fluciclovine PET/CT could reliably demonstrate the presence of recurring disease. We explored the association between <sup>18</sup>F-fluciclovine PET/CT positivity and prescan PSA, PSA doubling time, and PSA velocity in patients with biochemical recurrence (BCR) of PCa after curative-intent treatment. <b><i>Methods:</i></b> Data from 59 patients who underwent <sup>18</sup>F-fluciclovine PET/CT for BCR after radical prostatectomy or radiotherapy were retrieved from a single institution database. Patients already undergone salvage treatments at the time of PET/CT, with newly diagnosed PCa or with initial diagnosis of metastatic PCa were excluded. A 2-sided independent samples Bayesian <i>t</i> test and Bayesian Mann-Whitney U test were used to assess the association between PET/CT and prescan PSA, PSA doubling time, and PSA velocity. <b><i>Results:</i></b> Evidence for no difference between PET/CT-positive and -negative patients for log-transformed PSA was found (BF<sub>01</sub> 3.61, % error: 0.01). Robustness check and sequential analysis showed stability across a wide range of prior distribution specifications. The hypothesis of no difference in terms of PSA-dt and for PSA-vel between groups was found to be more likely compared to the alternative hypothesis (BF<sub>01</sub> of 3.44 and 3.48, respectively). <b><i>Conclusion:</i></b> PSA and PSA kinetics are unlikely to be associated with <sup>18</sup>F-fluciclovine PET/CT positivity in patients with BCR, and none of these serum biomarkers might be used as single predictors of PET/CT detection. Larger studies might be needed to evaluate the role of different predictors.

Prostate-specific antigen (PSA) kinetics in untreated, localized prostate cancer: PSA velocity vs PSA doubling time

2009 ◽  
Vol 103 (7) ◽  
pp. 872-876 ◽  
Author(s):  
Michael K. Ng ◽  
Nicholas Van As ◽  
Karen Thomas ◽  
Ruth Woode-Amissah ◽  
Alan Horwich ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Prostate Specific Antigen ◽  
Doubling Time ◽  
Specific Antigen ◽  
Localized Prostate Cancer ◽  
Psa Kinetics ◽  
Psa Doubling Time ◽  
Psa Velocity

Prostate-specific antigen kinetics and choline PET/CT in patients with biochemical relapse after primary treatment for prostate cancer

2011 ◽  
Vol 32 (6) ◽  
pp. 475-478 ◽  
Author(s):  
Paolo Castellucci ◽  
Chiara Fuccio ◽  
Maria Cristina Marzola ◽  
Adil Al-Nahhas ◽  
Domenico Rubello ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Prostate Specific Antigen ◽  
Specific Antigen ◽  
Primary Treatment ◽  
Biochemical Relapse ◽  
Choline Pet ◽  
Pet Ct

scholarly journals Incidental Detection of Occult Thyroid Carcinoma with 11C-Choline PET/CT for High Risk Prostate Cancer

2016 ◽  
Vol 10 (4) ◽  
pp. 217-220 ◽  
Author(s):  
Adama Ouattara ◽  
Tiago Ribeiro de Oliveira ◽  
Serge Holz ◽  
Hannes Van den Bossche ◽  
David Strybol ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
High Risk ◽  
Thyroid Carcinoma ◽  
Specific Antigen ◽  
Needle Aspiration ◽  
Adjuvant Radiation ◽  
Choline Pet ◽  
High Risk Prostate Cancer ◽  
Pet Ct ◽  
Risk Prostate Cancer

We report a case of a 65-year-old male patient with high-risk prostate cancer, re-staged with 11C-choline positron emission tomography/computed tomography (PET/CT) for prostate specific antigen recurrences 3 years after radical prostatectomy and adjuvant radiation therapy. In addition to 2 suspicious presacral lymph nodes which were resected and proven to be metastatic, PET/CT revealed a very high uptake in a calcified thyroid nodule. Evaluation with fine needle aspiration was suspicious for thyroid carcinoma and the patient underwent total thyroidectomy, confirming a non-metastatic encapsulated follicular variant of papillary thyroid carcinoma. To our knowledge, this is the first report of a thyroid cancer diagnosed with 11C-choline PET/CT for prostate cancer staging.

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