Comparison of Allopurinol And Febuxostat in Asymptomatic Hyperuricemic Patients and their Impact on Serum Creatinine

2019 ◽  
Vol 10 (1) ◽  
pp. 17-21
Author(s):  
Tafazzul Hussain ◽  
Musarrat Sultana ◽  
Syeda Amber Zaidi ◽  
Syed Saud Hasan ◽  
Mohsin Turab ◽  
...  
Keyword(s):  
Renal Function ◽  
Uric Acid ◽  
Serum Creatinine ◽  
Serum Uric Acid ◽  
Blood Parameters ◽  
Mean Difference ◽  
P Value ◽  
Baseline Serum ◽  
Group A ◽  
Group B

Objective: To determine the effect of Allopurinol & Febuxostat for the treatment of hyperuricemic patients & its influence on renal function by measuring serum creatinine level. Study Design & setting: The clinical trial was conducted at Dr. Ruth K M Pfau Civil Hospital, Karachi, during the period of September 2018 to March 2019 Methodology: 60 patients with sUA > 6.8 mg/dl were registered. A detailed history was taken, patient's baseline serum Uric Acid (sUA) & serum Creatinine were measured. Patients were divided into two groups to receive Allopurinol, 300 mg & Febuxostat 80 mg, daily for 90-days. The blood parameters were repeated at day 30 and 90. Results: Group-A (Allopurinol treated patients) baseline uric acid changed from mean 8.79 ± 0.98 mg/dl to 6.40 ± 0.86 mg/dl at day 90. In Group-B (Febuxostat treated patients) sUA baseline mean changed from 8.85 ± 0.97 mg/dl to 5.96 ± 0.68 mg/dl. Mean difference ± SD change of serum uric acid in Group-A was 2.39 ± 1.15 mg/dl and with Group-B it was 2.90 ± 0.87 mg/dl. Mean Serum Creatinine in Group-A changed from 1.54 ± 0.39 mg/dl to mean 1.48 ± 0.40 mg/dl compared with Group-B where it changed from 1.42 ± 0.30 mg/dl to 1.45 ± 0.31 mg/dl at day-90. Mean difference ± SD of serum Creatinine in Group-A was 0.11 ± 0.25 mg/dl & in Group-B it was, 0.03 ± 0.15 mg/dl. The above changes were statistically non-significant with p-value of 0.144. Conclusion: Allopurinol and Febuxostat treatment resulted in improvement of serum Uric Acid levels while maintaining their renal function

scholarly journals A STUDY OF SERUM URIC ACID LEVELS IN TYPE 2 DIABETES MELLITUS CASES AND ITS COMPARISON WITH THE SERUM CREATININE LEVELS

2021 ◽  
pp. 20-22
Author(s):  
Shajahan Shajahan ◽  
Koneru Sri Lahari ◽  
P. Kiranmai
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Uric Acid ◽  
Serum Creatinine ◽  
Serum Uric Acid ◽  
Fasting Blood Glucose ◽  
Control Group ◽  
P Value

BACKGROUND:Type 2 Diabetes Mellitus is a major non-communicable disease resulting from insulin resistance and is associated with cardiovascular,neurological and renal complications.Recent studies show association of hyperuricemia and Diabetes Mellitus.Uric acid increases oxidative stress that leads to vascular dysfunction and high intra glomerular pressure leading to renal complications.High serum creatinine is an indicator of renal compromise. OBJECTIVES: To evaluate serum uric acid and serum creatinine levels in type 2 diabetes mellitus patients and to find association between them. METHODOLOGY: The study was conducted in Osmania general hospital. Fifty cases of established Type 2 Diabetes Mellitus formed the study group and 50 normal healthy individuals formed the control group. Serum uric acid, Fasting Blood Glucose (FBS) and serum creatinine were estimated by colorimetric enzymatic methods on Beckman coulter AU5800.Mean values were compared in cases and controls using student t- test.Study group was further studied under 2 subgroups with serum Uric acid < 7 mg/dl and ≥7 mg/dl.In these 2 subgroups the association of Serum uric acid with FBS and creatinine was analysed statistically. RESULTS: Serum uric acid were found high in cases(7.63+/- 3.36)as compared to controls(4.48+/- 1.09) p value < 0.001.Serum creatinine were also high in cases(1.59+/- 1.39 )as compared to controls ( 0.87+/- 0.29) p value <0.005.Study subgroup with serum uric acid ≥7 mg/dl was associated with high creatinine and high fasting blood sugar levels when compared to subgroup with serum uric acid <7 mg/dl. CONCLUSION: Our study showed increased serum uric acid and serum creatinine levels in cases when compared to controls.There was significant association between high serum uric acid and high creatinine levels in cases.Therefore,it is important to measure serum uric acid and serum creatinine levels in diabetics for early detection of renal pathology.

scholarly journals Correlation of serum uric acid with renal function parameters in preeclampsia.

2020 ◽  
Vol 27 (12) ◽  
pp. 2703-2707
Author(s):  
Muddasir Zia ◽  
Rukhshan Khurshid ◽  
Uzma Jabbar ◽  
Adnan Riaz ◽  
Roohi Jabbar ◽  
...  
Keyword(s):  
Renal Function ◽  
Uric Acid ◽  
Serum Creatinine ◽  
Serum Uric Acid ◽  
Cross Sectional Study ◽  
Urinary Protein ◽  
Estimation Of Parameters ◽  
Cross Sectional ◽  
Significant Difference ◽  
Relationship Of

Objectives: Study was designed to find out the Correlation of serum uric acid with renal function parameters in Preeclampsia. Study Design: Cross Sectional study. Setting: Sir Ganga Ram Hospital Lahore. Period: July 2016 to July 2017. Material & Methods: Level of serum uric acid, serum creatinine and blood urea of 40 Preeclamptic women and 30 gestation-matched normotensive controls were estimated. Their Demographic and clinical characteristics were noted. The blood sample was analyzed for biochemical parameters, blood urea, serum uric acid, serum creatinine and urinary protein. Result: Mean age and gestational age of women was 25 weeks with BMI 29 Kg/m2. Level of serum uric acid and blood urea and serum creatinine were increased, but significant difference only observed with serum uric acid and blood urea with marked proteinuria. An inverse relationship of serum uric acid with urinary protein was observed. A direct relationship, of serum uric acid with serum creatinine was observed. Conclusion: it is concluded that estimation of parameters of renal function of preeclamptic women are important along with hyperuicaemia.

scholarly journals Correlation of raised serum uric acid in first trimester of pregnancy and the risk of gestational diabetes: a prospective study

2017 ◽  
Vol 6 (8) ◽  
pp. 3633
Author(s):  
Jayanthi Mohan ◽  
Janani Suriyamoorthi ◽  
Maya Menon
Keyword(s):  
Uric Acid ◽  
Gestational Diabetes ◽  
Serum Uric Acid ◽  
Serum Uric Acid Level ◽  
Mode Of Delivery ◽  
Challenge Test ◽  
First Trimester ◽  
Oral Glucose ◽  
Group A ◽  
Group B

Background: Prevalence of Gestational Diabetes Mellitus (GDM) is fast increasing in India. The association between serum uric acid levels and GDM is not well known. This study was conducted to assess the relationship between first trimester serum uric acid levels and the incidence of gestational diabetes.Methods: This prospective observational study included 85 antenatal women. Serum uric acid level and oral glucose challenge test (OGCT) were done in all three trimesters. Women with first trimester serum uric acid levels of <3.6 mg were classified as group A and >3.6 mg as group B. Both the groups were followed throughout the pregnancy to assess the development of gestational diabetes. Also, the mode of delivery, pregnancy outcome, and other maternal and neonatal complications were observed.Results: In the patients recruited into this study, 33.33% of group A (serum uric acid<3.6 mg/dl) and 17.5% of group B (serum uric acid>3.6 mg/dl) developed GDM.Conclusions: First trimester Serum Uric acid was not significantly related to development of GDM in the sampled women. Neither was it related to any adverse maternal or fetal outcomes.

Factors contributing to discrepant estimated glomerular filtration values measured by creatinine and cystatin C in patients with rheumatoid arthritis

2020 ◽  
Author(s):  
Mitsuhiro Kawano ◽  
Akikatsu Nakashima ◽  
Shigeto Horita ◽  
Takahiro Matsunaga ◽  
Ryo Inoue ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Diabetes Mellitus ◽  
Renal Function ◽  
Serum Creatinine ◽  
Cystatin C ◽  
Serum Cystatin C ◽  
Serum Cystatin ◽  
Stage 4 ◽  
Group A ◽  
Group B

Abstract Background This study aimed to clarify the factors underlying the discrepancy that has been noted between estimated glomerular filtration ratio (eGFR) measured using serum creatinine (Cr) and eGFR using serum cystatin C (CysC) in patients with rheumatoid arthritis (RA) and to identify those patients whose renal function should be evaluated using CysC.Methods We retrospectively evaluated clinical features, disease activity, radiological grading, and co-morbidities (diabetes mellitus, hypertension, dyslipidemia) in 238 RA patients. eGFR using serum creatinine (eGFR-Cr) and eGFR using serum cystatin C (eGFR-CysC) were calculated using the new Japanese coefficient-modified Modification of Diet in Renal Disease study equation. To clarify the cause(s) of differences of 20% or more between the two eGFRs, we divided our RA patients into Group A (eGFR-Cr/eGFR-CysC ≥ 1.2), with eGFR-Cr more than 20% higher than eGFR-CysC, and Group B (eGFR-Cr/eGFR-CysC < 1.2), and compared various clinical parameters between them.Results Forty-five patients (18.9%) were assigned to Group A, and 193 (81.1%) to Group B. Group A were older (73.8 ± 12.5 vs 63.2 ± 13.6 years), and had a longer disease duration (17.7 ± 14.0 vs 10.4 ± 9.5 years), lower body mass index (BMI) (20.0 ± 2.9 vs 22.4 ± 3.6 kg/m2), higher frequencies of hypertension and diabetes mellitus (55.6% vs 30.1% and 35.6% vs 11.0%, respectively), higher DAS28-ESR (3.1 ± 1.3 vs 2.6 ± 1.0), lower hemoglobin (Hb) (11.8 ± 1.8 vs 12.8 ± 1.4 g/dl), lower creatine kinase (CK) (63.9 ± 36.0 vs 92 ± 79 IU/L), higher frequency of Steinbrocker stage 4 (46.7% vs. 15.3%), and a lower frequency of nonsteroidal anti-inflammatory drugs (NSAID) use (13.3% vs 30.6%), all significantly (p < 0.01) by a univariate analysis. BMI (Odds Ratio [OR] 0.820, 95% confidence interval [CI] 0.675–0.996), Hb (OR 0.633, 95% CI 0.433–0.926), CK (OR 0.773 per 10 units, 95% CI 0.644–0.933), NSAID use (OR 0.099, 95% CI 0.020–0.494), diabetes mellitus (OR 6.024, 95% CI 1.508–24.390) and stage 4 Steinbrocker radiological grade (OR 10.309, 95% CI 2.994–35.714) were identified as independent relevant factors for Group A by a multifactorial analysis.Conclusion Renal function in RA patients with low BMI, diabetes, anemia and low CK may be overestimated using eGFR-Cr alone, and such patients need to be evaluated using eGFR-CysC.

scholarly journals Impact of Baseline Admission Serum Creatinine Level in ST Segment Elevated Myocardial Infarction (STEMI) Patient Undergoing Primary PCI: An Important Predictor of in-hospital and 12-month Survival Outcome

2020 ◽  
Vol 12 (2) ◽  
pp. 135-142
Author(s):  
AHM Waliul Islam ◽  
Shams Munwar ◽  
Shahabuddin Talukder ◽  
AQM Reza ◽  
Azfar H Bhuiyan ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Serum Creatinine ◽  
Serum Creatinine Level ◽  
Creatinine Level ◽  
Stemi Patient ◽  
Important Predictor ◽  
Primary Pci ◽  
Baseline Serum ◽  
Group A ◽  
Group B

Background: Several studies has shown that impaired renal function might be an important predictor of adverse cardiovascular events in patient with ST elevated myocardial Infarction (STEMI) undergoing primary percutaneous intervention (pPCI). Exact data on clinical impact of baseline or admission serum creatinine level of STEMI patient undergoing pPCI in our patient population not well established. Therefore, we have carried out this non-randomized study to see the effects of S. creatinine level on major adverse cardiovascular outcomes among STEMI patient undergoing pPCI. Methods: Patients were enrolled in this observational non-randomized prospective cohort between November 2017-July 2019, who were presented into our emergency department with acute onset of severe chest pain or angina with ECG evidenced of acute ST elevated myocardial infarction. Total 137 patient (F 12; Male 125) were enrolled in this study. Results: Out of 137 patients, female :12 (8.75%) vs Male: 125 (91.2%). Among, these patient females were more obese (BMI: Female 27.0 ± 2.2 vs male 25.4 ± 4.9) and developed CAD in advance age (Female 59.1 ± 14.5 vs Male 53.4 ± 10.5). Among the 137 patients, 89 (65%) were dyslipidemia, 72 (52.6%) were hypertensive, Diabetic 66(48%), Smoker 70 (51%) and FH positive for CAD were 31 (22.6%). According to the involvement of myocardium infarction, STEMI diagnosis of Anterior MI were 48.9% (n=67) and Inferior MI 51.1% (n=70). An elevated serum creatinine level was defined as creatinine >1.2mg/dl. Based on baseline serum creatinine level, patients were divided into group-A and Group-B. In Group-A. Total 68 patients have S. Creatinine level <1.2 and in Group-B, 69 patients have S. Creatinine level >1.2. Anterior MI were higher in group -B patient than Group-A; Ant MI as 35 (50.4%) vs 31(45.6%), Inf MIL: 34 (49.35) vs 34 (50%), Shock 11 (15.9%) vs 6 (8.8%0, CHB 4 (5.8%) vs 4 (5.9%), Death 12 (17.4%) vs 2 (2.9%) and LVF 5(7.2%) vs 1(1.5%) with 7 days in-hospital stay after primary PCI. Territory wise involvement of vessel in Group-B patient has more involvement of LAD 35 (50.7%) and Group-A has RCA 26(38.2%). Conclusion: In this present study, we found, that in acute STEMI patients, baseline higher serum creatinine level is associated with more AMI related complications and death than in lower serum creatinine level. Thus, we may conclude that baseline admission serum creatinine level may be an important predictor for both in-hospital and 12-month survival outcomes in STEMI patients undergoing pPCI. Cardiovasc. j. 2020; 12(2): 135-142

scholarly journals Effectiveness between Salam Leaf Booking Water and Red Ginger Towards Reducing Acid Levels in Patients of Gout Arthritis

2021 ◽  
Vol 2 (1) ◽  
pp. 6-11
Author(s):  
Hartono ◽  
Chicilia Puspita Darmaningrum
Keyword(s):  
Uric Acid ◽  
Sampling Technique ◽  
T Test ◽  
P Value ◽  
Test Analysis ◽  
Before And After ◽  
Group A ◽  
Group B ◽  
Red Ginger ◽  
Boiled Water

Background. The prevalence of Gout Arthritis in the world is 34.2%. Gout Arthritis is characterized by an increase in uric acid levels >7.2 mg/dl in men and >6 mg/dl in women. This disease can be treated pharmacologically and non-pharmacologically, one of which is bay leaf and red ginger. Research purposes. The purpose of this study was to determine the effectiveness of boiled water of bay leaves and red ginger on reducing uric acid levels in patients with gout arthritis. Methods. This research method is a pre-experimental static-group comparison design. The sampling technique used purposive sampling. A sample of 60 respondents was divided into two groups of 30 respondents each, group A intervention boiled bay leaf water for 7 days, group B intervention boiled red ginger water for 7 days. Both groups were observed uric acid levels before and after the procedure using the GCU tool. Result: The results of the paired t-test analysis of group A p = 0.000 and group B p = 0.005 p value <0.05 which means there is a difference between before and after intervention A and intervention B were given. The results of the Independent t-test analysis showed that there was a difference in uric acid levels. after intervention A and intervention B with p = 0.004. The results showed that boiled water of bay leaves was more effective than boiled water of red ginger in reducing uric acid levels. Conclusion. Boiled water of bay leaves is more effective than boiled water of red ginger in reducing uric acid levels in gout arthritis patients

Central Corneal Thickness: Ultrasound Pachymetry Verus Anterior Segment Optical Coherence Tomography

2021 ◽  
Vol 37 (4) ◽  
Author(s):  
Waqas Ali ◽  
Munira Shakir ◽  
Sahira Wasim ◽  
Ronak Afza
Keyword(s):  
Optical Coherence Tomography ◽  
Central Corneal Thickness ◽  
Corneal Thickness ◽  
Anterior Segment ◽  
Mean Difference ◽  
P Value ◽  
Optical Coherence ◽  
Ultrasound Pachymetry ◽  
Group A ◽  
Group B

Purpose: To determine the mean difference in central corneal thickness between ultrasound pachymetry and anterior segment optical coherence tomography in patients visiting tertiary care hospital of Karachi Study design: Cross sectional study Place and Duration of Study: Department of Ophthalmology, Liaquat National Hospital, Karachi from 27th December 2018 to 26th June 2019. Methods: Total 216 eyes of 108 patients were divided into two groups. Central corneal thickness was measured using ultrasound pachymeters in group A and with anterior segment optical coherence tomography in group B. Data was collected and analyzed using SPSS version 21. Mean central corneal thickness was compared between the two methods. Stratification was done on gender, age and post-stratification independent sample t-test was applied for mean difference CCT and P-value ? 0.05 was taken as significant. Results: Total 108 patients were equally divided into two groups. Mean age was 48.70±7.82 years in group A and 50.66±6.88 years in group B. In group A, there were 74.1% males and 25.9% females while in group B, there were 75.9% males and 24.1% females. There was statistically significant difference between the mean central corneal thickness of group A and group B for right and left eyes (p<0.001). Mean difference was also compared for gender and age groups. We found statistically significant differences in central corneal thickness in between the two methods in both age groups (?45 years and > 45 years). Conclusion: Central corneal thickness was more with pachymeters as compared to the AS-OCT (p value < 0.05) Key Words: Central Corneal Thickness, Anterior Segment Optical Coherence Tomography, Ultrasound Pachymetry.

Prednisone in Uric Acid Lowering in Symptomatic Heart Failure Patients with Hyperuricemia — The PUSH-PATH3 Study

2015 ◽  
Vol 42 (5) ◽  
pp. 866-869 ◽  
Author(s):  
Hong Meng ◽  
Gang Liu ◽  
Jianlong Zhai ◽  
Yuzhi Zhen ◽  
Qingzhen Zhao ◽  
...  
Keyword(s):  
Heart Failure ◽  
Renal Function ◽  
Uric Acid ◽  
Serum Creatinine ◽  
Serum Uric Acid ◽  
Clinical Status ◽  
Safety And Efficacy ◽  
Symptomatic Heart Failure ◽  
Heart Failure Patients ◽  
Short Time

Objective.To determine the safety and efficacy of prednisone in patients with symptomatic heart failure (HF) and hyperuricemia.Methods.Prednisone therapy was administered for a short time to 191 symptomatic HF patients with hyperuricemia (serum uric acid > 7 mg/dl).Results.Prednisone significantly reduced serum uric acid by 2.99 mg/dl (p < 0.01) and serum creatinine by 0.17 mg/dl (p < 0.01). These favorable effects were associated with a remarkable increase in urine output, improvement in renal function, and improvement in clinical status.Conclusion.Prednisone can be used safely in symptomatic HF patients with hyperuricemia.

scholarly journals EFFECT OF NADIFLOXACIN PHONOPHORESIS AND PULSED ULTRASOUND IN SUBJECTS WITH ACUTE SINUSITIS- A RANDOMIZED CLINICAL TRIAL

2020 ◽  
Vol 8 (9) ◽  
pp. 1179-1182
Author(s):  
Anil Rachappa Muragod ◽  
◽  
Anil S. Harugop ◽  
Kirti Khemlapure ◽  
Krupa Varahmurty ◽  
...  
Keyword(s):  
Rating Scale ◽  
Numerical Rating Scale ◽  
Mean Difference ◽  
Acute Sinusitis ◽  
P Value ◽  
Pulsed Ultrasound ◽  
Before And After ◽  
Numerical Rating ◽  
Group A ◽  
Group B

Aim: To find effectiveness of nadifloxacin phonophoresis over pulsed ultrasound in acute sinusitis subjects. Methods: Study was approved by Institutional Ethical Committee of KAHER Institute of Physiotherapy, Belagavi.40subjects with acute sinusitis were divided randomly into group A, treated with nadifloxacin phonophoresis and group B, treated with pulsed ultrasound. Subjects were assessed using Sinusitis Symptom Score, Numerical Rating scale and Sino-nasal outcome test-22 before and after 4 days of intervention. Result: For sinusitis symptom measure within the groups, mean difference were 6.16±1.97 and 6.27±1.8 with p-value of 0.001 for both the groups which was significant. For between the groups, p-value was 0.700 which was not significant. For numerical rating scale within the groups, mean difference was 0.37±0.14. and 0.27±0.08 with p-value of 0.001 for both the groups which was significant. For between the groups, p-value of 0.014 which was significant. For Sino nasal outcome test within the groups, mean difference was 16.33±9.55 and 7.50±1.85 with p-value of 0.001 for both the groups which was significant. For between the groups, p-value was 0.001 which was significant. Conclusion: Nadifloxacin phonophoresis was more effective than pulsed ultrasound in acute sinusitis.

scholarly journals Effects of CRRT on renal function and toxin clearance in patients with sepsis: a case–control study

2021 ◽  
Vol 49 (9) ◽  
pp. 030006052110429
Author(s):  
Jinzhong Wang ◽  
Zhongyong Wu ◽  
Quan Wen ◽  
Xiaozhi Wang
Keyword(s):  
Renal Function ◽  
Lactic Acid ◽  
Treatment Group ◽  
Mortality Rate ◽  
Serum Creatinine ◽  
The Body ◽  
Urea Nitrogen ◽  
Routine Treatment ◽  
Group A ◽  
Group B

Objective To explore the effects of continuous renal replacement therapy (CRRT) on renal function and toxin clearance in patients with sepsis and concurrent acute kidney injury (AKI). Method A retrospective analysis was performed using the medical records of 115 patients with sepsis and AKI. Among them, 60 patients received routine treatment (group A) and 55 patients received CRRT plus routine treatment (group B). Result After treatment, the clearance rates of serum creatinine, lactic acid, and urea nitrogen were significantly lower in group A than in group B. The decrease in high-sensitivity C-reactive protein and tumor necrosis factor-α levels after treatment was significantly higher in group B than in group A. For the Acute Physiology Chronic Health Evaluation (APACHE) II and Sequential Organ Failure Assessment (SOFA) scores from the two groups, the scores were significantly lower in group B than in group A. The mortality rate within 28 days was significantly higher in group A than in group B. Conclusion CRRT can effectively improve the condition of patients with sepsis and AKI, promote elimination of toxins (serum creatinine, lactic acid, and urea nitrogen) from the body, and reduce the mortality rate.

Sign in / Sign up

Export Citation Format

Share Document