scholarly journals Clinical outcomes of submucosal colorectal cancer diagnosed after endoscopic resection: a focus on the need for surgery

2020 ◽  
Vol 18 (1) ◽  
pp. 96-106 ◽  
Author(s):  
Yun Sik Choi ◽  
Wan Soo Kim ◽  
Sung Wook Hwang ◽  
Sang Hyoung Park ◽  
Dong-Hoon Yang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Clinical Outcomes ◽  
Endoscopic Resection ◽  
Submucosal Colorectal Cancer

Comparative Cost Analysis Between Endoscopic Resection and Surgery for Submucosal Colorectal Cancer

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Soo Min Noh ◽  
Sung Wook Hwang ◽  
Sang Hyoung Park ◽  
Dong-Hoon Yang ◽  
Byong Duk Ye ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cost Analysis ◽  
Endoscopic Resection ◽  
Comparative Cost ◽  
Submucosal Colorectal Cancer

Clinical outcomes of deep invasive submucosal colorectal cancer after ESD

2017 ◽  
Vol 32 (4) ◽  
pp. 2123-2130 ◽  
Author(s):  
Daisuke Watanabe ◽  
Takashi Toyonaga ◽  
Makoto Ooi ◽  
Tetsuya Yoshizaki ◽  
Yoshiko Ohara ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Clinical Outcomes ◽  
Submucosal Colorectal Cancer

Sa1506 Long-Term Outcome After Endoscopic Resection of Superficial Submucosal Colorectal Cancer Compared to Surgical Resection

2014 ◽  
Vol 79 (5) ◽  
pp. AB238
Author(s):  
Jeong-Sik Byeon ◽  
Ji-Beom Kim ◽  
Ho-Su Lee ◽  
Hyo Jeong Lee ◽  
Jae Seung Soh ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Surgical Resection ◽  
Endoscopic Resection ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Submucosal Colorectal Cancer

scholarly journals Microenvironmental markers are correlated with lymph node metastasis in invasive submucosal colorectal cancer

2021 ◽  
Author(s):  
Tamotsu Sugai ◽  
Noriyuki Yamada ◽  
Mitsumasa Osakabe ◽  
Mai Hashimoto ◽  
Noriyuki Uesugi ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Node Metastasis ◽  
Submucosal Colorectal Cancer

scholarly journals Baseline and Kinetic Circulating Tumor Cell Counts Are Prognostic Factors in a Prospective Study of Metastatic Colorectal Cancer

Diagnostics ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 502
Author(s):  
Virgílio Souza e Silva ◽  
Emne Ali Abdallah ◽  
Angelo Borsarelli Carvalho de Brito ◽  
Alexcia Camila Braun ◽  
Milena Shizue Tariki ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Drug Resistance ◽  
Prospective Study ◽  
Metastatic Colorectal Cancer ◽  
Clinical Outcomes ◽  
Predictive Biomarkers ◽  
Multi Drug Resistance ◽  
Cell Counts ◽  
Potential Clinical Benefit ◽  
A Prospective Study

The discovery of predictive biomarkers in metastatic colorectal cancer (mCRC) is essential to improve clinical outcomes. Recent data suggest a potential role of circulating tumor cells (CTCs) as prognostic indicators. We conducted a follow-on analysis from a prospective study of consecutive patients with mCRC. CTC analysis was conducted at two timepoints: baseline (CTC1; before starting chemotherapy), and two months after starting treatment (CTC2). CTC isolation/quantification were completed by ISET® (Rarecells, France). CTC expressions of drug resistance-associated proteins were evaluated. Progression-free survival (PFS) and overall survival (OS) were estimated by the Kaplan–Meier method. Seventy-five patients were enrolled from May 2012 to May 2014. A CTC1 cut-off of >1.5 CTCs/mL was associated with an inferior median OS compared to lower values. A difference of CTC2−CTC1 > 5.5 CTCs/mL was associated with a reduced median PFS. By multivariate analysis, CTC1 > 1.5 CTCs/mL was an independent prognostic factor for worse OS. Multi-drug resistance protein-1 (MRP-1) expression was associated with poor median OS. CTC baseline counts, kinetics, and MRP-1 expression were predictive of clinical outcomes. Larger studies are warranted to explore the potential clinical benefit of treating mCRC patients with targeted therapeutic regimens guided by CTC findings.

scholarly journals Metachronous advanced neoplasia after submucosal invasive colorectal cancer resection

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Tatsunori Minamide ◽  
Hiroaki Ikematsu ◽  
Tatsuro Murano ◽  
Tomohiro Kadota ◽  
Kensuke Shinmura ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Surgical Resection ◽  
Endoscopic Resection ◽  
Cumulative Incidence ◽  
Academic Medical Center ◽  
Significant Risk ◽  
Colonic Disease ◽  
Rectal Disease ◽  
Resection Group ◽  
Advanced Neoplasia

AbstractLittle is known about the incidence of metachronous advanced neoplasia (AN) following resection of submucosal invasive colorectal cancer (SM-CRC). Here, we aimed to assess the occurrence of metachronous AN following SM-CRC resection. We retrospectively reviewed consecutive patients who underwent SM-CRC resection at an academic medical center between 2005 and 2013. Among 343 patients, 250 (72.9%) underwent surgical resection or endoscopic resection followed by surgical resection and 93 (27.1%) underwent only endoscopic resection. During a median follow-up period of 61.5 months, the overall incidence of metachronous AN was 7.6%, and the cumulative incidence at 5 years was 6.1%. The cumulative incidence was significantly higher in the endoscopic resection group than in surgical resection group, in patients with colonic disease than in those with rectal disease, and in patients with synchronous AN than in those without. Multivariate analysis revealed that synchronous AN was the only significant risk factor for metachronous AN (HR 4.35; 95% CI 1.88–10.1). These findings imply that depending on synchronous AN, a surveillance protocol following SM-CRC resection can be changed for better detection of metachronous AN.

Long-term clinical outcomes of endoscopic resection for early gastric cancer

2014 ◽  
Vol 29 (5) ◽  
pp. 1223-1230 ◽  
Author(s):  
Jeongmin Choi ◽  
Sang Gyun Kim ◽  
Jong Pil Im ◽  
Joo Sung Kim ◽  
Hyun Chae Jung
Keyword(s):  
Gastric Cancer ◽  
Early Gastric Cancer ◽  
Clinical Outcomes ◽  
Endoscopic Resection

Su1167 Long Term Clinical Outcomes of Endoscopic Resection for Non-Ampullary Duodenal Epithelial Tumor

2017 ◽  
Vol 85 (5) ◽  
pp. AB299
Author(s):  
Moon Won Lee ◽  
Sungyong Han ◽  
Hye Kyung Jeon ◽  
Dong Hoon Baek ◽  
Bong Eun Lee ◽  
...  
Keyword(s):  
Clinical Outcomes ◽  
Endoscopic Resection ◽  
Epithelial Tumor
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