scholarly journals Cognitive Function May be a Predictor of Retinopathy Progression in Patients with Type 2 Diabetes

2016 ◽  
Vol 27 (3) ◽  
pp. 278-280 ◽  
Author(s):  
Marina Trento ◽  
Lorena Charrier ◽  
Martina Salassa ◽  
Stefano Merlo ◽  
Pietro Passera ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Multivariate Analysis ◽  
Cognitive Function ◽  
Prospective Study ◽  
Independent Predictor ◽  
Fundus Photographs ◽  
Microvascular And Macrovascular Complications ◽  
Insight Into ◽  
Over Time

Purpose Microvascular and macrovascular complications of diabetes, such as retinopathy and nephropathy, progress over time and may be associated with cognitive decline. In this article, we aim to gain further insight into the association between cognitive function and retinopathy in type 2 diabetes. Methods and Results In this observational 8-year prospective study of 498 outpatients, demographic and clinical variables were monitored, along with retinopathy, depression, anxiety, and cognitive function. Baseline fundus photographs were available in 477 patients, 240 with no retinopathy, 110 with mild retinopathy, and 127 with moderate/more severe retinopathy. Of the first 2 groups, 279 patients were reevaluated after 8 years, of whom 181 still had no/mild retinopathy and 98 had progressed to more severe stages. On multivariate analysis, retinopathy progression was associated with being insulin-treated (p = 0.036), and worse cognitive function (p = 0.025) at baseline. Conclusions Cognitive function may be an independent predictor of retinopathy progression.

scholarly journals The impact of Type 2 diabetes in Parkinson's disease

2021 ◽  
Author(s):  
Dilan Athauda ◽  
James Evans ◽  
Anna Wernick ◽  
Gurvir Virdi ◽  
Minee Liane-Choi ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Disease Progression ◽  
Independent Predictor ◽  
Motor Symptoms ◽  
Severity Scores ◽  
The Impact ◽  
Over Time

Importance: Type 2 diabetes (T2DM) is an established risk factor for developing Parkinson's disease (PD) but its effect on disease progression is not well understood. Objective: To examine the effects of co-morbid T2DM on Parkinson's disease progression and quality of life. Design: We analysed data from the Tracking Parkinson's study, a large multi-centre prospective study in the UK. Participants: The study included 1930 adults with recent onset PD, recruited between February 2012 and May 2014, and followed up regularly thereafter. Exposure: A diagnosis of pre-existing T2DM was based on self-report at baseline. After controlling for confounders, an evaluation of how T2DM affects PD was performed by comparing symptom severity scores; and analyses using multivariable mixed models was used to determine the effects of T2DM on Parkinson's disease progression. Main Outcomes and Measures: The impact of T2DM on Parkinsons disease severity was derived from scores collected using the Movement Disorders Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS), Non-Motor Symptoms Scale (NMSS), Montreal Cognitive Assessment (MoCA), Questionnaire for impulsive-compulsive disorders in PD (QUIP), Leeds Anxiety and Depression Scale (LADS), and Schwab and England ADL scale. Results: We identified 167 (8.7%) patients with PD and T2DM (PD+T2DM) and 1763 (91.3%) with PD without T2DM (PD). Patients with T2DM had more severe motor symptoms, as assessed by MDS-UPDS III 25.8 (0.9) vs 22.5 (0.3) p=0.002, had significantly faster motor symptom progression over time (p=0.012), and T2DM was an independent predictor for the development of substantial gait impairment (HR 1.55, CI 1.07-2.23, p=0.020). Patients were more likely to have loss of independence (OR 2.08, CI 1.34-3.25, p=0.001); and depression (OR 1.62, CI 1.10-2.39, p=0.015), and developed worsening mood (p=0.041) over time compared to the PD group. T2DM was also an independent predictor for the development mild cognitive impairment (HR 1.7, CI 1.24-2.51, p=0.002) over time Conclusions and relevance: T2DM is associated with faster disease progression in PD, highlighting an interaction between these two diseases. As it is a potentially modifiable, metabolic state, with multiple peripheral and central targets for intervention, it may represent a target for ameliorating parkinsonian symptoms, and progression to disability and dementia.

scholarly journals Changes in fruit, vegetable and juice consumption after the diagnosis of type 2 diabetes: a prospective study in men

2016 ◽  
Vol 117 (5) ◽  
pp. 712-719 ◽  
Author(s):  
Camilla Olofsson ◽  
Andrea Discacciati ◽  
Agneta Åkesson ◽  
Nicola Orsini ◽  
Kerstin Brismar ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Prospective Study ◽  
Mixed Models ◽  
Prospective Cohort ◽  
Fruits And Vegetables ◽  
Vegetables And Fruits ◽  
A Prospective Study ◽  
Changes Over Time ◽  
Over Time

AbstractGiven the importance of prevention of complications in type 2 diabetes (T2D), we aimed to examine changes over time in consumption of fruits, vegetables and juice among men who were diagnosed with T2D in comparison with men without diabetes. The prospective Cohort of Swedish Men, aged 45–79 years in 1997, was used to examine changes in diet after diagnosis of T2D. Dietary intake was assessed using FFQ in 1997 and 2009. In all, 23 953 men who were diabetes free at baseline (1997) and completed both FFQ were eligible to participate in the study. Diagnosis of T2D was reported by subjects and ascertained through registers. Multivariable linear mixed models were used to examine changes in mean servings/week over time. In total, 1741 men developed T2D during the study period. Increased consumption of vegetables and fruits was observed among those who developed T2D (equivalent to 1·6 servings/week, 95 % CI 1·08, 2·03) and men who remained diabetes free (0·7 servings/week, 95 % CI 0·54, 0·84). Consumption of juice decreased by 0·6 servings/week (95 % CI −0·71, −0·39) among those who developed T2D and increased by 0·1 servings/week (95 % CI 0·05, 0·15) in those who were diabetes free. Changes over time and between groups were statistically significant. Although improvements in diet were observed, only 36 % of those with T2D and 35 % of those without diabetes consumed ≥5 servings of fruits and vegetables/d in 2009.

1157-P: Two-Year Results of Multicenter, Prospective Study of Metabolic Surgery in Obese Type 2 Diabetes Mellitus Subjects in China

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 1157-P
Author(s):  
YUQIAN BAO ◽  
HUI LIANG ◽  
PIN ZHANG ◽  
CUNCHUAN WANG ◽  
TAO JIANG ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Prospective Study ◽  
Metabolic Surgery ◽  
Multicenter Prospective Study

The Mediterranean Diet and Two-Year Changes in Cognitive Function in Puerto Rican Adults With vs. Without Type 2 Diabetes

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 192-LB
Author(s):  
JOSIEMER MATTEI ◽  
SHERMAN J. BIGORNIA ◽  
MERCEDES SOTOS-PRIETO ◽  
TAMMY SCOTT ◽  
XIANG GAO ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Cognitive Function ◽  
Puerto Rican ◽  
Mediterranean Diet ◽  
The Mediterranean

P4-331: RELATIONSHIP BETWEEN GLYCAEMIC CONTROL AND COGNITIVE FUNCTION IN PATIENTS WITH TYPE 2 DIABETES AT ELEVATED CARDIOVASCULAR RISK

2014 ◽  
Vol 10 ◽  
pp. P907-P908 ◽  
Author(s):  
Jolien Janssen ◽  
Esther van den Berg ◽  
Michaela Mattheus ◽  
Odd Erik Johansen ◽  
Geert Jan Biessels
Keyword(s):  
Type 2 Diabetes ◽  
Cardiovascular Risk ◽  
Cognitive Function ◽  
Glycaemic Control
Sign in / Sign up

Export Citation Format

Share Document