scholarly journals Metformin-associated lactic acidosis and acute kidney injury in the era of COVID-19

10.52586/s563 ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 202
2018 ◽  
Vol 32 (2) ◽  
pp. 297-306 ◽  
Author(s):  
Paolo Greco ◽  
Giuseppe Regolisti ◽  
Umberto Maggiore ◽  
Elena Ferioli ◽  
Filippo Fani ◽  
...  

2019 ◽  
Vol 58 (5) ◽  
pp. 375-382 ◽  
Author(s):  
Anthony Corchia ◽  
Alain Wynckel ◽  
Julien Journet ◽  
Julie Moussi Frances ◽  
Nihel Skandrani ◽  
...  

2010 ◽  
Vol 43 (4) ◽  
pp. 1243-1248 ◽  
Author(s):  
Vassilios Devetzis ◽  
Ploumis Passadakis ◽  
Stelios Panagoutsos ◽  
Marios Theodoridis ◽  
Elias Thodis ◽  
...  

2011 ◽  
Vol 2011 ◽  
pp. 1-5 ◽  
Author(s):  
David Arroyo ◽  
Rosa Melero ◽  
Nayara Panizo ◽  
Marian Goicoechea ◽  
Patrocinio Rodríguez-Benítez ◽  
...  

Objectives. Metformin is the preferred oral antidiabetic agent for type 2 diabetes. Lactic acidosis is described as a rare complication, usually during an acute kidney injury (AKI).Material and Methods. We conducted a prospective observational study of metformin-associated AKI cases during four years. 29 cases were identified. Previous renal function, clinical data, and outcomes were recorded.Results. An episode of acute gastroenteritis precipitated the event in 26 cases. Three developed a septic shock. Three patients died, the only related factor being liver dysfunction. More severe metabolic acidosis hyperkalemia and anemia were associated with higher probabilities of RRT requirement. We could not find any relationship between previous renal dysfunction and the outcome of the AKI.Conclusions. AKI associated to an episode of volume depletion due to gastrointestinal losses is a serious complication in type 2 diabetic patients on metformin. Previous renal dysfunction (mild-to-moderate CKD) has no influence on the severity or outcome.


2018 ◽  
Vol 14 (1) ◽  
pp. 70-70 ◽  
Author(s):  
Samira Bell ◽  
Enrique Soto-Pedre ◽  
Paul Connelly ◽  
Shona Livingstone ◽  
Ewan Pearson

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