Effect of Oxygen Supply on Glycogen Recovery and AMPK Protein Expression in Post-Exercise

2012 ◽  
Vol 14 (4) ◽  
Keyword(s):  
Protein Expression ◽  
Oxygen Supply ◽  
Post Exercise ◽  
Effect Of Oxygen

Limitation of theophylline elimination by reduced oxygen availability in mouse hepatocytes and rat isolated livers

1985 ◽  
Vol 63 (8) ◽  
pp. 903-907 ◽  
Author(s):  
Kanji Nakatsu
Keyword(s):  
Oxygen Supply ◽  
Correlation Coefficients ◽  
Oxygen Availability ◽  
Isolated Perfused Rat Liver ◽  
Mouse Hepatocyte ◽  
Mouse Hepatocytes ◽  
Per Se ◽  
Theophylline Metabolism ◽  
Effect Of Oxygen ◽  
Rat Livers

The effect of oxygen availability on theophylline metabolism by mouse hepatocytes and rat isolated livers was examined. The elimination of theophylline by mouse hepatocytes and the metabolism of theophylline to dimethyluric acid by isolated, perfused rat livers was seriously impaired when the gas mixture supplied contained less than 28% oxygen. The correlation coefficients relating oxygen supply and the concentration of theophylline remaining in mouse hepatocyte suspensions were −0.74 to −0.84. In the isolated, perfused rat liver experiments, the correlation coefficient relating oxygen availability and dimethyluric acid production was 0.87. These observations are interpreted as supporting the hypothesis that oxygen availability per se is an important factor in determining the rate of theophylline metabolism.

Differential effect of oxygen supply and lactate concentration on keratan sulphate and glycoseminoglycuronan production in bovine cornea

1991 ◽  
Vol 19 (4) ◽  
pp. 354S-354S ◽  
Author(s):  
CESARE BALDUINI ◽  
GLANCARLO DE LUCA ◽  
ALBERTO PASSI ◽  
SIMONETTA RINDI ◽  
ROBERTA SALVINI ◽  
...  
Keyword(s):  
Differential Effect ◽  
Oxygen Supply ◽  
Lactate Concentration ◽  
Keratan Sulphate ◽  
Effect Of Oxygen

Effect of oxygen supply on energy metabolism in rats

1994 ◽  
Vol 13 ◽  
pp. 39
Author(s):  
Y. Mimura ◽  
K. Furuya ◽  
J. Maeda ◽  
M. Yamakawa ◽  
T. Oohara
Keyword(s):  
Energy Metabolism ◽  
Oxygen Supply ◽  
Effect Of Oxygen

scholarly journals Antioxidants Facilitate High–intensity Exercise IL–15 Expression in Skeletal Muscle

2018 ◽  
Vol 40 (01) ◽  
pp. 16-22 ◽  
Author(s):  
Alberto Pérez-López ◽  
Marcos Martin-Rincon ◽  
Alfredo Santana ◽  
Ismael Perez-Suarez ◽  
Cecilia Dorado ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Protein Expression ◽  
High Intensity ◽  
Human Skeletal Muscle ◽  
Vastus Lateralis ◽  
Acute Hypoxia ◽  
High Intensity Exercise ◽  
Oxygen Deficit ◽  
Post Exercise ◽  
Sprint Exercise

AbstractInterleukin (IL)-15 stimulates mitochondrial biogenesis, fat oxidation, glucose uptake and myogenesis in skeletal muscle. However, the mechanisms by which exercise triggers IL-15 expression remain to be elucidated in humans. This study aimed at determining whether high-intensity exercise and exercise-induced RONS stimulate IL-15/IL-15Rα expression and its signaling pathway (STAT3) in human skeletal muscle. Nine volunteers performed a 30-s Wingate test in normoxia and hypoxia (PIO2=75 mmHg), 2 h after placebo or antioxidant administration (α-lipoic acid, vitamin C and E) in a randomized double-blind design. Blood samples and muscle biopsies (vastus lateralis) were obtained before, immediately after, and 30 and 120 min post-exercise. Sprint exercise upregulated skeletal muscle IL-15 protein expression (ANOVA, P=0.05), an effect accentuated by antioxidant administration in hypoxia (ANOVA, P=0.022). In antioxidant conditions, the increased IL-15 expression at 120 min post-exercise (33%; P=0.017) was associated with the oxygen deficit caused by the sprint (r=–0.54; P=0.020); while, IL-15 and Tyr705-STAT3 AUCs were also related (r=0.50; P=0.036). Antioxidant administration promotes IL-15 protein expression in human skeletal muscle after sprint exercise, particularly in severe acute hypoxia. Therefore, during intense muscle contraction, a reduced PO2 and glycolytic rate, and possibly, an attenuated RONS generation may facilitate IL-15 production, accompanied by STAT3 activation, in a process that does not require AMPK phosphorylation.

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