scholarly journals Study of antitumor activity of natural type IFN-.GAMMA.(OH-6000) for nude mouse transplantability malignant melanoma ( SK-14 line ) and renal cancer ( RCC-1 line ).

Skin Cancer ◽  
1990 ◽  
Vol 5 (2) ◽  
pp. 476-486
Author(s):  
Toshio OGATA ◽  
Kazuyuki ISHIHARA ◽  
Naoya YAMAZAKI ◽  
Hideya SASAKI ◽  
Tsutomu KOIDE ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Antitumor Activity ◽  
Nude Mouse ◽  
Renal Cancer ◽  
Ifn Gamma ◽  
Natural Type

Raspberry pulp polysaccharides inhibit tumor growth via immunopotentiation and enhance docetaxel chemotherapy against malignant melanoma in vivo

2015 ◽  
Vol 6 (9) ◽  
pp. 3022-3034 ◽  
Author(s):  
Yong-Jing Yang ◽  
Han-Mei Xu ◽  
You-Rui Suo
Keyword(s):  
Malignant Melanoma ◽  
Antitumor Activity ◽  
Tumor Growth ◽  
Antitumor Effect ◽  
Inhibit Tumor Growth ◽  
Docetaxel Chemotherapy

Raspberry pulp polysaccharides exhibit antitumor activity in vivo against malignant melanoma through immunopotentiation and enhance the antitumor effect of docetaxel.

Toxic and Therapeutic Activity of 4'-Epi-Doxorubicin

1982 ◽  
Vol 68 (2) ◽  
pp. 105-111 ◽  
Author(s):  
Valeria Bonfante ◽  
Fabrizio Villani ◽  
Gianni Bonadonna
Keyword(s):  
Malignant Melanoma ◽  
Antitumor Activity ◽  
Acute Toxicity ◽  
Phase I ◽  
Cardiac Toxicity ◽  
Objective Response ◽  
Therapeutic Activity ◽  
Cardiac Damage ◽  
Noninvasive Methods ◽  
Advanced Malignancy

A Phase I-II study with 4'-epi-doxorubicin (epi-DX) was performed in 108 patients with various types of advanced malignancy. The pattern of acute toxicity was similar to that of doxorubicin (DX). However, epi-DX was better tolerated than DX because of comparative lower incidence of vomiting, stomatitis, complete alopecia and severe myelosuppression. Cardiac toxicity was studied by utilizing noninvasive methods, and the electrocardiographic results suggested a slightly lower cardiac damage after epi-DX compared to DX. Antitumor activity was documented in a variety of neoplasms, and objective response was also observed in those considered refractory to DX such as malignant melanoma and renal cancer.

ACTIVATED AKT PREVENTS ANTITUMOR ACTIVITY OF GEFITINIB IN RENAL CANCER CELLS

2009 ◽  
Vol 181 (4S) ◽  
pp. 159-159
Author(s):  
Kenji Kuroda ◽  
Akio Horiguchi ◽  
Makoto Sumitomo ◽  
Keiichi Ito ◽  
Takako Asano ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Cancer Cells ◽  
Renal Cancer

Localization of Protein Z (PZ) In Situ in Human Neoplastic Tissues.

Blood ◽  
2004 ◽  
Vol 104 (11) ◽  
pp. 3958-3958
Author(s):  
Ewa Sierko ◽  
Piotr Tokajuk ◽  
Rodryg Ramlau ◽  
Lech Zimnoch ◽  
Walter Kisiel ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Malignant Melanoma ◽  
Tumor Growth ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Renal Cancer ◽  
Malignant Tumors ◽  
Factor Xa ◽  
Protein Z

Abstract Tumor cells synthesize and release procoagulants that lead to multi-factorial activation of factor X and subsequent thrombin generation and fibrin formation that in turn contribute to tumor growth and metastatic spread. The activity of factor Xa is inhibited by TFPI (tissue factor pathway inhibitor). Another mechanism of direct inhibition of factor Xa involves protein Z (PZ). Protein Z is a 62-kD, vitamin K-dependent plasma nonpeptidase glycoprotein, which, in complex with PZ-dependent protease inhibitor (ZPI), inhibits factor Xa in the presence of Ca2+ and phospholipids. However, data on the presence of the PZ in tumor malignant tissue are lacking. Results obtained from randomized clinical trials indicate that inhibition of blood coagulation may improve the results of anticancer therapy in selected tumor types. The purpose of the study was to evaluate the localization of PZ in situ in colon, breast, gastric, laryngeal, pancreatic, renal, endometrial cancer, non-small cell lung cancer (NSCLC), malignant melanoma and glial neoplasms. Studies were performed on tumor fragments obtained at surgical treatment of proviously untreated patients. Immunohistochemical procedures using the ABC method employed a specific polyclonal antibody directed against human PZ antigen. Protein Z was localized in cancer cell bodies in all types of malignant tumors examined. Staining intensity was more pronounced in less differentiated cancer cells of anaplastic gliomas. In contrast, more differentiated cancer cells of gastric cancer revealed stronger staining than more malignant ones. Cancer cell bodies of NSCLC and renal cancer were characterized by weak intensity of staining for PZ. In the case of pancreatic and renal cancer, as well as malignant melanoma, the intensity of staining for PZ in cancer cell bodies was irregular: both high and low expression of PZ was observed independent of the degree of malignancy. The expression of PZ was also revealed in association with tumor infiltrating macrophages in colon cancer, NSCLC and malignant melanoma. Furthermore, PZ was localized in small blood vessels of colon, renal, endometrial, gastric cancer, NSCLC, malignant melanoma and glial neoplasms. The observed localization of PZ, particularly in association with cancer cells of all malignant tumors examined, suggests that this protein may exert regulatory effects on tumor growth and metastatic dissemination.

Antitumor activity and pharmacology of TT-232 (a novel somatostatin structural derivative) in malignant melanoma patients

2004 ◽  
Vol 22 (14_suppl) ◽  
pp. 3151-3151
Author(s):  
F. Gyergyay ◽  
M. Gödény ◽  
G. Sármay ◽  
J. Kralovanszky ◽  
E. Papp ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Antitumor Activity ◽  
Melanoma Patients

Antitumor activity and pharmacology of TT-232 (a novel somatostatin structural derivative) in malignant melanoma patients

2004 ◽  
Vol 22 (14_suppl) ◽  
pp. 3151-3151
Author(s):  
F. Gyergyay ◽  
M. Gödény ◽  
G. Sármay ◽  
J. Kralovanszky ◽  
E. Papp ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Antitumor Activity ◽  
Melanoma Patients

scholarly journals Evaluation of antitumor activity in a human breast tumor/nude mouse model with a special emphasis on treatment dose

Cancer ◽  
1989 ◽  
Vol 64 (8) ◽  
pp. 1577-1582 ◽  
Author(s):  
Makoto Inaba ◽  
Tomowo Kobayashi ◽  
Tazuko Tashiro ◽  
Yoshio Sakurai ◽  
Koji Maruo ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Mouse Model ◽  
Nude Mouse ◽  
Breast Tumor ◽  
Human Breast ◽  
Human Breast Tumor ◽  
Nude Mouse Model ◽  
Treatment Dose
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