scholarly journals Effect of Priming Principle on Propofol Dose Required to Induce General Anesthesia

2019 ◽  
Vol 10 (1) ◽  
pp. 40-43
Author(s):  
Hafiz Muhammad Hamid ◽  
Sarmad Masud ◽  
Aamir Waseem ◽  
Aamir Bashir ◽  
Asma Samreen ◽  
...  
Keyword(s):  
General Anesthesia ◽  
Conventional Method ◽  
Controlled Trial ◽  
Control Group ◽  
Surgical Patient ◽  
P Value ◽  
Dose Requirement ◽  
Priming Principle ◽  
Induction Dose ◽  
The Mean

Objective: To compare the mean induction dose of Propofol to induce general anesthesia by conventional method versus mean induction dose after applying priming principle. Study Design and Setting: Randomized controlled trial at Operation theatre complex, Shalamar Hospital, Lahore from November 2016 to May 2017. Methods: A total of 100 patients aged 18-55 years were equally divided into control and study groups. After standard anesthetic monitoring, intravenous propofol was used for induction of general anesthesia by conventional method in Control (C) group and by applying Priming principle in Study (S) group. Total dose requirement of propofol was noted. Data was analyzed in SPSS version 20 and paired sample t-test was applied. P-value of < 0.05 was considered as significant. Results: The mean induction dose of propofol was 70.90 ± 16.77 mg in study group (S) as compared to 94.60 ± 20.22 mg in the control group (C). The difference of mean induction dose in both groups was 23.7± 3.45 mg and thus p-value of 0.000. Conclusion: There was significant reduction of dose of propofol required to induce general anesthesia in elective surgical patient by applying priming principle

scholarly journals Use of priming principle in the induction dose requirement of propofol and its hemodynamic stability- A cross sectional study

2021 ◽  
Vol 8 (3) ◽  
pp. 367-372
Author(s):  
P Ramesh Kumar ◽  
S Suganya ◽  
A Mohanhariraj ◽  
P Jothianand ◽  
R Shankar
Keyword(s):  
Blood Pressure ◽  
Total Dose ◽  
Control Group ◽  
Induction Agent ◽  
Hemodynamic Parameters ◽  
Dose Requirement ◽  
Hemodynamic Stability ◽  
Priming Principle ◽  
Induction Dose ◽  
The Mean

In anesthesia propofol induction is administered at a dose of 2mg/kg as a single bolus and when given at this dose the commonest problem faced by the anesthetist is the sudden drop in the blood pressure, as the hypotensive effect of propofol is proportional to the dose and rate of administration.To study the effect of auto co-induction (priming principle) in the requirement of induction dose of propofol and the resulting hemodynamic parameters. A prospective randomized double blinded study was conducted for a period of one year in the department of anesthesia at a government medical college hospital in TamilNadu. A total of 60 patients were selected for our study and were randomly allocated into two groups of 30 each. Group A is the study group (priming) and group B is the control group (non-priming group). In the priming group, three minutes after premedication the co induction agent was administered (25% of the calculated dose of propofol) and two minutes later the patient received propofol at a rate of 30mg/10 sec until loss of vocalization was achieved. The hemodynamic parameters along with the total dose requirement of propofol and BIS values were monitored at regular intervals after induction.The mean total dose of propofol required among the priming group patients was 78.2 mg compared to the total dose requirement in the non-priming group which was 92.5 mg and the mean difference was found to be statistically significant. A statistically significant fall in the heart rate and blood pressure was observed at 1 min and 3 mins after induction in non priming group compared to priming group. By applying priming principle the induction dose of propofol was reduced by 14.25% with a good hemodynamic stability.

scholarly journals Ultrasonographic Assessment of Metoclopramide Administration Effectiveness in Accelerating Gastric Emptying Before Urgent Surgery in Patients with Insufficient NPO Time

2020 ◽  
Vol 10 (5) ◽  
Author(s):  
Shahram Sayyadi ◽  
Masoomeh Raoufi ◽  
Ali Arhami Dolatabadi ◽  
Marzieh Rostami ◽  
Elham Memary
Keyword(s):  
Gastric Emptying ◽  
General Anesthesia ◽  
Intervention Group ◽  
Test Method ◽  
Control Group ◽  
P Value ◽  
High Morbidity ◽  
Expert Radiologist ◽  
Number Of Patients ◽  
The Mean

Background: Aspiration is one of the important complications of general anesthesia, although infrequent as well as accompanying high morbidity and mortality. The volume of gastric content is considered as a risk factor in this regard. Therefore, it is normally mostly recommend to consider proper fasting time before induction of general anesthesia. Objectives: This study was conducted to assess the effect of metoclopramide on reducing gastric contents in patients with incomplete fasting before induction of general anesthesia. Methods: This quasi-experimental study was conducted on patients with urgent surgical indications with incomplete NPO time. Every other patient received metoclopramide or placebo. Patients in the intervention group received 10 mg (2 ml) of intravenous metoclopramide, and patients in the control group received 2 ml of distilled water as a placebo. Patients in both groups underwent ultrasonography before starting surgery by an expert radiologist to calculate gastric antral grade (GAG) and cross-sectional antral area (CSA). These measurements were then taken for the second time 30 minutes after intervention, before starting the surgery. The values were compared statistically. Results: The data of 60 patients were analyzed, of which 30 were in each group. The mean age, body mass index, type of the last consumed food (solid or fluid), NPO time in the two groups were not significantly different (P value > 0.05). The number of patients in the metoclopramide group with higher GAG (P value = 0.001) and the mean CSA (P value = 0.004) before the intervention was more than the control group. The GAG and mean CSA after intervention were not significantly different between the two groups; but the mean difference of decrease in CSA in the metoclopramide group was more than the control group (4.3 vs. 0.99; P value = 0.001), and changes of GAG after intervention to lower levels in the metoclopramide group was more than the control group (P value < 0.05). Conclusions: In the current study in which ultrasonographic indexes, including GAG and CSA, were assessed as a suboptimal gastric emptying test method, it was found that metoclopramide could accelerate gastric emptying compared to placebo in patients with incomplete fasting before induction of general anesthesia.

scholarly journals Transcutaneous electrical acupoint stimulation before induction of anesthesia reduces sufentanil-induced cough: a randomized, controlled trial

2021 ◽  
Keyword(s):  
Heart Rate ◽  
Randomized Controlled Trial ◽  
General Anesthesia ◽  
Controlled Trial ◽  
Inhibitory Effect ◽  
Common Side Effect ◽  
Control Group ◽  
Randomized Controlled ◽  
The Mean ◽  
Acupoint Stimulation

Background: Sufentanil-induced cough is a common side effect during the induction of general anesthesia. This study sought to determine the inhibitory effect of TEAS (transcutaneous electrical acupoint stimulation) on the incidence of sufentanil-induced cough. Methods: A total of 339 patients were recruited of which 300 patients were enrolled and randomly allocated into five groups (n = 60): Patients did not receive TEAS in the control group (C group); patients received 2 Hz TEAS at LI4/PC6 (Hegu/Neiguan) in the 2A group; patients received 100 Hz TEAS at LI4/PC6 in the 100A group; patients received 2 Hz TEAS at ST36/SP6 (Zusanli/sanyinjiao) in the 2B group; and patients received 100 Hz TEAS at ST36/SP6 in the 100B group. With the exception of the C group, all groups received TEAS for 30 minutes before induction. 0.5 µg/kg of IV sufentanil was given over 2 seconds, and the occurrence of cough was observed and recorded for 1 minute. The severity of cough was graded as mild (1-2 coughs), moderate (3-5 coughs), and severe (> 5 coughs). The mean arterial pressure (MAP) and heart rate (HR) before (T0) and 1 minute after (T1) sufentanil injection were recorded. Results: The incidence of sufentanil-induced cough in C group, 2A group, 2B group, 100A group and 100B group were 37%, 27%, 27%, 12% and 13%, respectively. Compared with the C group, the incidence of cough in the 100A group and the 100B group were significantly lower (P < 0.05). The MAP and HR between the five groups were not statistically different. Conclusion: The administration of 100 Hz TEAS for 30 minutes before sufentanil injection can effectively reduce the incidence of sufentanil-induced cough during the induction of general anesthesia.

scholarly journals The effect of vitamin D3 supplements on the 25(OH)D levels in the II and III trimester of pregnant women in Sleman, Indonesia: randomized controlled trial

2020 ◽  
Vol 9 (1) ◽  
pp. 22
Author(s):  
Amalina T. Susilani ◽  
Hertanto W. Subagio ◽  
Noor Pramono ◽  
Martha I. Kartasurya
Keyword(s):  
Pregnant Women ◽  
Vitamin D3 ◽  
Controlled Trial ◽  
Mean Value ◽  
Control Group ◽  
P Value ◽  
Control Group Design ◽  
Significant Difference ◽  
The Mean ◽  
Vitamin D3 Deficiency

Background: Pregnant women are among the groups at high risk of vitamin D3 deficiency due to the increased need for micro and macro nutrients during pregnancy. Vitamin D3 deficiency is associated with pregnancy complications, namely preterm birth, pre-eclampsia, gestational diabetes, and babies born small according to their gestational age.Methods: The study involved a randomized pretest-posttest control group design. Subjects selected include 80 pregnant women in second trimester. Data were collected in June 2020 to September 2020. The respondents were then randomly divided into 2 groups, comprising 40 each, where the first received 400 IU/day vitamin D3 supplementation for 12 weeks, and the second served as a control. Furthermore, 25 (OH) D were measured by using the ELISA method.Results: The mean value of the 25(OH)D levels after D3 supplementation and statistically showed a significant difference with a significance value of p<0.05 (0.01), compared to the control group.  Furthermore, the mean value of the 25(OH)D levels in the control group actually decreased by 2.7 ng/ml which was statistically significant with a p value of 0.00, compared to the control group. Furthermore, the mean value of the 25(OH)D levels in the control group actually decreased by 2.7 ng/ml which was statistically significant with a p value of 0.00.Conclusions: Vitamin D3 supplement of 400 IU per day can increase the levels of 25(OH)D in the II and III trimester of pregnant women in antenatal care (ANC), Sleman Regency, Yogyakarta.

Effectiveness of an e-health tennis-specific injury prevention programme: randomised controlled trial in adult recreational tennis players

2020 ◽  
Vol 54 (17) ◽  
pp. 1036-1041
Author(s):  
Haiko Ivo Maria Franciscus Lodewijk Pas ◽  
Babette M Pluim ◽  
Ozgur Kilic ◽  
Evert Verhagen ◽  
Vincent Gouttebarge ◽  
...  
Keyword(s):  
Primary Outcome ◽  
Controlled Trial ◽  
Secondary Outcome ◽  
Control Group ◽  
P Value ◽  
Injury Rates ◽  
Tennis Players ◽  
Outcome Scores ◽  
The Mean ◽  
Randomised Controlled

BackgroundDespite reported injury rates of up to 3 per 1000 hours exposure, there are no evidence-based prevention programmes in tennis.PurposeTo evaluate the effectiveness of an e-health prevention programme for reducing tennis injury prevalence.Study designTwo-arm, researcher-blinded randomised controlled trial.MethodsAdult tennis players of all playing levels were randomised in an unsupervised programme lasting 12 weeks (TennisReady group or control group). The primary outcome was the overall injury prevalence over a 16-week period, measured at 2 weekly intervals with the Oslo Sports and Trauma Research Centre questionnaire. Estimates for the primary outcome and associated 95% CIs were obtained using generalised estimating equation models. Secondary outcome scores included prevalence of substantial injuries, overall incidence, adherence and time-loss injuries.ResultsA total of 579 (83%) (TennisReady n=286, control n=293) participants were included in the primary analysis. The mean injury prevalence was 37% (95% CI 33% to 42%) in the TennisReady vs 38% (95% CI 34% to 42%) in the control group (adjusted p-value 0.93). The prevalence of substantial injuries was 11% (95% CI 9% to 14%) in the TennisReady vs 12% (95% CI 9% to 15%) in the control group (p value of 0.79). Analysis of the secondary outcome scores showed no difference between groups. The mean prevalence rates between high (8%) and low (92%) adherent groups were 32% (95% CI 23% to 44%) and 37% (95% CI 33% to 42%), respectively (p value 0.36).ConclusionProviding an unsupervised e-health tennis-specific exercise programme did not reduce the injury rates and should not be implemented.Trial registration numberNTR6443.

scholarly journals Efficacy of Priming Principle in Propofol Induction-A Randomised Controlled Trial

2021 ◽  
Author(s):  
Sri Sowmiya Dhanapalan ◽  
Manisha B Vyas
Keyword(s):  
Blood Pressure ◽  
Total Dose ◽  
Controlled Trial ◽  
Control Group ◽  
Chi Square ◽  
Priming Principle ◽  
Induction Dose ◽  
Elective Surgical Procedures ◽  
Student’S T ◽  
Randomised Controlled

Introduction: Priming refers to administration of a small calculated dose of a drug before giving the total induction dose. Priming principle is well-documented with the use of non-depolarising muscle relaxants. Over the years, propofol has emerged as an effective alternative to thiopentone for intravenous induction. Aim: To evaluate whether priming with propofol reduces the total induction dose of propofol. Materials and Methods: Fifty patients with American Society of Anaesthesiologists (ASA) I and II grades, aged 18-55 years, and undergoing elective surgical procedures under general anaesthesia were randomly allocated into two groups; with 25 patients each. Patients in Control Group (CG) received calculated induction dose of injection propofol 2 mg/kg whereas patients in Study Group (SG) received 20% of total calculated induction dose of propofol 2 mg/kg as a priming dose and remaining dose after 30 seconds titrated till the loss of the eyelash reflex. The total induction dose and the associated haemodynamic parameters were noted. The data thus obtained was then analysed using Chi-square test and Student’s t-test. Results: The CG required a higher dose of inj. propofol (2.15 mg/kg) as compared with the SG (1.77 mg/kg), i.e., there was 17.43% reduction of the total dose in the SG. The preoperative baseline vitals {Heart Rate (HR), Systolic Blood Pressure (SBP), Diastolic Blood Pressure (DBP), Mean Arterial Pressure (MAP)} in both the groups were comparable. The changes in HR, at 1 minute and 3 minutes after induction were higher in CG than SG, which was statistically significant. The MAP at 1 minute and 3 minutes after induction was higher in SG than CG and was statistically significant. Conclusion: The priming principle when applied to induction with propofol reduces the total dose requirements of propofol and reduces the hypotension that it causes, thereby proving a stable haemodynamic state.

scholarly journals The impact of vildagliptin on the daily glucose profile and coronary plaque stability in impaired glucose tolerance patients with coronary artery disease: VOGUE—A multicenter randomized controlled trial

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Hiroyuki Yamamoto ◽  
Akihide Konishi ◽  
Toshiro Shinke ◽  
Hiromasa Otake ◽  
Masaru Kuroda ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Controlled Trial ◽  
Control Group ◽  
Randomized Controlled ◽  
Fibrous Cap ◽  
Multicenter Randomized Controlled Trial ◽  
The Mean ◽  
Artery Disease ◽  
Fibrous Cap Thickness ◽  
The Impact

Abstract Background The impact of reduction in glycemic excursion on coronary plaques remains unknown. This study aimed to elucidate whether a dipeptidyl peptidase 4 inhibitor could reduce the glycemic excursion and stabilize the coronary plaques compared with conventional management in coronary artery disease (CAD) patients with impaired glucose tolerance (IGT). Methods This was a multicenter, randomized controlled trial including CAD patients with IGT under lipid-lowering therapy receiving either vildagliptin (50 mg once a day) or no medication (control group) regarding glycemic treatment. The primary endpoint was changes in the minimum fibrous cap thickness and lipid arc in non-significant native coronary plaques detected by optical coherence tomography at 6 months after intervention. Glycemic variability expressed as the mean amplitude of glycemic excursion (MAGE) measured with a continuous glucose monitoring system was evaluated before and 6 months after intervention. Results A total of 20 participants with 47 lesions were allocated to either the vildagliptin group (10 participants, 22 lesions) or the control group (10 participants, 25 lesions). The adjusted difference of mean changes between the groups was − 18.8 mg/dl (95% confidence interval, − 30.8 to − 6.8) (p = 0.0064) for the MAGE (vildagliptin, − 20.1 ± 18.0 mg/dl vs. control, 2.6 ± 12.7 mg/dl), − 22.8° (− 40.6° to − 5.1°) (p = 0.0012) for the mean lipid arc (vildagliptin, − 9.0° ± 25.5° vs. control, 15.8° ± 16.8°), and 42.7 μm (15.3 to 70.1 μm) (p = 0.0022) for the minimum fibrous cap thickness (vildagliptin, 35.7 ± 50.8 μm vs. control, − 15.1 ± 25.2 μm). Conclusions Vildagliptin could reduce the MAGE at 6 months and may be associated with the decreased lipid arc and increased minimum FCT of the coronary plaques in CAD patients with IGT as compared with the control group. These findings may represent its potential stabilization effect on coronary plaques, which are characteristic in this patient subset. Trial registration Registered in the UMIN clinical trial registry (UMIN000008620), Name of the registry: VOGUE trial, Date of registration: Aug 6, 2012, URL: https://upload.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000010058

scholarly journals The effect of opioid-free anesthesia on the quality of recovery after gynecological laparoscopy: study protocol for a prospective randomized controlled trial

Trials ◽  
2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Jae Yen Song ◽  
Hoon Choi ◽  
Minsuk Chae ◽  
Jemin Ko ◽  
Young Eun Moon
Keyword(s):  
General Anesthesia ◽  
Assessment Tool ◽  
Controlled Trial ◽  
Perioperative Period ◽  
Postoperative Outcomes ◽  
Control Group ◽  
Quality Of Recovery ◽  
Gynecological Laparoscopy ◽  
Prospective Randomized Controlled Trial

Abstract Background Because of the indiscriminate use of opioids during the perioperative period, opioid-free anesthesia (OFA) has been increasingly required. Nevertheless, the studies on the detailed techniques and effects of OFA are not sufficient. The Quality of Recovery-40 (QoR-40) questionnaire is a validated assessment tool for measuring recovery from general anesthesia. However, no study has used the QoR-40 to determine if OFA leads to better recovery than standard general anesthesia. Therefore, we aim to perform this study to determine the effects of OFA using dexmedetomidine and lidocaine on the quality of recovery as well as the various postoperative outcomes. Methods The participants (n = 78) will be allocated to one of the two groups; the study group will receive bolus and infusion of dexmedetomidine and lidocaine, and the control group will receive remifentanil infusion during general anesthesia for gynecological laparoscopy. The other processes including anesthetic and postoperative care will be performed similarly in the two groups. Intraoperative hemodynamic, anesthetic, and nociceptive variables will be recorded. Postoperative outcomes such as QoR-40, pain severity, and opioid-related side effects will be assessed. Additionally, an ancillary cytokine study (inflammatory cytokine, stress hormone, and reactive oxygen species) will be performed during the study period. Discussion This will be the first study to determine the effect of OFA, using the combination of dexmedetomidine and lidocaine, on the quality of recovery after gynecological laparoscopy compared with standard general anesthesia using remifentanil. The findings from this study will provide scientific and clinical evidence on the efficacy of OFA. Trial registration ClinicalTrials.gov NCT04409964. Registered on 28 May 2020

scholarly journals OP0159 EFFICACY OF COMPREHENSIVE TECHNOLOGY-ASSISTED HOME-BASED EXERCISE IN ANKYLOSING SPONDYLITIS: A RANDOMIZED, CONTROLLED TRIAL

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 100.3-100
Author(s):  
Y. Wang ◽  
X. Liu ◽  
Y. Shi ◽  
X. Ji ◽  
W. Wang ◽  
...  
Keyword(s):  
Exercise Intervention ◽  
Medical Center ◽  
Controlled Trial ◽  
Intervention Group ◽  
Exercise Program ◽  
Group Differences ◽  
Control Group ◽  
Home Based ◽  
The Mean

Background:Clinical practice guidelines recommend that exercise is an essential component in the self-management of Ankylosing Spondylitis (AS). Attending supervised interventions requiring periodic medical center visits can be burdensome and patients may decline participation, whereas, effective home-based exercise interventions that do not need regular medical center visits are likely to be more accessible and acceptable for patients with AS. Recently, increasing evidences have been accumulated that the wearable devices could facilitate patients with inflammatory arthritis by giving exercise instructions and improving self-efficacy. Therefore, patients with AS may benefit from an effective technology-assisted home-based exercise intervention.Objectives:To investigate the efficacy of a comprehensive technology-assisted home-based exercise intervention on disease activity in patients with AS.Methods:This study was a 16-week assessor-blinded, randomized, waiting-list controlled trial (ChiCTR1900024244). Patients with AS were randomly allocated to the home-based exercise intervention group and the waiting-list control group. A 16-week comprehensive exercise program consisting of a moderate intensity (64%-76% HRmax) aerobic training for 30min on 5 days/week and a functional training for 60min on 3 days/week was given to patients in the intervention group immediately after randomization, with 1.5h training sessions for two consecutive days by a study physical therapist at baseline and Week 8. The aerobic exercise intensity was controlled by a Mio FUSE Wristband with a smartphone application. The functional training consisted of the posture training, range of motion exercises, strength training, stability training and stretching exercises. Patients in control group received standard care during the 16-week follow-up and started to receive the exercise program at Week 16. The primary outcome was ASDAS at Week 16. The secondary outcomes were BASDAI, BASFI, BASMI, ASAS HI, peak oxygen uptake, body composition and muscle endurance tests. The mean difference between groups in change from baseline was analyzed with the analysis of covariance.Results:A total of 54 patients with AS were enrolled (26 in intervention group and 28 in control group) and 46 (85.2%) patients completed the 16-week follow-up. The mean difference of ASDAS between groups in change from baseline to 16-week follow-up was −0.2 (95% CI, −0.4 to 0.003, P = 0.032), and the mean change from baseline was -0.4 (95% CI, -0.5 to -0.2) in the intervention group vs -0.1 (95% CI, -0.3 to 0.01) in the control group, respectively. Significant between-group differences were found between groups for BASDAI (−0.5 [95% CI, −0.9 to −0.2], P = 0.004), BASMI (−0.7 [95% CI, −1.1 to −0.4], P <0.001), BASFI (−0.3 [95% CI, −0.6 to 0.01], P=0.035), peak oxygen uptake (2.7 [95% CI, 0.02 to 5.3] ml/kg/min, P=0.048) and extensor endurance test (17.8 [95% CI, 0.5 to 35.2]s, P=0.044) at Week 16. Between-group differences were detected in ASAS HI (−0.9 [95% CI, −1.7 to −0.1], P=0.030), body fat percentage (−1.0 [95% CI, −2.0 to −0.01] %, P=0.048) and visceral adipose tissue (−4.9 [95% CI, −8.5 to −1.4] cm2, P=0.008) at Week 8, but not at Week 16. No significant between-group differences were detected in the total lean mass, time up and go test and the flexor endurance test during the follow-up.Conclusion:Comprehensive technology-assisted home-based exercise has been shown to have beneficial effects on disease activity, physical function, spinal mobility, aerobic capacity, and body composition as well as in improving fatigue and morning stiffness of patients with AS.References:[1]van der Heijde D, Ramiro S, Landewé R, et al. Ann Rheum Dis 2017;76:978–991.Disclosure of Interests:None declared

scholarly journals Mobile Health to Improve Adherence and Patient Experience in Heart Transplantation Recipients: The mHeart Trial

Healthcare ◽  
2021 ◽  
Vol 9 (4) ◽  
pp. 463
Author(s):  
Mar Gomis-Pastor ◽  
Sonia Mirabet Perez ◽  
Eulalia Roig Minguell ◽  
Vicenç Brossa Loidi ◽  
Laura Lopez Lopez ◽  
...  
Keyword(s):  
Heart Transplantation ◽  
Patient Experience ◽  
Mobile Application ◽  
Standard Care ◽  
Controlled Trial ◽  
Intervention Group ◽  
Group Versus ◽  
Control Group ◽  
P Value ◽  
Adherence Score

Non-adherence after heart transplantation (HTx) is a significant problem. The main objective of this study was to evaluate if a mHealth strategy is more effective than standard care in improving adherence and patients’ experience in heart transplant recipients. Methods: This was a single-center, randomized controlled trial (RCT) in adult recipients >1.5 years post-HTx. Participants were randomized to standard care (control group) or to the mHeart Strategy (intervention group). For patients randomized to the mHeart strategy, multifaceted theory-based interventions were provided during the study period to optimize therapy management using the mHeart mobile application. Patient experience regarding their medication regimens were evaluated in a face-to-face interview. Medication adherence was assessed by performing self-reported questionnaires. A composite adherence score that included the SMAQ questionnaire, the coefficient of variation of drug levels and missing visits was also reported. Results: A total of 134 HTx recipients were randomized (intervention N = 71; control N = 63). Mean follow-up was 1.6 (SD 0.6) years. Improvement in adherence from baseline was significantly higher in the intervention group versus the control group according to the SMAQ questionnaire (85% vs. 46%, OR = 6.7 (2.9; 15.8), p-value < 0.001) and the composite score (51% vs. 23%, OR = 0.3 (0.1; 0.6), p-value = 0.001). Patients’ experiences with their drug therapy including knowledge of their medication timing intakes (p-value = 0.019) and the drug indications or uses that they remembered (p-value = 0.003) significantly improved in the intervention versus the control group. Conclusions: In our study, the mHealth-based strategy significantly improved adherence and patient beliefs regarding their medication regimens among the HTx population. The mHeart mobile application was used as a feasible tool for providing long-term, tailor-made interventions to HTx recipients to improve the goals assessed.

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