Impact of Valsalva Maneuver on Central Choroid, Central Macula, and Disk Fiber Layer Thickness Among High Myopic and Hyperopic Patients

2016 ◽  
Vol 27 (3) ◽  
pp. 331-335 ◽  
Author(s):  
Isil Kurultay-Ersan ◽  
Sinan Emre
Keyword(s):  
Axial Length ◽  
Choroidal Thickness ◽  
Valsalva Maneuver ◽  
Significant Negative Correlation ◽  
Macular Thickness ◽  
Enhanced Depth Imaging ◽  
Central Macular Thickness ◽  
Fiber Layer ◽  
Rnfl Thickness ◽  
Before And After

Purpose To evaluate the alterations in mean central choroidal, central macular, and disk retinal nerve fiber layer (RNFL) thickness measured by optical coherence tomography (OCT) during Valsalva maneuver among patients with high refractive errors. Methods A total of 60 high myopic (≥-6.0 D) and 50 high hyperopic (≥ + 3.0 D) eyes of 58 patients aged 19-65 years with visual acuity of 20/20 and without any ophthalmologic or systemic diseases were evaluated by OCT before and after the Valsalva maneuver. The choroidal thickness was measured with enhanced depth imaging OCT method. Central macular thickness, disk RNFL thickness, and axial length were also assessed. Results Mean choroidal thickness increased significantly from 275.0 ± 27.2 μm at rest to 279.8 ± 31.6 μm after Valsalva maneuver in high myopic patients, and from 308.2 ± 27.3 μm to 313.6 ± 28.5 μm in high hyperopic patients (p<0.01 for each). A significant negative correlation of the choroidal thickness was noted with axial length (r = -0.509, p<0.01) and age (r = -0.224, p = 0.01) in the overall study population. Mean central macular thickness was 242.9 ± 44.4 μm and 254.0 ± 22.8 μm, while mean disk RNFL thickness was 81.6 ± 12.4 μm and 98.4 ± 13.3 μm in high myopic and hyperopic patients, respectively. Valsalva maneuver was not associated with significant change in central macular or disk RNFL thickness. Conclusions Significant association of Valsalva maneuver with an increase in choroidal thickness was noted among patients with high degree of myopia and hyperopia. Our findings emphasize the likelihood of increase in choroidal volume due to venous distension to be responsible for the increase observed in choroidal thickness after Valsalva maneuver.

Evaluation of optical coherence tomography findings in adolescents with genetic generalized epilepsy

2021 ◽  
pp. 112067212110497
Author(s):  
Aysin Tuba Kaplan ◽  
Sibel Oskan Yalcın ◽  
Safiye Gunes Sager
Keyword(s):  
Optical Coherence Tomography ◽  
Regression Analysis ◽  
Macular Thickness ◽  
Central Macular Thickness ◽  
Optical Coherence ◽  
Monotherapy Group ◽  
Newly Diagnosed ◽  
Fiber Layer ◽  
Rnfl Thickness ◽  
Generalized Epilepsy

Objective To evaluate retinal nerve fiber layer (RNFL) thickness, central macular thickness (CMT), and subfoveal choroid thickness (CT) by using optical coherence tomography (OCT) in adolescents with newly diagnosed epilepsy and patients who had been using Na valproate (VPA) for at least 1 year. Methods We examined 60 patients with genetic generalized epilepsy (GGE) aged 8–17 years. Thirty patients with newly diagnosed GGE who were evaluated before the beginning of the therapy and another 30 patients who were chosen from among adolescents with epilepsy using VPA for at least 1 year were included in the study. Results Nasal quadrant RNFL thickness and CMT measurements were significantly lower in the monotherapy group compared with the newly diagnosed group ( p = 0.044 and p = 0.032, respectively). CT measurements were not significantly different between the groups ( p = 0.413). There was a negative correlation in regression analysis between the duration of drug use and RNFL thickness in all quadrants. Conclusion According to our study, we observed thinning of the nasal RNFL and macular thickness in adolescents with epilepsy who were using Na valproate for at least 1 year and that as the duration of use increased, the thinning occurred in all RNFL quadrants. Further studies with larger series are needed to better understand the effects of both epilepsy and VPA on the eye.

scholarly journals Normal Reference Ranges of Optical Coherence Tomography Parameters in Children

Folia Medica ◽  
2020 ◽  
Vol 62 (2) ◽  
pp. 338-344
Author(s):  
Silviya Krumova ◽  
Nelly Sivkova ◽  
Vassil Marinov ◽  
Desislava Koleva-Georgieva ◽  
Desislava Voynikova
Keyword(s):  
Optical Coherence Tomography ◽  
Anterior Chamber ◽  
Axial Length ◽  
Anterior Chamber Depth ◽  
Macular Thickness ◽  
Reference Ranges ◽  
Central Macular Thickness ◽  
Optical Coherence ◽  
Macular Volume ◽  
Rnfl Thickness

Aim: To measure the macular thickness, macular volume and peripapillary retinal nerve fiber layer (RNFL) in healthy Caucasian chil&shy;dren using spectral domain optical coherence tomography (SDOCT) and analyze the correlation of these values with age, refraction, and biometric measurements. Materials and methods: In this cross-sectional study, we recruited 270 healthy children (150 female and 120 male) aged 6 to 17 years with no ocular abnormalities. All children underwent a detailed eye examination. The measurements were obtained using a SDOCT device (SOCT Copernicus REVO). Main outcome measures were macular thickness, macular volume and RNFL thickness. Their correlations with age, refractive error, anterior chamber depth (ACD) and axial length (AL) was analyzed. Right eyes of all subjects were selected for analysis. Results: In this study group (mean age 10.70&plusmn;2.82 years), the average peripapillary RNFL thickness was 117.11&plusmn;9.15 &mu;m, the central macular thickness was 232.10&plusmn;15.81 &mu;m, the average macular thickness was 286.70&plusmn;9.82 &mu;m, and the average macular volume was 8.01&plusmn;0.28 mm&sup3;. The average values for the biometric data were: axial length &ndash; 23.16&plusmn;0.94 mm, anterior chamber depth &ndash; 3.64&plusmn;0.26 mm, the spherical equivalent (SE) value &ndash; +0.81&plusmn;0.58 diopter. Central macular thickness, inner macular thickness (superior, inferior, nasal, temporal quadrants) values, total macular thickness and macular volume were significantly higher in males than in females. We found a positive correlation between central macular thickness, inner nasal macular thickness, outer inferior macular thickness values, and age. Also, we found a significant correlation between the average macular thickness values and the average macular volume values (p<0.0001). RNFL measurements did not correlate with age (p=0.199). Almost all macular parameters were consistently positively cor&shy;related with SE. A significant correlation was also found between the central macular thickness, inner inferior macular thickness, inner nasal macular thickness and the ACD. We found a significant correlation between the average macular thickness, macular volume, inner superior macular thickness, outer macular thickness (superior, inferior, nasal, temporal quadrants) values and the AL. Conclusion: This study found normal reference ranges for RNFL and macular parameters measured by SOCT Copernicus REVO in healthy Caucasian children aged 6-17 years. This normative values could be very useful in early diagnosing and monitoring of optic neuropathy, glaucoma and macular diseases in childhood.

scholarly journals Subfoveal Choroidal Thickness in Myopia: An OCT-Based Study in Young Chinese Patients

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Fen Xiong ◽  
Jun Tu ◽  
Tian Mao ◽  
Li Yu ◽  
Nana Lin ◽  
...  
Keyword(s):  
Axial Length ◽  
Choroidal Thickness ◽  
Significant Negative Correlation ◽  
Multivariate Regression Analysis ◽  
Posterior Pole ◽  
Chinese Patients ◽  
Enhanced Depth Imaging ◽  
Depth Imaging ◽  
Axial Elongation ◽  
Imaging Optical Coherence Tomography

Myopia is a common cause of visual impairment worldwide. Choroidal thickness (ChT) reflects the characteristic changes in myopic children and may be used as an important index of myopia. The purpose of this study was to investigate ChT and its distribution across the posterior pole in young myopic Chinese patients using enhanced depth imaging optical coherence tomography (EDI-OCT) and to explore the factors associated with it. A total of 402 myopic Chinese patients aged 6–16 years who underwent complete ophthalmic examinations, including those for axial length, cycloplegic refraction, and intraocular pressure, were examined with EDI-OCT. The mean subfoveal ChT was 303.08 ± 76.87 μm and displayed large variations at different positions (p<0.05). The thickest sector was located 3 mm temporally from the fovea. Multivariate regression analysis showed a significant negative correlation of the subfoveal ChT values with axial length (AL), whereas the ChT was moderately influenced by the patient’s sex. AL accounted for 7.9% of the ChT variance, whereas sex explained 9.6% of the ChT variance. In the population aged 11 years and older, AL accounted for 13.1% of the ChT variance. However, in those younger than 11 years, age was the only significant explanatory factor accounting for 5.2% of the ChT variance. In conclusion, we found a significant decrease in ChT with age in myopic children younger than 11 years. The negative association between age and ChT in children aged 11 years and older may be offset by the choroidal thickening mediated by pubertal growth spurts. The positive correlation between ChT and spherical equivalent in myopic adolescents aged 11 years and older suggests that the protective effect of lens thinning against rapid axial elongation disappears with age. Axial elongation becomes the dominant determinant of ChT in this age group.

scholarly journals Correlation of Optical Coherence Tomographic Findings with Clinical Features in High Myopia

2019 ◽  
Vol 05 (01) ◽  
pp. 019-025
Author(s):  
Evangeline Rao ◽  
Maithili Mishra ◽  
Sheela Kerkar ◽  
Arjun Ahuja
Keyword(s):  
Clinical Features ◽  
Axial Length ◽  
High Myopia ◽  
Macular Thickness ◽  
Optical Coherence ◽  
Spherical Equivalent ◽  
Fiber Layer ◽  
Cross Sectional ◽  
Rnfl Thickness ◽  
Better Than

AbstractThis is a cross-sectional observational study to correlate relationship between macular and retinal nerve fiber layer (RNFL) thickness in relation to clinical features in high myopia. A total of 100 eyes of 50 consecutive patients underwent optical coherence tomography (OCT) of the macula and RNFL. It was observed that correlation of RNFL thickness to the axial length is better than that of RNFL thickness to the spherical equivalent. The macular thickness in the parafoveal region was observed to be thicker than the perifoveal region in all quadrants. This study therefore emphasizes the need to have macular thickness nomogram for high myopes to avoid misinterpretation of OCT results due to axial length and refractive error and, also, the need for a routine baseline OCT scan for all high myopia patients.

Correlation between Choroidal Thickness and Degree of Myopia Assessed with Enhanced Depth Imaging Optical Coherence Tomography

2017 ◽  
Vol 27 (5) ◽  
pp. 577-584 ◽  
Author(s):  
Amany A. El-Shazly ◽  
Yousra A. Farweez ◽  
Marwa E. ElSebaay ◽  
Walid M.A. El-Zawahry
Keyword(s):  
Optical Coherence Tomography ◽  
Axial Length ◽  
High Myopia ◽  
Choroidal Thickness ◽  
Significant Negative Correlation ◽  
Enhanced Depth Imaging ◽  
Temporal Region ◽  
Optical Coherence ◽  
Depth Imaging ◽  
Imaging Optical Coherence Tomography

Purpose To assess the choroidal thickness in different degrees of myopia using enhanced depth imaging optical coherence tomography (EDI-OCT) compared with healthy subjects. Methods We included 240 patients with myopia and 60 emmetropes as controls. Participants underwent full ophthalmologic examination, axial length measurement, and EDI-OCT imaging of the choroid. Choroidal thickness (CT) was measured at 5 locations, including subfoveal (SFCT), 2 mm nasal, temporal, upper, and lower to fovea. Results Choroidal thickness was significantly lower in myopic eyes compared to controls. Regardless of the degree of myopia, nasal regions showed the lowest CT with decremental pattern with advance of myopia (low myopia 279.00 ± 24.50 µm, moderate myopia 269.58 ± 20.69 µm, high myopia 189.58 ± 25.95 µm, advanced myopia 96.75 ± 24.83 µm). Highest CT was variable according to the degree of myopia with decremental pattern with advance of myopia (low myopia in subfoveal region 354.40 ± 35.14 µm, moderate myopia in temporal region 337.87 ± 35.75 µm, high myopia in lower region 312.15 ± 38.90 µm, and advanced myopia in upper region 201.25 ± 18.27 µm). Axial length showed significant negative correlation with SFCT and CT in different studied regions. Conclusions Different degrees of myopia showed thinner choroidal thickness than that of normal control eyes with decremental thinning with progress of myopia. This might be secondary to the longer axial length, which was the determining factor in some locations such as subfoveal, nasal, and upper CT.

Subfoveal choroidal thickness and peripapillary retinal nerve fiber layer thickness in young obese males

2020 ◽  
pp. 112067212098289
Author(s):  
Ceylan Uslu Dogan ◽  
Damla Culha
Keyword(s):  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Choroidal Thickness ◽  
Obese Group ◽  
Fiber Layer ◽  
Subfoveal Choroidal Thickness ◽  
Young Males ◽  
Rnfl Thickness ◽  
Patient Groups ◽  
Temporal Quadrant

Objective: Regarding the effect of obesity on subfoveal choroidal thickness (CT) and peripapillary retinal nerve fiber layer (RNFL) thickness, controversial results have been reported in different patient groups. This study aimed to evaluate the effect of obesity on these parameters among young male subjects in comparison with age-matched non-obese healthy males. Methods: This prospective, cross-sectional study included both eyes of 50 obese young males and 50 healthy non-obese young males. The obese and the non-obese groups included subjects with a BMI of ⩾30 and ⩽25 kg/m², respectively. Subfoveal choroidal thickness and RNFL analyses were conducted by spectral domain optical coherence tomography (SD-OCT). Results: Subfoveal choroidal thickness (321.0 ± 46.7 vs 338.4±35.3, p = 0.002) and RNFL thickness at temporal quadrant (73.4 ± 9.9 vs 76.4 ± 9.3, p = 0.008) was significantly lower in the obese group when compared to the non-obese group. The groups did not differ regarding peripapillary RNFL thickness at other quadrants (superior, inferior, or nasal) or regarding mean peripapillary RNFL thickness. Conclusion: Findings of this study demonstrated a negative correlation of obesity with subfoveal choroidal thickness and temporal quadrant peripapillary RNFL thickness. Larger studies on different patient groups with longer-term follow-up are warranted to better elucidate the ophthalmological effects of obesity.

scholarly journals Factors related to retinal nerve fiber layer thickness in bipolar disorder patients and major depression patients

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Yanhong Liu ◽  
Yongsheng Tong ◽  
Lvzhen Huang ◽  
Jingxu Chen ◽  
Shaoxiao Yan ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Major Depression ◽  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Macular Thickness ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Rnfl Thickness ◽  
Normal People ◽  
Retinal Nerve Fiber

Abstract Background We analyzed the correlation of the clinical data with retinal nerve fiber layer (RNFL) thickness and macular thickness in bipolar disorder patients and major depression patients. The aim of this study is to explore factors that affect RNFL thickness in bipolar disorder patients and major depression patients, with a view to providing a new diagnostic strategy. Methods Eighty-two bipolar disorder patients, 35 major depression patients and 274 people who were age and gender matched with the patients were enrolled. Demographic information and metabolic profile of all participants were collected. Best-corrected visual acuity of each eye, intraocular pressure (IOP), fundus examination was performed. RNFL and macular thickness were measured by optical coherence tomography (OCT). Correlations between RNFL and macular thickness and other data were analyzed. Results RNFL and macula lutea in bipolar dipolar patients and major depression patients are thinner than normal people. Triglyceride and UA levels are the highest in the bipolar disorder group, while alanine aminotransferase (ALT) and glutamic oxalacetic transaminase (AST) levels in the depression group are the highest. Age onset and ALT are positively while uric acid (UA) is negatively correlated with RNFL thickness in bipolar dipolar patients. Cholesterol level is positively correlated with RNFL thickness while the duration of illness is correlated with RNFL thickness of left eye in major depression patients. Conclusions RNFL and macula lutea in bipolar dipolar patients and major depression patients are thinner than normal people. In bipolar disorder patients, age-onset and ALT are potential protective factors in the progress of RNFL thinning, while UA is the pathological factor.

scholarly journals Choroidal thickness and retinal nerve fiber layer analysis in acute systemic brucellosis

2021 ◽  
Vol 19 ◽  
pp. 205873922110406
Author(s):  
Kürşad Ramazan Zor ◽  
Tuğba Arslan Gülen ◽  
Gamze Yıldırım Biçer ◽  
Erkut Küçük ◽  
Ayfer İmre ◽  
...  
Keyword(s):  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Choroidal Thickness ◽  
Control Group ◽  
Fiber Layer ◽  
Subfoveal Choroidal Thickness ◽  
Nerve Fiber Layer ◽  
Rnfl Thickness ◽  
The Mean ◽  
Retinal Nerve Fiber

Introduction This study aims to detect changes in choroidal thickness and retinal nerve fiber layer (RNFL) thickness in acute stage brucellosis. Methods Fnewly diagnosed patients with acute brucellosis and 19 healthy individuals as control group were included in the study. Choroidal thickness and RNFL thickness were measured using the Spectral Domain Cirrus OCT Model 400 (Carl Zeiss Meditec, Jena, Germany) for each participant in the patient and control group. Results In the brucella group, in the right eyes, the mean nasal choroidal thickness was 272.77 ± 50.26 μm ( p = 0.689), the mean subfoveal choroidal thickness was 321.14 ± 33.08 μm ( p = 0.590), the mean temporal choroidal thickness was 278.86 ± 48.84 μm ( p = 0.478), and the mean RNFL thickness was 90.43 ± 8.93 μm ( p = 0.567). In the left eyes, the mean nasal choroidal thickness was 282.29 ± 48.93 μm ( p = 0.715), the mean subfoveal choroidal thickness was 316.79 ± 39.57 μm ( p = 0.540), the mean temporal choroidal thickness was 284.93 ± 50.57 μm ( p = 0.392), and the mean RNFL thickness was 92.64 ± 8.95 μm ( p = 0.813). Conclusion No difference was found between the control and the brucella groups regarding to all choroidal regions and RNFL thickness.

Early detection of cognitive dysfunction in patients with multiple sclerosis: Implications on outcome

2019 ◽  
Vol 21 (2) ◽  
pp. 208-216
Author(s):  
Maged Abdel Naseer ◽  
Shereen Fathi ◽  
Dalia M. Labib ◽  
Dalia H. Khalil ◽  
Alshaimaa M. Aboulfotooh ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cognitive Impairment ◽  
Early Detection ◽  
Negative Correlation ◽  
Cognitive Rehabilitation ◽  
Word Association ◽  
Significant Negative Correlation ◽  
Fiber Layer ◽  
Rnfl Thickness ◽  
Increased Risk

AbstractObjective:Cognitive impairment in multiple sclerosis (MS) has a complex relationship with disease progression and neurodegeneration. The aim of this study was to shed light on the importance of early detection of cognitive impairment in MS patients.Methods:The study comprised two groups of definite MS patients, relapsing remitting multiple sclerosis (RRMS) and secondary progressive multiple sclerosis (SPMS), each with 25 patients. Physical disability was assessed using the Expanded Disability Status Scale (EDSS), while the risk of secondary progression was assessed using the Bayesian Risk Estimate for Multiple Sclerosis (BREMS). Cognitive functions were assessed using the Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS) and Controlled Oral Word Association Test (COWAT). Assessment of neurodegeneration was done using optical coherence tomography (OCT) via quantification of retinal nerve fiber layer (RNFL).Results:MS patients with higher RNFL thickness demonstrated a larger learning effect size than patients who had lower values in RNFL thickness regardless of MS type. RRMS patients showed significant improvement in delayed recall after giving cues than SPMS. The symbol digit modalities test was the only neuropsychological test that showed a significant negative correlation with EDSS (P = 0.009). There was a statistically significant negative correlation between BREMS scores and performance in all neuropsychological tests.Conclusion:Inclusion of neurocognitive evaluation in the periodic assessment of MS patients is mandatory to detect patients at increased risk of secondary progression. The thickness of RNFL is suggested as a method to estimate the expected benefit of cognitive rehabilitation, regardless of MS type.

Sign in / Sign up

Export Citation Format

Share Document