scholarly journals Malignant melanoma with unknown primary lesion. Malignant melanoma of which primary lesion could not be confirmed because tumor developed on the right axilla.

Skin Cancer ◽  
1998 ◽  
Vol 13 (2) ◽  
pp. 101-105
Author(s):  
Shigeruko IIJIMA ◽  
Tomoe KOTSUJI ◽  
Fujio OTSUKA
Keyword(s):  
Malignant Melanoma ◽  
Primary Lesion ◽  
Unknown Primary ◽  
The Right

Ganglioside analysis of metastatic malignant melanoma with unknown primary lesion

1990 ◽  
Vol 1 (2) ◽  
pp. 116
Author(s):  
Junji Nakano ◽  
Takashi Imamura ◽  
Sumiko Hamanaka ◽  
Takahisa Ota ◽  
Chidori Asagami
Keyword(s):  
Malignant Melanoma ◽  
Metastatic Malignant Melanoma ◽  
Primary Lesion ◽  
Unknown Primary

Malignant melanoma of the chest wall with an unknown primary lesion

1998 ◽  
Vol 46 (5) ◽  
pp. 399-401 ◽  
Author(s):  
Goichi Yotsumoto ◽  
Shinji Shimokawa ◽  
Akihiro Yamaoka ◽  
Shun-ichi Watanabe ◽  
Yoshifumi Matsushita ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Chest Wall ◽  
Primary Lesion ◽  
Unknown Primary

Malignant melanoma of the stomach presenting with an unknown primary lesion

2003 ◽  
Vol 26 (3) ◽  
pp. 153-155 ◽  
Author(s):  
T. G. Iconomou ◽  
D. Tsoutsos ◽  
K. Frangia ◽  
H. Gogas ◽  
S. Papadopoulos ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Primary Lesion ◽  
Unknown Primary

Metastatic Malignant Melanoma of the Inguinal Lymph Node with Unknown Primary Lesion: A Case Report

2017 ◽  
Vol 3 (2) ◽  
pp. 13
Author(s):  
Guddi Rani Singh ◽  
Jiut Ram Keshari ◽  
Bhim Ram ◽  
Vijayanand choudhary ◽  
Ravi Bhushan Raman
Keyword(s):  
Case Report ◽  
Lymph Node ◽  
Malignant Melanoma ◽  
Inguinal Lymph Node ◽  
Metastatic Malignant Melanoma ◽  
Primary Lesion ◽  
Unknown Primary

scholarly journals Metastatic Malignant Melanoma of the Inguinal Lymph Node with Unknown Primary Lesion

2015 ◽  
Vol 2015 ◽  
pp. 1-4 ◽  
Author(s):  
Sherif Ali Eltawansy ◽  
Ryane Panasiti ◽  
Samaa Hasanien ◽  
Dennis Lourdusamy ◽  
David Sharon
Keyword(s):  
Lymph Node ◽  
Malignant Melanoma ◽  
Spontaneous Regression ◽  
Inguinal Lymph Node ◽  
Cutaneous Lesion ◽  
Metastatic Malignant Melanoma ◽  
Primary Lesion ◽  
Primary Site ◽  
Unknown Primary ◽  
Cutaneous Lesions

Background. Malignant melanoma could present with metastasis with unknown primary (MUP) and this happens in 2-3% according to the studies. Around 90% of melanomas have cutaneous origin, but still there are melanomas that could be found in visceral organs or lymph nodes with unknown primary site. Spontaneous regression of the primary site could be an explanation.Case Report. We report a 58-year-old Caucasian male who presented with a right sided swelling in the inguinal region. Surgery was performed and biopsy showed metastatic malignant melanoma. No cutaneous lesions were identified by history or physical examination. Work up could not detect the primary lesion and patient was started on radiotherapy and immunotherapy.Conclusion. We present a case of malignant melanoma of unknown primary presenting in an unusual place which is the inguinal lymph node. Theories try to explain the pathway of development of such tumors and one of the theories mentions that it could be a spontaneous regression of the primary cutaneous lesion. Another theory is that it could be from transformation of aberrant melanocyte within the lymph node. Prognosis is postulated to be better in this case than in melanoma with a known primary.

scholarly journals Paraneoplastic Cerebellar Degeneration Secondary to BRAF Mutant Melanoma Metastasis from an Occult Primary Cancer

2020 ◽  
Vol 13 (2) ◽  
pp. 633-642
Author(s):  
Omar Jiménez-Zarazúa ◽  
Lourdes Noemí Vélez-Ramírez ◽  
María Alcocer-León ◽  
Diego Armando Hernández-Domínguez ◽  
Juana Elizabeth Tadeo-González ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Movement Disorders ◽  
Mapk Pathway ◽  
Neuropsychiatric Symptoms ◽  
Cerebellar Degeneration ◽  
Paraneoplastic Cerebellar Degeneration ◽  
Unknown Primary ◽  
Melanoma Metastasis ◽  
Primary Cancer ◽  
The Right

Melanoma metastasis from an unknown primary cancer has an incidence of 3.2% among melanoma patients. Furthermore, paraneoplastic neurological syndromes (PNS) are rare, occurring in 1–3% of patients with malignancies. Paraneoplastic cerebellar degeneration (PCD) is one of the classic PNS and is characterized by acute or subacute onset of ataxia and/or presence of onconeural antibodies. A 61-year-old male with ataxia, vertigo, and headache later developed dysarthria, multidirectional nystagmus, hyperactive delirium, auditory hallucinations, psychomotor agitation, and myoclonus. Toxicological, metabolic, infectious, and autoimmune etiologies were assessed and reported negative. An osteolytic lesion was observed in the right iliac crest via computed tomography (CT). A positron emission tomography-CT reported increased fluorodeoxyglucose uptake of a right iliac and right inguinal ganglion. After biopsy of the right inguinal ganglion, a BRAF mutation-positive melanoma metastasis from an occult primary cancer was diagnosed. Dermatologic, ophthalmologic, and endoscopic gastrointestinal assessment did not reveal a primary malignant melanoma. The patient’s movement disorders and neuropsychiatric symptoms improved with quetiapine, prednisone, azathioprine, and cyclophosphamide. Oncological management was conducted with MAPK pathway inhibitors (i.e., dabrafenib and trametinib). Movement disorders associated with neuropsychiatric symptoms are complex to diagnose. PNS are rare and often associated with antibodies against neural antigens expressed by the tumor. The case presented above describes a patient with a BRAF-positive malignant melanoma metastasis from an occult primary associated with PCD – to the best of our knowledge, the first reported in the literature.

Isolated Metastatic Malignant Melanoma of the Right Inguinal Lymph Node with Unknown Primary Lesion

2018 ◽  
Vol 8 (3) ◽  
pp. 174-176
Author(s):  
Debasish Das ◽  
Deb Prosad Paul ◽  
Kazi Sohel Iqbal
Keyword(s):  
Lymph Node ◽  
Malignant Melanoma ◽  
Inguinal Lymph Node ◽  
Uv Light ◽  
Light Exposure ◽  
Metastatic Malignant Melanoma ◽  
Lymph Node Biopsy ◽  
Primary Lesion ◽  
Unknown Primary ◽  
Complete Excision

Malignant melanoma develops from the pigment containing cells known as melanocytes. Melanoma is more common in men than in women. It is found typically in the skin. It is also found in the mouth, intestine, eye and other sites. Melanoma may develop from a mole with changes including an increasing in size, irregular edges, changes in color, itchiness or skin breakdown. Prognosis is poor if it is not treated early. The primary cause of melanoma is UV light exposure. Patients with history of affected family members and poor immune function are at greater risk. Diagnosis is by biopsy from any affected skin lesion. Recurrence is common even many years after the initial diagnosis. Here we present a case of malignant melanoma of the inguinal lymph node with unknown primary lesion. Surgery was done with complete excision of inguinal lymph node. Biopsy report showed metastatic malignant melanoma.J Enam Med Col 2018; 8(3): 174-176

scholarly journals Metastatic malignant melanoma of unknown primary in temporalis muscle

2020 ◽  
Vol 2020 (6) ◽  
Author(s):  
Alexia Grech ◽  
Naomi Mercieca ◽  
Jean Calleja-Agius ◽  
Rachel Abela
Keyword(s):  
Metastatic Malignant Melanoma ◽  
Primary Lesion ◽  
Unknown Primary ◽  
Melanocytic Lesion ◽  
Skin Involvement ◽  
Extensive Investigation ◽  
Temporalis Muscle ◽  
Temporal Area ◽  
Melanocytic Lesions ◽  
The Right

Abstract Metastatic melanoma of unknown primary (MUP) is an uncommon melanocytic lesion found in distant sites with no evident skin involvement. This case report presents a 75-year-old woman who underwent local excision for a lump in the right temporal area, which had been present for 6 months and had been suspected to be a lipoma. Histology confirmed that the tissue excised from the temporalis muscle was composed of atypical, heavily pigmented melanocytes. Her history was negative for melanocytic lesions, and examination and extensive investigation including imaging had failed to identify a primary lesion. The patient is currently being followed up.

scholarly journals Undifferentiated Nasopharyngeal Carcinoma Presenting with Shoulder Mass

2020 ◽  
Vol 2020 ◽  
pp. 1-3
Author(s):  
Cosphiadi Irawan ◽  
Rahmat Cahyanur ◽  
Reyhan Eddy Yunus
Keyword(s):  
Palliative Chemotherapy ◽  
Nasopharyngeal Cancer ◽  
Bone Tumour ◽  
Undifferentiated Carcinoma ◽  
Neck Mass ◽  
Definitive Treatment ◽  
Unknown Primary ◽  
Common Cancer ◽  
Stage Ivb ◽  
The Right

Nasopharyngeal cancer (NPC) is the most common cancer among head and neck cancer that usually presented with unilateral neck mass. Unusual symptoms of NPC can lead us to diagnosis misleading and delayed definitive treatment. We present a case of NPC with bone metastasis in the shoulder. A 33-year-old female presented with right shoulder mass caused by undifferentiated carcinoma of unknown primary, based on biopsy of shoulder mass. After four months, she was complaining painless neck swelling, headache, and hearing impairment in the left ear. Bone MRI showed malignant bone tumour in the right humerus. Neck CT scan showed mass in the nasopharyngeal and bilateral lymphadenopathy. Biopsy in nasopharyngeal revealed undifferentiated carcinoma of nasopharyngeal cancer (WHO-3 type A). The patient was diagnosed as NPC stage IVb and thus was treated with palliative chemotherapy. After three cycles of cisplatin docetaxel, patient condition improved.

scholarly journals Metastatic Amelanotic Malignant Melanoma with Unknown Primary - A Case Report

2004 ◽  
Vol 60 (3) ◽  
pp. 295-296 ◽  
Author(s):  
Nikhil Moorchung ◽  
B Mukherjee ◽  
V Srinivas ◽  
H Subramanya
Keyword(s):  
Case Report ◽  
Malignant Melanoma ◽  
Unknown Primary ◽  
Amelanotic Malignant Melanoma
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