scholarly journals Assessment of intensity modulated radiation therapy in left breast cancer including regional nodes without the internal mammary node: secondary cancer risks on thyroid and stomach

2021 ◽  
Vol 19 (4) ◽  
pp. 921-928
Author(s):  
H. Jang ◽  
J.G. Baek ◽  
W. Kim ◽  
J.H. Sohn ◽  
◽  
...  
Keyword(s):  
Breast Cancer ◽  
Radiation Therapy ◽  
Intensity Modulated Radiation Therapy ◽  
Left Breast ◽  
Secondary Cancer ◽  
Cancer Risks ◽  
Internal Mammary Node ◽  
Intensity Modulated ◽  
Internal Mammary

scholarly journals Secondary cancer risk after whole-breast radiation therapy: field-in-field versus intensity modulated radiation therapy versus volumetric modulated arc therapy

2019 ◽  
Vol 92 (1102) ◽  
pp. 20190317 ◽  
Author(s):  
Emel Haciislamoglu ◽  
Yunus Cinar ◽  
Fatih Gurcan ◽  
Emine Canyilmaz ◽  
Gorkem Gungor ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Cancer Risk ◽  
Radiation Treatment ◽  
Volumetric Modulated Arc Therapy ◽  
Intensity Modulated Radiation Therapy ◽  
Secondary Cancer ◽  
Cancer Risks ◽  
Intensity Modulated ◽  
Arc Therapy ◽  
Secondary Cancer Risk

Objective: In this study, we used the concept of organ-equivalent dose (OED) to evaluate the excess absolute risk (EAR) for secondary cancer in various organs after radiation treatment for breast cancer. Methods: Using CT data set of 12 patients, we generated three different whole-breast radiation treatment plans using 50 Gy in 2 Gy fractions: three-dimensional conformal radiotherapy with a field-in-field (FinF) technique, intensity modulated radiation therapy (IMRT), and volumetric modulated arc therapy (VMAT). The OEDs were calculated from differential dose–volume histograms on the basis of the “linear–exponential,” “plateau,” and “full mechanistic” dose–response models. Secondary cancer risks of the contralateral breast (CB), contralateral lung (CL), and ipsilateral lung (IL) were estimated and compared. Results: The lowest EARs for the CB, CL, and IL were achieved with FinF, which reduced the EARs by 77%, 88%, and 56% relative to those with IMRT, and by 77%, 84%, and 58% relative to those with VMAT, respectively. The secondary cancer risk for FinF was significantly lower than those of IMRT and VMAT. OED-based secondary cancer risks for CB and IL were similar when IMRT and VMAT were used, but the risk for CL was statistically lower when VMAT was used. Conclusion: The overall estimation of EAR indicated that the radiation-induced cancer risk of breast radiation therapy was lower with FinF than with IMRT and VMAT. Therefore, when secondary cancer risk is a major concern, FinF is considered to be the preferred treatment option in irradiation of whole-breast. Advances in knowledge: Secondary malignancy estimation after breast radiotherapy is becoming an important subject for comparative treatment planning.When secondary cancer risk a major concern, FinF technique is considered the preferred treatment option in whole breast patients.

Role of Internal Mammary Node Radiation as a Part of Modern Breast Cancer Radiation Therapy: A Systematic Review

2016 ◽  
Vol 95 (2) ◽  
pp. 617-631 ◽  
Author(s):  
Vivek Verma ◽  
Frank Vicini ◽  
Rahul D. Tendulkar ◽  
Atif J. Khan ◽  
Jessica Wobb ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Systematic Review ◽  
Radiation Therapy ◽  
Internal Mammary Node ◽  
Internal Mammary
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