Correlation of Platelet-Lymphocyte Ratio towards the Incidence of Follicular Thyroid Carcinoma

2021 ◽  
Vol 8 (9) ◽  
pp. 36-42
Author(s):  
Gagang Guntaran Kalbuningwang ◽  
Dwi Hari Susilo ◽  
Marjono Dwi Wibowo
Keyword(s):  
Thyroid Carcinoma ◽  
Complete Blood Count ◽  
Follicular Thyroid Carcinoma ◽  
Benign Lesion ◽  
P Value ◽  
Pathology Report ◽  
Research Subjects ◽  
Lymphocyte Ratio ◽  
Platelet Lymphocyte Ratio ◽  
Significant Difference

Background: Recently, there is some consistent evidence that the inflammatory process is related to the development and progression of cancer. Platelet-lymphocyte ratio (PLR) may acts as simple biomarker for predicting the occurrence of cancer. Since fine needle aspiration could not distinguish between follicular thyroid carcinoma and benign lesion, the researchers were interested in conducting research correlation of PLR towards incidence of follicular thyroid carcinoma in Dr Soetomo Hospital Surabaya. Methods: This study used secondary data from medical record of surgical pathology report diagnosed with follicular thyroid carcinoma who had undergone thyroid surgery at RSUD Dr. Soetomo Surabaya. Preoperative complete blood count was investigated then platelet-lymphocyte ratio was counted. Results: The total research subjects were 40 people, consisting of 31 women (77.5%), 9 men (22.5%). Among three analyses between gender, age, and PLR towards follicular thyroid carcinoma, there is only one analysis which statistically had significant difference, that is correlation between PLR value towards incidence of follicular thyroid carcinoma (p value = 0.003). Two remaining analyses showed there were no statistically significant difference between gender (p value = 0.451) and age (p value = 0.336) towards follicular thyroid carcinoma. It was also found that patients with the higher PLR value had eight point five times higher suffering follicular thyroid carcinoma than those who had low PLR value. Conclusion: According to this study, there was a statistically significant difference between PLR towards incidence of follicular thyroid carcinoma. The higher platelet-lymphocyte ratio (PLR) value, it is more likely to develop follicular thyroid carcinoma. Keywords: Platelet lymphocyte ratio, platelet-lymphocyte ratio, follicular thyroid carcinoma

The Trend of Platelet-To-Lymphocyte Ratio (PLR) and Absolute-Lymphocyte-Count (ALC) in the Severity of Covid-19 Patients

2021 ◽  
Vol 2 (4) ◽  
Author(s):  
Markus Gatot Sura Wijaya ◽  
Arie Utariani ◽  
Hamzah Hamzah ◽  
Bambang Pujo Semedi ◽  
Prananda Surya Airlangga
Keyword(s):  
Lymphocyte Count ◽  
Time Course ◽  
Complete Blood Count ◽  
Absolute Lymphocyte Count ◽  
P Value ◽  
Research Subjects ◽  
Platelet To Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Severity Class ◽  
Critical Patients

Background: Cytokine storms and severe immune injury are suspected as the cause of the occurrence of Acute Respiratory Distress Syndrome (ARDS), sepsis and various another organ failure. The trend of Platelet-to-Lymphocyte Ratio (PLR) and Absolute Lymphocyte Count (ALC) were expected to show the inflammatory process and the cytokine storm in the severity of Covid-19 patients. This research’s purpose is to analyze the time course and dynamic changes of PLR and ALC in each severity. Method: The research method used was an observational analytic study with a prospective cohort design. The research sample taken was Covid-19 patients admitted from July to October 2020 who met the inclusion and exclusion criteria. PLR, ALC was counted from the CBC (Complete Blood Count) examination checked every three days. The PLR and ALC trend of 14-days were then analyzed. Result: A total of 119 research subjects were involved in this study. PLR is significantly different at day-0 and the day-3 with p-value <0.001 and 0.003. On the 3rd day of treatment, PLR of moderate severity rose rapidly. Mild, severe, and critical cases’ PLR rose until day-6. After the day-6, PLR of all severity class tend to decrease. ALC was significantly different on day-0, day-3, day-6 and day-9 with p-value <0.001, 0.006, 0.024 and 0.001. ALC day-0 in critical patients is the lowest, and tend to be the lowest throughout the 14 days. ALC in mild, moderate and severe declined until day 6, then began to rise until day 14. Conclusion: In Conclusion, PLR tend to increase from day-0 of treatment and peak in day-3 or day-6 of treatment and then decreased gradually until day-14 of the treatment. Meanwhile, ALC tend to decrease from day-0 of treatment and reach the lowest point at day-6 of treatment and then increased gradually until day-14 of the treatment. PLR was significantly different among the severity in day-0 and day-3 with p-value <0.001 and 0.003. ALC was significantly different among the severity in day-0, day-3, day-6 and day-9 with p-value <0.001, 0.006, 0.024 and 0.001.

Comparison of hematological parameters and perinatal outcomes between COVID-19 pregnancies and healthy pregnancy cohort

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Esin Merve Erol Koç ◽  
Rahime Bedir Fındık ◽  
Hatice Akkaya ◽  
Işılay Karadağ ◽  
Eda Özden Tokalıoğlu ◽  
...  
Keyword(s):  
Complete Blood Count ◽  
Perinatal Outcomes ◽  
Control Group ◽  
Strong Positive Correlation ◽  
Monocyte Count ◽  
Distribution Width ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Significant Difference ◽  
Adverse Perinatal Outcomes

AbstractObjectivesTo evaluate the relationship between Coronavirus Disease 2019 (COVID-19) in pregnancy and adverse perinatal outcomes. The secondary aim is to analyze the diagnostic value of hematologic parameters in COVID-19 complicated pregnancies.MethodsThe current study is conducted in a high volume tertiary obstetrics center burdened by COVID-19 pandemics, in Turkey. In this cohort study, perinatal outcomes and complete blood count indices performed at the time of admission of 39 pregnancies (Study group) complicated by COVID-19 were compared with 69 uncomplicated pregnancies (Control group).ResultsThere was no significant difference between the obstetric and neonatal outcomes of pregnancies with COVID-19 compared to data of healthy pregnancies, except the increased C-section rate (p=0.026). Monocyte count, red cell distribution width (RDW), neutrophil/lymphocyte ratio (NLR), and monocyte/lymphocyte ratio (MLR) were significantly increased (p<0.0001, p=0.009, p=0.043, p<0.0001, respectively) whereas the MPV and plateletcrit were significantly decreased (p=0.001, p=0.008) in pregnants with COVID-19. ROC analysis revealed that the optimal cut-off value for MLR was 0.354 which indicated 96.7% specificity and 59.5% sensitivity in diagnosis of pregnant women with COVID-19. A strong positive correlation was found between the MLR and the presence of cough symptom (r=41.4, p=<0.0001).ConclusionsThe study revealed that, pregnancies complicated by COVID-19 is not related with adverse perinatal outcomes. MLR may serve as a supportive diagnostic parameter together with the Reverse Transcriptase Polymerase Chain Reaction (RT-PCR) in assessment of COVID-19 in pregnant cohort.

scholarly journals Can Hematological Parameters Play a Role in the Differential Diagnosis of Adrenal Tumors?

Uro ◽  
2021 ◽  
Vol 1 (2) ◽  
pp. 39-44
Author(s):  
Mehmet Gürkan Arıkan ◽  
Göktan Altuğ Öz ◽  
Nur Gülce İşkan ◽  
Necdet Süt ◽  
İlkan Yüksel ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Inflammatory Markers ◽  
Blood Count ◽  
Complete Blood Count ◽  
Low Cost ◽  
Easy Access ◽  
Adrenal Tumors ◽  
Tumor Diameter ◽  
Lymphocyte Ratio ◽  
Significant Difference

There have been few studies reported with conflicting results in the use of neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), redcell-distribution-width (RDW), etc. for predicting prognosis and differential diagnosis of adrenal tumors. The aim of this study is to investigate the role of inflammatory markers through a complete blood count, which is an easy access low-cost method, for the differential diagnosis of adrenocortical adenoma (ACA), adrenocortical carcinoma (ACC), and pheochromocytoma. The data of patients who underwent adrenalectomy between the years of 2010–2020 were retrospectively analyzed. Systemic hematologic inflammatory markers based on a complete blood count such as neutrophil ratio (NR), lymphocyte ratio (LR), NLR, PLR, RDW, mean platelet volume (MPV), and maximum tumor diameter (MTD) were compared between the groups. A statistically significant difference was found between the three groups in terms of PLR, RDW, and MTD. With post-hoc tests, a statistically significant difference was found in PLR and MTD between the ACA and ACC groups. A statistically significant difference was found between the ACA and pheochromocytoma groups in PLR and RDW values. In conclusion, it could be possible to plan a more accurate medical and surgical approach using PLR and RDW, which are easily calculated through an easy access low-cost method such as a complete blood count, together with MTD in the differential diagnosis of ACC, ACA, and pheochromocytoma.

Prediction of Troponin elevation in Non- ST Acute Coronary Syndrome Patients presenting to The Emergency Department Using Neutrophil-lymphocyte ratio

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Sarah Mohamed Mahmoud ◽  
Bassam Sobhy ◽  
Ramy Raymond
Keyword(s):  
Emergency Department ◽  
Acute Coronary Syndrome ◽  
Complete Blood Count ◽  
P Value ◽  
Troponin Elevation ◽  
Positive Group ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Coronary Syndrome

Abstract Background The neutrophil–lymphocyte ratio (NLR) is considered an independent predictor of mortality and myocardial infarction (MI) in stable coronary artery disease (SCAD). Also NLR have prognostic value in patients with acute coronary syndromes (ACSs). However the diagnostic power of NLR in patients suspected of ACS is still under study Objective is to determine the ability of neutrophil-lymphocyte ratio to predict troponin elevation in patients presenting to emergency department with acute coronary syndrome Material and Methods From June 2018 to March 2019, 100 patients were enrolled who presented to the ER with NST-ACS. Patients were divided into 2 groups based upon the troponin positivity in the 12- to 24-hour follow-up. Baseline Complete blood count with calculation of NLR is done Results The study population was divided into 2 groups: troponin- negative group (n = 50) and troponin-positive group (n = 50). Mean age was 55.8 ± 11.3. 77% of the patients were male. No significance difference in the level of hemoglobin, WBCs and platelets between the 2 groups. The neutrophil count was significantly higher in the troponin-positive group (p &lt; 0.001). The median admission. NLR was significantly higher in the troponin-positive group (2 vs. 3.9, P &lt; 0.001). A cutoff point of 3.4 for NLR measured on admission had 84% sensitivity and 84% specificity in predicting follow-up troponin positivity. A highly significant correlation was found between NLR and level of troponin change (p value &lt;0.01) Conclusion NLR can be used as a diagnostic tool in the differentiation of patients with acute coronary syndrome. NLR is a non-expensive, simple and available parameter that can be used in diagnosis of NSTEMI.

scholarly journals Platelet-to-lymphocyte ratio (PLR) and Plateletcrit (PCT) in young patients with morbid obesity

2019 ◽  
Vol 65 (9) ◽  
pp. 1182-1187 ◽  
Author(s):  
Emrah Erdal ◽  
Mehmet İnanir
Keyword(s):  
Morbid Obesity ◽  
Healthy Subjects ◽  
Complete Blood Count ◽  
Young Patients ◽  
Obese Group ◽  
Platelet To Lymphocyte Ratio ◽  
Distribution Width ◽  
Lymphocyte Ratio ◽  
Platelet Counts ◽  
Significant Difference

SUMMARY OBJECTIVE To compare the complete blood counts, namely the plateletcrit (PCT) and Platelet-To-Lymphocyte Ratio (PLR) of healthy subjects and those with morbid obesity in the young population. METHODS We included 45 patients with morbid obesity (body mass index -BMI - greater than or equal to 45 kg/m2) and 45 healthy subjects (BMI less than or equal to 25 kg/m2) in our study. Blood samples were obtained from the participants following a 12-hour fasting period. Then we evaluated the levels of hemoglobin (Hb), hematocrit (HCT), red cell distribution width (RDW), mean platelet volume (MPV), white blood cell (WBC), PLR, platelet counts, and PCT in the complete blood count. RESULTS The morbid obesity group had significantly higher platelet counts and PCT values (p<0.001), and PLR values (p=0.033). The value of WBC was also higher in the obese group (p=0.001). MPV was lower in the obesity group but not statistically significant (p=0.815). No significant difference was found between hemoglobin and hematocrit values in these groups; but RDW valuewere higher and statistically significant in the obese group (p=0.001). CONCLUSION PLR or PCT may be more useful as a marker in determining an increased thrombotic state and inflammatory response in morbid obesity.

scholarly journals Identification of Senior High School Students' Problem-Solving Skill on Static Electricity Based on Gender

2021 ◽  
Vol 9 (2) ◽  
pp. 208
Author(s):  
Nurul Atqiya ◽  
Dibyaratna Sy. ◽  
M. Pathurrozi ◽  
Sentot Kusairi
Keyword(s):  
High School Students ◽  
Problem Solving ◽  
Sampling Technique ◽  
Female Students ◽  
Male Students ◽  
P Value ◽  
Research Subjects ◽  
School Students ◽  
Male And Female ◽  
Significant Difference

This research aimed to identify differences in problem solving skill between male and female students. The research subjects were 50 students (21 male and 29 female) who were taken by random sampling technique from two high schools in Malang. The research instrument was adapted from problem solving instruments of Maries & Singh (2018). The data was analyzed by statistic descriptive and Kruskall Wallis test (p-value <0.05). The results showed that overall, there was no significant difference between male and female students (p-value>0.05). However male students performed better than female students on preparing the action (p-value<0.05). The results of this research can be a consideration and input for practitioners of education to improve the quality of education, especially in Indonesia.

scholarly journals ROLE OF HEMATOLOGICAL PARAMETERS IN EARLY DIAGNOSIS OF COVID-19 IN A TERTIARY CARE CENTRE

2021 ◽  
Vol 5 (6) ◽  
Author(s):  
Angira Saha ◽  
Sakar Saxena ◽  
Romi Srivastava ◽  
Sanjeev Narang
Keyword(s):  
Early Diagnosis ◽  
Hematological Parameters ◽  
Tertiary Care ◽  
Tertiary Care Centre ◽  
College Hospital ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Platelet Lymphocyte Ratio ◽  
Significant Difference

Aim: To evaluate the role of biomarkers from blood samples of COVID-19 patients admitted in Index Medical College Hospital & R.C. Material & Methods: Hematological parameters such as Neutrophil lymphocyte ratio (NLR), Platelet lymphocyte ratio (PLR) & Systemic Inflammatory Index (SII) were studied in RT-PCR positive patients to evaluate the utility of these parameters for early diagnosis of COVID-19. Results: The study showed that there was statistically significant difference in test groups in reference to Neutrophil lymphocyte ratio (NLR) & SII values (p<0.05). But no statistically significant difference was observed between test groups in reference to Platelet lymphocyte ratio (PLR) values (p>0.05). Conclusion: Leukocyte, Neutrophil, NLR & SII values can be used in the early diagnosis of COVID-19. Keywords: NLR, SII, Leukocyte, Neutrophil

scholarly journals Recipient Pre-Operative Neutrophil Lymphocyte Ratio Better Predicts Delayed Graft Function than Platelet Lymphocyte Ratio in Donation after Brain Death Kidney Transplantation

2019 ◽  
Vol 2 (2) ◽  
pp. 209-216
Author(s):  
Dilip Baral ◽  
Yunying Yang ◽  
Gaurav Katwal ◽  
Shiyi Li ◽  
Shengjie Wang ◽  
...  
Keyword(s):  
Graft Function ◽  
Delayed Graft Function ◽  
Full Blood Count ◽  
P Value ◽  
Kidney Transplant Patient ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Patient Demographics ◽  
Platelet Lymphocyte Ratio ◽  
The Status

Background: Neutrophil lymphocyte Ratio (NLR) and Platelet lymphocyte Ratio (PLR) are an indicator of the status of inflammation. The objective of this study was to evaluate the relationship between recipient pre-operative Neutrophil lymphocyte Ratio (NLR) and Platelet lymphocyte Ratio (PLR) with delayed graft function in the kidney transplant patient. Methods: The preoperative full blood count, data regarding patient demographics and postoperative graft function was retrospectively evaluated from the database of our institution. All statistical calculations were carried out using SPSS 20.0 version (SPSS Inc., Chicago, IL, USA). A p-value<0.05 was considered statistically significant. Results: 289 patients were included in this study. DGF occurred in 33 cases. Elevated preoperative NLR had a sensitivity of 75.75% and specificity of 76.56% whereas elevated preoperative PLR had a sensitivity of 72.72% and specificity of 58.20% for predicting DGF. The area under the ROC curve was found to be 0.762 and 0.655 for NLR and PLR, respectively. Multivariate analysis showed NLR>3.5 and PLR>120 independently responsible for DGF. Conclusion: Recipient preoperative NLR and PLR can predict the occurrence of DGF following DBD renal transplantation. In addition, NLR is better than PLR in predicting DGF. DGF prolongs the total ICU and in-hospital stay.

scholarly journals PENGARUH SIT STRETCHING TERHADAP PERUBAHAN SKALA NYERI PUNGGUNG BAWAH PADA KARYAWAN DI PT. RIFAN FINANCINDO BERJANGKA CABANG SEMARANG

2018 ◽  
Vol 1 (1) ◽  
pp. 1
Author(s):  
Gamalia Anggriya Dwi Putra ◽  
Asti Nuraeni ◽  
Mamat Supriyono
Keyword(s):  
Back Pain ◽  
Lower Back Pain ◽  
Intervention Group ◽  
P Value ◽  
Research Subjects ◽  
Lower Back ◽  
Group Research ◽  
Significant Difference ◽  
Post Test ◽  
Female Employees

Lower back pain is one of musculoskeletal disorder in the shape of pain in the back bone, to be exact is in the forth lumbar to the first sacrum. It is caused by the not appropriate posture (not ergonomic) while working or doing the activities, such as very long standing or sitting. This complaint can be reduced by sit stretching regularly. The aim of this study is to find out impact of sit stretching towards the changes of scale of lower back pain on employees at PT. Rifan Financindo Berjangka Branch Semarang. The method of research is quasy experiment designed in pre test and post test with compare group. Research subjects are 30 male and female employees. Sample taking uses total sampling. Statisitic test utilizes Mann Whitney with level of meaning (α=0,05). The result of pre test statisitc test is p-value = 0,467 (> 0,05), it means that  there is no significant difference scale of lower back pain between intervention group and compare group  before performing sit stretching to intervention  group. The post test statisitic the result is p-value = 0,001 (> 0,05), it means there is a significant difference scale of lower back pain at intervention group with compare group after performing sit stretching on the intervention group. Based on result of p-value on post test can be concluded that there is an impact of sit stretching towards the changes in scale of lower back pain on the employees at PT. Rifan Financindo Berjangka Branch Semarang.

scholarly journals Peripheral Neutrophil- Lymphocyte Ratio as a Predictor of Seizure in Preterm Infants with Intra-Ventricular Hemorrhage

2021 ◽  
pp. 13-21
Author(s):  
Heba Ibrahim Ashraf ◽  
Abd El-Rahman Mohamed El-Mashad ◽  
Mai Rabie El-Sheikh
Keyword(s):  
Preterm Infants ◽  
University Hospital ◽  
Neurological Dysfunction ◽  
P Value ◽  
Cranial Ultrasound ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Significant Difference ◽  
Ventricular Hemorrhage ◽  
Peripheral Neutrophil

Background: Preterm infants with Intra-Ventricular Hemorrhage (IVH) are at risk for developing significant complications, including post hemorrhagic hydrocephalus and seizures. Neonatal seizures are the most common overt manifestation of neurological dysfunction in the newborn, and is associated with short- and long-term adverse effects. Objective: The aim of the study is to evaluate the value of Peripheral Neutrophil- lymphocyte ratio (NLR) as a predictor of seizure in preterm infants with intra-ventricular hemorrhage. Methods: This prospective cohort study that comprised 60 Preterm infants with IVH admitted at NICU pediatric department Tanta university hospital from November 2019 to May 2020, Preterm infants were divided into two groups according to incidence of seizure. Preterm infants in this study subjected to Careful history taking, clinical examination and investigations (laboratory and Trans-cranial ultrasound) as well as analysis of result and follow up clinical status for development of seizure. Results: There was a statistically highly significant difference regarding NLR and development of seizure with p value <0.001 (NLR ≥ 2.3 with sensitivity 96%, specificity 93%, Area under the curve 0.849 and accuracy 84.9%). Conclusion: NLR is a predictor of seizure in preterm infants with intra-ventricular hemorrhage.

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