Vitamin D Across the Life Cycle with the Special Emphasis on Latin America

2013 ◽  
Vol 2013 (4) ◽  
Author(s):  
Rana Mokhtar
Keyword(s):  
Vitamin D ◽  
Latin America ◽  
Life Cycle

scholarly journals One Century of Study: What We Learned about Paracoccidioides and How This Pathogen Contributed to Advances in Antifungal Therapy

2021 ◽  
Vol 7 (2) ◽  
pp. 106
Author(s):  
Erika Seki Kioshima ◽  
Patrícia de Souza Bonfim de Mendonça ◽  
Marcus de Melo Teixeira ◽  
Isis Regina Grenier Capoci ◽  
André Amaral ◽  
...  
Keyword(s):  
Latin America ◽  
Life Cycle ◽  
Antifungal Activity ◽  
Molecular Biology ◽  
Antifungal Therapy ◽  
High Toxicity ◽  
Development Stages ◽  
Thioredoxin System ◽  
Nanostructured Systems ◽  
Advanced Development

Paracoccidioidomycosis (PCM) is a notable fungal infection restricted to Latin America. Since the first description of the disease by Lutz up to the present day, Brazilian researchers have contributed to the understanding of the life cycle of this pathogen and provided the possibility of new targets for antifungal therapy based on the structural and functional genomics of Paracoccidioides. In this context, in silico approaches have selected molecules that act on specific targets, such as the thioredoxin system, with promising antifungal activity against Paracoccidioides. Some of these are already in advanced development stages. In addition, the application of nanostructured systems has addressed issues related to the high toxicity of conventional PCM therapy. Thus, the contribution of molecular biology and biotechnology to the advances achieved is unquestionable. However, it is still necessary to transcend the boundaries of synthetic chemistry, pharmaco-technics, and pharmacodynamics, aiming to turn promising molecules into newly available drugs for the treatment of fungal diseases.

scholarly journals The Influence of Vitamin D on Bone Health Across the Life Cycle

2005 ◽  
Vol 135 (11) ◽  
pp. 2726S-2727S ◽  
Author(s):  
Michael F. Holick
Keyword(s):  
Vitamin D ◽  
Life Cycle ◽  
Bone Health

Less than Adequate Vitamin D Status and Intake in Latin America and the Caribbean: A Problem of Unknown Magnitude

2013 ◽  
Vol 34 (1) ◽  
pp. 52-64 ◽  
Author(s):  
Alex Brito ◽  
Héctor Cori ◽  
Manuel Olivares ◽  
María Fernanda Mujica ◽  
Gustavo Cediel ◽  
...  
Keyword(s):  
Vitamin D ◽  
Latin America ◽  
Vitamin D Status ◽  
The Caribbean
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