scholarly journals Ameliorative role of melatonin against cypermethrin or gamma irradiation induced testicular damage in male rats

2020 ◽  
Vol 18 (4) ◽  
pp. 765-776
Author(s):  
E.M. Kamal El-Dein Kamal El-Dein ◽  
L.M. Anees ◽  
◽  
Keyword(s):  
Gamma Irradiation ◽  
Male Rats ◽  
Testicular Damage

Acute, subacute and subchronic administration of methyl parathion-induced testicular damage in male rats and protective role of vitamins C and E

2007 ◽  
Vol 87 (2) ◽  
pp. 115-122 ◽  
Author(s):  
Meltem Uzunhisarcikli ◽  
Yusuf Kalender ◽  
Kerem Dirican ◽  
Suna Kalender ◽  
Ayse Ogutcu ◽  
...  
Keyword(s):  
Methyl Parathion ◽  
Protective Role ◽  
Male Rats ◽  
Testicular Damage

scholarly journals NLRP3 Inflammasome: A New Pharmacological Target for Reducing Testicular Damage Associated with Varicocele

2021 ◽  
Vol 22 (3) ◽  
pp. 1319
Author(s):  
Pietro Antonuccio ◽  
Antonio Girolamo Micali ◽  
Carmelo Romeo ◽  
Jose Freni ◽  
Giovanna Vermiglio ◽  
...  
Keyword(s):  
Nlrp3 Inflammasome ◽  
Male Rats ◽  
Sham Operation ◽  
Testicular Damage ◽  
Cell Numbers ◽  
Testosterone Levels ◽  
Caspase 1 ◽  
Ultrastructural Damage ◽  
Pharmacological Target

Many bioactive natural compounds are being increasingly used for therapeutics and nutraceutical applications to counteract male infertility, particularly varicocele. The roles of selenium and Polydeoxyribonucleotide (PDRN) were investigated in an experimental model of varicocele, with particular regard to the role of NLRP3 inflammasome. Male rats underwent sham operation and were daily administered with vehicle, seleno-L-methionine (Se), PDRN, and with the association Se-PDRN. Another group of rats were operated for varicocele. After twenty-eight days, sham and varicocele rats were sacrificed and both testes were weighted and analyzed. All the other rats were challenged for one month with the same compounds. In varicocele animals, lower testosterone levels, testes weight, NLRP3 inflammasome, IL-1β and caspase-1 increased gene expression were demonstrated. TUNEL assay showed an increased number of apoptotic cells. Structural and ultrastructural damage to testes was also shown. PDRN alone significantly improved all considered parameters more than Se. The Se-PDRN association significantly improved all morphological parameters, significantly increased testosterone levels, and reduced NLRP3 inflammasome, caspase-1 and IL-1β expression and TUNEL-positive cell numbers. Our results suggest that NLRP3 inflammasome can be considered an interesting target in varicocele and that Se-PDRN may be a new medical approach in support to surgery.

scholarly journals Role of Vitamin E on Antispermatogenic Effects of Indomethacin on Number of Sperm Containing Seminiferous Tubules of Testes in Long Evans Rats

1970 ◽  
Vol 7 (1) ◽  
pp. 5-9
Author(s):  
Md Jahangir Alam ◽  
Monira Khatun ◽  
Manowara Begum ◽  
Muazzem Hossain ◽  
Jesmin Akhter ◽  
...  
Keyword(s):  
Vitamin E ◽  
The Other ◽  
Male Rats ◽  
Seminiferous Tubules ◽  
Testicular Damage ◽  
Other Hand ◽  
Group I ◽  
Long Evans ◽  
Different Doses

Context: Indomethacin is the most commonly and widely used nonsteroidal antiinflammatory analgesic and antipyretic drug. Despite its effectiveness as an antiinflammatory use, indomethacin causes inhibition of spermatogenesis leading to infertility. On the other hand, vitamin E enhances spermatogenesis. Therefore, the present study was designed to observe the protective role of vitamin E on indomethacin induced testicular damage. Objective: To observe the effects of vitamin E on indomethacin induced testicular damage in Long Evans rats. Study design: An experimental study. Place and period of study: The study was carried out in the Department of Anatomy, Sir Salimullah Medical College, Dhaka. Materials and methods: Eightyfour mature Long Evans male rats were divided into four groups (I, II, III and IV). The rats of group I, II and III were treated with indomethacin at different doses and duration. Group IV rats were treated with indomethacin and vitamin E at different doses for 49 days. Histologically the number of sperm containing and nonsperm containing seminiferous tubules were counted. Results: There was significant reduction (P<0.001) in number of sperm containing seminiferous tubules when the rats were treated with indomethacin at low (2 mg/kg body wt/day) and high dose (10 mg/kg body wt/day) for 7, 14 and 42 days, respectively. On the other hand, rats treated with indomethacin and vitamin E for 49 days showed increase in number of sperm containing seminiferous tubules compared to the other groups (P<0.001). Conclusion: It can be concluded from this study that vitamin E has potential role in the prevention of the antispermatogenic effects of indomethacin. Key words: Seminiferous tubules, Indomethacin, Vitamin E    doi: 10.3329/bja.v7i1.3009 Bangladesh Journal of Anatomy January 2009, Vol. 7 No. 1 pp. 5-9

scholarly journals Amelioration of Monosodium Glutamate-induced Testicular Damage and Infertility in Male Rats by Water Melon and Cantaloupe Seeds Extract and Juices

2019 ◽  
pp. 1-16
Author(s):  
Shimaa El-Masry ◽  
Mai Elsayed
Keyword(s):  
Monosodium Glutamate ◽  
Testicular Tissue ◽  
Food Additive ◽  
Male Rats ◽  
Testicular Damage ◽  
Group 2 ◽  
Melon Seeds ◽  
Water Melon ◽  
Group 1

Aims: Monosodium glutamate (MSG) is extensively used as food additive and flavor enhancer, there is a growing concern that this may affect the male reproductive system and fertility. The objective of this study is to investigate the effect of MSG on fertility and testes of mature male rats and the ameliorative role of water melon and cantaloupe (seeds extract and juices). Study Design: Thirty-six male Sprague - Dawely rats (150-180 g) were randomly assigned into six groups (n=6). Group (1): orally administered with distilled water. Group (2): orally administered with 60 mg/kg of MSG. Groups (3 and 4): orally administered with 60 mg/kg of MSG + 200 mg/kg of water melon seeds extract and juice respectively. Groups (5 and 6): orally administered with 60 mg/kg of MSG + 200 mg/kg of cantaloupe seeds extract and juice respectively. Results: Results showed that administration of MSG for 6 weeks caused abnormalities of semen characteristics, increased DNA damage and up-regulation of caspase3 expression in the testes tissue. Also, the levels of plasma sex hormones were decreased and the oxidant-antioxidant status was disturbed, moreover, MSG caused alteration in the histopathological structures of testicular tissue. Administration of seeds extract or juices of water melon and cantaloupe almost corrected the biochemical and histopathological alteration produced by MSG. Conclusion: This study concluded that water melon and cantaloupe seeds and juice extracts have an ameliorative role against MSG-induced testicular damage and infertility in rats.

Anti-apoptotic role of spermine against lead and/or gamma irradiation-induced hepatotoxicity in male rats

2017 ◽  
Vol 24 (31) ◽  
pp. 24272-24283 ◽  
Author(s):  
Rasha Abu-Khudir ◽  
Mahmoud E. Habieb ◽  
Marwa A. Mohamed ◽  
Asrar M. Hawas ◽  
Tarek M. Mohamed
Keyword(s):  
Gamma Irradiation ◽  
Male Rats

Protective effect of green tea extract against cadmium-induced testicular damage in rats in respect of oxidant/antioxidant equilibrium and androgen production

2020 ◽  
Vol 21 (1) ◽  
pp. 31-35
Author(s):  
Basma El-Desoky ◽  
Shaimaa El-Sayed ◽  
El-Said El-Said
Keyword(s):  
Gene Expression ◽  
Single Dose ◽  
Green Tea ◽  
Serum Testosterone ◽  
Green Tea Extract ◽  
Male Rats ◽  
Controlled Study ◽  
Control Group ◽  
Testicular Damage ◽  
Tea Extract

Objective: Investigating the effect of green tea extract (GTE) on the testicular damage induced by cadmium chloride CdCl2 in male rats. Design: Randomized controlled study. Animals: 40 male Wistar rats. Procedures: Rats were randomly divided into four groups: A) control group (each rat daily received pellet diet); B) GTE group each rat daily received pellet diet as well as 3 ml of 1.5 % w/v GTE, C) CdCl2 group each rat was I/P injected a single dose of 1 mg/kg CdCl2, then daily received pellet diet, and D) CdCl2+GTE group each rat was I/P injected a single dose of 1 mg/kg CdCl2 then daily received pellet diet as well as 3 ml of 1.5 % w/v GTE. After 30 days, blood samples were collected for hormonal assays (testosterone, FSH, and LH). In addition, both testes were collected; one of them was used for quantification of 17-beta hydroxysteroid dehydrogenase III (17β-HSDIII) gene expression using a real-time PCR. The other testis was used for determination of catalase and reduced glutathione; GSH, Nitric oxide (NO) and malondialdehyde (MDA) levels. Results: CdCl2 decreased serum testosterone levels and its synthesis pathway (17β-HSDIII testicular gene expression). While antioxidants catalase and GSH were reduced, oxidants MDA were enriched in the testes of CdCl2-poisoned rats. This CdCl2-promoted testicular dysfunction was corrected via the administration of GTE to male rats. Conclusion and clinical relevance: GTE could be used as a remedy for protecting against CdCl2-induced testicular damage in male rats.

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