scholarly journals Pathogenesis of SARS-CoV-2 and Immune Response in COVID-19

2020 ◽  
Author(s):  
Mehmet Demirci ◽  
Özge Ünlü ◽  
Akın Yiğin ◽  
Fadime Yıldız Zeyrek
Keyword(s):  
Immune Response ◽  
Immune Responses ◽  
Host Immune Response ◽  
Amino Acid Sequences ◽  
Receptor Binding Site ◽  
The Third ◽  
Protease Cleavage ◽  
The World ◽  
Short Time ◽  
First Time

SARS-CoV-2, which emerged in Wuhan province of China for the first time in December 2019 and spread rapidly all over the world, is still causing an epidemic. SARS-CoV-2 is the third coronavirus outbreak we encountered after SARS-CoV and MERS-CoV infections. Due to SARS-CoV and MERS-CoV infections, we have gained experience about the pathogenesis and immune responses of coronaviruses. However, studies have shown that, unlike the information derived from our experience, SARS-CoV-2 is both very infectious and its effect on cells is different. Therefore, we aimed to compile the data of the published studies on the pathogenesis of SARS-CoV-2 and the resulting host immune response. In many studies, it has been reported that not only the presence of the host ACE2 receptor is sufficient for the infection of the host cell, but also the cleavage of the structural S protein by proteases should be materialized. It has been shown that, unlike SARS-CoV-2, SARS-CoV and MERS-CoV, it contains different protease cleavage systems and amino acid sequences in the ACE2 receptor binding site. In SARS-CoV-2 infection, as reported in studies conducted up to now, Th1 and Th2-mediated cytokine and chemokine levels in the host are different than SARS-CoV infection, and also different chemokines can be upregulated compared to other CoVs. Considering that effective vaccines have not been developed for the infectious RNA viruses despite the ongoing trials for many years, in order to reveal all these differences in the pathogenesis and immune response process and to develop effective antivirals against SARS-CoV-2 within a short time. the need for comprehensive studies on host immune response is evident.

scholarly journals Efficacy of compressed sodium chloride (CSC) against E. coli and Candida auris in minutes and methods improvement for testing

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Lan N. Truong ◽  
Brayden D. Whitlock
Keyword(s):  
Sodium Chloride ◽  
Improved Method ◽  
Candida Auris ◽  
Antimicrobial Surfaces ◽  
E Coli ◽  
Route Of Transmission ◽  
The World ◽  
Short Time ◽  
First Time ◽  
Time Point

AbstractControlling infections has become one of the biggest problems in the world, whether measured in lives lost or money spent. This is worsening as pathogens continue becoming resistant to therapeutics. Antimicrobial surfaces are one strategy being investigated in an attempt to decrease the spread of infections through the most common route of transmission: surfaces, including hands. Regulators have chosen two hours as the time point at which efficacy should be measured. The objectives of this study were to characterize the new antimicrobial surface compressed sodium chloride (CSC) so that its action may be understood at timepoints more relevant to real-time infection control, under two minutes; to develop a sensitive method to test efficacy at short time points; and to investigate antifungal properties for the first time. E. coli and Candida auris are added to surfaces, and the surfaces are monitored by contact plate, or by washing into collection vats. An improved method of testing antimicrobial efficacy is reported. Antimicrobial CSC achieves at least 99.9% reduction of E. coli in the first two minutes of contact, and at least 99% reduction of C. auris in one minute.

scholarly journals The features of host immune response with respect to microsatellite status of colorectal cancer

2007 ◽  
Vol 15 (1-2) ◽  
pp. 5-9
Author(s):  
Attila Fenyvesi
Keyword(s):  
Colorectal Cancer ◽  
Immune Response ◽  
Immune Responses ◽  
Continuous Production ◽  
Tumor Infiltrating Lymphocytes ◽  
Host Immune Response ◽  
Genetic Alterations ◽  
Clinicopathological Characteristics ◽  
Melting Point Analysis ◽  
Peritumoral Stroma

Background: The genetic alterations in colorectal cancer (CRC) progression are determined by two separate pathways, chromosomal and microsatellite instability (MSI). The CRCs with MSI have distinct clinicopathological characteristics with pronounced tumor-associated immune responses. The aim of our study was to investigate the intensity of host immune response in CRC tissue by comparing microsatellite stable (MSS) and instable tumors. Methods: The study was performed on CRC specimens from 28 patients with MSI and compared with 30 MSS tumors. The microsatellite status was evaluated with two markers by PCR and melting point analysis. The immunostaining with anti-CD3 pan-T cell antibody was used to quantify the number of tumor infiltrating lymphocytes. The lymphocytes in peritumoral stromal and the Crohn?s-like peritumoral reaction were counted on H&E slides. Results: No significant differences were found in the average number of lymphocytes in peritumoral stroma and in clinicopathological characteristics of CRCs. The conspicuous Crohn?s-like lymphoid reactions were present in 67.86% of CRCs with MSI versus 26.66% of MSS cases. The CRCs with MSI cases carried significantly higher numbers of tumor infiltrating T-lymphocytes (13.21 versus 7.47) (p<0.0001). Conclusion: The presences of peritumoral Crohn?s-like lymphoid and intraepithelial lymphocytic reaction were intensive markers for MSI in colorectal carcinomas in our study. The peculiar genetic instability in MSI tumors may lead to a continuous production of abnormal peptides, which act as neoantigens. They could induce specific antitumor immune responses effective in limiting tumor growth and spread. Abnormal peptides are potentially promising in immunotherapy advancing and in the design of a vaccine against colorectal tumors with MSI.

scholarly journals mSphere of Influence: Role of IRGM1 in Disease Control

mSphere ◽  
2021 ◽  
Vol 6 (2) ◽  
Author(s):  
Sumanta Kumar Naik
Keyword(s):  
Immune Response ◽  
Quality Control ◽  
Mycobacterium Tuberculosis ◽  
Immune Responses ◽  
Disease Control ◽  
Host Immune Response ◽  
Specific Interest ◽  
Mitochondrial Quality Control ◽  
Content Type

ABSTRACT Sumanta K. Naik works in the tuberculosis field, with a specific interest in the host immune response to Mycobacterium tuberculosis infection. In this mSphere of Influence article, he reflects on how the paper “IRGM1 links mitochondrial quality control to autoimmunity” by Prashant Rai et al. (Nat Immunol, 22:312–321, 2021, https://doi.org/10.1038/s41590-020-00859-0) impacted his research by revealing new roles for Irgm1 in immune responses.

scholarly journals Impact of Toll-Like Receptor-Specific Agonists on the Host Immune Response to the Yersinia pestis Plague rF1V Vaccine

2021 ◽  
Vol 12 ◽  
Author(s):  
Sergei Biryukov ◽  
Jennifer L. Dankmeyer ◽  
Zain Shamsuddin ◽  
Ivan Velez ◽  
Nathaniel O. Rill ◽  
...  
Keyword(s):  
Immune Response ◽  
Immune Responses ◽  
Fusion Protein ◽  
Yersinia Pestis ◽  
Vaccine Efficacy ◽  
Host Immune Response ◽  
Toll Like Receptor ◽  
Vaccine Strategy ◽  
Pneumonic Plague ◽  
Plague Vaccine

Relatively recent advances in plague vaccinology have produced the recombinant fusion protein F1-V plague vaccine. This vaccine has been shown to readily protect mice from both bubonic and pneumonic plague. The protection afforded by this vaccine is solely based upon the immune response elicited by the F1 or V epitopes expressed on the F1-V fusion protein. Accordingly, questions remain surrounding its efficacy against infection with non-encapsulated (F1-negative) strains. In an attempt to further optimize the F1-V elicited immune response and address efficacy concerns, we examined the inclusion of multiple toll-like receptor agonists into vaccine regimens. We examined the resulting immune responses and also any protection afforded to mice that were exposed to aerosolized Yersinia pestis. Our data demonstrate that it is possible to further augment the F1-V vaccine strategy in order to optimize and augment vaccine efficacy.

scholarly journals COVID-19 pathology and therapeutics

2020 ◽  
Author(s):  
Khaled Sorour ◽  
Hadeer El-Menshawy
Keyword(s):  
Immune Response ◽  
Standard Care ◽  
Host Immune Response ◽  
Severe Form ◽  
Current Situation ◽  
The World ◽  
Primary Driver ◽  
Inflammatory Processes ◽  
Lack Of Knowledge

The SARS-CoV-2 pandemic has hit the world by surprise since its first outbreak in Wuhan, China resulting in millions of cases and thousands of deaths around the globe. The current situation is challenged by the lack of knowledge about the COVID-19 pathogenesis. Experts are not sure about the primary driver for mortality, is it the virus or the host immune response. The highly noted difference in outcomes reflects that individuals could react uniquely in response to infection where the inflammatory processes appear to impact the course and outcome of infection. Moreover, findings that came from COVID-19 autopsies suggest that SARS-CoV-2 pneumonia could transform to a severe form of ARDS. This paper aims at addressing briefly various complications observed in COVID-19 patients and providing a list of drugs that could be incorporated as a part of standard care for patients that are most severely affected by SARS-CoV-2 infection.

Understanding the immune responses involved in mediating protection or immunopathology during leishmaniasis

2021 ◽  
Author(s):  
Thalia Pacheco-Fernandez ◽  
Greta Volpedo ◽  
Chaitenya Verma ◽  
Abhay R. Satoskar
Keyword(s):  
Immune Response ◽  
Immune Responses ◽  
Public Health Problem ◽  
Host Immune Response ◽  
Sand Fly ◽  
Leishmania Infection ◽  
Major Public Health Problem ◽  
Wide Range ◽  
Vector Borne ◽  
Leishmania Parasites

Leishmaniasis is a vector-borne Neglected Tropical Disease (NTD) transmitted by the sand fly and is a major public health problem worldwide. Infections caused by Leishmania clinically manifest as a wide range of diseases, such as cutaneous (CL), diffuse cutaneous (DCL), mucosal (MCL) and visceral leishmaniasis (VL). The host innate and adaptative immune responses play critical roles in the defense against leishmaniasis. However, Leishmania parasites also manipulate the host immune response for their survival and replication. In addition, other factors such as sand fly salivary proteins and microbiota also promote disease susceptibility and parasite spread by modulating local immune response. Thus, a complex interplay between parasite, sand fly and the host immunity governs disease severity and outcome. In this review, we discuss the host immune response during Leishmania infection and highlight the factors associated with resistance or susceptibility.

Russian Idea, the

2018 ◽  
Author(s):  
Andrzej Walicki
Keyword(s):  
Russian History ◽  
Russian Culture ◽  
The Third ◽  
Peter The Great ◽  
First Case ◽  
The World ◽  
History Of ◽  
First Time ◽  
Vladimir Solov'ev ◽  
Russian Idea

‘The Russian Idea’ is a term used by Russian thinkers to define specific features of Russian culture, the spiritual make-up of the Russian nation, the meaning of Russian history and, as a rule (although not always), Russia’s unique mission in the universal history of humanity. The term was introduced for the first time in 1861 by Dostoevskii, for whom the essence of the Russian Idea was the ‘universal humanity’ (or ‘all-humanity’) of the Russian spirit. At the same time however, Dostoevskii linked the Russian Idea with Russian imperial messianism. Thus, the notion of the Russian Idea included from its beginning a characteristic tension between striving for universalism and nationalist self-assertion.. The first philosopher to devote a special separate work to the Russian Idea (l’Idée russe, Paris, 1888) was Vladimir Solov’ëv, for whom the national idea was ‘not what a given nation thinks about itself in time, but what God thinks about it in eternity’. He was influenced by Dostoevskii but, challenging Russian nationalists, put much greater emphasis on universalism, stressing that the peculiar greatness of the Russians consisted in their capacity for ‘self-renunciation’. The first case of this self-renunciation was the so-called ‘calling of the Varangians’, that is, the voluntary acceptance of foreign rule; the second was the reforms of Peter the Great: rejection of native traditions for the sake of universal progress. Now the Russian nation should commit itself to the third, most important act of self-renunciation: to submit itself to the authority of the pope, restoring thereby the unity of the Universal Church and bringing about the reconciliation between East and West. But this act of humility was seen by Solov’ëv as a precondition from the fulfilment of Russia’s great mission of creating the universal, freely theocratic Christian Empire. Solov’ëv invoked in this connection the monk Philotheus’ idea of ‘Moscow as the Third Rome’ but reversed its meaning by putting emphasis on symbolic Rome, that is, not on national isolationism and keeping intact the purity of the Orthodox faith, but on ecumenical universalism and the messianic task of the Christian transformation of the world. Owing to Solov’ëv, the term ‘Russian Idea’ came to be applied retrospectively, as a designation of a set of problems characteristic for Russian philosophical discussions about the essence of ‘Russianness’. Most historians agree that these problems were formulated under the reign of Nicholas I and that the first thinker who posed them forcefully was Pëtr Chaadaev.

scholarly journals Clone-specific immune reactions in a trematode-crustacean system

Parasitology ◽  
2011 ◽  
Vol 139 (1) ◽  
pp. 128-136 ◽  
Author(s):  
ANSON V. KOEHLER ◽  
ROBERT POULIN
Keyword(s):  
Immune Response ◽  
Immune Responses ◽  
Microsatellite Markers ◽  
Immune Reaction ◽  
Host Immune Response ◽  
Ecological Immunology ◽  
Experimental Exposure ◽  
Immune Reactions ◽  
Essential Aspect

SUMMARYVariability of immune responses is an essential aspect of ecological immunology, yet how much of this variability is due to differences among parasite genotypes remains unknown. Here, variation in immune response of the crab, Macrophthalmus hirtipes, is examined as a function of experimental exposure to 10 clonal cercarial lineages of the trematode Maritrema novaezealandensis. Our goals were (1) to assess the variability of the host immune reaction elicited by 10 parasite clones, (2) to test if the heterozygosity–fitness correlation, whereby organisms with higher heterozygosities achieve a higher fitness than those with lower heterozygosities, applies to heterozygous parasites eliciting weak immune responses, and (3) to see how concomitant infections by other macroparasites influence the crab's immune response to cercariae. Parasite clones were distinguished and heterozygosities calculated using 20 microsatellite markers. We found that exposure to cercariae resulted in increased haemocyte counts, and that although interclonal differences in immune response elicited were detected, parasite heterozygosity did not correlate with host immune response. Additionally, the presence of other pre-existing parasites in hosts did not influence their immune response following experimental exposure to cercariae. Overall, the existence of variability in immune response elicited by different parasite clones is promising for future ecological immunology studies using this system.

scholarly journals An AI-guided invariant signature places MIS-C with Kawasaki disease in a continuum of host immune responses

2021 ◽  
Author(s):  
Debashis Sahoo ◽  
Gajanan Dattatray ◽  
Chisato Shimizu ◽  
Jihoon Kim ◽  
Soni Khandelwal ◽  
...  
Keyword(s):  
Immune Response ◽  
Kawasaki Disease ◽  
Immune Responses ◽  
Clinical Course ◽  
Host Immune Response ◽  
Rna Sequences ◽  
Host Immune Responses ◽  
Transcript Signature ◽  
Inflammatory Syndrome ◽  
Formalin Fixed

A significant surge in cases of multisystem inflammatory syndrome in children (MIS-C, also called Pediatric Inflammatory Multisystem Syndrome - PIMS) has been observed amidst the COVID-19 pandemic. MIS-C shares many clinical features with Kawasaki disease (KD), although clinical course and outcomes are divergent. We analyzed whole blood RNA sequences, serum cytokines, and formalin fixed heart tissues from these patients using a computational toolbox of two gene signatures, i.e., the 166-gene viral pandemic (ViP) signature, and its 20-gene severe (s)ViP subset that were developed in the context of SARS-CoV-2 infection and a 13-transcript signature previously demonstrated to be diagnostic for KD. Our analyses revealed that KD and MIS-C are on the same continuum of the host immune response as COVID-19 but diverge with two different cardiac phenotypes. The ViP signatures helped unravel the nature of the host immune response (IL15-centric) in MIS-C and KD, reveal unique targetable cytokine pathways in MIS-C, place MIS-C farther along in the spectrum in severity compared to KD and pinpoint key clinical (reduced cardiac function) and laboratory (thrombocytopenia and eosinopenia) parameters that can be useful to monitor severity.

scholarly journals FEATURES OF THE AMERICAN PERIOD OF ICON PAINTER P.M. SOFRONOV’S WORK

2020 ◽  
Vol 23 (4) ◽  
pp. 214-220
Author(s):  
Tatiyana V. Yurieva ◽  
Keyword(s):  
Significant Contribution ◽  
Scientific Literature ◽  
The United States ◽  
Wall Painting ◽  
The Third ◽  
The World ◽  
Church Art ◽  
First Time ◽  
The Church

The article for the first time gives an analysis of the work of the world famous, but little studied in Russia, Old Believer icon painter and restorer icons Pimen Maksimovich Sofronov in the third, American period. The author systematizes scattered information about his artistic activities in the United States, makes a chronology of the creation of his works during this period, and makes an analysis of them. The description of the temples where P.M. Sofronov worked, and the painting of their interiors, is given for the first time in scientific literature. Analyzing the biographical data and the work of the icon painter in the third, American period, which turned out to be the longest, the author of the article concludes that at this time the quality of the master's work is changing. Since, in Europe, P.M. Sofronov gained the experience of wall painting of churches, now, in North America, he was able to fully realize this side of his talent by making the transition from easel icon painting to monumental painting. Now the researcher's attention has been given to extensive temple complexes, often consisting of both stenographs and iconostases, which have their own specific program. The author interprets the canon in accordance with the architectural space that is provided to him for painting. Each time it is a new theological and artistic task. Having completed such major works as paintings of the interiors of Trinity Cathedral in Brooklyn, the Church of the Three Saints in Ansonia, the Church of Peter and Paul in Syracuse, the Vladimir Church in Trenton, St. Trinity in Weinland, the artist made a significant contribution to the church art of Russian emigration.

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