scholarly journals Time Evolution ofin VivoArticular Cartilage Repair Induced by Bone Marrow Stimulation and Scaffold Implantation in Rabbits

2015 ◽  
Vol 38 (4) ◽  
pp. 210-223 ◽  
Author(s):  
María Sancho-Tello ◽  
Francisco Forriol ◽  
Pablo Gastaldi ◽  
Amparo Ruiz-Saurí ◽  
José J. Martín de Llano ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Time Evolution ◽  
Cartilage Repair ◽  
Bone Marrow Stimulation ◽  
Marrow Stimulation

scholarly journals 062 BONE-MARROW STIMULATION BY DRILLING VERSUS MICROFRACTURE LEADS TO BETTER CARTILAGE REPAIR IN RABBITS

2009 ◽  
Vol 17 ◽  
pp. S42-S43
Author(s):  
H. Chen ◽  
C.D. Hoemann ◽  
J. Sun ◽  
V. Lascau-Coman ◽  
W. Ouyang ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Cartilage Repair ◽  
Bone Marrow Stimulation ◽  
Marrow Stimulation

scholarly journals Depth of subchondral perforation influences the outcome of bone marrow stimulation cartilage repair

2011 ◽  
Vol 29 (8) ◽  
pp. 1178-1184 ◽  
Author(s):  
Hongmei Chen ◽  
Caroline D. Hoemann ◽  
Jun Sun ◽  
Anik Chevrier ◽  
Marc D. McKee ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Cartilage Repair ◽  
Bone Marrow Stimulation ◽  
Marrow Stimulation

scholarly journals CARGEL Bioscaffold improves cartilage repair tissue after bone marrow stimulation in a minipig model

2020 ◽  
Vol 7 (1) ◽  
Author(s):  
K. Hede ◽  
B. B. Christensen ◽  
M. L. Olesen ◽  
J. S. Thomsen ◽  
C. B. Foldager ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Cartilage Repair ◽  
Bone Marrow Stimulation ◽  
Repair Tissue ◽  
Marrow Stimulation

Debridement, Curettage, and Bone Marrow Stimulation: Proceedings of the International Consensus Meeting on Cartilage Repair of the Ankle

2018 ◽  
Vol 39 (1_suppl) ◽  
pp. 16S-22S ◽  
Author(s):  
Charles P. Hannon ◽  
Steve Bayer ◽  
Christopher D. Murawski ◽  
Gian Luigi Canata ◽  
Thomas O. Clanton ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Cartilage Repair ◽  
Consensus Meeting ◽  
Osteochondral Lesions ◽  
Bone Marrow Stimulation ◽  
International Consensus ◽  
Marrow Stimulation ◽  
Consensus Statements ◽  
Working Groups ◽  
Strong Consensus

Background: The evidence supporting best practice guidelines in the field of cartilage repair of the ankle are based on both low quality and low levels of evidence. Therefore, an international consensus group of experts was convened to collaboratively advance toward consensus opinions based on the best available evidence on key topics within cartilage repair of the ankle. The purpose of this article is to report the consensus statements on “Debridement, Curettage and Bone Marrow Stimulation” developed at the 2017 International Consensus Meeting on Cartilage Repair of the Ankle. Methods: Seventy-five international experts in cartilage repair of the ankle representing 25 countries and 1 territory were convened and participated in a process based on the Delphi method of achieving consensus. Questions and statements were drafted within 11 working groups focusing on specific topics within cartilage repair of the ankle, after which a comprehensive literature review was performed and the available evidence for each statement was graded. Discussion and debate occurred in cases where statements were not agreed upon in unanimous fashion within the working groups. A final vote was then held, and the strength of consensus was characterized as follows: consensus, 51% to 74%; strong consensus, 75% to 99%; unanimous, 100%. Results: A total of 14 statements on debridement, curettage, and bone marrow stimulation reached consensus during the 2017 International Consensus Meeting on Cartilage Repair of the Ankle. One achieved unanimous support, 12 reached strong consensus (greater than 75% agreement), and 1 achieved consensus. All statements reached at least 72% agreement. Conclusions: This international consensus derived from leaders in the field will assist clinicians with debridement, curettage and bone marrow stimulation as a treatment strategy for osteochondral lesions of the talus.

Guided bone marrow stimulation for articular cartilage repair through a freeze-dried chitosan microparticle approach

Materialia ◽  
2020 ◽  
Vol 9 ◽  
pp. 100609
Author(s):  
Caroline D. Hoemann ◽  
Jessica Guzmán-Morales ◽  
Geneviève Picard ◽  
Gaoping Chen ◽  
Daniel Veilleux ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Articular Cartilage ◽  
Cartilage Repair ◽  
Bone Marrow Stimulation ◽  
Articular Cartilage Repair ◽  
Marrow Stimulation ◽  
Freeze Dried

Intra-articular Injection of Bevacizumab Enhances Bone Marrow Stimulation–Mediated Cartilage Repair in a Rabbit Osteochondral Defect Model

2021 ◽  
pp. 036354652110051
Author(s):  
Hajime Utsunomiya ◽  
Xueqin Gao ◽  
Haizi Cheng ◽  
Zhenhan Deng ◽  
Gilberto Nakama ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Cartilage Repair ◽  
Collagen Type ◽  
Osteochondral Defect ◽  
Defect Model ◽  
Bone Marrow Stimulation ◽  
Marrow Stimulation ◽  
Hematoxylin And Eosin ◽  
Hematoxylin And Eosin Staining

Background: Bone marrow stimulation (BMS) via microfracture historically has been a first-line treatment for articular cartilage lesions. However, BMS has become less favorable because of resulting fibrocartilage formation. Previous studies have shown that angiogenesis blockade promotes cartilage repair. Bevacizumab is a Food and Drug Administration–approved medication used clinically to prevent angiogenesis. Hypothesis: The intra-articular injection of bevacizumab would prevent angiogenesis after BMS and lead to improved cartilage repair with more hyaline-like cartilage. Study Design: Controlled laboratory study. Methods: The dose of bevacizumab was first optimized in a rabbit osteochondral defect model with BMS. Then, 48 rabbits (n = 8/group/time point) were divided into 3 groups: osteochondral defect (defect), osteochondral defect + BMS (BMS group), and osteochondral defect + BMS + bevacizumab intra-articular injection (bevacizumab group). Rabbits were sacrificed at either 6 or 12 weeks after surgery. Three-dimensional (3D) micro–computed tomography (microCT), macroscope score, modified O’Driscoll histology scores, collagen type 2, Herovici staining, and hematoxylin and eosin staining were performed. Angiogenesis markers were also evaluated. Results: The intra-articular dose of 12.5 mg/0.5 mL bevacizumab was found to be effective without deleteriously affecting the subchondral bone. Intra-articular injection of bevacizumab resulted in significantly improved cartilage repair for the bevacizumab group compared with the BMS or the defect group based on 3D microCT, the macroscope score (both P < .05), the modified O’Driscoll histology score ( P = .0034 and P = .019 vs defect and BMS groups, respectively), collagen type 2, Herovici staining, and hematoxylin and eosin staining at 6 weeks. Cartilage in the bevacizumab group had significantly more hyaline cartilage than did that in other groups. At 12 weeks, the cartilage layer regenerated in all groups; however, the bevacizumab group showed more hyaline-like morphology, as demonstrated by microCT, histology scores ( P < .001 and .0225 vs defect and BMS groups, respectively), histology, and immunohistochemistry. The bevacizumab injection did not significantly change mRNA expressions of smooth muscle actin, vascular endothelial growth factor, or hypoxia-inducible factor-1 alpha. Conclusion: Intra-articular injection of bevacizumab significantly enhanced the quality and quantity of hyaline-like cartilage after BMS in a rabbit model. Future large-animal and human studies are necessary to evaluate the clinical effect of this therapy, which may lead to improved BMS outcomes and thus the durability of the regenerated cartilage. Clinical Relevance: The use of bevacizumab may be an important clinical adjunct to improve BMS-mediated cartilage repair.

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