Circulating Dipeptidyl Peptidase-4 Activity is Associated with Diabetic Retinopathy in Type 1 Diabetic Patients

2015 ◽  
Vol 25 (4) ◽  
pp. 328-332 ◽  
Author(s):  
Kristina Blaslov ◽  
Tomislav Bulum ◽  
Lea Duvnjak
Keyword(s):  
Diabetic Retinopathy ◽  
Dipeptidyl Peptidase ◽  
Diabetic Patients ◽  
Dipeptidyl Peptidase 4 ◽  
Type 1 Diabetic Patients

The effect of insulin pump therapy in retinal vasculature in type 1 diabetic patients

2021 ◽  
pp. 112067212199057
Author(s):  
Tomás de Oliveira Loureiro ◽  
João Nobre Cardoso ◽  
Carlos Diogo Pinheiro Lima Lopes ◽  
Ana Rita Carreira ◽  
Sandra Rodrigues-Barros ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Metabolic Control ◽  
Insulin Pump Therapy ◽  
Vascular Density ◽  
Diabetic Patients ◽  
Retinal Vasculature ◽  
Increased Risk ◽  
The Mean ◽  
Type 1 Diabetic Patients

Background/objectives: Continuous subcutaneous insulin infusion (CSII) is a treatment for type 1 diabetes that improves metabolic control and reduces micro and macrovascular complications. The aim of this study was to compare the effect of CSII versus traditional multiple daily injections (MDI) therapy on retinal vasculature. Methods: We performed a prospective study with type 1 diabetic patients with no prior history of ocular pathology other than mild diabetic retinopathy. The patients were divided into two groups according to their therapeutic modality (CSII vs MDI). The retinal nerve fiber layers thickness and vascular densities were compared between groups in both macula and optic disc. The correlations between vascular density and clinical features were also determined. Statistical significance was defined as p < 0.05. Results: The study included 52 eyes, 28 in the insulin CSII group. The mean age was 36.66 ± 12.97 years, with no difference between groups ( p = 0.49). The mean glycated hemoglobin (HbA1c) was found to be lower in the CSII group (7.1% ± 0.7 vs 7.5% ± 0.7 p < 0.01). The parafoveal vascular density was found to be higher in the CSII group (42.5% ± 0.4 vs 37.7% ± 0.6, p < 0.01). We found an inverse correlation between HbA1c value and parafoveal vascular densities ( p < 0.01, r = −0.50). Conclusion: We found that CSII provided better metabolic control than MDI and this seemed to result in higher parafoveal vascular density. As lower vascular density is associated with an increased risk of diabetic retinopathy, these results suggest that CSII could be the safest therapeutic option to prevent retinopathy.

Associations Between Diabetic Retinopathy and Plasma Levels of High-sensitive C-reactive Protein or Von Willebrand Factor in Long-term Type 1 Diabetic Patients

2012 ◽  
Vol 38 (1) ◽  
pp. 174-179 ◽  
Author(s):  
Jonas Vejvad Nørskov Laursen ◽  
Stine Skovbo Hoffmann ◽  
Anders Green ◽  
Mads Nybo ◽  
Anne Katrin Sjølie ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Diabetic Patients ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Von Willebrand ◽  
Type 1 Diabetic Patients ◽  
Willebrand Factor ◽  
Term Type

scholarly journals Selective Loss of Inner Retinal Layer Thickness in Type 1 Diabetic Patients with Minimal Diabetic Retinopathy

2009 ◽  
Vol 50 (7) ◽  
pp. 3404 ◽  
Author(s):  
Hille W. van Dijk ◽  
Pauline H. B. Kok ◽  
Mona Garvin ◽  
Milan Sonka ◽  
J. Hans DeVries ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Layer Thickness ◽  
Diabetic Patients ◽  
Retinal Layer ◽  
Selective Loss ◽  
Type 1 Diabetic Patients

scholarly journals Retinal Blood Flow in Type 1 Diabetic Patients With No or Mild Diabetic Retinopathy During Euglycemic Clamp

Diabetes Care ◽  
2010 ◽  
Vol 33 (9) ◽  
pp. 2038-2042 ◽  
Author(s):  
B. Pemp ◽  
E. Polska ◽  
G. Garhofer ◽  
M. Bayerle-Eder ◽  
A. Kautzky-Willer ◽  
...  
Keyword(s):  
Blood Flow ◽  
Diabetic Retinopathy ◽  
Retinal Blood Flow ◽  
Diabetic Patients ◽  
Euglycemic Clamp ◽  
Type 1 Diabetic Patients
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