Combined use of Intravenous and Topical Tranexamic Acid following Cementless Total Hip Arthroplasty: A Randomised Clinical Trial

2015 ◽  
Vol 26 (1) ◽  
pp. 36-42 ◽  
Author(s):  
Jinwei Xie ◽  
Jun Ma ◽  
Chen Yue ◽  
Pengde Kang ◽  
Fuxing Pei
Keyword(s):  
Clinical Trial ◽  
Total Hip Arthroplasty ◽  
Tranexamic Acid ◽  
Hip Arthroplasty ◽  
Randomised Clinical Trial ◽  
Total Hip ◽  
Cementless Total Hip Arthroplasty ◽  
Combined Use ◽  
Topical Tranexamic Acid

scholarly journals Effect of Additional Administration of Topical Tranexamic Acid in Patients Undergoing Primary Total hip Arthroplasty Without Drainage

2021 ◽  
Author(s):  
Jing Yao Jin ◽  
Qing Song Li ◽  
Taek Rim Yoon ◽  
Sheng Yu Jin ◽  
Min Gwang Kim ◽  
...  
Keyword(s):  
Total Hip Arthroplasty ◽  
Propensity Score ◽  
Blood Loss ◽  
Tranexamic Acid ◽  
Propensity Score Matching ◽  
Hip Arthroplasty ◽  
Total Blood ◽  
Total Hip ◽  
Topical Tranexamic Acid ◽  
Primary Total Hip Arthroplasty

Abstract Introduction: This study was designed to compare the clinical results of additional administration of topical tranexamic acid (TXA) with intravenous TXA (IV-TXA) and to determine its effect in patients undergoing primary total hip arthroplasty (THA) without drainage using propensity score matching analysis.Methods: A total of 248 patients (248 hips) underwent primary THA from March 2016 to June 2018. Patients who received topical TXA and IV-TXA were included in the combined group (46 patients), and patients who received IV-TXA were included in the IV only group (202 patients). After propensity score matching, both groups consisted of 44 patients (88 patients in total). We compared the results of total blood loss (TBL), haemoglobin (Hb) level, Hb drop, and the incidence of deep vein thrombosis (DVT) and pulmonary embolism (PE). Results: In the combined group, the TBL was 280.4 ± 64.2 mL, which was significantly lower than that in the IV only group (335.3 ± 75.3 mL; p < 0.001). From the preoperative period to 1-week postoperatively, Hb levels were not significantly different between the two groups. There was significantly more Hb drop in the IV only Group from immediate postoperative to postoperative day 3 (POD 3). In both groups, no patient presented with postoperative symptomatic DVT or PE. Conclusion: In patients undergoing primary THA without drainage, combined use of IV-TXA and topical TXA can significantly decrease blood loss without influencing postoperative complications.

scholarly journals Subgroup Analysis of Topical Tranexamic Acid in Primary Total Hip Arthroplasty

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Walter Anazonwu ◽  
John Tuttle ◽  
Lee Rubin
Keyword(s):  
Total Hip Arthroplasty ◽  
Tranexamic Acid ◽  
Hip Arthroplasty ◽  
Blood Product Transfusion ◽  
Specific Patient ◽  
Total Hip ◽  
Patient Groups ◽  
Topical Tranexamic Acid ◽  
Consistent Response ◽  
Primary Total Hip Arthroplasty

Tranexamic acid (TXA) is an antifibrinolytic agent that can effectively be utilized for the reduction of blood loss when administered via intravenous or intraarticular injection following total joint arthroplasty. Despite data published to date, it remains unclear as to which specific patient groups undergoing primary total hip arthroplasty (THA) would benefit most regarding transfusion reduction from TXA administration. Using a retrospective cohort study model involving 123 THA patients who received topical TXA compared against 111 THA controls who did not receive TXA, we assessed data within the following subgroups: age, gender, BMI, preoperative hemoglobin, and surgical approach. Critical analysis of these subgroups revealed that the most reliable and consistent response to TXA was found in patients who were female and over 65 years old. Continued study of TXA administration in THA is essential to help reduce blood losses, minimize blood product transfusion, and improve outcomes following THA.

scholarly journals Use of Topical Tranexamic Acid Reduces Direct and Indirect Blood Loss and Transfusion Rates in Revision Total Hip Arthroplasty

2019 ◽  
Vol 16 (S2) ◽  
pp. 285-292
Author(s):  
Elina Huerfano ◽  
Manuel Huerfano ◽  
Kate Shanaghan ◽  
Maureen Barlow ◽  
Stavros Memtsoudis ◽  
...  
Keyword(s):  
Total Hip Arthroplasty ◽  
Blood Loss ◽  
Tranexamic Acid ◽  
Hip Arthroplasty ◽  
Revision Total Hip Arthroplasty ◽  
Total Hip ◽  
Topical Tranexamic Acid
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