scholarly journals A subchronic toxicity test of ethyl acetate extract from endophytic fungus Penicillium sp. of kunyit putih (Curcuma zedoaria) against Swiss albino mice

2018 ◽  
Vol 27 (2) ◽  
pp. 123-130
Author(s):  
Yohandini Heni
Keyword(s):  
Ethyl Acetate ◽  
Endophytic Fungus ◽  
Toxicity Test ◽  
Ethyl Acetate Extract ◽  
Curcuma Zedoaria ◽  
Subchronic Toxicity ◽  
Swiss Albino Mice ◽  
Penicillium Sp ◽  
Albino Mice

Evaluation of immunomodulatory activity of ethyl acetate extract of Leucas aspera in Swiss albino mice

2014 ◽  
Vol 8 (2) ◽  
pp. 84 ◽  
Author(s):  
BibinBaby Augustine ◽  
Suvakanta Dash ◽  
Mangala Lahkar ◽  
VenketeswaraRao Amara ◽  
PavanKumar Samudrala ◽  
...  
Keyword(s):  
Ethyl Acetate ◽  
Ethyl Acetate Extract ◽  
Immunomodulatory Activity ◽  
Swiss Albino Mice ◽  
Leucas Aspera ◽  
Albino Mice

scholarly journals Methanol, ethyl acetate and n-hexane extracts of Tragia involucrata L. leaves exhibit anxiolytic, sedative and analgesic activity in Swiss albino mice

Heliyon ◽  
2021 ◽  
Vol 7 (1) ◽  
pp. e05814
Author(s):  
Md. Shofiqul Islam ◽  
Samiron Sana ◽  
Md. Ehsanul Haque ◽  
S.M. Mushiur Rahman ◽  
Abdus Samad ◽  
...  
Keyword(s):  
Ethyl Acetate ◽  
Analgesic Activity ◽  
Swiss Albino Mice ◽  
Hexane Extracts ◽  
Albino Mice

scholarly journals Isolasi Senyawa Kimia Stigmastan-3,5-Diena Yang Mempunyai Daya Toksik Dari Daun Ekaliptus (Eucalyptus Deglupta Blume.)

2017 ◽  
Vol 15 (1) ◽  
pp. 1
Author(s):  
Sari Setianingsih ◽  
Rudi Kartika ◽  
Partomuan Simanjuntak
Keyword(s):  
Ethyl Acetate ◽  
Toxicity Test ◽  
Ethyl Acetate Extract ◽  
Chemical Compounds ◽  
Gas Chromatography Mass Spectrometry ◽  
Test Results ◽  
Phytochemical Screening ◽  
Isolation And Identification ◽  
Lc50 Value ◽  
Ms Analysis

This study was started by extraction of Eucalyptus deglupta Blume. Using organic solvent   (n-hexane, ethyl acetate, ethanol and water) followed by phytochemical screening and toxicity test using Brine Shrimp Lethality Test (BSLT) method. Isolation and identification of chemical compounds contained in the fraction were done by column chromatography and Gas Chromatography-Mass Spectrometry (GC-MS) analysis. Phytochemical screening revealed the presence of alkaloids, flavonoids, steroids and phenolics in the extract. Toxicity test results showed that the ethyl acetate extract was potentially active with LC50 value of  617.95 ppm. The extract was continued to isolation stage and gave fraction EKEA-3.1 with LC50 value of 2759.93 ppm. Identification of chemical compounds in EKEA-3.1 with KG-MS analysis showed that EKEA-3.1 was suspected to be Stigmastan-3,5-diene.

scholarly journals New Pyrenocines from an Endophytic Fungus

2008 ◽  
Vol 3 (10) ◽  
pp. 1934578X0800301 ◽  
Author(s):  
Karsten Krohn ◽  
Md. Hossain Sohrab ◽  
Siegfried Draeger ◽  
Barbara Schulz
Keyword(s):  
Ethyl Acetate ◽  
Endophytic Fungus ◽  
Ethyl Acetate Extract

Three new pyrenocines, F (6), G (7), and H (8), along with the known pyrenocine A (1) were isolated from the ethyl acetate extract of an unidentified endophytic fungus. Metabolites 1 and 7 exhibited good antifungal and algicidal activities.

scholarly journals Oxandrastins: Antibacterial Meroterpenes from an Australian Mud Dauber Wasp Nest-Associated Fungus, Penicillium sp. CMB-MD14

Molecules ◽  
2021 ◽  
Vol 26 (23) ◽  
pp. 7144
Author(s):  
Ahmed H. Elbanna ◽  
Zeinab G. Khalil ◽  
Robert J. Capon
Keyword(s):  
Antibacterial Activity ◽  
Ethyl Acetate ◽  
Spectroscopic Analysis ◽  
Ethyl Acetate Extract ◽  
Culture Media ◽  
Rice Cultivation ◽  
Chemical Investigation ◽  
Penicillium Sp ◽  
Vancomycin Resistant Enterococci ◽  
Vancomycin Resistant

The ethyl acetate extract of an ISP-2 agar cultivation of the wasp nest-associated fungus Penicillium sp. CMB-MD14 exhibited promising antibacterial activity against vancomycin-resistant enterococci (VRE), with a bioassay guided chemical investigation yielding the new meroterpene, oxandrastin A (1), the first andrastin-like metabolite with an extra oxygenation at C-2. A culture media optimisation strategy informed a scaled-up rice cultivation that yielded 1, together with three new oxandrastins B–D (2–4), two known andrastins C (5) and F (6), and a new meroterpene of the austalide family, isoaustalide F (7). Structures of 1–7 were assigned based on detailed spectroscopic analysis and chemical interconversion. A GNPS molecular networking analysis of the rice cultivation extract detected the known austalides B (8), H (9), and H acid (10), tentatively identified based on molecular formulae and co-clustering with 7. That the anti-VRE properties of the CMB-MD14 extract were exclusively attributed to 1 (IC50 6.0 µM, MIC99 13.9 µM), highlights the importance of the 2-OAc and 3-OAc moieties to the oxandrastin anti-VRE pharmacophore.

scholarly journals Uji Fitokimia dan Toksisitas Ekstrak Etil Asetat Kulit Batang Melochia umbellata (Houtt) Stapf. var. Visenia dengan Metode Brine Shirmp Lethality Test (BSLT)

2017 ◽  
Vol 4 (2) ◽  
pp. 378-381 ◽  
Author(s):  
Fauziah Ahmad ◽  
Nunuk H. Soekamto ◽  
Firdaus Firdaus
Keyword(s):  
Ethyl Acetate ◽  
Toxicity Test ◽  
Ethyl Acetate Extract ◽  
Artemia Salina ◽  
Bark Extract ◽  
Steroid Compound ◽  
Value Analysis ◽  
South Sulawesi ◽  
The People ◽  
Test Result

Melochia umbellata (Houtt) Stapf. var. Visenia is plant species included in Malvaceae family. This spesies is known as paliasa and used as traditional medicine by the people of South Sulawesi. This study aimed to determine the secondary metabolites by reagents and toxicity characteristic testing from bark extract of Melochia umbellata (Houtt) Stapf. var. Visenia using Brine Shirmp Lethality Test (BSLT) method. The extract was prepeared by maceration ethyl acetate. Phytochemical test result showed that the ethyl acetate extract was containing the steroid compound, alkaloids and terpenoids. Toxicity test performed by shrimp Artemia salina Leach larvae was at 48 hours. The toxic effects of the extract were identified by the percentage of the number of shrimp larvae mortality using probit value analysis (LC50). The toxicity test of bark Melochia umbellata (Houtt) Stapf. var. Visenia extract showed that the ethyl acetate extract is toxic to A. salina  LC50 = 54,55 mg / mL.

scholarly journals The Antioxcidant, Antibacterial Activity and Toxicity of Kesambi (Schleichera Oleosa (Lour) Oken) Brak Extracts

2020 ◽  
Vol 4 (3) ◽  
Author(s):  
Puspita Sari
Keyword(s):  
Antioxidant Activity ◽  
Antibacterial Activity ◽  
Ethyl Acetate ◽  
Toxicity Test ◽  
Ethyl Acetate Extract ◽  
Hexane Extract ◽  
Diffusion Method ◽  
Toxicity Tests ◽  
Agar Diffusion ◽  
Schleichera Oleosa

Abstract This study aimed to compare antioxidant, antibacterial and toxicity tests of various types of kesambi tree bark extract (Schleichera oleosa (Lour) Oken). The research stages included extraction of kesambi stem skin from Mancak Serang sub-district with multilevel maceration techniques using 3 solvents: Methanol, n-hexane, and ethyl acetate. The extract was then tested for antioxidant activity, antibacterial, and toxicity. The results of antioxidant testing using the DPPH method, antibacterial with agar diffusion method, and toxicity test with BSLT method, the results showed that ethyl acetate extract had better antioxidant activity (IC50 7,723 ppm.) compared to extract of methanol (IC50 7,801 ppm), and n-hexane extract (IC50 8,568 ppm). Antibacterial activity showed the ability to inhibit the growth of Streptococcus aureus compared to Escherichia coli at a concentration of 10000 ppm, and the results of the toxicity test showed that ethyl acetate extract had better activity (LC50 305,17 ppm) than n-hexane extract (LC50 374, 96 ppm) and methanol extract (LC50 431,26 ppm).Keywords: DPPH, BSLT, Agar Diffusion, Schleichera oleosa (Lour) Oken

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