scholarly journals Efficacy of Infliximab Rescue Therapy in Hospitalized Patients with Steroid-Refractory Ulcerative Colitis: Single Center Experience

2012 ◽  
Vol 10 (2) ◽  
pp. 152 ◽  
Author(s):  
Jun Hyung Cho ◽  
Chang Kyun Lee ◽  
Hyo Jong Kim ◽  
Jae Jun Shim ◽  
Jae Young Jang ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Rescue Therapy ◽  
Hospitalized Patients ◽  
Single Center ◽  
Single Center Experience ◽  
Steroid Refractory

scholarly journals The Use of Infliximab for Treatment of Hospitalized Patients with Acute Severe Ulcerative Colitis

2008 ◽  
Vol 22 (11) ◽  
pp. 937-940 ◽  
Author(s):  
B Bressler ◽  
JK Law ◽  
N Al Nahdi Sheraisher ◽  
K Atkinson ◽  
MF Byrne ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Life Experience ◽  
Rescue Therapy ◽  
Real Life ◽  
Case Series ◽  
Hospitalized Patients ◽  
Severe Ulcerative Colitis ◽  
Duration Of Disease ◽  
Intravenous Steroids ◽  
Steroid Refractory

BACKGROUND/AIM: The use of infliximab in severe ulcerative colitis (UC) is established; however, its role in severe acute UC requires clarification. The present multicentre case series evaluated infliximab in hospitalized patients with steroid-refractory severe UC.METHODS: Patients from six hospitals were retrospectively evaluated. Data collection included demographics, duration of disease and previous treatments. The primary end point was response to in-hospital infliximab; defined as discharge without colectomy.RESULTS: Twenty-one patients (median age 26 years) were admitted between May 2006 and May 2008 with severe UC requiring intravenous steroids and given infliximab (median time to infusion eight days). Sixteen (76%) patients were discharged home without colectomy; three of these underwent colectomy at a later date. Of the remaining 13 patients (62%), all but two did not require further courses of steroids; six patients had infliximab as a bridge to azathioprine and seven patients were maintained on regular infliximab. Five patients required in-hospital colectomy after the initial infliximab.CONCLUSIONS: In this real-life experience of infliximab in patients with steroid-refractory severe UC, infliximab appears to be a viable rescue therapy. The majority of patients were discharged without surgery and 62% maintained response either as a bridge to azathioprine or maintenance infliximab.

W1116 Sequential Ciclosporine and Infliximab Rescue Therapy in Steroid Refractory Ulcerative Colitis

2009 ◽  
Vol 136 (5) ◽  
pp. A-657 ◽  
Author(s):  
Aoibhlinn M. O'Toole ◽  
Denise Keegan ◽  
Hugh Mulcahy ◽  
Diarmuid P. O'Donoghue
Keyword(s):  
Ulcerative Colitis ◽  
Rescue Therapy ◽  
Steroid Refractory

Efficacy and safety of tacrolimus in refractory ulcerative colitis and Crohnʼs disease: A single-center experience

2008 ◽  
Vol 14 (1) ◽  
pp. 7-12 ◽  
Author(s):  
Aaron Benson ◽  
Terrence Barrett ◽  
Marshall Sparberg ◽  
Alan L. Buchman
Keyword(s):  
Ulcerative Colitis ◽  
Efficacy And Safety ◽  
Single Center ◽  
Single Center Experience

Surgery is a real alternative to rescue therapy in patients with steroid-refractory ulcerative colitis

2012 ◽  
Vol 28 (3) ◽  
pp. 425-427 ◽  
Author(s):  
Krisztina Gecse ◽  
Klaudia Farkas ◽  
Gábor Horváth ◽  
Zoltán Szepes ◽  
Ferenc Nagy ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Rescue Therapy ◽  
Steroid Refractory
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