Problem-Based Review: Calcium Channel Blocker (CCB) Poisoning

2011 ◽  
Vol 10 (3) ◽  
pp. 153-155
Author(s):  
Tom Heaps ◽  

A 56-year-old female presents to the emergency department 6h after taking an overdose of verapamil MR 120mg x 28 capsules. She has a past medical history of hypertension and atrial flutter. On admission her GCS is 15, HR 50/min, BP 100/64, Capillary blood glucose (CBG) 10.2. ECG shows sinus bradycardia with prolongation of the PR interval. You estimate her weight to be 60kg.

Author(s):  
Mrinmoy Adhikary ◽  
Vinoth Gnana Chellaiyan ◽  
Ranadip Chowdhury ◽  
Shailaja Daral ◽  
Neha Taneja ◽  
...  

Background: Diabetes mellitus has reached epidemic proportions globally. India has largest number of diabetic population constituting major proportion worldwide. The epidemic of diabetes in India is due to the rapid epidemiological transition attributed to changes in dietary patterns and decreased physical activity apart from the role of genetic factors in the disease causation. The objectives of the study was to assess the risk factors of type 2 diabetes and to find the relation between risk factors of type 2 diabetes and fasting capillary blood glucose level among the study population.Methods: A cross sectional community based study was carried out using a semi structured, pretested, questionnaire among 432 study subjects aged 30 years and above in a randomly selected sahoorpur village under Fatehpur Beri primary health centre. The study duration was from March 2011 to February 2012. Means and proportions were calculated. Multivariate logistic regression was applied. Results: The mean (SD) age of the study population was 45 (±11.9) years. Positive family history of Diabetes was present in 14.4% of study population. History of smoking and alcohol was found in 37.5% and 8.3% respectively. Prevalence of overweight and obesity was 48.8% and 17.2% respectively. Regression showed age more than 60 years (OR 1.135, 95% CI 0.037 – 0.492), family history of diabetes (OR 4.181, 95% CI 1.734 – 10.083), higher waist circumference (OR 13.414, 95% CI 4.991 – 36.051), sedentary work (OR 3.133, 95% CI 0.032 – 0.592), obesity (OR 4.709, 95% CI 1.790 – 12.394) had higher odds of having higher fasting capillary blood glucose level. Conclusions: The study found a higher prevalence of risk factors among the study population. Risk factors showed a significant relation with higher fasting capillary blood glucose. There is a mandate for health education to motivate change in lifestyle modification among the study population. 


2021 ◽  
pp. 10.1212/CPJ.0000000000001048
Author(s):  
Stefan Williams ◽  
Joshua Kirby ◽  
Ana Maria Garcia

A 78 year old lady, with a past medical history of hypertension, presented to the Accident & Emergency department after a sudden onset of right sided involuntary movements while she was having afternoon tea with her friends. Examination showed isolated unilateral chorea, affecting the right arm and leg (video). Her blood glucose and sodium levels were normal. The MRI head scan showed a left globus pallidus infarct (figure 1). Tetrabenazine was prescribed with very good response, and weaned off after 4 weeks. Hyperkinetic movement disorders are uncommon in acute stroke (1%)1. Lesions in regions functionally connected to the posterolateral putamen are implicated in hyperkinetic movement disorders2. The differential diagnosis includes hyperglycaemia, hyponatraemia and drug-induced chorea. In cases of sudden onset, it is important to recognise stroke as a possible cause to avoid missing reperfusion therapy opportunities


2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Esther H. G. Park ◽  
Frances O’Brien ◽  
Fiona Seabrook ◽  
Jane Elizabeth Hirst

Abstract Background There is increasing pressure to get women and babies home rapidly after birth. Babies born to mothers with gestational diabetes mellitus (GDM) currently get 24-h inpatient monitoring. We investigated whether a low-risk group of babies born to mothers with GDM could be defined for shorter inpatient hypoglycaemia monitoring. Methods Observational, retrospective cohort study conducted in a tertiary maternity hospital in 2018. Singleton, term babies born to women with GDM and no other risk factors for hypoglycaemia, were included. Capillary blood glucose (BG) testing and clinical observations for signs of hypoglycaemia during the first 24-h after birth. BG was checked in all babies before the second feed. Subsequent testing occurred if the first result was < 2.0 mmol/L, or clinical suspicion developed for hypoglycaemia. Neonatal hypoglycaemia, defined as either capillary or venous glucose ≤ 2.0 mmol/L and/or clinical signs of neonatal hypoglycaemia requiring oral or intravenous dextrose (lethargy, abnormal feeding behaviour or seizures). Results Fifteen of 106 babies developed hypoglycaemia within the first 24-h. Maternal and neonatal characteristics were not predictive. All babies with hypoglycaemia had an initial capillary BG ≤ 2.6 mmol/L (Area under the ROC curve (AUC) 0.96, 95% Confidence Interval (CI) 0.91–1.0). This result was validated on a further 65 babies, of whom 10 developed hypoglycaemia, in the first 24-h of life. Conclusion Using the 2.6 mmol/L threshold, extended monitoring as an inpatient could have been avoided for 60% of babies in this study. Whilst prospective validation is needed, this approach could help tailor postnatal care plans for babies born to mothers with GDM.


2015 ◽  
Vol 37 (2) ◽  
pp. 189
Author(s):  
Henrique Amancio Ferreira ◽  
Gabriel Luís Silva Lima ◽  
Helena Moretti Bressane ◽  
Alessandra Cristina Pupin Silvério ◽  
Ciderleia Castro de Lima

Jurnal NERS ◽  
2020 ◽  
Vol 14 (2) ◽  
pp. 224
Author(s):  
Muflih Muflih ◽  
Suwarsi Suwarsi ◽  
Fajarina Lathu Asmarani

ABSTRACTIntroduction: The examination of patients with diabetes mellitus (DM) can be done by reviewing their complaints and through a capillary blood glucose level test to determine the value of their Random Blood Glucose Level. QRMA (Quantum Resonance Magnetic Analyzer) is claimed to be able to check the patient’s bodily condition (including blood glucose) with an accuracy of 85%. The purpose of this study was to verify the validity of the QRMA tool and its accuracy by comparing the results of the anamnesis and the examination conducted using the capillary blood glucose test method.Methods: The research method used was a cross-sectional design. The total sample consisted of 44 respondents in the working area of the Community Health Centers in Yogyakarta with the risk factor being blood sugar level instability. The sampling technique used was purposive sampling. The main variable in this study was the value of the blood sugar level measured based on the coefficient value of the QRMA tool and the value of Random Blood Glucose obtained through the capillary blood glucose test.Results: The blood glucose value was not correlated significantly with the coefficient value of QRMA. The value of blood glucose when examined alongside the result of the respondent's anamnesis showed there to be a significant difference. The value of the QRMA coefficient when examined against the results from the history of the respondents showed no significant difference. Linear regression showed that the variables of height, body weight, and IMT had a correlation with the QRMA coefficient value.Conclusion: The QRMA tool was not able to provide a picture of the actual condition of the blood glucose level of the respondents when compared with the results of the anamnesis and the blood glucose value from the capillary blood glucose test. Non-invasive health measurement devices such as QRMA are not used by nurses as a standard for determining the health status of DM patients.


Diabetes Care ◽  
1989 ◽  
Vol 12 (4) ◽  
pp. 298-301 ◽  
Author(s):  
P. A. Lawrence ◽  
M. C. Dowe ◽  
E. K. Perry ◽  
S. Strong ◽  
G. P. Samsa

2018 ◽  
Vol 18 (1) ◽  
Author(s):  
Emminarie Luisiana Lucas Garcia ◽  
David Debensason ◽  
Loïc Capron ◽  
Antoine Flahault ◽  
Jeanine Pommier

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