A case of nevus cell aggregates in lymph nodes discovered in a sentinel lymph node biopsy of breast cancer

Skin Cancer ◽  
2021 ◽  
Vol 36 (1) ◽  
pp. 86-89
Author(s):  
Yuto MIZUNO ◽  
Hideyuki ISHIKAWA ◽  
Rie FUKUZAWA ◽  
Masakazu FUJIMOTO ◽  
Shinichi ANSAI ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Sentinel Lymph Node Biopsy ◽  
Lymph Nodes ◽  
Lymph Node Biopsy ◽  
Cell Aggregates ◽  
Node Biopsy ◽  
Nevus Cell

scholarly journals EXPERIENCE OF SENTINEL LYMPH NODE BIOPSY AFTER NEOADJUVANT CHEMOTHERAPY

2020 ◽  
Vol 66 (4) ◽  
pp. 370-375
Author(s):  
Vladimir Semiglazov ◽  
E. Zhiltsova ◽  
Petr Krivorotko ◽  
S. Kanaev ◽  
E. Trufanova ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Sentinel Lymph Node Biopsy ◽  
Neoadjuvant Chemotherapy ◽  
Lymph Nodes ◽  
False Negative ◽  
False Negative Rate ◽  
Lymph Node Biopsy ◽  
Node Biopsy

Objective: to evaluate the diagnostic accuracy of sentinel lymph node biopsy after neoadjuvant chemotherapy. Materials and methods: the study included 264 patients with early (operable) and locally advanced breast cancer (cT1N1-3, cT2N0-3, cT3N0-3, cT4N0-3). All patient underwent corebiopsy with histological examination and ICH (to determine the tumor grade (G), expression of ER, PR, Ki67, Her2), fine needle aspiration of suspicious axillary lymph nodes. Before, during and after the neoadjuvant therapy, all patients undergo: physical examination (palpation), mammography, ultrasound, SPECT-CT. The effect of neoadjuvant chemotherapy was evaluated after the 2nd, 4th, and 6th cycles of therapy. 197 patients (74.6%) had tumors more than 2 cm (cT2), 210 (79.8%) were N + (cN1-N3), 174 patients (65.9%) had luminal tumors (ER+), 84 patients (31.8%) had triple-negative breast cancer (ER-, PR-, HER2-) and 53 patients (20%) had HER2-positive breast cancer. Most patients (56.4%) had a high level (> 30%) of Ki67 expression. Results: 210 of 263 patients (79.8%) had metastases in regional lymph nodes before treatment. Almost half of them had a decrease in the stage from N + to ycN0 after NACT. According to the ultrasound data 48 patients had decreasing of the stage to ycN0. Sentinel lymph node biopsy showed ypN0 category in 35 patients and ypN+ in 13 patients. The false-negative rate was 5.7%. The sensitivity of the method was 94.3%, the accuracy of ultrasound was 95.8%. According to the SPET-CT data 51 patients had decreasing of the stage to ycN0. Sentinel lymph node biopsy showed ypN0 category in 35 patients and ypN+ in 16 patients. The false-negative rate was 2.85%. The sensitivity of SLNB after NACT in patients cN0/cN+ → ycN0 was 91.2%, accuracy - 96.3%, predictive value of the negative result - 92.4%. Conclusion: SLNB can be performed in cN0/cN+ → ycN0 patients after NACT, provided that 3 or more sentinel lymph nodes are removed and there are no tumor cells in them.

Influence of Imaging Features and Technique on US-guided Tattoo Ink Marking of Axillary Lymph Nodes Removed at Sentinel Lymph Node Biopsy in Women With Breast Cancer

2021 ◽  
Vol 3 (5) ◽  
pp. 583-590
Author(s):  
Marlen Pajcini ◽  
Irene Wapnir ◽  
Jacqueline Tsai ◽  
Joanne Edquilang ◽  
Wendy DeMartini ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Sentinel Lymph Node Biopsy ◽  
Lymph Nodes ◽  
Lymph Node Biopsy ◽  
Axillary Lymph Nodes ◽  
Axillary Lymph ◽  
Node Biopsy ◽  
Initial Biopsy

Abstract Objective To describe tattoo ink marking of axillary lymph nodes (TIMAN) and the elements leading to successful removal at sentinel lymph node biopsy (SLNB). Methods An IRB-approved retrospective image review was conducted of breast cancer patients who underwent SLNB after TIMAN from February 2013 to August 2017, noting patient and tattooed lymph node (TLN) features, initial biopsy type, time to surgery, if the TLN was identified at surgery, and correlation with the SLN. Cases were divided into two groups: the presurgical group, which had primary surgery, and the pre-neoadjuvant chemotherapy (NACT) group, which underwent surgery after completing NACT. Results Of 30 patients who underwent 32 TIMAN procedures, 10 (33.3%) were presurgical and 20 (66.7%) were pre-NACT. The average lymph node (LN) depth from the skin was 1.6 cm, with an average of 0.3 mL of tattoo ink injected. Of 32 procedures, 29 (90.6%) had US images demonstrating the injection. Of these, 10 (34.5%) were injected in the LN cortex surface and 19 (65.5%) in the middle cortex. Seven (24.1%) were injected in the LN lateral aspect, 12 (41.4%) in the mid aspect, and 10 (34.5%) in the medial aspect. Of 32 LNs, 28 (87.5%) were tattooed immediately after initial biopsy and 4 (12.5%) at a later date. At SLNB, all 32 (100%) TLNs were identified, all correlated with the SLN, and 10 (31.3%) were positive for cancer. Conclusion Using an average of 0.3 mL of tattoo ink, all TLNs were successfully identified for removal at surgery, despite variability in LN and injection factors.

Axillary lymphadenectomy can be safely avoided in patients with breast cancer and negative sentinel lymph node biopsy

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 10787-10787
Author(s):  
E. Millastre ◽  
M. Ruiz-Echarri Sr. ◽  
M. Ortega ◽  
J. I. Mayordomo ◽  
R. Lastra ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Sentinel Lymph Node Biopsy ◽  
Lymph Nodes ◽  
Lymph Node Dissection ◽  
Lymph Node Biopsy ◽  
Node Dissection ◽  
Node Biopsy ◽  
Axillary Lymphadenectomy

10787 Background: Patients with breast cancer in which sentinel lymph node biopsy is histologically negative for tumor cells, have a low probability of having involvement of additional regional lymph nodes. Lymph node dissection may be avoided in these cases. Methods: Ninety-six consecutive patients with invasive breast cancer and tumour size less than 2 centimeters by mammography, had lymphoscintigraphy with colloidal 99Tc and radioisotope-guided sentinel lymph node biopsy in the University Hospital of Zaragoza from 1999 to 2005.Pathological assessment included serial sections of the sentinel lymph node with immunohistochemistry for cytokeratins in selected cases. Results: Sentinel lymph node biopsy was negative in 57 patients. There were 56 females and 1 male. Median age was 57 years (range 24–87). Median pathological tumor size was 15 mm (range 5–31). Location of the sentinel lymph node was axillary in 47patients, internal mammary in 0 patients, and both in 10 patients. Median number of resected lymph nodes was 2 (range 1–4). With median follow-up of 33 months, no local or systemic relapses have occurred. Conclusions: Avoidance of regional lymph node dissection is safe in patients with breast cancer and histologically negative sentinel lymph node biopsy. No significant financial relationships to disclose.

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