scholarly journals Frequency of Dyslipidemia In Type 2 Diabetic Patients In Karachi

2019 ◽  
Vol 09 (02) ◽  
pp. 133-136
Author(s):  
Sehrish Shafique ◽  
Daud Mirza ◽  
Summayya Shawana ◽  
Shahneela Tabassum ◽  
Naveed Faraz
Keyword(s):  
Low Density Lipoprotein ◽  
Elevated Serum ◽  
Density Lipoprotein ◽  
Cross Sectional Study ◽  
P Value ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Cross Sectional ◽  
Type 2 Diabetic

Objective: To find out the frequency of dyslipidemias in type 2 diabetic patients. Study Design and Setting: This was cross-sectional study and conducted in a different clinics in Karachi during 3 months period. Methodology: Those patients who fulfilled the inclusion criteria and attended the OPD were selected. Patient were advised to bring their lipid profile report in next visit if not already done. The total dyslipidemias were presented by their frequencies and percentages with 95% confidence interval. Results: Out of 383 patients with diabetes mellitus 210 (55 %) had dyslipidemia. Among which 76% had elevated lowdensity lipoprotein (LDL), 66.6 % had elevated serum cholesterol, 57% patient had elevated triglyceride. p- value of 0.05 was taken as statistically significant. Conclusion: It was concluded that increased frequency of dyslipidemias, with elevated low-density lipoprotein, cholesterol and triglycerides levels seen in diabetic patients.

scholarly journals Interaction between CETP polymorphism and dietary insulin index and load in relation to cardiovascular risk factors in diabetic adults

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Faezeh Abaj ◽  
Masoumeh Rafiee ◽  
Fariba Koohdani
Keyword(s):  
Risk Factors ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Cross Sectional Study ◽  
Diabetic Patients ◽  
Cvd Risk Factors ◽  
Cvd Risk ◽  
Type 2 Diabetic Patients ◽  
Cross Sectional

AbstractGene–diet interactions may play an important role in the inter individual diversity observed in on cardiovascular disease (CVD) risk factors. Therefore, in the current study, we examined the interaction of CETP TaqB1 polymorphism with dietary insulin index and load (DII and DIL), in altering on CVD risk factors among type 2 diabetes mellitus (T2DM). In this cross-sectional study, blood samples were collected from 220 type 2 diabetic patients (134 females and 86 male) with a mean age of 52.24 years in Tehran, Iran. DIL and DII were obtained via validated food-frequency questionnaire (FFQ). Taq1B polymorphism was genotyped by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Biochemical markers including total cholesterol (TC), low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglyceride (TG), superoxide dismutase (SOD), C-reactive protein (CRP), total antioxidant capacity (TAC), pentraxin-3 (PTX3), isoprostaneF2α (PGF2α). interleukin 18 (IL18), leptin and ghrelin were measured by standard protocol. Patients with B1B1 genotype had lower lipid profiles include LDL/HDL (P < 0.001) and TG (P = 0.04) when they consumed diets higher on the DIL and DII index. Moreover, carriers of B2B2 genotype who were in the last tertile of DIL had higher antioxidant and inflammatory markers include SOD (P = 0.01), PGF2α (P = 0.04) and CRP (P = 0.02). Further, a significant interaction between CETP TaqB1 and DII was shown in terms of WC (P = 0.01), where the highest WC were observed in B2B2 genotype carriers following a DII score. However, the highest inflammatory and antioxidant markers include CRP (P = 0.04), TAC (P = 0.01), SOD (P = 0.02), and PGF2α (P = 0.02) were observed in B2B2 genotype carriers when they consumed diets higher on the DII index. Based on the current study, it could be proposed that CETP polymorphism may be associated with CVD risk factors in T2DM patients with high following insulin indices, including DII and DIL. It seems that CETP Taq1B polymorphism can invert the result produced by insulin. This conclusion illustrates that the CETP Taq1B B1 allele could counteract the CVD risk induced by high DII and DIL.

scholarly journals A Hospital Based Cross-Sectional Study on Asymptomatic Cardiac Changes in Patients with Type 2 Diabetes Mellitus at a Tertiary Care Hospital, Khammam

2021 ◽  
Vol 8 (16) ◽  
pp. 1015-1019
Author(s):  
Krishna Chaitanya Alam ◽  
Durga Sai Kumar Reddi
Keyword(s):  
Diabetes Mellitus ◽  
Density Lipoprotein ◽  
Cross Sectional Study ◽  
Diabetic Patients ◽  
Sectional Study ◽  
Ecg Changes ◽  
Type 2 Diabetic Patients ◽  
Cross Sectional ◽  
Type 2 Diabetic

BACKGROUND Silent ischemia can be predicted with simple, non-invasive and cost-effective technique called electrocardiogram (ECG) in asymptomatic diabetic patients. Risk of morbidity and mortality due to cardiac diseases is high in those with diabetes mellitus. Data on electrocardiogram changes is scarce in India in type-2 diabetic patients without symptoms. Therefore, this study was undertaken to study ECG changes in type-2 diabetic patients without symptoms of heart disease. METHODS Hospital based cross-sectional study was carried out over 18 months among 50 cases of type 2 diabetic patients without cardiovascular disease symptoms. Haematological investigations performed for all patients included lipid profile, fasting blood sugar, and HbA1c. 12-lead electrocardiogram in resting position was carried out, and abnormalities in the recorded electrocardiogram were noted in the study questionnaire. RESULTS Mean age of patients was 53.86 ± 3.34 years. Mean duration of diabetes was 11.27 ± 4.19 years. Majority (44 %) were using oral hypoglycaemic drugs and insulin. Mean values of fasting blood sugar (204.92 ± 22.83) and HbA1c (7.32 ± 0.60 %) were raised. Total cholesterol was 188.4 ± 20.39 mg / dl; high density lipoprotein was 40.24 ± 5.67 mg / dl; low density lipoprotein was 98.64 ± 14.01 and the triglycerides were 182.9 ± 18.44 mg / dl. 28 % had ECG changes and among them the most common was ST depression with T wave inversion in 35.7 % followed by left ventricular hypertrophy (LVH) in 28.6 %. Among variables compared between the two groups, only duration of diabetes (years), and HbA1c (%) were found to be statistically significant (P < 0.05). CONCLUSIONS This study shows that type 2 diabetes patients especially of longer duration should undergo cardiac evaluation even though they do not have any symptoms relating to cardiovascular system. KEYWORDS Diabetes, ECG, Cardiac Changes, Evaluation, Symptoms

scholarly journals Lipid Profile of Type 2 Diabetic and Hypertensive Patients in the Jamaican Population

2010 ◽  
Vol 2 (01) ◽  
pp. 025-030 ◽  
Author(s):  
Lorenzo Gordon ◽  
Dalip Ragoobirsingh ◽  
Errol Y St A Morrison ◽  
Eric Choo-Kang ◽  
Donovan McGrowder ◽  
...  
Keyword(s):  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Diabetic Patients ◽  
Low Density ◽  
Low Density Lipoprotein Cholesterol ◽  
Type 2 Diabetic Patients ◽  
Type 2 Dm ◽  
Type 2 Diabetic

ABSTRACT Aims: Previous studies have shown that diabetes mellitus (DM) increases the risk of cardiovascular diseases in females to a greater extent than in males. In this cross-sectional study, we evaluated the lipid profiles of type 2 diabetic males and females. Materials and Methods: The study included 107 type 2 diabetic patients (41 males and 66 females), and 122 hypertensive type 2 diabetic patients (39 males and 83 females), aged 15 years and older. Total cholesterol (TC), triglycerides (TG), low density lipoprotein-cholesterol (LDL-C), very low density lipoprotein-cholesterol (VLDL-C) and high density lipoprotein-cholesterol (HDL-C) concentrations were assayed for each group using standard biochemical methods. Results: The mean TC, TG, VLDL-C, HDL-C and LDL-C concentrations, TG/HDL and LDL/HDL ratios were higher in type 2 diabetic and hypertensive type 2 diabetic patients compared with non-diabetic, and hypertensive non-diabetic control subjects, although these were not significant (P > 0.05). Hypertensive type 2 diabetic females had significantly higher serum TC (7.42 ± 1.63 mmol/L) than hypertensive non-diabetic males (5.76±1.57 mmol/L; P < 0.05). All the other lipid and lipoprotein parameters except HDL-C were non-significantly higher in females with type 2 DM and those with hypertension and type 2 DM, compared with type 2 diabetic and hypertensive type 2 diabetic males, respectively (P > 0.05). Conclusion: This study demonstrated that dyslipidemia exists in our type 2 diabetic population with greater TC in hypertensive type 2 diabetic females compared with hypertensive type 2 diabetic males. This suggests that hypertensive type 2 diabetic females are exposed more profoundly to risk factors including atherogenic dyslipidemia compared with males.

scholarly journals Effect of atorvastatin on oxidative stress parameters and lipid profile in type 2 diabetic patients

2020 ◽  
Vol 7 (2) ◽  
Author(s):  
Najah RH ◽  
Mohammad AAH ◽  
Ammar RMR
Keyword(s):  
Oxidative Stress ◽  
Lipid Profile ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Oxidative Stress Parameters ◽  
Type 2 Diabetic ◽  
Stress Parameters

Introduction: Evidence has long existed regarding the relationship between oxidative stress and diabetes. The present study was conducted to assess the effect of atorvastatin on selected oxidative stress parameters in the form of reduced glutathione (GSH), lipid peroxidation byproduct malondialdehyde (MDA) levels, glutathione –S- transferase (GST) activity and catalase (CAT) activity) and its effect on lipid profile (total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL), low density lipoprotein (LDL) and very low density lipoprotein (VLDL) in dyslipidaemic type 2 diabetic patients . Materials and Methods: Fifty nine dyslipidaemic type 2 diabetic patients were included in this study. Full history was taken and general examination of patients was performed. Patients studied were taking glibenclamide (an oral hypoglycaemic drug) during the study as a treatment for their disease. These patients were followed up for 60 days and divided randomly into 2 groups. Group I (n = 31): no drug was given and served as dyslipidaemic diabetic control. Group II (n = 28): received atorvastatin tablets 20 mg once daily at night. Of the 59 Fifty patients, 46 completed the study while 13 patients withdrew. This is due to non compliance of the patients. Blood samples were drawn from the patients at the beginning and after 60 days of follow up between 8:30 & 10:30 am after at least 12-14 hours fast. Fasting blood glucose, lipid profile, selected oxidative stress parameters (GSH, MDA levels, GST and CAT activities) were measured. Renal and hepatic functions were also assessed. Results: This study revealed that: atorvastatin treatment increased serum GSH; reduced MDA levels significantly while did not significantly affect CAT and GST activity. In atorvastatin treatment, TC, TG, LDL and VLDL decreased significantly while HDL increased significantly. Conclusion: There was insignificant correlations between atorvastatin induced changes in the oxidation markers and the observed changes of the lipid profile.

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