Temporary Elevation of Serum Creatinine Kinase Level in a Patient Confined in a Rural Area for 24 Hours: A Case Report

2013 ◽  
Vol 11 (4) ◽  
pp. 185-186
Author(s):  
Ertan Sal ◽  
Avni Kaya ◽  
Eren Cagan ◽  
Murat Basaranoglu ◽  
Murat Dogan ◽  
...  
2002 ◽  
Vol 22 (3) ◽  
pp. 252-256 ◽  
Author(s):  
Haggai Hermesh ◽  
Iris Manor ◽  
Roni Shiloh ◽  
Dov Aizenberg ◽  
Yoav Benjamini ◽  
...  

Author(s):  
Adi Basuki ◽  
Agustini Song ◽  
Nabila Viera Yovita ◽  
Kevin Leonard Suryadinata ◽  
Asian Edward Sagala
Keyword(s):  

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
Fahd Khan ◽  
Aizaz Ali ◽  
Jamie Willows ◽  
Didem Tez

Abstract Introduction Acute uric acid nephropathy (UAN) is characterized by acute kidney injury (AKI) due to uric acid crystal precipitation within the distal tubules and collecting ducts. We present a young woman, with a history of hyperuricaemia, who was treated with allopurinol for acute UAN during her first pregnancy. She also continued allopurinol treatment during her second pregnancy for prevention of further acute UAN. To the author’s knowledge, this is the first case report of biopsy-confirmed acute UAN during pregnancy. Case report A 20 year old woman, who was 13 weeks pregnant, was admitted with AKI. Past medical history included chronic kidney disease (CKD) and gout since the age of 17. She had an extensive family history of CKD and gout (without diagnosis, despite genetic testing). She had been on daily allopurinol 300mg, but this was stopped 8 weeks prior by her rheumatology team due to concerns about teratogenicity. At that time serum creatinine was at her baseline of 100 μmol/L (normal range 50-120 μmol/L) and serum uric acid had been 740 μmol/L (normal range 140-360 μmol/L). On admission, she felt well and was euvolemic. Serum creatinine was now 352 μmol/L and her serum uric acid level was 1720 μmol/L, with an elevated urine uric acid to creatinine ratio of 1.1. She underwent renal biopsy, which showed significant deposition of uric acid crystals in the renal tubules, confirming a diagnosis of acute UAN. She was given intravenous fluids. The uncertainties of allopurinol use in pregnancy were discussed with her, and she was restarted on allopurinol 200 mg daily. Over the next 3 weeks, serum uric acid decreased to 470 μmol/L and serum creatinine to 116 μmol/L. She was maintained on allopurinol during her pregnancy and delivered a healthy baby girl. She was advised against further pregnancies due to increased risk of maternal and fetal complications. However, three years later she presented at 15 weeks’ gestation. After a discussion regarding the potential teratogenic effects of allopurinol versus the risk of recurrent severe AKI due to acute UAN if it was again discontinued, she chose to continue allopurinol. The pregnancy proceeded without complication. Her daughters are now 8 and 5 years old. They do not have any congenital malformations, though both have mild to moderate learning difficulties. Discussion Allopurinol is approved for the treatment of hyperuricaemia outside of pregnancy, but given it interrupts purine synthesis there is a biologically plausible concern regarding teratogenicity. However, in our patient with long-standing hyperuricaemia it was the discontinuation of allopurinol that precipitated AKI due to the resultant crystal formation when serum uric acid reached very high levels. Biopsy confirmation of acute UAN was vital in this case, given the possibility of missing an alternative diagnosis and the risks of giving empirical allopurinol therapy. Once the diagnosis for her severe AKI was confirmed, it was clear our patient would benefit from uric acid lowering therapy. Our patient had two healthy girls despite using allopurinol from week 16 in her first pregnancy and throughout her second pregnancy. Unfortunately, both girls have mild to moderate learning needs, though it is unprovable whether allopurinol was causative as no study has followed up long term outcomes after foetal exposure during pregnancy.


2019 ◽  
Vol 14 (1) ◽  
pp. 116-119
Author(s):  
Yusuke Watanabe ◽  
Kenichi Sakakura ◽  
Honoka Kotoku ◽  
Shota Mashimo ◽  
Maiko Nakata ◽  
...  

Burns ◽  
2004 ◽  
Vol 30 (7) ◽  
pp. 680-683 ◽  
Author(s):  
Jürgen Kopp ◽  
Bernd Loos ◽  
Gerald Spilker ◽  
Raymund E. Horch

2020 ◽  
Vol 10 (3) ◽  
Author(s):  
Thais Wyatt ◽  
Manoella Carrera ◽  
Thaís Lacerda ◽  
Janinne Rocha ◽  
Bárbara Pinto ◽  
...  

Spotted fever is a severe and emergent zoonosis caused by Rickettsia and transmitted by ticks, it can be fatal if not diagnosed and treated in the begging of clinical symptoms. The following report is the description of a case of a pediatric patient residing in a rural area in the countryside of the state of Espírito Santo, Brazil, with spotted fever presenting unfavorable evolution. The diagnosis was confirmed by the indirect immunofluorescence test after death. Considering the high lethality and prevalence of the disease in the southeastern and southern regions of Brazil, this differential diagnosis should be considered in the presence of symptomatology and epidemiology suggestive of this disease, in order to reduce the morbidity and mortality of the affected population.


1994 ◽  
Vol 40 (1) ◽  
pp. 160-161 ◽  
Author(s):  
R Venta ◽  
B G Cecchini ◽  
S A Geijo ◽  
C Lopez-Ortín ◽  
C G Bao ◽  
...  

1986 ◽  
Vol 20 (11) ◽  
pp. 860-862 ◽  
Author(s):  
Neil E. Henann ◽  
Julian R. Morales

A case report of acute flank pain with reversible renal failure in a young adult after taking three doses of suprofen is presented. Blood urea nitrogen and serum creatinine values returned to normal from significantly elevated levels on admission.


2001 ◽  
Vol 43 (6) ◽  
pp. 343-346 ◽  
Author(s):  
Análida Elizabeth PINILLA ◽  
Myriam Consuelo LÓPEZ ◽  
Orlando RICAURTE ◽  
Blanca CASTILLO ◽  
Martha Isabel MURCIA ◽  
...  

A case is reported of a woman who lived in a rural area with a chronic illness that consisted of weight loss and abdominal pain in the epigastrium and upper right quadrant. The initial diagnosis was a mass in the liver, which was later, demonstrated, both by direct and histological examination, to be an abscess caused by Ascaris lumbricoides. Eggs of Ascaris lumbricoides and abundant Charcot-Leyden Crystals were found.


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