scholarly journals Eficacia de la terapia de pareja con pacientes con cáncer: una revisión sistemática

2020 ◽  
Vol 17 (1) ◽  
pp. 73-89
Author(s):  
Noelia González Viniegra ◽  
Juan Antonio Cruzado
Keyword(s):  
Breast Cancer ◽  
Prostate Cancer ◽  
Clinical Trial ◽  
Sex Therapy ◽  
Cáncer De Mama ◽  
Cáncer De Próstata ◽  
Cancer Breast ◽  
Palabras Clave ◽  
Revisión Sistemática ◽  
Couple Sex Therapy

Objetivo: Conocer la eficacia o utilidad de la terapia de pareja en casos donde uno de los miembros de la pareja padece cáncer. Así como conocer en qué casos o en qué momentos puede ser más útil este tipo de terapia. Método: Se realizó una búsqueda sistemática en las bases de datos electrónicas: Scopus, Pubmed y PsycInfo, utilizándose palabras clave, tales como: Couple sex therapy, Cancer, Breast cancer, Prostate cancer, Couple psychological therapy, Intimacy, Clinical trial y Efficacy; y sus múltiples combinaciones. Se han incluido artículos en inglés de entre los años 2007 y 2019. Resultados: Los 11 estudios seleccionados únicamente trataban de cáncer de mama y próstata y la mayoría de ellos se lleva a cabo con una media relativamente pequeña. La mayoría de los tratamientos se aplica desde la corriente cognitivo-conductual y existen mejores resultados si el tratamiento está manualizado. En los casos de cáncer de próstata se trata con más normalidad aspectos relacionados con la sexualidad que en casos de cáncer de mama. Se observan mayores mejoras en cáncer de próstata ya que tienen que ver con aspectos sexuales además de psicológicos (pese a que con tiempo se pierdan dichas mejoras). Conclusiones: Se aprecia eficacia inicial en lo que a satisfacción de la relación y problemas sexuales en la pareja se refiere, pero estos resultados no se mantienen a lo largo del tiempo. Por lo que en general hablaríamos de una eficacia real baja.

scholarly journals Câncer de mama e próstata no Brasil: análise epidemiológica / Breast cancer and prostate in Brazil: epidemiological analysis

2021 ◽  
Vol 66 (1u) ◽  
pp. 1
Author(s):  
Lindcy Maticolli Cesar ◽  
Lucas Boa Sorte Faccin ◽  
Maiana Gueretta Martinez ◽  
Angélica Augusta Grigoli Dominato
Keyword(s):  
Breast Cancer ◽  
Prostate Cancer ◽  
Mortality Rate ◽  
Female Breast Cancer ◽  
Cáncer De Mama ◽  
Cáncer De Próstata ◽  
Age Related ◽  
Incidence And Mortality ◽  
Breast And Prostate Cancer ◽  
Epidemiological Profile

Introdução: O câncer está entre as principais doenças causadoras de morbimortalidade mundial relacionada com a idade, sendo mais comum entre pacientes com menos de 70 anos, e associado ao sexo com o câncer de mama feminino e de próstata para os homens. Objetivo: Traçar o perfil epidemiológicodos brasileiros acometidos pelo câncer próstata e de mama nas mulheres, comparar suas incidências e taxas de mortalidade nas macrorregiões do país. Metodologia: O estudo é descritivo do tipo ecológico com abordagem quantitativa dos dados da taxa de mortalidade, obtidos sobre o câncer de mama feminino e de próstata nas macrorregiões brasileiras, entre os anos de 2009 a 2018. Resultados: Os dados levantados mostraram que o total de óbitos entre mulheres nos anos do estudo foi de 5.315.155, sendo que 2,72% a foi causado pelo câncer de mama. Enquanto que, o número de óbitos entre os homens foi de 6.911.531, sendo 2,02% atribuídos ao câncer de próstata. Conclusão: Observou-se aumento da mortalidade de pacientes com câncer de mamae próstata no país ao longo do tempo do estudo, assim como aumento da taxa de mortalidade para ambos. Palavras chave: Câncer de mama, Câncer de próstata,Epidemiologia, Mortalidade, Incidência ABSTRACTIntroduction: Cancer is among the main diseases causing age-related morbidity and mortality worldwide, being more common among patients under 70 years, and associated with gender with breast cancer for women and prostatecancer for men. Objective: To trace the epidemiological profile of Brazilians affected by prostate and breast cancer in women, compare their incidence and mortality rates in the macro-regions of the country. Methodology: The study is descriptive of ecological type with quantitative approach of mortality rate data, obtained on female breast cancer and prostate cancer in Brazilian macro-regions, between the years 2009 to 2018. Results: The data surveyed showed that the total number of deaths among women in the years of the study was 5,315,155, 2.72% a was caused by breast cancer. Whereas, the number of deaths among men was 6,911,531, with 2.02% attributed to prostate cancer. Conclusion: We observed an increase in mortality of patients with breast and prostate cancer in the country over the time of the study, as well as an increase in the mortality rate for both.Keywords: Breast cancer, Prostate cancer, Epidemiology, Mortality, Incidence

scholarly journals Is “Movember” an Effective Prostate Cancer Awareness Campaign Beyond the English Language? Insights From Google Trends Among Spanish Speakers

2021 ◽  
Vol 2 (6) ◽  
pp. 362-369
Author(s):  
Daniel A. González-Padilla ◽  
Rodrigo España-Navarro ◽  
José Daniel Subiela ◽  
Raj Kumar ◽  
Luis G. Medina ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Prostate Cancer ◽  
English Language ◽  
Spanish Language ◽  
Google Trends ◽  
Cáncer De Mama ◽  
Cancer Awareness ◽  
Awareness Campaign ◽  
Cáncer De Próstata ◽  
The Impact

Objective To evaluate the impact of the “Movember” awareness campaign (men’s health campaign that takes place every November) on internet search trends for information online about prostate cancer and to compare the results with those for “Pinktober” (the breast cancer awareness campaign that takes place in October) in the Spanish language as an indirect measure of its effectiveness. Methods Google Trends was used to evaluate the monthly relative search volumes (RSV) of the terms “cáncer de próstata” (prostate cancer), “cáncer de mama” (breast cancer), and “Movember” from January 2009 to December 2019 both in Spain and worldwide (in the Spanish language). Breast cancer was used as a comparator of the campaign impact. Mean increase in RSV on-campaign and off-campaign was calculated and compared using the Mann-Whitney U test and Joinpoint regression analysis to assess loss or gain of interest. Results The term “cáncer de próstata” showed a statistically significant increase during the campaign months both in Spain (17.4%; P < 0.001) and worldwide (35.4%; P < 0.001). Both “cáncer de próstata” and Movember showed a decreasing trend worldwide and in Spain, while “cáncer de mama” showed an increasing trend. Conclusion The Movember campaign generates a statistically significant increase in the search trends on “cancer de próstata” (prostate cancer) during the month of November (both in Spain and worldwide); when compared with the breast cancer campaign “Pinktober” these increases are of a lesser magnitude but still significant, suggesting that the campaign is effective beyond the English language, although the interest has been decreasing throughout the years.

scholarly journals Lack of Association between Common Polymorphisms in Selenoprotein P Gene and Susceptibility to Colorectal Cancer, Breast Cancer, and Prostate Cancer: A Meta-Analysis

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Hanjiang Xu ◽  
Fan Mo ◽  
Jun Zhou ◽  
Zongyao Hao ◽  
Xianguo Chen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Prostate Cancer ◽  
Colorectal Cancer ◽  
Cancer Susceptibility ◽  
Meta Analysis ◽  
Selenoprotein P ◽  
Tumor Type ◽  
Cancer Breast ◽  
P Gene ◽  
Breast And Prostate Cancer

Background and Objective. Selenoprotein P (SEPP1) is the major selenoprotein in plasma. Previous studies have demonstrated that SEPP1 expression was reduced in human prostate and colon tumors. Nowadays, studies concerning SEPP1 gene polymorphisms and cancer susceptibility have been extensively investigated, whereas results from these studies remain debatable rather than conclusive. Thus, we performed the present meta-analysis to comprehensively assess the association between two common polymorphisms (rs3877899 and rs7579) in SEPP1 and cancer susceptibility. Method. We search the PubMed, Embase, Google Scholar, and Wanfang (China) databases (up to December 1, 2020) to identify all eligible publications. The pooled odds ratio (OR) correspondence with 95% confidence interval (CI) was calculated to evaluate the associations. Results. Finally, nine eligible studies with 7,157 cases and 6,440 controls and five studies with 2,278 cases and 2,821 controls were enrolled in rs3877899 and rs7579 polymorphisms, individually. However, a null significant association was detected between the two polymorphisms in SEPP1 and susceptibility to colorectal, breast, and prostate cancer in all comparison models. Subsequently, subgroup analysis based on tumor type, no significant association was identified for prostate, breast, and colorectal cancer. In addition, when the stratification analyses were conducted by the source of control, HWE status, and ethnicity, yet no significant association was found. Conclusions. The current meta-analysis shows that SEPP1 rs3877899 and rs7579 polymorphisms may not be associated with susceptibility to colon cancer, breast cancer, and prostate cancer, and further well-designed studies with a larger sample size are warranted to validate our findings.

scholarly journals Qualidade de Vida Relacionada à Saúde de Pacientes com Câncer de Mama: Revisão Integrativa da Literatura

2020 ◽  
Vol 66 (1) ◽  
Author(s):  
Monique Binotto ◽  
Gilberto Schwartsmann
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Cáncer De Mama ◽  
Life Questionnaire ◽  
European Organization ◽  
Quality Of Life Questionnaire ◽  
Cancer Breast ◽  
Eortc Qlq C30 ◽  
Eortc Qlq

Introdução: O câncer de mama pode alterar a qualidade de vida relacionada à saúde das pacientes. Objetivo: Compreender o impacto da quimioterapia para câncer de mama na qualidade de vida relacionada à saúde de pacientes. Método: Trata-se de uma revisão integrativa da literatura, compreendendo artigos publicados entre 2007 e 2019, disponíveis nas bases de dados PubMed, LILACS e SciELO. Analisaram-se 25 artigos na íntegra. Resultados: Os questionários mais frequentemente utilizados nos estudos foram o European Organization for Research and Treatment of Cancer Core Quality of Life Questionnaire (EORTC QLQ-C30) e o módulo complementar European Organization for Research and Treatment of Cancer Breast Cancer-specific Quality of Life Questionnaire (EORTC QLQ-BR23). Em relação às alterações da qualidade de vida, a saúde global diminui durante a quimioterapia, mas pode melhorar após o término do tratamento. O aumento dos sintomas é relatado em diversos estudos e prejudicou a qualidade de vida relacionada à saúde das pacientes. Entretanto, os sintomas diminuem após o término da quimioterapia, exceto para algumas escalas. As escalas de imagem corporal, função sexual e funcionamento físico pioram ao longo do tratamento. A qualidade de vida mental/psicológica tem oscilações durante o tratamento, assim como a escala sobre as relações sociais. Conclusão: A qualidade de vida relacionada à saúde de mulheres com câncer de mama é afetada negativamente pelo tratamento quimioterápico, expressando maior impacto nas escalas de sintomas.

A genome-wide association study (GWAS) of docetaxel-induced peripheral neuropathy in CALGB 90401 (Alliance).

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. 11053-11053
Author(s):  
Daniel Louis Hertz ◽  
Kouros Owzar ◽  
Susan Halabi ◽  
William Kevin Kelly ◽  
Hitoshi Zembutsu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Prostate Cancer ◽  
Clinical Trial ◽  
Peripheral Neuropathy ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Genome Wide ◽  
A Genome ◽  
Grade 3

11053 Background: There are currently no effective methods for predicting, preventing, or treating chemotherapy-induced peripheral neuropathy. We performed a genome-wide association study in a clinical trial of castration-resistant prostate cancer (CRPC) to discover variants that may be useful for identifying patients at high risk of neuropathy during docetaxel treatment. Methods: Treatment and toxicity data were collected prospectively on the Cancer and Leukemia Group B (CALGB) 90401 trial of chemotherapy naïve CRPC patients treated with docetaxel and prednisone ± bevacizumab. Genotyping was performed by the RIKEN Institute using the Illumina HumanHap610-Quad platform. Genetically defined European subjects were included in the discovery analysis of all single nucleotide polymorphisms (SNPs) that passed quality control. The primary endpoint was the cumulative dose level triggering a grade 3+ sensory neuropathy. The inference was conducted within the framework of a competing risk model accounting for early treatment termination induced by death or progression, or other toxicities. SNPs that were highly associated with neuropathy were assessed for a broader taxane effect in a cohort of paclitaxel-treated patients from a breast cancer clinical trial, CALGB 40101. Results: 623 Caucasian patients and 498,022 SNPs were included in the discovery analysis. The incidence of grade 3 neuropathy was 8%. One intergenic SNP (rs11017056) was associated with increased risk of neuropathy (HR=2.83, p=4.7x10-7). This association surpassed the genome-wide significance threshold after covariate adjustment (p=7.2x10-8). However, none of the 7 SNPs selected for replication were associated with neuropathy in the paclitaxel-treated breast cancer cohort. Conclusions: Using a prospectively enrolled prostate cancer patient cohort we identified multiple SNPs that may identify risk of docetaxel-induced peripheral neuropathy, but not paclitaxel-induced neuropathy. However, since it is unknown whether the genetic factors that affect taxane neuropathy are drug-specific, further replication studies in docetaxel-treated cohorts are of great interest.

Low-fat dietary pattern and long-term breast cancer incidence and mortality: The Women’s Health Initiative randomized clinical trial.

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. 520-520 ◽  
Author(s):  
Rowan T. Chlebowski ◽  
Aaron K Aragaki ◽  
Garnet L Anderson ◽  
Kathy Pan ◽  
Marian L Neuhouser ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Clinical Trial ◽  
Dietary Pattern ◽  
Dietary Intervention ◽  
Breast Cancer Incidence ◽  
Intervention Group ◽  
Fat Intake ◽  
Breast Cancers ◽  
Low Fat ◽  
Cancer Breast

520 Background: Observational studies of dietary fat intake and breast cancer have inconsistent findings. To address this issue, the Women’s Health Initiative (WHI) Dietary Modification (DM) clinical trial assessed a low-fat dietary pattern influence on breast cancer incidence and outcome. Methods: The WHI DM trial is a randomized, controlled clinical trial conducted at 40 US centers, where 48,835 postmenopausal women, aged 50-79 years, with no previous breast cancer and dietary fat intake ≥32% of total energy, were randomly assigned, from 1993-1998, to a usual diet comparison group (60%) or dietary intervention group (40%) with goals to reduce fat intake to 20% of energy and increase vegetables, fruit, and grain intake. This study is registered as: NCT00000611. Results: The dietary intervention significantly reduced fat intake; increased fruit, vegetable and grain intake with modest weight loss (3%) (all P< 0.001). During 8.5 years of dietary intervention, there were 8% fewer breast cancers and deaths from breast cancer were somewhat lower in the intervention group but the rates were not significantly different. However, deaths after breast cancer (breast cancer followed by death from any cause) were significantly reduced in the intervention group, both during intervention (hazard ratio [HR] 0·65 95% confidence interval [CI] 0·45-0·95) and through 16.1 year (median) cumulative follow-up. Now, after long- term, cumulative 19.6 year (median) follow-up, with 3,374 incident breast cancers, the significant reduction in deaths after breast cancer continued (with 1,011 deaths, HR 0·85 95% CI 0·74-0·96) and a significant reduction in deaths from breast cancer (breast cancer followed by death attributed to the breast cancer) emerged (with 383 deaths, HR 0·79 95% CI 0·64-0·97). Conclusions: Adoption of a low-fat dietary pattern associated with increased vegetable, fruit, and grain intake, demonstrably achievable by many, significantly reduced the risk of death from breast cancer in postmenopausal women. To our review, these findings provide the first randomized clinical trial evidence that a dietary change can reduce a postmenopausal woman’s risk of dying from breast cancer. Clinical trial information: NCT00000611.

scholarly journals Personalized Medicine in Screening for Malignant Disease: A Review of Methods and Applications

2013 ◽  
Vol 8 ◽  
pp. BMI.S11153 ◽  
Author(s):  
F. Schmalfuss ◽  
P.L. Kolominsky-Rabas
Keyword(s):  
Breast Cancer ◽  
Prostate Cancer ◽  
Colorectal Cancer ◽  
Personalized Medicine ◽  
Literature Search ◽  
Malignant Disease ◽  
Decisive Role ◽  
Routine Clinical Practice ◽  
Cancer Breast ◽  
Potential Applications

Personalized medicine (PM) is currently a hot topic in the professional world. It is often called the medicine of the future and has already achieved resounding success in the area of targeted therapy. Nevertheless, integration of the concepts of PM into routine clinical practice is slow. This review is intended to give an overview of current and potential applications of PM in oncology. PM could soon play a decisive role, especially in screening. The relevance of PM in screening was examined in the case of four common cancers (colorectal cancer, lung cancer, breast cancer, and prostate cancer). A literature search was performed. This showed that biomarkers in particular play a crucial role in screening. In summary, it can be emphasized that there are already numerous known promising biomarkers in malignant disease. This results in several possibilities for individualizing and revolutionizing screening.

scholarly journals Doença Oncológica: Perfil Epidemiológico em Unidade de Referência na Amazônia

2020 ◽  
Vol 11 (3) ◽  
Author(s):  
Mayrla Santana Picanço ◽  
Lucyelle Gleyce Ferreira Pádua ◽  
Francineide Pereira da Silva Pena ◽  
Maria Virginia Filgueiras de Assis Mello ◽  
Walter De Souza Tavares
Keyword(s):  
Prostate Cancer ◽  
Cáncer De Mama ◽  
Male Population ◽  
Cross Sectional ◽  
Female Population ◽  
Primary Schooling ◽  
Cáncer De Próstata ◽  
Epidemiological Profile ◽  
National Profile

Objetivo: Identificar o perfil epidemiológico, sociodemográfico, clínico e os cuidados de enfermagem no seguimento de pessoas com doença oncológica no estado do Amapá. Metodologia: Estudo transversal, descritivo, documental. Os dados foram coletados dos prontuários, por roteiro sistematizado, na amostra de 320 prontuários, no período de 2014 a 2018. Resultados: Predomínio do sexo feminino (55%), faixa etária entre 60 – 69 anos (21%), escolaridade ensino fundamental incompleto (40%). O câncer de colo uterino (33%) foi predominante no sexo feminino, e o de próstata (30%) no sexo masculino. Conclusão: O perfil identificado no Amapá para a população masculina foi o câncer de próstata, que se semelhou ao perfil nacional, já para a população feminina, fugiu do perfil nacional, onde o câncer de mama responde pelo topo do ranking, enquanto no Amapá é o de colo uterino.Descritores: Neoplasias; Epidemiologia; Enfermagem.ONCOLOGICAL DISEASE: EPIDEMIOLOGICAL PROFILE IN A REFERENCE UNIT IN THE AMAZONObjective: To identify the epidemiological, sociodemographic, clinical profile and the nursing care in the follow up of peoples with oncological disease in the state of Amapá. Methodology: cross-sectional, descriptive, documentary study. The data were collected from the medical records by a systematized script, with a sample of 320 records of interventions that occurred in the period from 2014 to 2018. Results: The predominance was female (55%), aged over 60 (21% ), incomplete primary schooling (40%). Cervical cancer was the most identified (33%) in the female sex, and the prostate cancer (30%) in the male sex. Conclusion: The profile identified in Amapá for the male population admits prostate cancer, a characteristic similar to the national profile, already for the female population, runs away from the national profile, where breast cancer is at the top of the ranking, while in Amapá it is the uterine cervix.Descriptors: Neoplasms; Epidemiology; Nursing.ENFERMEDAD ONCOLÓGICA: PERFIL EPIDEMIOLÓGICO EN UNA UNIDAD DE REFERENCIA EN LA AMAZONÍAObjetivo: Identificar el perfil epidemiológico, sociodemográfico, clínico y la atención de enfermería en el seguimiento de personas con enfermedad oncológica en el estado de Amapá. Metodología: Estudio transversal, descriptivo, documental. Los datos fueron recolectados de los prontuarios, por itinerario sistematizado, teniendo una muestra de 320 prontuarios, de intervenciones ocurridas en el período de 2014 a 2018. Resultados: Ocurrió el predominio del sexo femenino (55%), del grupo de edad superior a los 60 (21%) de la escolaridad escolar incompleta (40%). El cáncer de cuello uterino fue el más identificado (33%) en el sexo femenino, y el de próstata (30%) en el sexo masculino. Conclusión: El perfil identificado en Amapá para la población masculina admite el cáncer de próstata, característica similar al perfil nacional, ya para la población femenina, huye del perfil nacional, donde el cáncer de mama es el que está en la cima del ranking, en el Amapá es el de cuello uterino. Descriptores: Neoplasias; Epidemiología; Enfermería.

scholarly journals Genetic associations between CYP24A1 polymorphisms and predisposition of cancer: A meta-analysis

2020 ◽  
Vol 35 (4) ◽  
pp. 71-79
Author(s):  
Guoqiang Zhang ◽  
Maohe Jin
Keyword(s):  
Breast Cancer ◽  
Prostate Cancer ◽  
Literature Search ◽  
Web Of Science ◽  
Meta Analysis ◽  
Genetic Associations ◽  
Asian Ethnicity ◽  
Cancer Breast ◽  
Comprehensive Literature Search

Background: CYP24A1 polymorphisms may affect predisposition of cancer, but the results of published studies remain inconclusive. Therefore, the authors conducted this meta-analysis to more robustly assess relationships between CYP24A1 polymorphisms and the predisposition of cancer by pooling the findings of published studies. Materials and methods: A comprehensive literature search of PubMed, Embase, Web of Science, Wanfang, and CNKI was endorsed by the authors to identify eligible studies; 17 studies were finally found to be eligible for pooled meta-analysis. Results: The pooled meta-analysis results showed that genotypic frequencies of the rs4809960 polymorphism among cancerous patients and controls of Caucasian ethnicity differed significantly, and genotypic frequencies of the rs6022999 polymorphism among cancerous patients and controls of Asian ethnicity also differed significantly. Moreover, we found that genotypic frequencies of the rs2585428 polymorphism among patients with prostate cancer and controls differed significantly, and genotypic frequencies of the rs6068816 polymorphism among patients with prostate cancer/breast cancer and controls also differed significantly. Conclusions: This meta-analysis suggests that the rs4809960 polymorphism may affect the predisposition of cancer in Caucasians, and the rs6022999 polymorphism may affect the predisposition of cancer in Asians. Moreover, the rs2585428 polymorphism may affect the predisposition of prostate cancer, while the rs6068816 polymorphism may affect the predisposition of prostate cancer and breast cancer.

Synthesis and Anticancer Potentials of Quinoline Analogues: A Review of Literature

2020 ◽  
Vol 17 ◽  
Author(s):  
Ajay Kumar ◽  
Salahuddin ◽  
Avijit Mazumder ◽  
Mohammad Shahar Yar ◽  
Rajnish Kumar ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Prostate Cancer ◽  
Colon Cancer ◽  
Pancreas Cancer ◽  
New Drugs ◽  
Cancer Breast ◽  
Privileged Structures ◽  
Approved Drugs ◽  
New Research ◽  
Cancer Côlon

Abstract: New drugs introduced on the market each year have privileged structures specifically for anticancer targets, of which quinoline-based analogues also play an important role. This review lit up quinoline and its derivatives, which have great potency against various cancer cells including prostate cancer, breast cancer, colon cancer, pancreas cancer and many more. This review describes the most likely process-scale synthetic approaches of quinoline and its derivatives having specific pharmacophore, for anticancer targets along. It is also described the undergoing development and recently approved drugs in tabular form. Quinoline moiety as privileged structural pharmacophore has most effective activity against different cancer cell lines like prostate cancer, breast cancer, stomach cancer, pancreas cancer, Colon cancer, CNS cancer and renal cancer. Because of this advantage, it has the potency to grow with new research works about the anticancer as well as enhancing the value of the investigative process in the field of medicinal chemistry by introducing new effective alignments of substituents. It can be used as lead compounds for further research in the subject of anticancer drug discovery.

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