scholarly journals Can vitamin D supplementation help control inflammation in inflammatory bowel disease beyond its classical role in bone health?

2019 ◽  
Vol 17 (2) ◽  
pp. 157-159 ◽  
Author(s):  
Sung Wook Hwang
Keyword(s):  
Inflammatory Bowel Disease ◽  
Vitamin D ◽  
Bone Health ◽  
Bowel Disease ◽  
Vitamin D Supplementation ◽  
Inflammatory Bowel

scholarly journals Managing vitamin D deficiency in inflammatory bowel disease

2019 ◽  
Vol 10 (4) ◽  
pp. 394-400 ◽  
Author(s):  
Ole Haagen Nielsen ◽  
Thomas Irgens Hansen ◽  
John Mark Gubatan ◽  
Kim Bak Jensen ◽  
Lars Rejnmark
Keyword(s):  
Inflammatory Bowel Disease ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Bowel Disease ◽  
Therapeutic Strategy ◽  
Critical Role ◽  
Vitamin D Supplementation ◽  
Disease Outcomes ◽  
Immunological Effects ◽  
Inflammatory Bowel

Management of inflammatory bowel disease (IBD), including ulcerative colitis and Crohn’s disease, is generally cumbersome for patients and is a massive health-economic burden. In recent years, the immunomodulating effects of vitamin D have gained a huge interest in its possible pathogenic influence on the pathophysiology of IBD. Vitamin D deficiency is frequent among patients with IBD. Several clinical studies have pointed to a critical role for vitamin D in ameliorating disease outcomes. Although causation versus correlation unfortunately remains an overwhelming issue in the illusive chicken versus egg debate regarding vitamin D and IBD, here we summarise the latest knowledge of the immunological effects of vitamin D in IBD and recommend from available evidence that physicians regularly monitor serum 25(OH)D levels in patients with IBD. Moreover, we propose an algorithm for optimising vitamin D status in patients with IBD in clinical practice. Awaiting well-powered controlled clinical trials, we consider vitamin D supplementation to be an affordable and widely accessible therapeutic strategy to ameliorate IBD clinical outcomes.

scholarly journals The Role of Vitamin D in Inflammatory Bowel Disease: Mechanism to Management

Nutrients ◽  
2019 ◽  
Vol 11 (5) ◽  
pp. 1019 ◽  
Author(s):  
Jane Fletcher ◽  
Sheldon C. Cooper ◽  
Subrata Ghosh ◽  
Martin Hewison
Keyword(s):  
Inflammatory Bowel Disease ◽  
Vitamin D ◽  
Bowel Disease ◽  
Active Form ◽  
Vitamin D Supplementation ◽  
Gastrointestinal Microbiota ◽  
Beneficial Effects ◽  
Inflammatory Bowel ◽  
Anti Inflammatory ◽  
Low Serum

Vitamin D has been linked to human health benefits that extend far beyond its established actions on calcium homeostasis and bone metabolism. One of the most well studied facets of extra-skeletal vitamin D is its activity as an immuno-modulator, in particular its potent anti-inflammatory effects. As a consequence, vitamin D deficiency has been associated with inflammatory diseases including inflammatory bowel disease (IBD). Low serum levels of the major circulating form of vitamin D, 25-hydroxyvitamin D (25-OH-D) are significantly more prevalent in patients with IBD, particularly in the winter and spring months when UV-induced synthesis of vitamin D is lower. Dietary malabsorption of vitamin D may also contribute to low serum 25(OH)D in IBD. The benefits of supplementation with vitamin D for IBD patients are still unclear, and improved vitamin D status may help to prevent the onset of IBD as well as ameliorating disease severity. Beneficial effects of vitamin D in IBD are supported by pre-clinical studies, notably with mouse models, where the active form of vitamin D, 1,25-dihydroxyvitamin D (1,25-(OH)2D) has been shown to regulate gastrointestinal microbiota function, and promote anti-inflammatory, tolerogenic immune responses. The current narrative review aims to summarise the different strands of data linking vitamin D and IBD, whilst also outlining the possible beneficial effects of vitamin D supplementation in managing IBD in humans.

scholarly journals Vitamin D supplementation dose needs to be higher in patients with inflammatory bowel disease: interventional study

2019 ◽  
Vol 65 (7-8) ◽  
pp. 470-474
Author(s):  
Vladimír Kojecký ◽  
Jan Matouš ◽  
Zdena Zádorová ◽  
Martin Gřiva ◽  
Bohuslav Kianička ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Vitamin D ◽  
Bowel Disease ◽  
Vitamin D Supplementation ◽  
Interventional Study ◽  
Inflammatory Bowel

Effects of oral Vitamin D supplementation on inflammatory bowel disease: a systematic review and meta-analysis

2021 ◽  
Author(s):  
Yiwen Guo ◽  
Tao Zhang ◽  
Yandan Wang ◽  
Ruijie Liu ◽  
Ming Chang ◽  
...  
Keyword(s):  
Systematic Review ◽  
Inflammatory Bowel Disease ◽  
Vitamin D ◽  
Bowel Disease ◽  
Effective Properties ◽  
Meta Analysis ◽  
Critical Role ◽  
Vitamin D Supplementation ◽  
Oral Vitamin ◽  
Inflammatory Bowel

Vitamin D (VitD) is a fat-soluble micronutrient that plays a critical role in inflammatory bowel disease (IBD). Although the effective properties of VitD in anti-inflammatory and immune moderation were reviewed,...

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