Immunotherapy for Recurrent Pregnancy Loss: A Review

Modern medicine has made extraordinary progress in the last few decades. But little success has been achieved in the management of recurrent pregnancy losses and implantation failures post in vitro fertilization. It results in extreme duress and financial burden on the couples seeking treatment. To prevent such pregnancy losses a lot of new therapies are offered to them. Immunotherapies like Allogenic Lymphocyte Immunization, Corticosteroid therapy, Intravenous Immunoglobulin, etc., are being researched and tried. We searched current literature for evidence pertaining to all the different immunotherapies for treatment. We studied trials, meta-analyses and review articles on it. This review has summarized the current status of research and evidence on all these therapies. We concluded that the causation and mechanism of alteration of immune system has been well documented in most of the therapies. Clinical evidence indicating definite benefit is conflicting and at times lacking. More research and studies need to be done to validate these therapies for routine clinical use. Keywords: Recurrent pregnancy loss, Recurrent implantation failure, Immunotherapy, Abortions.