Assessment of Degree of Health of the Stomach by Concomitant Measurement of Serum Pepsinogen and Serum Helicobacter Pylori Antibodies

2010 ◽  
Vol 25 (4) ◽  
pp. 207-212 ◽  
Author(s):  
Kazuhiko Inoue ◽  
Tomoo Fujisawa ◽  
Ken Haruma
Keyword(s):  
Helicobacter Pylori ◽  
Gastrointestinal Endoscopy ◽  
Upper Gastrointestinal Endoscopy ◽  
Gastric Adenoma ◽  
Fundic Gland ◽  
Peptic Ulcers ◽  
Serum Pepsinogen ◽  
Group A ◽  
Group B ◽  
Upper Gastrointestinal

The stomach was assessed by measuring serum pepsinogen (PG) and Helicobacter pylori (Hp) antibodies by immunoassay, based on the findings of upper gastrointestinal endoscopy performed on the same day. The assessment involved 1,636 individuals who visited the hospital for general medical checkups. Those negative for Hp antibodies and PG were grouped in group A, Hp-positive/PG-negative subjects were included in group B, and PG-positive subjects in group C. Group A comprised 660 subjects (40.3%), group B 514 (31.4%), and group C 462 (28.2%). Gastric cancer was detected in 0.87% (4/462) in group C, 0.19% (1/514) in group B, and 0% (0/660) in group A. All four patients with gastric adenoma were in group C. Hyperplastic polyps were detected most frequently in group C followed by group B, while there were no cases in group A. By contrast, most fundic gland polyps were found in group A. The detection rate of peptic ulcers was highest in group B, while that of reflux esophagitis was highest in group A. These findings suggest that the “degree of health” of the stomach can be assessed by measuring serum PG and Hp antibodies.

scholarly journals Prevention of White Flocculate Precipitation with Simethicone During Upper Gastrointestinal Endoscopy: A Double‐Blinded, Multi‐Center, Randomized Study

2020 ◽  
Author(s):  
Xueqin Chen ◽  
Ning Dai ◽  
Yanyong Deng ◽  
Xin Sun ◽  
Mingqing Zhang ◽  
...  
Keyword(s):  
Gastrointestinal Endoscopy ◽  
Randomized Study ◽  
Upper Gastrointestinal Endoscopy ◽  
Controlled Trials ◽  
Mixed Solution ◽  
Group A ◽  
Group B ◽  
Lukewarm Water ◽  
Double Blinded ◽  
Upper Gastrointestinal

Abstract Background: The reformulated simethicone emulsion from Berlin Chemical AG might develop white flocculate precipitation covering gastric mucosa when used before esophagogastroduodenoscopy (EGD). We aim to investigate whether combining reformulated simethicone emulsion with 5% NaHCO3 solution could prevent the development of white precipitation and improve visibility during EGD. Methods: Our study involved 523 patients. They were randomly assigned to two groups: In Group A patients received a warm mixed solution containing 30 ml 5% NaHCO3 solution and 15 ml reformulated simethicone emulsion. In Group B patients received 45 ml 40℃ lukewarm water. Visibility scores were recorded and analyzed. In addition, flush times, volume of flush water, overall time taken for EGD and complications during or after procedure were also recorded. Results: We found that no white precipitation was observed during EGD in Group A. Moreover, visibility scores in Group A were significantly lower (P < 0.01). Patients in Group A had fewer flush times (P < 0.01) and smaller volumes of flush water (P < 0.01). In addition, overall time taken for EGD procedure was significantly shorter in Group A (P < 0.01). The percentage of patients who had no adverse response is significantly higher in patients in Group A compared to Group B (P < 0.01). Conclusions: Premedication with mixed solution of 15ml reformulated simethicone emulsion and 30ml 5% NaHCO3 solution can prevent the development of white precipitation, substantially enhance mucosal visibility safely.Trial registration: The registered name of the trial is “Efficacy of using premedication with reformulated simethicone emulsion during upper gastrointestinal endoscopy examination”. Current Controlled Trials ChiCTR1900021689, as well as the date of registration is 11 September 2019. Retrospectively registered, http://www.medresman.org.cn/uc/sindex.aspx.

scholarly journals Premedication with reformulated simethicone and sodium bicarbonate improves mucosal visibility during upper gastrointestinal endoscopy: a double-blind, multicenter, randomized controlled trial

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Xueqin Chen ◽  
Ning Dai ◽  
Yanyong Deng ◽  
Xin Sun ◽  
Mingqing Zhang ◽  
...  
Keyword(s):  
Sodium Bicarbonate ◽  
Gastrointestinal Endoscopy ◽  
Controlled Trial ◽  
Sodium Bicarbonate Solution ◽  
Upper Gastrointestinal Endoscopy ◽  
Mixed Solution ◽  
Multicenter Randomized Controlled Trial ◽  
Group A ◽  
Group B ◽  
Upper Gastrointestinal

Abstract Background The reformulated simethicone emulsion from Berlin Chemical AG might develop white flocculate precipitate covering the gastric mucosa when used before esophagogastroduodenoscopy (EGD). We aim to investigate whether combining the reformulated simethicone emulsion with 5% sodium bicarbonate solution could prevent the development of white precipitate and improve visibility during EGD. Methods Our clinical study involved 523 patients. They were randomly assigned to two groups. In Group A, patients received a warm solution containing 30 ml 5% sodium bicarbonate solution and 15 ml reformulated simethicone emulsion. In Group B, patients received 45 ml 40 °C lukewarm water. Visibility scores were recorded and analyzed. Flushes, volume of flush water, overall time taken for EGD and complications during or after the procedure were also recorded. Results We found that no white precipitate was observed during EGD in Group A. Moreover, visibility scores in Group A were significantly lower (P < 0.01). Patients in Group A had fewer flushes (P < 0.01) and smaller volume of flush water (P < 0.01). In addition, the overall time taken for the EGD procedure was significantly shorter in Group A (P < 0.01). The percentage of patients who had no adverse response was significantly higher in Group A than in Group B (P < 0.01). Conclusions Premedication with a mixed solution of 15 ml reformulated simethicone emulsion and 30 ml 5% sodium bicarbonate solution can prevent the development of white precipitate, substantially enhancing mucosal visibility safely. Trial registration: The registered name of the trial is “Efficacy of using premedication with reformulated simethicone emulsion during upper gastrointestinal endoscopy examination”. Its Current Controlled Trials number is ChiCTR1900021689. Its date of registration is 11 September 2019. Retrospectively registered, http://www.medresman.org.cn/uc/sindex.aspx.

scholarly journals Accuracy of the 14C-urea breath test for the diagnosis of Helicobacter pylori

2002 ◽  
Vol 120 (3) ◽  
pp. 68-70 ◽  
Author(s):  
Ana Thereza Britto Gomes ◽  
Luciano Kowalsky Coelho ◽  
Marie Secaf ◽  
José Luiz Pimenta Módena ◽  
Luiz Ernesto de Almeida Troncon ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Breath Test ◽  
Gastrointestinal Endoscopy ◽  
Urea Breath Test ◽  
Simple Device ◽  
Upper Gastrointestinal Endoscopy ◽  
Urease Test ◽  
Great Relevance ◽  
Study Setting ◽  
Upper Gastrointestinal

CONTEXT: The development of simple, accurate and low-expense techniques for detection of Helicobacter pylori infection has great relevance. OBJECTIVE: To determine the accuracy of a rapid 14C-urea breath test (UBT) employing a very simple device for breathed air collection. DESIGN: Prospective study. SETTING: Hospital das Clinicas of the Faculty of Medicine of Ribeirão Preto. PARTICIPANTS: One hundred and thirty-seven adult patients who underwent upper gastrointestinal endoscopy in the Clinical Hospital. MAIN MEASUREMENTS: Histology for Helicobacter pylori (HP); urease test; urea breath test (UBT). RESULTS: One hundred and fifteen patients were infected by HP (HP+) according to both histology and the urease test, and 22 patients were HP-negative (HP-), according to the same two tests. UBT was capable of discriminating between HP+ and HP- in a way that was similar to the combination of urease test and histology. When this combination of results is taken as the "gold standard" for HP infection, the sensitivity and specificity of UBT are both greater than 90% for a range of cut-off points and breathed air collection times. CONCLUSION: The rapid UBT employing a simple device for air collection has a high accuracy in determining HP infection.

scholarly journals 1445Antibiotic susceptibility of Helicobacter pylori in Arctic Canadian Indigenous communities

2021 ◽  
Vol 50 (Supplement_1) ◽  
Author(s):  
Lauren Lindsey ◽  
Doug Quilty ◽  
Taylor Cromarty ◽  
Ali Assi ◽  
Sander Veldhuyzen van Zanten ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Disease Burden ◽  
Gastrointestinal Endoscopy ◽  
Indigenous Communities ◽  
Upper Gastrointestinal Endoscopy ◽  
Antibiotic Resistant ◽  
Resistance Patterns ◽  
Gastric Biopsies ◽  
Antibiotic Resistance Patterns ◽  
Upper Gastrointestinal

Abstract Background Our community-driven projects address concerns of Canadian Arctic Indigenous communities about Helicobacter pylori (Hp) infection, responsible for elevated gastric cancer mortality in the region. A key concern is poor effectiveness of anti-Hp treatment. We aimed to describe antibiotic resistance patterns in Hp isolated from project participants. Methods Participants in 7 communities underwent upper gastrointestinal endoscopy with 2 gastric biopsies taken for tissue culture during 2008-2017. We tested Hp isolates for resistance to 7 antibiotics by Etest and assessed 4 outcomes: resistance to metronidazole, clarithromycin, 1+ antibiotics, and 2+ antibiotics. We tabulated proportion positive among isolates tested with 95% confidence intervals (CI) and used logistic regression to assess the relation of age and sex to resistance outcomes. Results Of 259 Hp isolates tested, resistance to metronidazole, clarithromycin, 1+ antibiotics, and 2+ antibiotics were (% [CI]): respectively, 35 [29-41], 19 [15-25], 44 [38-50], and 12 [8-17] overall; 38 [30-47], 24 [17-32], 49 [41-58], and 16 [11-23] in 146 isolates from women; and 30 [22-39], 13 [8-21], 36 [27-46], and 6 [3-12] in 113 isolates from men. Odds of resistance to clarithromycin, 1+ antibiotics, 2+ antibiotics, and, to a lesser degree metronidazole, were elevated in women relative to men after age adjustment and increased with age in women but not men. Conclusion In Arctic Indigenous communities in Canada, women were more likely than men to harbor antibiotic-resistant Hp, and their frequency of resistant Hp infection increased with age. Key messages Community-driven research answers questions posed by those who bear the disease burden.

scholarly journals Helicobacter pylori eradication in renal transplant candidates

2022 ◽  
Author(s):  
Mariana E. Maioli ◽  
Raquel F. N. Frange ◽  
Cintia M. C. Grion ◽  
Vinicius D. A. Delfino
Keyword(s):  
Chronic Kidney Disease ◽  
Helicobacter Pylori ◽  
Gastrointestinal Endoscopy ◽  
Eradication Rate ◽  
Upper Gastrointestinal Endoscopy ◽  
Rapid Urease Test ◽  
Urease Test ◽  
Transplant Candidates ◽  
H Pylori ◽  
Upper Gastrointestinal

Abstract Introduction: Treatment for Helicobacter pylori (H. pylori) infection is recommended in transplant candidates due to the association between this infection and gastrointestinal disorders, which could significantly increase morbidity after renal transplantation with the use of immunosuppression. The objective of this study was to analyze the rate of eradication of H. pylori after antimicrobial treatment in chronic kidney disease patients who are candidates for kidney transplantation. Methods: A multicenter prospective cohort study was conducted. All adult chronic kidney disease patients seen at our institution were included. In the pre-transplantation evaluation, 83 patients underwent an upper gastrointestinal endoscopy with 2 diagnostic methods to detect H. pylori: histology and the rapid urease test. In total, 33 patients with H. pylori infection received treatment with 20 mg omeprazole, 500 mg amoxicillin, and 500 mg clarithromycin once daily for 14 days. Another upper gastrointestinal endoscopy was performed 8 to 12 weeks after the end of treatment to check for healing. Results: The study showed a prevalence of H. pylori in 51 (61.4%) patients. Histology was positive in 50 (98%) patients and the rapid urease test was positive in 31 (60.8%). The infection eradication rate was 48.5% (16 patients). Conclusions: There was a high prevalence rate of H. pylori and a low eradication rate after the long-term antimicrobial triple scheme used. The association of the rapid urease test with gastric mucosa histology did not increase the detection rate of H. pylori.

Sign in / Sign up

Export Citation Format

Share Document