Polycythemia Vera Complicated by Portal Vein Thrombosis and Budd-Chiari Syndrome:

2021 ◽  
Vol 10 (02) ◽  
pp. 163-165
Author(s):  
Nabeela Iqbal ◽  
Syed Khalid Shah ◽  
Shamima Haneef
Keyword(s):  
Blood Pressure ◽  
Portal Vein ◽  
Polycythemia Vera ◽  
Portal Vein Thrombosis ◽  
Medical Condition ◽  
Abdominal Distension ◽  
Budd Chiari Syndrome ◽  
Massive Ascites ◽  
Vein Thrombosis ◽  
Chiari Syndrome

Polycythemia vera is a medical condition characterized by raised hematocrit. Owing to increased viscosity, the blood flow in the vessels become sluggish leading to the clinical features of polycythemia such as headache, blurring of vision, red skin, dizziness, raised blood pressure, itching and more serious medical events like vaso occlusion, thrombosis and strokes. In this case report, polycythemia vera presenting unusually with heamatemesis, melena and abdominal distension. Physical examination of this case revealed massive ascites with dilated veins around the umbilicus. The diagnosis of polycythemia vera complicated by Budd Chiari Syndrome and Portal Vein Thrombosis was made. Patients with polycythemia vera are at risk of vaso occlusive sequelea like portal vein thrombosis and Budd chiari syndrome

scholarly journals Portal vein thrombosis and Budd-Chiari syndrome as onset of polycythemia vera

2013 ◽  
pp. 196-205
Author(s):  
Aurelio Seidita ◽  
Delia Sprini ◽  
Accursia Bongiovì ◽  
Tiziana Catalano ◽  
Filippo Barbiera ◽  
...  
Keyword(s):  
Portal Vein ◽  
Polycythemia Vera ◽  
Portal Vein Thrombosis ◽  
Laboratory Data ◽  
Genetic Diagnosis ◽  
Vena Cava ◽  
Budd Chiari Syndrome ◽  
Vein Thrombosis ◽  
Clinical Onset ◽  
Chiari Syndrome

Budd-Chiari syndrome may be defined as a heterogeneous group of vascular disorders characterized by obstruction of hepatic venous return to the level of hepatic venules, supra-hepatic veins, inferior vena cava or right atrium. The main cause of this syndrome is represented by myeloproliferative diseases and, in particular, by polycythemia vera. The latter may cause multiple splanchnic thrombosis, including portal vein thrombosis, particularly important for its clinical outcomes (ascites, collateral vessels genesis, etc.). We report 2 cases of a Budd-Chiari syndrome induced by polycythemia vera characterized by an abnormal clinical onset, both as regards subjects’ age (29 and 39 years old, respectively) and set of symptoms, signs and laboratory data. After a complete clinical, instrumental and genetic diagnosis, the patients were treated with combined therapy, using acetylsalicylic acid and hydroxyurea. The therapy proved successful and patients are still in follow up in our institution. Polycythemia vera should be suspected in patients affected with portal vein thrombosis and Budd-Chiari syndrome even if its clinical onset might be unusual. Every effort should be made to make a correct and early diagnosis in order to start appropriate therapy as soon as possible and to prevent patients from useless diagnostic and therapeutic treatments.

scholarly journals Inherited Prothrombotic Defects in Budd-Chiari Syndrome and Portal Vein Thrombosis

2004 ◽  
Vol 121 (6) ◽  
pp. 844-847 ◽  
Author(s):  
Maitreyee Bhattacharyya ◽  
Govind Makharia ◽  
M. Kannan ◽  
R.P.H. Ahmed ◽  
P.K. Gupta ◽  
...  
Keyword(s):  
Portal Vein ◽  
Portal Vein Thrombosis ◽  
Budd Chiari Syndrome ◽  
Vein Thrombosis ◽  
Chiari Syndrome

Portal Vein Thrombosis and Budd–Chiari Syndrome

2009 ◽  
Vol 13 (1) ◽  
pp. 127-144 ◽  
Author(s):  
Paulo Lisboa Bittencourt ◽  
Cláudia Alves Couto ◽  
Daniel Dias Ribeiro
Keyword(s):  
Portal Vein ◽  
Portal Vein Thrombosis ◽  
Budd Chiari Syndrome ◽  
Vein Thrombosis ◽  
Chiari Syndrome

scholarly journals Increased CD11b neutrophil expression in Budd-Chiari syndrome or portal vein thrombosis secondary to polycythaemia vera

2004 ◽  
Vol 124 (3) ◽  
pp. 329-335 ◽  
Author(s):  
Alberto Alvarez-Larrán ◽  
Juan Carlos García-Pagán ◽  
Juan G. Abraldes ◽  
Eduardo Arellano ◽  
Juan Carlos Reverter ◽  
...  
Keyword(s):  
Portal Vein ◽  
Portal Vein Thrombosis ◽  
Polycythaemia Vera ◽  
Budd Chiari Syndrome ◽  
Vein Thrombosis ◽  
Chiari Syndrome

Budd-Chiari syndrome and portal vein thrombosis due to right atrial myxoma

2004 ◽  
Vol 78 (1) ◽  
pp. 333-334 ◽  
Author(s):  
George K Anagnostopoulos ◽  
George Margantinis ◽  
Panagiotis Kostopoulos ◽  
Glyceria Papadopoulou ◽  
Athanassios Roulias ◽  
...  
Keyword(s):  
Portal Vein ◽  
Portal Vein Thrombosis ◽  
Atrial Myxoma ◽  
Right Atrial ◽  
Budd Chiari Syndrome ◽  
Vein Thrombosis ◽  
Chiari Syndrome ◽  
Right Atrial Myxoma

Budd-Chiari Syndrome and Portal Vein Thrombosis in Crohnʼs Disease

2016 ◽  
Vol 111 ◽  
pp. S815-S816
Author(s):  
Yezaz A. Ghouri ◽  
Akhil V. Shenoy ◽  
Heather L. Stevenson ◽  
Shehzad Merwat
Keyword(s):  
Portal Vein ◽  
Portal Vein Thrombosis ◽  
Budd Chiari Syndrome ◽  
Vein Thrombosis ◽  
Chiari Syndrome

Myeloproliferative neoplasms in Budd-Chiari syndrome and portal vein thrombosis: a meta-analysis

Blood ◽  
2012 ◽  
Vol 120 (25) ◽  
pp. 4921-4928 ◽  
Author(s):  
Jasper H. Smalberg ◽  
Lidia R. Arends ◽  
Dominique C. Valla ◽  
Jean-Jacques Kiladjian ◽  
Harry L. A. Janssen ◽  
...  
Keyword(s):  
Portal Vein ◽  
Portal Vein Thrombosis ◽  
Myeloproliferative Neoplasms ◽  
Meta Analysis ◽  
Random Effects Model ◽  
Budd Chiari Syndrome ◽  
Vein Thrombosis ◽  
High Prevalence ◽  
Diagnostic Role ◽  
Chiari Syndrome

Abstract Myeloproliferative neoplasms (MPNs) are the most common cause of Budd-Chiari syndrome (BCS) and nonmalignant, noncirrhotic portal vein thrombosis (PVT). In this meta-analysis, we determined the prevalence of MPNs and their subtypes as well as JAK2V617F and its diagnostic role in these uncommon disorders. MEDLINE and EMBASE databases were searched. Prevalence of MPNs, JAK2V617F, and MPN subtypes were calculated using a random-effects model. A total of 1062 BCS and 855 PVT patients were included. In BCS, mean prevalence of MPNs and JAK2V617F was 40.9% (95% CI, 32.9%-49.5%) and 41.1% (95% CI, 32.3%-50.6%), respectively. In PVT, mean prevalence of MPNs and JAK2V617F was 31.5% (95% CI, 25.1%-38.8%) and 27.7% (95% CI, 20.8%-35.8%), respectively. JAK2V617F and MPNs were more frequent in BCS compared with PVT (P = .03 and P = .09, respectively). Polycythemia vera was more prevalent in BCS than in PVT (P = .001). JAK2V617F screening in splanchnic vein thrombosis (SVT) patients without typical hematologic MPN features identified MPN in 17.1% and 15.4% of screened BCS and PVT patients, respectively. These results demonstrate a high prevalence of MPNs and JAK2V617F in SVT patients and show differences in underlying etiology between these disorders. Furthermore, these results validate routine inclusion of JAK2V617F in the diagnostic workup of SVT patients.

Sign in / Sign up

Export Citation Format

Share Document