scholarly journals Non-local multiscale approaches for tumour-oncolytic viruses interactions

2020 ◽  
Vol 99 (99) ◽  
pp. 1-27
Author(s):  
Abdulhamed Alsisi ◽  
Raluca Eftimie ◽  
Dumitru Trucu
Keyword(s):  
Moving Boundary ◽  
Oncolytic Viruses ◽  
Viral Spread ◽  
Cell Matrix ◽  
Macro Scale ◽  
Non Local ◽  
Spatio Temporal ◽  
Boundary Model ◽  
Virus Interactions ◽  
Cell Cell

Oncolytic virus (OV) therapy is a promising treatment for cancer due to the OVs selective ability to infect and replicate inside cancer cells, thus killing them, without harming healthy cells. In this work, we present a new non-local multiscale moving boundary model for the spatio-temporal cancer-OV interactions. This model explores an important double feedback loop that links the macro-scale dynamics of cancer-virus interactions and the micro-scale dynamics of proteolytic activity taking place at the tumour interface. The cancer cell-cell and cell-matrix interactions are assumed to be nonlocal, while the cell-virus interactions are assumed local. With the help of this model we investigate computationally various cancer treatment scenarios involving oncolytic viruses (i.e., the effect of injecting the OV inside the tumour, or outside it). Moreover, we investigate the effect of different cell-cell and cell-matrix interaction strengths on the success of OV spreading throughout the tumour, and the effect of constant or density-dependent virus diffusion coefficients on viral spread.

Spatially Selective Imaging of Cell‐Matrix and Cell‐Cell Junctions by Electrochemiluminescence

2021 ◽  
Author(s):  
Hao Ding ◽  
Ping Zhou ◽  
Wenxuan Fu ◽  
Lurong Ding ◽  
Weiliang Guo ◽  
...  
Keyword(s):  
Cell Junctions ◽  
Cell Matrix ◽  
Cell Cell

scholarly journals Spatio-temporal integration in plant tropisms

2019 ◽  
Vol 16 (154) ◽  
pp. 20190038 ◽  
Author(s):  
Yasmine Meroz ◽  
Renaud Bastien ◽  
L. Mahadevan
Keyword(s):  
Response Function ◽  
Shoot Growth ◽  
Analytic Solution ◽  
Temporal Integration ◽  
Time Varying ◽  
Local Response ◽  
History Of ◽  
Non Local ◽  
Spatio Temporal ◽  
Plant Shoots

Tropisms, growth-driven responses to environmental stimuli, cause plant organs to respond in space and time and reorient themselves. Classical experiments from nearly a century ago reveal that plant shoots respond to the integrated history of light and gravity stimuli rather than just responding instantaneously. We introduce a temporally non-local response function for the dynamics of shoot growth formulated as an integro-differential equation whose solution allows us to qualitatively reproduce experimental observations associated with intermittent and unsteady stimuli. Furthermore, an analytic solution for the case of a pulse stimulus expresses the response function as a function of experimentally tractable variables, which we calculate for the case of the phototropic response of Arabidopsis hypocotyls. All together, our model enables us to predict tropic responses to time-varying stimuli, manifested in temporal integration phenomena, and sets the stage for the incorporation of additional effects such as multiple stimuli, gravitational sagging, etc.

scholarly journals Complex partial synchronization patterns in networks of delay-coupled neurons

2019 ◽  
Vol 377 (2153) ◽  
pp. 20180128 ◽  
Author(s):  
D. Nikitin ◽  
I. Omelchenko ◽  
A. Zakharova ◽  
M. Avetyan ◽  
A. L. Fradkov ◽  
...  
Keyword(s):  
Nonlinear Dynamics ◽  
Temporal Dynamics ◽  
Delay Systems ◽  
Theme Issue ◽  
Partial Synchronization ◽  
Multiplex Network ◽  
Control Scheme ◽  
Non Local ◽  
Spatio Temporal ◽  
Fast Oscillations

We study the spatio-temporal dynamics of a multiplex network of delay-coupled FitzHugh–Nagumo oscillators with non-local and fractal connectivities. Apart from chimera states, a new regime of coexistence of slow and fast oscillations is found. An analytical explanation for the emergence of such coexisting partial synchronization patterns is given. Furthermore, we propose a control scheme for the number of fast and slow neurons in each layer. This article is part of the theme issue ‘Nonlinear dynamics of delay systems’.

Dynamic Simulation of an Organic Rankine Cycle (ORC) System Driven by Exhaust

2015 ◽  
Vol 738-739 ◽  
pp. 986-990
Author(s):  
Zhi Gang Wang ◽  
Jia Guang Cheng ◽  
Yan Wang ◽  
Qiang Shen
Keyword(s):  
Low Temperature ◽  
Control Strategy ◽  
Fossil Fuels ◽  
Moving Boundary ◽  
Organic Rankine Cycle ◽  
Rankine Cycle ◽  
Energy Crisis ◽  
Transient Phenomena ◽  
Simulation Results ◽  
Boundary Model

Organic Rankine Cycle (ORC) is one of the most promising technologies for low-temperature energy conversion. In recent years, it has gotten more attention due to the energy crisis and environmental problems caused by the combustion of fossil fuels. In this paper, a moving boundary model is introduced to describe the transient phenomena of evaporator and condenser, which are the important components of ORC. The simulation results are given to illustrate the efficiency and feasibility of the proposed control strategy.

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