scholarly journals Association of Platelet Lymphocyte Ratio (PLR) and Neutrophil Lymphocyte Ratio (NLR) with Global Registry of Acute Coronary Events (GRACE) Score in Acute Coronary Syndrome

2021 ◽  
Vol 8 (5) ◽  
pp. 1-6
Author(s):  
Baginda Yusuf Siregar ◽  
Refli Hasan ◽  
Rahmad Isnanta
Keyword(s):  
Acute Coronary Syndrome ◽  
High Risk ◽  
Risk Stratification ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Coronary Syndrome ◽  
Platelet Lymphocyte Ratio ◽  
Coronary Events ◽  
Global Registry ◽  
Grace Score

Introduction: Acute Coronary Syndrome (ACS) has morbidity and mortality significantly increase, it requires risk stratification for the assessment and selection of initial invasive strategies. The Global Registry of Acute Coronary Events (GRACE) scores recommended as risk stratification of ACS. Some of studies found that the combination of GRACE scores with other clinical and laboratory parameters can increase predictive value of ACS. Platelet Lymphocyte Ratio (PLR) and Neutrophil Lymphocyte Ratio (NLR) act as parameter of systemic inflammation in ACS. Aims of the study to determine the association between PLR and NLR with risk stratification GRACE score. Method: This study is analytical with a cross-sectional retrospective design. This study included 70 patients with a diagnosis of ACS based on medical record data. Data analysis was performed using the Statistical Package for the Social Sciences (SPSS) 22.0. P-value <0.05 was considered statistically significant. Results: This study was found a positive correlation between PLR and NLR with the GRACE score of patients ACS (r=0.485, p<0.001; r=0.570, p<0.001). The PLR and NLR were both found the significantly higher in the high risk GRACE score respectively (188 ± 47, p < 0.001; 7.9± 2.7, p<0.001). The ROC curve analysis, cutt-off PLR of 123 and above (sensitivity of 72.7 %; specificity of 70.3), while cutt-off NLR of 4 and above (sensitivity of 78.8%; specificity of 70.3%) to detect high risk GRACE score. Conclusion: There is a significant association between PLR and NLR with GRACE score Keywords: Platelet Lymphocyte Ratio, Neutrophil Lymphocyte Ratio, GRACE score, Acute Coronary Syndrome.

scholarly journals Association of Neutrophil Lymphocyte Ratio (NLR) with Global Registry of Acute Coronary Events (GRACE) Scores in Acute Coronary Syndrome

2020 ◽  
Vol 2 (3) ◽  
pp. 162-170
Author(s):  
Baginda Yusuf Siregar ◽  
Refli Hasan ◽  
Rahmad Isnanta
Keyword(s):  
Acute Coronary Syndrome ◽  
Risk Stratification ◽  
Design Data ◽  
Cross Sectional ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Coronary Syndrome ◽  
Coronary Events ◽  
Global Registry ◽  
Grace Score

Background. Inflammation plays an important role in the initiation of atherosclerosis from the beginning of plaque to rupture cause Acute Coronary Syndrome (ACS). Neutrophil Lymphocyte Ratio (NLR) indicator of systemic inflammation in ACS. Risk stratification was needed for assessment and selection of initial invasive strategies and find the best strategy in ACS. The Global Registry of Acute Coronary Events (GRACE) scores recommended risk stratification of ACS. Aims of the study to determine the association and cut-off value NLR with risk stratification GRACE score. Method. This study is analytical with a cross-sectional retrospective design. Data were analyzed after distribution test, then mean difference and correlation test was using the SPPS program where p <0.05 was considered statistically significant. Results. This study showed significantly higher NLR value in the high risk stratification and intermediate-risk compared to low risk stratification (7.9 ± 2.7 vs 3.6 ± 1.7; p=0.001) (5.2 ± 2.3 vs 3.6 ± 1.7; p=0.018). Significant correlation between NLR ​​with GRACE scores (r=0.570; p<0.001). Significant AUC values ​​were obtained (0.782, p <0.001, IK95% 0.674-0.89), and cut-off values NLR 4 ​​with sensitivity (78.8%) and specificity (70.3%) on the GRACE score. Conclusion. The significant association between NLR ​​with GRACE risk score in ACS.

scholarly journals Decision Support System to Risk Stratification in the Acute Coronary Syndrome Using Fuzzy Logic

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Hui Xiao ◽  
Shah Nazir ◽  
Hanmin Li ◽  
Habib Ullah Khan ◽  
Chengwei Li
Keyword(s):  
Blood Flow ◽  
Acute Coronary Syndrome ◽  
Decision Support ◽  
High Risk ◽  
Decision Support System ◽  
Risk Stratification ◽  
Support System ◽  
Probabilistic Approach ◽  
Coronary Syndrome ◽  
Grace Score

Acute coronary syndrome (ACS) is a set of symptoms and signs which define a range of conditions related with the unexpected reduced blood flow to the heart. In ACS, the heart muscles cannot function properly due to the decrease of blood flow. Myocardial infarction (MI) is a condition which comes under the umbrella of acute coronary syndrome. The aim of risk stratification (RS) in ACS is to recognize patients at high risk of ischemic events. Yet, no investigative study is available to identify the patients at high risk. Therefore, to facilitate this process, it would be ideal to have a reliable and trustworthy method by the help of which the doctors can make early and easy decisions for the patient and for detecting the related disease. This research used the features of GRACE Score to RS in the ACS and presented decision support system (DSS). The concept of probabilistic approach has been used as a tool to model the identified features for decision-making (DM). This technique can be further used for DM purposes to RS in the ACS in healthcare. Furthermore, the result of the proposed method has proved closer and more reliable DM of patient and then eventually can be used for advice of medicine and rest accordingly by the doctors.

scholarly journals In-hospital mortality in patients with NON-ST segment elevation myocardial infarction in relation to high risk global registry of acute cardiac events score.

2020 ◽  
Vol 27 (11) ◽  
pp. 2433-2437
Author(s):  
Ariz Samin ◽  
Syed Hassan Mustafa ◽  
Sajid Khan ◽  
Saamia Arshad ◽  
Noor ul Huda ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
High Risk ◽  
Risk Stratification ◽  
Hospital Mortality ◽  
Risk Scores ◽  
Outcome Variable ◽  
Cardiac Events ◽  
Coronary Syndrome ◽  
Global Registry ◽  
Grace Score

Objectives: Presage for early risk stratification is consequential for long term clinical outcomes in patients with non-ST elevation acute coronary syndrome. Thrombolysis in Myocardial Infarction risk scores (TIMI) and Global Registry of Acute Cardiac Events (GRACE) have been most extensively investigated risk scores till date for risk stratification in patients admitted with Cardiovascular disease. Study Design: Descriptive Case Series. Setting: Department of Cardiology Ayub Teaching Hospital, Abbottabad. Period: 4th August 2016 to 4th April 2017. Material & Methods: 199 patients diagnosed with NSTEMI were included in the study after obtaining an apprised consent. Risk stratification of each patient was done according to GRACE score. Patients were followed up during their hospital stay and their outcome was recorded on a pre-designed pro forma. The outcome was described as either death or discharge. Results: Mean±SD GRACE score was 156.12±20.65. The overall mortality in the study population was 11.6% (n=23). When the outcome variable was stratified according to age, gender, diabetes mellitus, obesity and hypertension, results were found in case of hypertension (p< 0.05), and statistically no significant in the case of other variables. Conclusion: A high risk GRACE score is associated with increased in-hospital mortality in patients with NSTEMI.

scholarly journals Walking Beyond the GRACE (Global Registry of Acute Coronary Events) Model in the Death Risk Stratification During Hospitalization in Patients With Acute Coronary Syndrome

2012 ◽  
Vol 5 (11) ◽  
pp. 1117-1125 ◽  
Author(s):  
Sergio Raposeiras-Roubín ◽  
Emad Abu-Assi ◽  
Pilar Cabanas-Grandío ◽  
Rosa María Agra-Bermejo ◽  
Santiago Gestal-Romarí ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Risk Stratification ◽  
Death Risk ◽  
Coronary Syndrome ◽  
Coronary Events ◽  
Global Registry

scholarly journals Association between serum S100A1 level and Global Registry of Acute Coronary Events score in patients with non-ST-segment elevation acute coronary syndrome

2018 ◽  
Vol 46 (7) ◽  
pp. 2670-2678
Author(s):  
Yuanmin Li ◽  
Chenjun Han ◽  
Peng Zhang ◽  
Wangfu Zang ◽  
Rong Guo
Keyword(s):  
Acute Coronary Syndrome ◽  
Venous Blood ◽  
Cardiac Events ◽  
Coronary Syndrome ◽  
Kaplan Meier ◽  
St Segment ◽  
Potential Biomarker ◽  
Coronary Events ◽  
Global Registry ◽  
Grace Score

Objective Acute coronary syndrome (ACS) is associated with several clinical syndromes, one of which is acute non-ST-segment ACS (NSTE-ACS). S100A1 is a calcium-dependent regulator of heart contraction and relaxation. We investigated the association between the serum S100A1 level and the Global Registry of Acute Coronary Events (GRACE) risk score in patients with NSTE-ACS and the potential of using the serum S100A1 level to predict the 30-day prognosis of NSTE-ACS. Methods The clinical characteristics of 162 patients with NSTE-ACS were analyzed to determine the GRACE score. The serum S100A1 concentration was determined using fasting antecubital venous blood. The patients were divided into different groups according to the serum S100A1 level, and the 30-day NSTE-ACS prognosis was evaluated using Kaplan–Meier analysis. Results The serum S100A1 levels differed significantly among the groups. Correlation analysis showed that the serum S100A1 level was positively correlated with the GRACE score. Kaplan–Meier analysis revealed that the number of 30-day cardiac events was significantly higher in patients with an S100A1 level of >3.41 ng/mL. Conclusions S100A1 is a potential biomarker that can predict the progression of NSTE-ACS and aid in its early risk stratification and prognosis.

Prediction of Troponin elevation in Non- ST Acute Coronary Syndrome Patients presenting to The Emergency Department Using Neutrophil-lymphocyte ratio

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Sarah Mohamed Mahmoud ◽  
Bassam Sobhy ◽  
Ramy Raymond
Keyword(s):  
Emergency Department ◽  
Acute Coronary Syndrome ◽  
Complete Blood Count ◽  
P Value ◽  
Troponin Elevation ◽  
Positive Group ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Coronary Syndrome

Abstract Background The neutrophil–lymphocyte ratio (NLR) is considered an independent predictor of mortality and myocardial infarction (MI) in stable coronary artery disease (SCAD). Also NLR have prognostic value in patients with acute coronary syndromes (ACSs). However the diagnostic power of NLR in patients suspected of ACS is still under study Objective is to determine the ability of neutrophil-lymphocyte ratio to predict troponin elevation in patients presenting to emergency department with acute coronary syndrome Material and Methods From June 2018 to March 2019, 100 patients were enrolled who presented to the ER with NST-ACS. Patients were divided into 2 groups based upon the troponin positivity in the 12- to 24-hour follow-up. Baseline Complete blood count with calculation of NLR is done Results The study population was divided into 2 groups: troponin- negative group (n = 50) and troponin-positive group (n = 50). Mean age was 55.8 ± 11.3. 77% of the patients were male. No significance difference in the level of hemoglobin, WBCs and platelets between the 2 groups. The neutrophil count was significantly higher in the troponin-positive group (p &lt; 0.001). The median admission. NLR was significantly higher in the troponin-positive group (2 vs. 3.9, P &lt; 0.001). A cutoff point of 3.4 for NLR measured on admission had 84% sensitivity and 84% specificity in predicting follow-up troponin positivity. A highly significant correlation was found between NLR and level of troponin change (p value &lt;0.01) Conclusion NLR can be used as a diagnostic tool in the differentiation of patients with acute coronary syndrome. NLR is a non-expensive, simple and available parameter that can be used in diagnosis of NSTEMI.

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